Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Gerber JS and Zaoutis TE | Azithromycin Prophylaxis for Laboring Mothers. | 2017 | Pediatrics | pmid:28130431 |
Oluwalana C et al. | Azithromycin in Labor Lowers Clinical Infections in Mothers and Newborns: A Double-Blind Trial. | 2017 | Pediatrics | pmid:28130432 |
Shan LS et al. | Effects of methylprednisolone or immunoglobulin when added to standard treatment with intravenous azithromycin for refractory Mycoplasma pneumoniae pneumonia in children. | 2017 | World J Pediatr | pmid:28130749 |
Lahra MM et al. | Treatment guidelines after an outbreak of azithromycin-resistant Neisseria gonorrhoeae in South Australia. | 2017 | Lancet Infect Dis | pmid:28134103 |
Massip C et al. | Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump. | 2017 | J. Antimicrob. Chemother. | pmid:28137939 |
Fohner AE et al. | PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics. | 2017 | Pharmacogenet. Genomics | pmid:28146011 |
Mohammed H et al. | First line dual therapy for gonorrhoea to limit the spread of antimicrobial resistance. | 2017 | BMJ | pmid:28153820 |
Ullah S et al. | Creatinine-based non-phospholipid vesicular carrier for improved oral bioavailability of Azithromycin. | 2017 | Drug Dev Ind Pharm | pmid:28157445 |
Braam JF et al. | High prevalence of the A2058T macrolide resistance-associated mutation in Mycoplasma genitalium strains from the Netherlands. | 2017 | J. Antimicrob. Chemother. | pmid:28158595 |
Giguère S | Treatment of Infections Caused by Rhodococcus equi. | 2017 | Vet. Clin. North Am. Equine Pract. | pmid:28161038 |
Afghani T et al. | Preventing Long-Term Ocular Complications of Trachoma With Topical Azithromycin: A 3-Year Follow-up Study. | 2017 Jan-Feb | Asia Pac J Ophthalmol (Phila) | pmid:28161923 |
Ginouvès M et al. | In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28167598 |
Boggess KA et al. | Risk Factors for Postcesarean Maternal Infection in a Trial of Extended-Spectrum Antibiotic Prophylaxis. | 2017 | Obstet Gynecol | pmid:28178058 |
Thakur SD et al. | Resistance to Ceftriaxone and Azithromycin in Neisseria gonorrhoeae Isolates From 7 Countries of South America and the Caribbean: 2010-2011. | 2017 | Sex Transm Dis | pmid:28178114 |
Ivanová L et al. | Estimation of amount of selected pharmaceuticals sorbed onto digested sludge from wastewater treatment plant Bratislava-Petržalka. | 2017 | Environ. Res. | pmid:28183039 |
González-Beiras C et al. | Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28193743 |
Ramappa M et al. | Successful Medical Management of Presumptive Pythium insidiosum Keratitis. | 2017 | Cornea | pmid:28207431 |
Teng F et al. | In vitro characterization of pH-sensitive azithromycin-loaded methoxy poly (ethylene glycol)-block-poly (aspartic acid-graft-imidazole) micelles. | 2017 | J Colloid Interface Sci | pmid:28209540 |
Zhang M et al. | Electrophysiologic Studies on the Risks and Potential Mechanism Underlying the Proarrhythmic Nature of Azithromycin. | 2017 | Cardiovasc. Toxicol. | pmid:28213753 |
Shmarina G et al. | Steady-State Therapy with Azithromycin or Low-Dose Prednisolone in Paediatric Cystic Fibrosis Patients: Inflammatory Markers and Disease Progression. | 2017 | Int. Arch. Allergy Immunol. | pmid:28219060 |
Sharpton R et al. | Do cystic fibrosis patients on azithromycin need electrocardiogram monitoring? | 2017 | Pulm Pharmacol Ther | pmid:28219728 |
Wiesenfeld HC | Screening for Chlamydia trachomatis Infections in Women. | 2017 | N. Engl. J. Med. | pmid:28225683 |
Demczuk W et al. | Neisseria gonorrhoeae Sequence Typing for Antimicrobial Resistance, a Novel Antimicrobial Resistance Multilocus Typing Scheme for Tracking Global Dissemination of N. gonorrhoeae Strains. | 2017 | J. Clin. Microbiol. | pmid:28228492 |
Allan RN et al. | Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms. | 2017 | Nitric Oxide | pmid:28235635 |
Stieler Stewart AL et al. | Effects of clarithromycin, azithromycin and rifampicin on terbutaline-induced sweating in foals. | 2017 | Equine Vet. J. | pmid:28238211 |
