Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Community-Acquired Infections D017714 8 associated lipids
Pelvic Pain D017699 7 associated lipids
Aortic Aneurysm, Abdominal D017544 5 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Neisseriaceae Infections D016870 3 associated lipids
Ureaplasma Infections D016869 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

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What genes are associated with Azithramycine?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Tkadlec J et al. Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLS(B) Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment. 2015 Microb. Drug Resist. pmid:25826283
Weinberger M et al. Diffuse panbronchiolitis in a 10-year-old boy. 2015 Pediatr. Pulmonol. pmid:25824890
Dave J and Sefton A Enteric fever and its impact on returning travellers. 2015 Int Health pmid:25808163
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Kerani RP et al. Gonorrhea treatment practices in the STD Surveillance Network, 2010-2012. 2015 Sex Transm Dis pmid:25504294
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Hocking JS et al. Treatment of rectal chlamydia infection may be more complicated than we originally thought. 2015 J. Antimicrob. Chemother. pmid:25480490
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Bauquier JR et al. Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays. 2015 J. Vet. Pharmacol. Ther. pmid:25407884
Kirkcaldy RD et al. Analysis of Neisseria gonorrhoeae azithromycin susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013. 2015 Antimicrob. Agents Chemother. pmid:25451056
Jeong BH et al. Intermittent antibiotic therapy for nodular bronchiectatic Mycobacterium avium complex lung disease. 2015 Am. J. Respir. Crit. Care Med. pmid:25393520
Radhakrishnan SV et al. Preventive azithromycin treatment reduces noninfectious lung injury and acute graft-versus-host disease in a murine model of allogeneic hematopoietic cell transplantation. 2015 Biol. Blood Marrow Transplant. pmid:25445642
Chi KH et al. Molecular differentiation of Treponema pallidum subspecies in skin ulceration clinically suspected as yaws in Vanuatu using real-time multiplex PCR and serological methods. 2015 Am. J. Trop. Med. Hyg. pmid:25404075
Nonaka L et al. Novel macrolide-resistance genes, mef(C) and mph(G), carried by plasmids from Vibrio and Photobacterium isolated from sediment and seawater of a coastal aquaculture site. 2015 Lett. Appl. Microbiol. pmid:25765542
Cocco G and Jerie P Torsades de pointes induced by the concomitant use of ivabradine and azithromycin: an unexpected dangerous interaction. 2015 Cardiovasc. Toxicol. pmid:25158669
Kashkouli MB et al. Oral azithromycin versus doxycycline in meibomian gland dysfunction: a randomised double-masked open-label clinical trial. 2015 Br J Ophthalmol pmid:25138765
Gundevia Z et al. Positivity at test of cure following first-line treatment for genital Mycoplasma genitalium: follow-up of a clinical cohort. 2015 Sex Transm Infect pmid:25096921
Hussain S et al. N-acetylcysteine and azithromycin affect the innate immune response in cystic fibrosis bronchial epithelial cells in vitro. 2015 Exp. Lung Res. pmid:25058850
Lai PC et al. Azithromycin enhances phagocytic killing of Aggregatibacter actinomycetemcomitans Y4 by human neutrophils. 2015 J. Periodontol. pmid:25186779
Martinez MA et al. Clinical and histologic features of azithromycin-induced liver injury. 2015 Clin. Gastroenterol. Hepatol. pmid:25111234
Ratjen F et al. Response to letter. 2015 Pediatr. Pulmonol. pmid:24700677
Tayob N and Murray S Nonparametric tests of treatment effect based on combined endpoints for mortality and recurrent events. 2015 Biostatistics pmid:24719282
Lahra MM and Enriquez RP Australian Gonococcal Surveillance Programme, 1 April to 30 June 2015. 2015 Commun Dis Intell Q Rep pmid:26779739
Salman S et al. Pharmacokinetics of Transfer of Azithromycin into the Breast Milk of African Mothers. 2015 Antimicrob. Agents Chemother. pmid:26711756
Geisler WM et al. Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection. 2015 N. Engl. J. Med. pmid:26699167
Smith C et al. Use and safety of azithromycin in neonates: a systematic review. 2015 BMJ Open pmid:26656010
Solomon AW et al. Trachoma and Yaws: Common Ground? 2015 PLoS Negl Trop Dis pmid:26633176
Ruíz del Olmo I et al. [Severe neutropenia as side effect of medical treatment in nontuberculous mycobacterial adenitis]. 2015 Rev Chilena Infectol pmid:26633119
Woodruff AE et al. Azithromycin-Induced, Biopsy-Proven Acute Interstitial Nephritis in an Adult Successfully Treated with Low-Dose Corticosteroids. 2015 Pharmacotherapy pmid:26598102
Jensen EA et al. Evidence-Based Pharmacologic Therapies for Prevention of Bronchopulmonary Dysplasia: Application of the Grading of Recommendations Assessment, Development, and Evaluation Methodology. 2015 Clin Perinatol pmid:26593077
Fan WG et al. Male Paraurethral Duct Infection and Subsequent Paraurethral Duct Dilation. 2015 Chin. Med. J. pmid:26608997
Wise J Early use of azithromycin may reduce severity of wheezing, study finds. 2015 BMJ pmid:26582751
Yan M et al. Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. 2015 Eur J Med Chem pmid:26402728
García-Quintanilla M et al. Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii. 2015 Int. J. Antimicrob. Agents pmid:26391380
