Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Tkadlec J et al. | Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLS(B) Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment. | 2015 | Microb. Drug Resist. | pmid:25826283 |
Weinberger M et al. | Diffuse panbronchiolitis in a 10-year-old boy. | 2015 | Pediatr. Pulmonol. | pmid:25824890 |
Shigemura K et al. | Azithromycin resistance and its mechanism in Neisseria gonorrhoeae strains in Hyogo, Japan. | 2015 | Antimicrob. Agents Chemother. | pmid:25712352 |
Dave J and Sefton A | Enteric fever and its impact on returning travellers. | 2015 | Int Health | pmid:25808163 |
Mitjà O et al. | Mass treatment with single-dose azithromycin for yaws. | 2015 | N. Engl. J. Med. | pmid:25693010 |
Li X et al. | Preparation and characterization of azithromycin--Aerosil 200 solid dispersions with enhanced physical stability. | 2015 | Int J Pharm | pmid:25794608 |
Kazura JW | Yaws eradication--a goal finally within reach. | 2015 | N. Engl. J. Med. | pmid:25693007 |
da Cunha Filho RR et al. | Acute generalized exanthematous pustulosis by azithromycin. | 2015 | Int. J. Dermatol. | pmid:25784092 |
Eberly MD et al. | Azithromycin in early infancy and pyloric stenosis. | 2015 | Pediatrics | pmid:25687145 |
Bala M et al. | Trends of resistance to antimicrobials recommended currently and in the past for management of gonorrhea in the Apex STD center in India and comparison of antimicrobial resistance profile between 2002-2006 and 2007-2012. | 2015 | Sex Transm Dis | pmid:25763675 |
Unger HW et al. | Impact of intermittent preventive treatment in pregnancy with azithromycin-containing regimens on maternal nasopharyngeal carriage and antibiotic sensitivity of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus: a cross-sectional survey at delivery. | 2015 | J. Clin. Microbiol. | pmid:25673788 |
Waag DM | Efficacy of postexposure therapy against glanders in mice. | 2015 | Antimicrob. Agents Chemother. | pmid:25645854 |
Moi H et al. | Spontaneous Regression of Untreatable Mycoplasma genitalium Urethritis. | 2015 | Acta Derm. Venereol. | pmid:25634824 |
Ghinai R et al. | A cross-sectional study of 'yaws' in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control. | 2015 | PLoS Negl Trop Dis | pmid:25632942 |
Pettus K et al. | In vitro assessment of dual drug combinations to inhibit growth of Neisseria gonorrhoeae. | 2015 | Antimicrob. Agents Chemother. | pmid:25624328 |
Hildebrand F et al. | Efficacy of gamithromycin for the treatment of foals with mild to moderate bronchopneumonia. | 2015 | J. Vet. Intern. Med. | pmid:25619521 |
Denlinger CE | Matrix metalloproteinases and bronchiolitis obliterans: Wrapping the enigma in a riddle. | 2015 | J. Thorac. Cardiovasc. Surg. | pmid:25618413 |
Khosropour CM et al. | Efficacy of standard therapies against Ureaplasma species and persistence among men with non-gonococcal urethritis enrolled in a randomised controlled trial. | 2015 | Sex Transm Infect | pmid:25616607 |
Singh N et al. | Cat-scratch fever and lymphadenopathy in a rheumatoid arthritis patient on tocilizumab. | 2015 | J Clin Rheumatol | pmid:25539435 |
Bissessor M et al. | Macrolide resistance and azithromycin failure in a Mycoplasma genitalium-infected cohort and response of azithromycin failures to alternative antibiotic regimens. | 2015 | Clin. Infect. Dis. | pmid:25537875 |
Kerani RP et al. | Gonorrhea treatment practices in the STD Surveillance Network, 2010-2012. | 2015 | Sex Transm Dis | pmid:25504294 |
Yadav S et al. | Orofacial granulomatosis responding to weekly azithromycin pulse therapy. | 2015 | JAMA Dermatol | pmid:25494221 |
Stevens K et al. | Neisseria gonorrhoeae isolates with high-level resistance to azithromycin in Australia. | 2015 | J. Antimicrob. Chemother. | pmid:25480491 |
Hocking JS et al. | Treatment of rectal chlamydia infection may be more complicated than we originally thought. | 2015 | J. Antimicrob. Chemother. | pmid:25480490 |
Valcanis M et al. | Outbreak of locally acquired azithromycin-resistant Shigella flexneri infection in men who have sex with men. | 2015 | Pathology | pmid:25474524 |
Rihani FB | Azithromycin and congenital heart disease. | 2015 | Int J Oral Maxillofac Surg | pmid:25444481 |
Dey S et al. | In Vitro Anti-inflammatory and Immunomodulatory Effects of Ciprofloxacin or Azithromycin in Staphylococcus aureus-Stimulated Murine Macrophages are Beneficial in the Presence of Cytochalasin D. | 2015 | Inflammation | pmid:25429758 |
Fraser LA et al. | Calcium channel blocker-clarithromycin drug interaction did not increase the risk of nonvertebral fracture: a population-based study. | 2015 | Ann Pharmacother | pmid:25429094 |
Solleti VS et al. | Antimicrobial properties of liposomal azithromycin for Pseudomonas infections in cystic fibrosis patients. | 2015 | J. Antimicrob. Chemother. | pmid:25416744 |
Chou HW et al. | Risks of cardiac arrhythmia and mortality among patients using new-generation macrolides, fluoroquinolones, and β-lactam/β-lactamase inhibitors: a Taiwanese nationwide study. | 2015 | Clin. Infect. Dis. | pmid:25409476 |
Beigelman A et al. | Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. | 2015 | J. Allergy Clin. Immunol. | pmid:25458910 |
Bauquier JR et al. | Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays. | 2015 | J. Vet. Pharmacol. Ther. | pmid:25407884 |
Kirkcaldy RD et al. | Analysis of Neisseria gonorrhoeae azithromycin susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013. | 2015 | Antimicrob. Agents Chemother. | pmid:25451056 |
Radhakrishnan SV et al. | Preventive azithromycin treatment reduces noninfectious lung injury and acute graft-versus-host disease in a murine model of allogeneic hematopoietic cell transplantation. | 2015 | Biol. Blood Marrow Transplant. | pmid:25445642 |
Chi KH et al. | Molecular differentiation of Treponema pallidum subspecies in skin ulceration clinically suspected as yaws in Vanuatu using real-time multiplex PCR and serological methods. | 2015 | Am. J. Trop. Med. Hyg. | pmid:25404075 |
Vora GK et al. | Conjunctival pseudotumor caused by herpes simplex virus infection. | 2015 | JAMA Ophthalmol | pmid:25232655 |
Nonaka L et al. | Novel macrolide-resistance genes, mef(C) and mph(G), carried by plasmids from Vibrio and Photobacterium isolated from sediment and seawater of a coastal aquaculture site. | 2015 | Lett. Appl. Microbiol. | pmid:25765542 |
Cocco G and Jerie P | Torsades de pointes induced by the concomitant use of ivabradine and azithromycin: an unexpected dangerous interaction. | 2015 | Cardiovasc. Toxicol. | pmid:25158669 |
Kashkouli MB et al. | Oral azithromycin versus doxycycline in meibomian gland dysfunction: a randomised double-masked open-label clinical trial. | 2015 | Br J Ophthalmol | pmid:25138765 |
Gundevia Z et al. | Positivity at test of cure following first-line treatment for genital Mycoplasma genitalium: follow-up of a clinical cohort. | 2015 | Sex Transm Infect | pmid:25096921 |
Wan YF et al. | Azithromycin attenuates pulmonary inflammation and emphysema in smoking-induced COPD model in rats. | 2015 | Respir Care | pmid:25249648 |
Lai PC et al. | Azithromycin enhances phagocytic killing of Aggregatibacter actinomycetemcomitans Y4 by human neutrophils. | 2015 | J. Periodontol. | pmid:25186779 |
Ratjen F et al. | Response to letter. | 2015 | Pediatr. Pulmonol. | pmid:24700677 |
Quinn TC and Gaydos CA | Treatment for Chlamydia Infection--Doxycycline versus Azithromycin. | 2015 | N. Engl. J. Med. | pmid:26699174 |
Lahra MM and Enriquez RP | Australian Gonococcal Surveillance Programme, 1 April to 30 June 2015. | 2015 | Commun Dis Intell Q Rep | pmid:26779739 |
Salman S et al. | Pharmacokinetics of Transfer of Azithromycin into the Breast Milk of African Mothers. | 2015 | Antimicrob. Agents Chemother. | pmid:26711756 |
Geisler WM et al. | Azithromycin versus Doxycycline for Urogenital Chlamydia trachomatis Infection. | 2015 | N. Engl. J. Med. | pmid:26699167 |
Smith C et al. | Use and safety of azithromycin in neonates: a systematic review. | 2015 | BMJ Open | pmid:26656010 |
Solomon AW et al. | Trachoma and Yaws: Common Ground? | 2015 | PLoS Negl Trop Dis | pmid:26633176 |
RuÃz del Olmo I et al. | [Severe neutropenia as side effect of medical treatment in nontuberculous mycobacterial adenitis]. | 2015 | Rev Chilena Infectol | pmid:26633119 |
Yan M et al. | Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. | 2015 | Eur J Med Chem | pmid:26402728 |
GarcÃa-Quintanilla M et al. | Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii. | 2015 | Int. J. Antimicrob. Agents | pmid:26391380 |
Muralidharan V and Striepen B | Teaching old drugs new tricks to stop malaria invasion in its tracks. | 2015 | BMC Biol. | pmid:26349580 |
Hare KM et al. | Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo. | 2015 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:26363637 |
Phoon YW et al. | Isolation of multidrug-resistant Salmonella in Singapore. | 2015 | Singapore Med J | pmid:26311915 |
Unemo M | Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge. | 2015 | BMC Infect. Dis. | pmid:26293005 |
Trembizki E et al. | Direct real-time PCR-based detection of Neisseria gonorrhoeae 23S rRNA mutations associated with azithromycin resistance. | 2015 | J. Antimicrob. Chemother. | pmid:26338048 |
Lin L et al. | Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens. | 2015 | EBioMedicine | pmid:26288841 |
Pollock E and Hasse B | [CME. Pertussis]]. | 2015 | Praxis (Bern 1994) | pmid:26331198 |
Hancock RE | Rethinking the Antibiotic Discovery Paradigm. | 2015 | EBioMedicine | pmid:26288830 |
Xue J et al. | Occurrence of high-level azithromycin-resistant Neisseria gonorrhoeae isolates in China. | 2015 | J. Antimicrob. Chemother. | pmid:26316384 |
Jensen JS and Bradshaw C | Management of Mycoplasma genitalium infections - can we hit a moving target? | 2015 | BMC Infect. Dis. | pmid:26286546 |
McCallum GB et al. | Further clinical trials on macrolides for bronchiolitis in infants are unnecessary. | 2015 | J. Allergy Clin. Immunol. | pmid:26316096 |
Pavlova A and Gumbart JC | Parametrization of macrolide antibiotics using the force field toolkit. | 2015 | J Comput Chem | pmid:26280362 |
Puri K et al. | Bartonella Osteomyelitis of the Acetabulum: Case Report and Review of the Literature. | 2015 | Vector Borne Zoonotic Dis. | pmid:26273806 |
Beigelman A and Bacharier LB | Reply: To PMID 25458910. | 2015 | J. Allergy Clin. Immunol. | pmid:26309182 |
Marks M et al. | Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. | 2015 | PLoS Negl Trop Dis | pmid:26241484 |
Stellari F et al. | In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa and its modulation by azithromycin. | 2015 | J Transl Med | pmid:26239109 |
Haruki Y et al. | [Investigation of Intravenous Azithromycin Treatment Safety When Reducing Solvent for Intensive Care Unit Patients]. | 2015 | Yakugaku Zasshi | pmid:26234357 |
Wetherbee EE et al. | Self-reported alcohol intake and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study. | 2015 | Int J Chron Obstruct Pulmon Dis | pmid:26229455 |
Arnež M and Ružić-Sabljić E | Azithromycin Is Equally Effective as Amoxicillin in Children with Solitary Erythema Migrans. | 2015 | Pediatr. Infect. Dis. J. | pmid:26186104 |
Vandermeulen E et al. | BAL neutrophilia in azithromycin-treated lung transplant recipients: Clinical significance. | 2015 | Transpl. Immunol. | pmid:26168736 |
Llata E et al. | Management of Pelvic Inflammatory Disease in Selected U.S. Sexually Transmitted Disease Clinics: Sexually Transmitted Disease Surveillance Network, January 2010-December 2011. | 2015 | Sex Transm Dis | pmid:26165434 |
Washington AZ et al. | Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel. | 2015 | Bioorg. Med. Chem. | pmid:26037612 |
Tabidze IL et al. | Adherence to Centers for Disease Control and Prevention Gonococcal Treatment Guidelines Among Chicago Health Care Providers, 2011-2012. | 2015 | Sex Transm Dis | pmid:26165433 |
Schreeg ME et al. | Rapid High-Resolution Melt Analysis of Cytauxzoon felis Cytochrome b To Aid in the Prognosis of Cytauxzoonosis. | 2015 | J. Clin. Microbiol. | pmid:26019197 |
Kirby A | Comment on: Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3 clinical trial data. | 2015 | J. Antimicrob. Chemother. | pmid:26157112 |
Pérez-Doñate V et al. | [Is azithromycin really a therapeutic option in intestinal salmonellosis?]. | 2015 | An Pediatr (Barc) | pmid:26006271 |
Furfaro LL et al. | In vitro activity of solithromycin and its metabolites, CEM-214 and N-acetyl-CEM-101, against 100 clinical Ureaplasma spp. isolates compared with azithromycin. | 2015 | Int. J. Antimicrob. Agents | pmid:26141231 |
Teo A et al. | Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission. | 2015 | Malar. J. | pmid:26006260 |
Chazan B et al. | Susceptibility of Group A Streptococcus to Antimicrobial Agents in Northern Israel: A Surveillance Study. | 2015 | Microb. Drug Resist. | pmid:26430943 |
Farber FR et al. | Atraumatic splenic rupture from Babesia: A disease of the otherwise healthy patient. | 2015 | Ticks Tick Borne Dis | pmid:26123434 |
Ahmed N et al. | Donovanosis causing lymphadenitis, mastoiditis, and meningitis in a child. | 2015 | Lancet | pmid:26122163 |
Barni S et al. | Azithromycin is more allergenic than clarithromycin in children with suspected hypersensitivity reaction to macrolides. | 2015 | J Investig Allergol Clin Immunol | pmid:25997306 |
Jo KW et al. | The efficacy of prophylactic azithromycin on bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. | 2015 | Int. J. Hematol. | pmid:26121954 |
Earl CS et al. | