Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Lin C and Lietman T | Trachoma control: is azithromycin the answer for trichiasis too? | 2007 | Arch. Ophthalmol. | pmid:17562994 |
West SK et al. | Single-dose azithromycin prevents trichiasis recurrence following surgery: randomized trial in Ethiopia. | 2006 | Arch. Ophthalmol. | pmid:16534049 |
Miyagawa T et al. | Azithromycin recovers reductions in barrier function in human gingival epithelial cells stimulated with tumor necrosis factor-α. | 2016 | Arch. Oral Biol. | pmid:26655749 |
Pawlowski KS et al. | Ototoxicity of topical azithromycin solutions in the guinea pig. | 2010 | Arch. Otolaryngol. Head Neck Surg. | pmid:20479380 |
Brook I and Hausfeld JN | Effect of telithromycin and azithromycin on nasopharyngeal bacterial flora in patients with acute maxillary sinusitis. | 2006 | Arch. Otolaryngol. Head Neck Surg. | pmid:16618915 |
Chan KH et al. | Efficacy of a new macrolide (azithromycin). For acute otitis media in the chinchilla model. | 1988 | Arch. Otolaryngol. Head Neck Surg. | pmid:2844210 |
Wu ML et al. | Enterocolonic Mycobacterium avium-intracellulare. | 2002 | Arch. Pathol. Lab. Med. | pmid:11860323 |
Fadlallah A et al. | Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis. | 2012 May-Jun | Arq Bras Oftalmol | pmid:22872200 |
Frota LC et al. | Helicobacter pylori eradication using tetracycline and furazolidone versus amoxicillin and azithromycin in lansoprazole based triple therapy: an open randomized clinical trial. | 2005 Apr-Jun | Arq Gastroenterol | pmid:16127567 |
Assmann G et al. | Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study. | 2009 | Arthritis Res. Ther. | pmid:19772564 |
St Clair EW et al. | The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. | 2001 | Arthritis Rheum. | pmid:11357896 |
Carter JD et al. | Combination antibiotics as a treatment for chronic Chlamydia-induced reactive arthritis: a double-blind, placebo-controlled, prospective trial. | 2010 | Arthritis Rheum. | pmid:20155838 |
Jiang B et al. | Quantification of azithromycin in human plasma by liquid chromatography tandem mass spectrometry: application to a bioequivalence study. | 2012 | Arzneimittelforschung | pmid:22344571 |
Wildfeuer A and Haberreiter A | Intracellular activity of azithromycin against Mycobacterium avium complex in human macrophages. | 1997 | Arzneimittelforschung | pmid:9272246 |
Sultana TA et al. | Comparative pharmacokinetic and relative bioavailability study of coated and uncoated azithromycin powder for suspension in healthy Bangladeshi male volunteers. | 2011 | Arzneimittelforschung | pmid:22164968 |
Koytchev R et al. | Assessment of the bioequivalence of different formulations containing azithromycin (tablets and suspension). | 2004 | Arzneimittelforschung | pmid:15497663 |
Setiawati E et al. | Bioequivalence study of two azithromycin formulations in healthy subjects. | 2009 | Arzneimittelforschung | pmid:19856795 |
Afghani T et al. | Preventing Long-Term Ocular Complications of Trachoma With Topical Azithromycin: A 3-Year Follow-up Study. | 2017 Jan-Feb | Asia Pac J Ophthalmol (Phila) | pmid:28161923 |
Magri V et al. | Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis: retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction. | 2011 | Asian J. Androl. | pmid:21765442 |
Karanth SS et al. | A rare case of community acquired Burkholderia cepacia infection presenting as pyopneumothorax in an immunocompetent individual. | 2012 | Asian Pac J Trop Biomed | pmid:23569891 |
Jirapongsananuruk O et al. | Recurrent Campylobacter lari bacteremia in X-linked agammaglobulinemia: a case report and review. | 2006 Jun-Sep | Asian Pac. J. Allergy Immunol. | pmid:17136884 |
Llor Vilà C | [I'd rather give azithromycin for three days. That way the patient complies]. | 2003 | Aten Primaria | pmid:12735886 |
Schriever C et al. | Red wine, resveratrol, Chlamydia pneumoniae and the French connection. | 2003 | Atherosclerosis | pmid:14644410 |
Hotomi M et al. | Nontypeable Haemophilus influenzae isolated from intractable acute otitis media internalized into cultured human epithelial cells. | 2010 | Auris Nasus Larynx | pmid:19505782 |