Hare KM et al. Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo. 2015 Eur. J. Clin. Microbiol. Infect. Dis. pmid:26363637
Unemo M Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge. 2015 BMC Infect. Dis. pmid:26293005
Trembizki E et al. Direct real-time PCR-based detection of Neisseria gonorrhoeae 23S rRNA mutations associated with azithromycin resistance. 2015 J. Antimicrob. Chemother. pmid:26338048
Lin L et al. Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens. 2015 EBioMedicine pmid:26288841
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Hancock RE Rethinking the Antibiotic Discovery Paradigm. 2015 EBioMedicine pmid:26288830
Xue J et al. Occurrence of high-level azithromycin-resistant Neisseria gonorrhoeae isolates in China. 2015 J. Antimicrob. Chemother. pmid:26316384
Jensen JS and Bradshaw C Management of Mycoplasma genitalium infections - can we hit a moving target? 2015 BMC Infect. Dis. pmid:26286546
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Marks M et al. Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. 2015 PLoS Negl Trop Dis pmid:26241484
Stellari F et al. In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa and its modulation by azithromycin. 2015 J Transl Med pmid:26239109
Taylor SP et al. Azithromycin for the Prevention of COPD Exacerbations: The Good, Bad, and Ugly. 2015 Am. J. Med. pmid:26291905
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Kong FY and Hocking JS Treatment challenges for urogenital and anorectal Chlamydia trachomatis. 2015 BMC Infect. Dis. pmid:26220080
Vandermeulen E et al. BAL neutrophilia in azithromycin-treated lung transplant recipients: Clinical significance. 2015 Transpl. Immunol. pmid:26168736
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Kirby A Comment on: Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3 clinical trial data. 2015 J. Antimicrob. Chemother. pmid:26157112
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Furfaro LL et al. In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin. 2015 Int. J. Antimicrob. Agents pmid:26141231
Teo A et al. Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission. 2015 Malar. J. pmid:26006260
Farber FR et al. Atraumatic splenic rupture from Babesia: A disease of the otherwise healthy patient. 2015 Ticks Tick Borne Dis pmid:26123434
Ahmed N et al. Donovanosis causing lymphadenitis, mastoiditis, and meningitis in a child. 2015 Lancet pmid:26122163
Barni S et al. Azithromycin is more allergenic than clarithromycin in children with suspected hypersensitivity reaction to macrolides. 2015 J Investig Allergol Clin Immunol pmid:25997306
Jo KW et al. The efficacy of prophylactic azithromycin on bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. 2015 Int. J. Hematol. pmid:26121954
Earl CS et al. Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance. 2015 EMBO Mol Med pmid:25995336
Koepke R et al. Widespread Bordetella parapertussis Infections-Wisconsin, 2011-2012: Clinical and Epidemiologic Features and Antibiotic Use for Treatment and Prevention. 2015 Clin. Infect. Dis. pmid:26113655
Hoffmann K et al. Prevalence and resistance patterns of commensal S. aureus in community-dwelling GP patients and socio-demographic associations. A cross-sectional study in the framework of the APRES-project in Austria. 2015 BMC Infect. Dis. pmid:25981559
Qin YH et al. Transdermal application of azithromycin-amlodipine-heparin gel enhances survival of infected random ischaemic flap. 2015 J Plast Surg Hand Surg pmid:26083309
Lietman TM et al. The distribution of the prevalence of ocular chlamydial infection in communities where trachoma is disappearing. 2015 Epidemics pmid:25979286
Missov E and Cogswell R Sudden cardiac death, mitral valve prolapse, and long QT syndrome. 2015 Am. J. Med. pmid:26071830
Hauser G et al. Probiotics for standard triple Helicobacter pylori eradication: a randomized, double-blind, placebo-controlled trial. 2015 Medicine (Baltimore) pmid:25929897
Craig AP et al. Is it time to switch to doxycycline from azithromycin for treating genital chlamydial infections in women? Modelling the impact of autoinoculation from the gastrointestinal tract to the genital tract. 2015 BMC Infect. Dis. pmid:25925662
Cusini M Therapy for Gonococcal and Non-gonococcal Genital Infections is a Major Problem for Clinicians. 2015 Acta Derm. Venereol. pmid:25917593
Harding-Esch E et al. Costs of testing for ocular Chlamydia trachomatis infection compared to mass drug administration for trachoma in the Gambia: application of results from the PRET study. 2015 PLoS Negl Trop Dis pmid:25901349
Rudoler N et al. Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. 2015 Parasit Vectors pmid:25888870
Chandra R et al. Comparison of azithromycin plus chloroquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in children in Africa: a randomized, open-label study. 2015 Malar. J. pmid:25881046
Brusselle GG Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? 2015 Thorax pmid:25870311
Gose SO et al. Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California. 2015 Sex Transm Dis pmid:25868141
Franco M et al. Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy. 2015 Transpl Infect Dis pmid:25846671
Hung AM and Hakim RM Dialysate and serum potassium in hemodialysis. 2015 Am. J. Kidney Dis. pmid:25828570