Mathew A et al. | Antimicrobial and Immunomodulatory Surface-Functionalized Electrospun Membranes for Bone Regeneration. | 2017 | Adv Healthc Mater | pmid:28240815 |
Salman S et al. | Optimal Antimalarial Dose Regimens for Sulfadoxine-Pyrimethamine with or without Azithromycin in Pregnancy Based on Population Pharmacokinetic Modeling. | 2017 | Antimicrob. Agents Chemother. | pmid:28242669 |
Mei J et al. | Implications of intrapartum azithromycin on neonatal microbiota. | 2017 | Lancet Infect Dis | pmid:28244378 |
Garcia-Vidal C et al. | Levofloxacin versus azithromycin for treating legionella pneumonia: a propensity score analysis. | 2017 | Clin. Microbiol. Infect. | pmid:28267637 |
Ito S et al. | Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities. | 2017 | Sex Transm Dis | pmid:28282645 |
Leeyaphan C et al. | Treatment Outcomes for Rectal Lymphogranuloma Venereum in Men Who Have Sex with Men Using Doxycycline, Azithromycin, or Both: A Review of Clinical Cases. | 2017 | Sex Transm Dis | pmid:28282652 |
Çelik Payçu DG and Büyükbaba Boral Ö | [Effects of azithromycin and Chlorella vulgaris treatment on certain cytokine values and NK cell activity in an acute murine toxoplasmosis model]. | 2017 | Mikrobiyol Bul | pmid:28283010 |
Ishiguro N et al. | Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients. | 2017 | PLoS ONE | pmid:28288170 |
Halhal B et al. | Pertussis Outbreak Among Soldiers During Basic Training: The Need for Updated Protocols. | 2017 | Mil Med | pmid:28291499 |
Checa R et al. | Efficacy, safety and tolerance of imidocarb dipropionate versus atovaquone or buparvaquone plus azithromycin used to treat sick dogs naturally infected with the Babesia microti-like piroplasm. | 2017 | Parasit Vectors | pmid:28292316 |
Emerging risk of untreatable gonorrhea and what to do about it. | 2017 | Can Fam Physician | pmid:28292798 | |
Girard AE et al. | Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. | 1987 | Antimicrob. Agents Chemother. | pmid:2830841 |
Thompson CN et al. | Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance: An Individual Patient Data Analysis of 2092 Participants Enrolled into 4 Randomized, Controlled Trials in Nepal. | 2017 | Clin. Infect. Dis. | pmid:28329181 |
Watson JR et al. | Healthcare Claims Data: An Underutilized Tool for Pediatric Outpatient Antimicrobial Stewardship. | 2017 | Clin. Infect. Dis. | pmid:28329388 |
Eyre DW et al. | WGS to predict antibiotic MICs for Neisseria gonorrhoeae. | 2017 | J. Antimicrob. Chemother. | pmid:28333355 |
Kong FY et al. | Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men. | 2017 | PLoS ONE | pmid:28350806 |
Bojang E et al. | Short-term increase in prevalence of nasopharyngeal carriage of macrolide-resistant Staphylococcus aureus following mass drug administration with azithromycin for trachoma control. | 2017 | BMC Microbiol. | pmid:28351345 |
Murphy TK et al. | A Double-Blind Randomized Placebo-Controlled Pilot Study of Azithromycin in Youth with Acute-Onset Obsessive-Compulsive Disorder. | 2017 | J Child Adolesc Psychopharmacol | pmid:28358599 |
Tung NT et al. | Formulation and biopharmaceutical evaluation of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. | 2018 | Eur J Pharm Biopharm | pmid:28359878 |
White AC | Treatment of Early Syphilis in HIV: What Do We Really Know? | 2017 | Clin. Infect. Dis. | pmid:28362951 |
Vandooren J et al. | Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. | 2017 | PLoS ONE | pmid:28369077 |
Chang HR and Pechère JC | In vitro effects of four macrolides (roxithromycin, spiramycin, azithromycin [CP-62,993], and A-56268) on Toxoplasma gondii. | 1988 | Antimicrob. Agents Chemother. | pmid:2837140 |
Wind CM et al. | A Case-Control Study of Molecular Epidemiology in Relation to Azithromycin Resistance in Neisseria gonorrhoeae Isolates Collected in Amsterdam, the Netherlands, between 2008 and 2015. | 2017 | Antimicrob. Agents Chemother. | pmid:28373191 |
Ma Q et al. | A Waterborne Outbreak of Shigella sonnei with Resistance to Azithromycin and Third-Generation Cephalosporins in China in 2015. | 2017 | Antimicrob. Agents Chemother. | pmid:28373192 |
Husein-ElAhmed H | Single nontender ulcer on the glans. | 2017 | J Fam Pract | pmid:28375399 |
Szczepanska B et al. | Prevalence and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolated from children and environmental sources in urban and suburban areas. | 2017 | BMC Microbiol. | pmid:28376713 |
Lahra MM and Enriquez RP | Australian Gonococcal Surveillance Programme, 1 July to 30 September 2016
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El Hennawi DED et al. | Management of recurrent tonsillitis in children. | Am J Otolaryngol | pmid:28385329 | |
Barry AL et al. | In vitro activities of azithromycin (CP 62,993), clarithromycin (A-56268; TE-031), erythromycin, roxithromycin, and clindamycin. | 1988 | Antimicrob. Agents Chemother. | pmid:2840016 |
Araujo FG et al. | Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii. | 1988 | Antimicrob. Agents Chemother. | pmid:2840017 |
Doan T et al. | Gut Microbial Diversity in Antibiotic-Naive Children After Systemic Antibiotic Exposure: A Randomized Controlled Trial. | 2017 | Clin. Infect. Dis. | pmid:28402408 |
Venekamp RP and Schilder AGM | Clinical failure is more common in young children with acute otitis media who receive a short course of antibiotics compared with standard duration. | 2017 | Evid Based Med | pmid:28404603 |
Kneidinger N et al. | Lung volumes predict survival in patients with chronic lung allograft dysfunction. | 2017 | Eur. Respir. J. | pmid:28404648 |
Yang Z et al. | Azithromycin Causes a Novel Proarrhythmic Syndrome. | 2017 | Circ Arrhythm Electrophysiol | pmid:28408648 |
Koštrun S et al. | Around the macrolide - Impact of 3D structure of macrocycles on lipophilicity and cellular accumulation. | 2017 | Eur J Med Chem | pmid:28410508 |
Menzel M et al. | Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. | 2017 | Oncotarget | pmid:28415826 |
Papp JR et al. | Azithromycin Resistance and Decreased Ceftriaxone Susceptibility in Neisseria gonorrhoeae, Hawaii, USA. | 2017 | Emerging Infect. Dis. | pmid:28418303 |
Pavlova A et al. | Toward the rational design of macrolide antibiotics to combat resistance. | 2017 | Chem Biol Drug Des | pmid:28419786 |
Trifirò G et al. | Use of azithromycin and risk of ventricular arrhythmia. | 2017 | CMAJ | pmid:28420680 |
Quinn KL et al. | Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. | 2017 | Drug Saf | pmid:28421551 |
Rutenberg D et al. | Efficacy of Tulathromycin for the Treatment of Foals with Mild to Moderate Bronchopneumonia. | 2017 | J. Vet. Intern. Med. | pmid:28421633 |
Snelling PJ et al. | Rhabdomyolysis Complicating Typhoid Fever in A Child and Review of the Literature. | 2017 | Pediatr. Infect. Dis. J. | pmid:28430751 |
Foerster S et al. | A new rapid resazurin-based microdilution assay for antimicrobial susceptibility testing of Neisseria gonorrhoeae. | 2017 | J. Antimicrob. Chemother. | pmid:28431096 |
Park HS et al. | Subantibiotic dose of azithromycin attenuates alveolar bone destruction and improves trabecular microarchitectures in a rat model of experimental periodontitis: A study using micro-computed tomography. | 2017 | Int. Immunopharmacol. | pmid:28432937 |
Yourassowsky E et al. | Rate of bactericidal activity for Branhamella catarrhalis of a new macrolide, CP-62,993, compared with that of amoxicillin-clavulanic acid. | 1988 | Chemotherapy | pmid:2843324 |
Savaris RF et al. | Antibiotic therapy for pelvic inflammatory disease. | 2017 | Cochrane Database Syst Rev | pmid:28436019 |
Veskitkul J et al. | Recurrent Acute Rhinosinusitis Prevention by Azithromycin in Children with Nonallergic Rhinitis. | J Allergy Clin Immunol Pract | pmid:28438539 | |
Chan KH et al. | Efficacy of a new macrolide (azithromycin). For acute otitis media in the chinchilla model. | 1988 | Arch. Otolaryngol. Head Neck Surg. | pmid:2844210 |
van Wagensveld L et al. | [Persistent, therapy-resistant conjunctivitis: consider infection with Chlamydia trachomatis]. | 2017 | Ned Tijdschr Geneeskd | pmid:28443807 |
Shastay A | The Absence of a Drug-Disease Interaction Alert Leads to a Child's Death. | 2017 | Home Healthc Now | pmid:28471797 |
Bhargava A et al. | Scrub typhus in Uttarakhand & adjoining Uttar Pradesh: Seasonality, clinical presentations & predictors of mortality. | 2016 | Indian J. Med. Res. | pmid:28474627 |
Bermudez LE and Young LS | Activities of amikacin, roxithromycin, and azithromycin alone or in combination with tumor necrosis factor against Mycobacterium avium complex. | 1988 | Antimicrob. Agents Chemother. | pmid:2847644 |
Latif AS et al. | Antimicrobial susceptibility in isolates from five sentinel surveillance sites in Zimbabwe, 2015-2016. | 2018 | Sex Transm Infect | pmid:28476914 |
Waetzig V et al. | Neurodegenerative effects of azithromycin in differentiated PC12 cells. | 2017 | Eur. J. Pharmacol. | pmid:28479141 |
Allen GP and Harris KA | Resistance Selection in Shigella flexneri by Azithromycin, Ceftriaxone, Ciprofloxacin, Levofloxacin, and Moxifloxacin. | 2017 | Antimicrob. Agents Chemother. | pmid:28483960 |
Lopes Dos Santos Santiago G et al. | Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma. | 2017 | BMC Microbiol. | pmid:28486933 |
Houinei W et al. | Haemophilus ducreyi DNA is detectable on the skin of asymptomatic children, flies and fomites in villages of Papua New Guinea. | 2017 | PLoS Negl Trop Dis | pmid:28489855 |
Campanón-Toro MV et al. | Acute generalized exanthematous pustulosis (AGEP) induced by azithromycin. | 2017 | Contact Derm. | pmid:28497632 |
Vodstrcil LA et al. | Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS). | 2017 | PLoS ONE | pmid:28498845 |
Revello R et al. | Prediction of chorioamnionitis in cases of intraamniotic infection by ureaplasma urealyticum in women with very preterm premature rupture of membranes or preterm labour. | 2018 | J. Matern. Fetal. Neonatal. Med. | pmid:28502201 |
Wind CM et al. | Decreased Azithromycin Susceptibility of Neisseria gonorrhoeae Isolates in Patients Recently Treated with Azithromycin. | 2017 | Clin. Infect. Dis. | pmid:28510723 |
Karalius VP et al. | Bordetella parapertussis outbreak in Southeastern Minnesota and the United States, 2014. | 2017 | Medicine (Baltimore) | pmid:28514288 |
Jordan SJ et al. | Lower Levels of Cervicovaginal Tryptophan Are Associated With Natural Clearance of Chlamydia in Women. | 2017 | J. Infect. Dis. | pmid:28520912 |
Volgers C et al. | Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection. | 2017 | Inflammopharmacology | pmid:28528362 |
Lee N et al. | Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: A randomized controlled trial. | 2017 | Antiviral Res. | pmid:28535933 |
Jiang FX et al. | Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from Hefei (2014-2015): genetic characteristics of antimicrobial resistance. | 2017 | BMC Infect. Dis. | pmid:28545411 |
Katz AR et al. | Cluster of Neisseria gonorrhoeae Isolates With High-level Azithromycin Resistance and Decreased Ceftriaxone Susceptibility, Hawaii, 2016. | 2017 | Clin. Infect. Dis. | pmid:28549097 |
Ra SW et al. | Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori. | 2017 | Respir. Res. | pmid:28558695 |
Dixit S et al. | Carbamoylated azithromycin incorporated zirconia hybrid monolith for enantioseparation of acidic chiral drugs using non-aqueous capillary electrochromatography. | 2017 | J Chromatogr A | pmid:28558906 |
Sonavane AD and Rathi PM | Fitz-Hugh-Curtis syndrome. | 2017 | Indian J. Med. Res. | pmid:28574030 |
Kimura S et al. | Azithromycin Modulates 3',5'-cyclic Diguanylic Acid Signaling in Pseudomonas aeruginosa. | 2017 | J. Infect. Chemother. | pmid:28579350 |
Osman EY et al. | Analysis of Azithromycin Monohydrate as a Single or a Combinatorial Therapy in a Mouse Model of Severe Spinal Muscular Atrophy. | J Neuromuscul Dis | pmid:28598854 | |
Batteiger BE | Azithromycin Efficacy in Asymptomatic Rectal Chlamydial Infection in Men Who Have Sex With Men: A More Definitive Answer Soon? | 2017 | Sex Transm Dis | pmid:28604482 |
Smith KS et al. | Biological and Behavioral Factors Associated With Positive Chlamydia Retests. | 2017 | Sex Transm Dis | pmid:28608791 |
Bakshi SS | In reference to 'Therapeutic efficacy of azithromycin and acetylcysteine in chronic otitis media with effusion'. | 2018 | Eur Arch Otorhinolaryngol | pmid:28612316 |