Shimizu T and Suzaki H | Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan. | 2016 | Auris Nasus Larynx | pmid:26441370 |
Hirsch R | Periodontal healing and bone regeneration in response to azithromycin. | 2010 | Aust Dent J | pmid:20604763 |
O'Rourke VJ | Azithromycin as an adjunct to non-surgical periodontal therapy: a systematic review. | 2017 | Aust Dent J | pmid:27492140 |
Higgins TJ | Azithromycin. | 2010 | Aust Dent J | pmid:21133950 |
Saleh A et al. | Comparison of adjunctive azithromycin and amoxicillin/metronidazole for patients with chronic periodontitis: preliminary randomized control trial. | 2016 | Aust Dent J | pmid:26836781 |
Fujise O et al. | Regenerative effect of azithromycin on periodontitis with different levels of gingival inflammation: three case reports. | 2014 | Aust Dent J | pmid:24861402 |
Pradeep AR et al. | Local drug delivery of 0.5% azithromycin in the treatment of chronic periodontitis among smokers. | 2013 | Aust Dent J | pmid:23441790 |
Gomi K et al. | Full-mouth scaling and root planing combined with azithromycin to treat peri-implantitis. | 2015 | Aust Dent J | pmid:25439282 |
Bowden FJ and Skov SJ | Treating donovanosis. | 1999 | Aust Fam Physician | pmid:10615749 |
Heal C et al. | Genital Chlamydia trachomatis infection - a study of general practice management in northern Queensland. | 2012 | Aust Fam Physician | pmid:22762073 |
Pereira A et al. | Acute onset of widespread pustular eruption. | 2015 | Aust Fam Physician | pmid:26209988 |
Redmond AM et al. | Epidemic syphilis exhibits diverse manifestations. | 2007 | Aust Fam Physician | pmid:17885710 |
SendaÄŸ F et al. | Single dose oral azithromycin versus seven day doxycycline in the treatment of non-gonococcal mucopurulent endocervicitis. | 2000 | Aust N Z J Obstet Gynaecol | pmid:10870778 |
van der Griend B et al. | An uncommon cause of a destructive vulval lesion. | 2001 | Aust N Z J Obstet Gynaecol | pmid:11787928 |
Tsubouchi K et al. | Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4. | 2017 | Autophagy | pmid:28613983 |
Luo H et al. | Identification of ribosomal RNA methyltransferase gene ermF in Riemerella anatipestifer. | 2015 | Avian Pathol. | pmid:25690020 |
Juricic D et al. | Vanishing bile duct syndrome associated with azithromycin in a 62-year-old man. | 2010 | Basic Clin. Pharmacol. Toxicol. | pmid:19906050 |
Srivastava P et al. | Azithromycin treatment modulates cytokine production in Chlamydia trachomatis infected women. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19389045 |
Mary N and Mahmood TA | Preventing infective complications relating to induced abortion. | 2010 | Best Pract Res Clin Obstet Gynaecol | pmid:20542471 |
Legrand T et al. | An optimal LC-MS/MS method for determination of azithromycin in white blood cells: application to pediatric samples. | 2014 | Bioanalysis | pmid:25383741 |
Cigana C et al. | Anti-inflammatory effects of azithromycin in cystic fibrosis airway epithelial cells. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17045242 |
Berquand A et al. | Real-time imaging of drug-membrane interactions by atomic force microscopy. | 2004 | Biochim. Biophys. Acta | pmid:15328052 |
Fa N et al. | Decrease of elastic moduli of DOPC bilayers induced by a macrolide antibiotic, azithromycin. | 2007 | Biochim. Biophys. Acta | pmid:17537401 |
Kitsiouli E et al. | Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells. | 2015 | Biochim. Biophys. Acta | pmid:25791017 |
Wu Y et al. | Studies on electrochemical oxidation of azithromycin and its interaction with bovine serum albumin. | 2004 | Bioelectrochemistry | pmid:15219252 |
Saini H et al. | Antimicrobial and antifouling efficacy of urinary catheters impregnated with a combination of macrolide and fluoroquinolone antibiotics against Pseudomonas aeruginosa. | 2016 | Biofouling | pmid:26982572 |
Radhakrishnan SV et al. | Preventive azithromycin treatment reduces noninfectious lung injury and acute graft-versus-host disease in a murine model of allogeneic hematopoietic cell transplantation. | 2015 | Biol. Blood Marrow Transplant. | pmid:25445642 |
Williams KM et al. | Fluticasone, Azithromycin, and Montelukast Treatment for New-Onset Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation. | 2016 | Biol. Blood Marrow Transplant. | pmid:26475726 |
Yadav H et al. | Azithromycin for the Treatment of Obliterative Bronchiolitis after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. | 2016 | Biol. Blood Marrow Transplant. | pmid:27575542 |
Asano N et al. | Limited Azithromycin Localization to Rabbit Meibomian Glands Revealed by LC-MS-Based Bioanalysis and DESI Imaging. | 2017 | Biol. Pharm. Bull. | pmid:28867744 |
Togami K et al. | Subcellular distribution of azithromycin and clarithromycin in rat alveolar macrophages (NR8383) in vitro. | 2013 | Biol. Pharm. Bull. | pmid:23995662 |
Gilbert D and Gerber MA | Regarding "antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders". | 2005 | Biol. Psychiatry | pmid:16242119 |
Budman C et al. | Regarding "antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders". | 2005 | Biol. Psychiatry | pmid:16242121 |
Snider LA et al. | Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. | 2005 | Biol. Psychiatry | pmid:15820236 |
Toti US et al. | Targeted delivery of antibiotics to intracellular chlamydial infections using PLGA nanoparticles. | 2011 | Biomaterials | pmid:21652065 |
Rivulgo V et al. | Comparative plasma exposure and lung distribution of two human use commercial azithromycin formulations assessed in murine model: a preclinical study. | 2013 | Biomed Res Int | pmid:24073402 |
Liu F et al. | Sensitive liquid chromatography/mass spectrometry assay for the quantification of azithromycin in human plasma. | 2007 | Biomed. Chromatogr. | pmid:17604364 |
Sharma K and Mullangi R | A concise review of HPLC, LC-MS and LC-MS/MS methods for determination of azithromycin in various biological matrices. | 2013 | Biomed. Chromatogr. | pmid:23553351 |
Ben-Eltriki M et al. | A liquid chromatography-mass spectrometric method for the quantification of azithromycin in human plasma. | 2013 | Biomed. Chromatogr. | pmid:23494651 |
Song Z and Wang C | Ultrasensitive assay of azithromycin in medicine and bio-fluids based on its enhanced luminol-H(2)O(2) chemiluminescence reaction using flow injection technique. | 2003 | Bioorg. Med. Chem. | pmid:14642581 |
Miura T et al. | Novel azalides derived from 16-membered macrolides. Part II: Isolation of the linear 9-formylcarboxylic acid and its sequential macrocyclization with an amino alcohol or an azidoamine. | 2008 | Bioorg. Med. Chem. | pmid:18986810 |
Jakopović IP et al. | Synthesis and properties of macrolones characterized by two ether bonds in the linker. | 2010 | Bioorg. Med. Chem. | pmid:20688524 |
Kapić S et al. | 6-Alkylquinolone-3-carboxylic acid tethered to macrolides synthesis and antimicrobial profile. | 2010 | Bioorg. Med. Chem. | pmid:20673633 |
Pavlović D and Mutak S | Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. | 2016 | Bioorg. Med. Chem. | pmid:26860929 |
Kapić S et al. | Synthesis and activity of new macrolones: conjugates between 6(7)-(2'-aminoethyl)-amino-1-cyclopropyl-3-carboxylic acid (2'-hydroxyethyl) amides and 4″-propenoyl-azithromycin. | 2011 | Bioorg. Med. Chem. | pmid:22041174 |
MaraÄić S et al. | 1,2,3-Triazole pharmacophore-based benzofused nitrogen/sulfur heterocycles with potential anti-Moraxella catarrhalis activity. | 2015 | Bioorg. Med. Chem. | pmid:26578325 |
Hutinec A et al. | An automated, polymer-assisted strategy for the preparation of urea and thiourea derivatives of 15-membered azalides as potential antimalarial chemotherapeutics. | 2011 | Bioorg. Med. Chem. | pmid:21316974 |
Washington AZ et al. | Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel. | 2015 | Bioorg. Med. Chem. | pmid:26037612 |
Wang Y et al. | Synthesis and antibacterial activity of novel 4″-O-(1-aralkyl-1,2,3-triazol-4-methyl-carbamoyl) azithromycin analogs. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28655423 |
Zhang L et al. | Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23937982 |
Ma S et al. | Synthesis and antibacterial activity of 4'',11-di-O-arylalkylcarbamoyl azithromycin derivatives. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19232491 |
Denis A and Agouridas C | Synthesis of 6-O-methyl-azithromycin and its ketolide analogue via Beckmann rearrangement of 9(E)-6-O-methyl-erythromycin oxime. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9873555 |
Cheng H et al. | Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent Gram-positive and Gram-negative antibacterial agents. | 2002 | Bioorg. Med. Chem. Lett. | pmid:12161150 |
Ito S et al. | Effect of macrolide antibiotics on uptake of digoxin into rat liver. | 2007 | Biopharm Drug Dispos | pmid:17253595 |
Fuksa L et al. | Amiodarone modulates pharmacokinetics of low-dose methotrexate in rats. | 2008 | Biopharm Drug Dispos | pmid:18548509 |
Davila D et al. | Pharmacokinetics of azithromycin after single oral dosing of experimental animals. | 1991 | Biopharm Drug Dispos | pmid:1657238 |
Togami K et al. | Distribution characteristics of clarithromycin and azithromycin, macrolide antimicrobial agents used for treatment of respiratory infections, in lung epithelial lining fluid and alveolar macrophages. | 2011 | Biopharm Drug Dispos | pmid:21812004 |
Najib NM et al. | Bioequivalence assessment of Azomycin (Julphar, UAE) as compared to Zithromax (Pfizer, USA)--two brands of azithromycin--in healthy human volunteers. | 2001 | Biopharm Drug Dispos | pmid:11745903 |
Tayob N and Murray S | Nonparametric tests of treatment effect based on combined endpoints for mortality and recurrent events. | 2015 | Biostatistics | pmid:24719282 |
Cameron ST | Patient-delivered partner therapy for chlamydia: a realistic public health measure in the UK. | 2009 | BJOG | pmid:19187365 |
Melvin L et al. | Preferred strategies of men and women for managing chlamydial infection. | 2009 | BJOG | pmid:19187367 |
Cameron ST et al. | Expedited partner therapy for Chlamydia trachomatis at the community pharmacy. | 2010 | BJOG | pmid:20497415 |
Cameron ST et al. | Willingness of gynaecologists, doctors in family planning, GPs, practice nurses and pharmacists to adopt novel interventions for treating sexual partners of women with chlamydia. | 2007 | BJOG | pmid:17877773 |
Heikkinen T et al. | The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. | 2000 | BJOG | pmid:10847234 |
Muralidharan V and Striepen B | Teaching old drugs new tricks to stop malaria invasion in its tracks. | 2015 | BMC Biol. | pmid:26349580 |
Wilson DW et al. | Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum. | 2015 | BMC Biol. | pmid:26187647 |
van Bijnen EM et al. | Primary care treatment guidelines for skin infections in Europe: congruence with antimicrobial resistance found in commensal Staphylococcus aureus in the community. | 2014 | BMC Fam Pract | pmid:25413920 |
Silva FM et al. | Short-term triple therapy with azithromycin for Helicobacter pylori eradication: low cost, high compliance, but low efficacy. | 2008 | BMC Gastroenterol | pmid:18510773 |
Marumo S et al. | Effectiveness of azithromycin in aspiration pneumonia: a prospective observational study. | 2014 | BMC Infect. Dis. | pmid:25491126 |
Dukers-Muijrers NH et al. | Design of the FemCure study: prospective multicentre study on the transmission of genital and extra-genital Chlamydia trachomatis infections in women receiving routine care. | 2016 | BMC Infect. Dis. | pmid:27502928 |
Yuan ZF et al. | Clinically mild encephalitis/encephalopathy with a reversible splenial lesion associated with Mycoplasma pneumoniae infection. | 2016 | BMC Infect. Dis. | pmid:27230114 |
Ab Rahman N et al. | Antibiotic prescribing in public and private practice: a cross-sectional study in primary care clinics in Malaysia. | 2016 | BMC Infect. Dis. | pmid:27188538 |
Kadota T et al. | Analysis of drug treatment outcome in clarithromycin-resistant Mycobacterium avium complex lung disease. | 2016 | BMC Infect. Dis. | pmid:26818764 |
Cole MJ et al. | Overall Low Extended-Spectrum Cephalosporin Resistance but high Azithromycin Resistance in Neisseria gonorrhoeae in 24 European Countries, 2015. | 2017 | BMC Infect. Dis. | pmid:28893203 |
Unemo M | Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge. | 2015 | BMC Infect. Dis. | pmid:26293005 |
Hoffmann K et al. | Prevalence and resistance patterns of commensal S. aureus in community-dwelling GP patients and socio-demographic associations. A cross-sectional study in the framework of the APRES-project in Austria. | 2015 | BMC Infect. Dis. | pmid:25981559 |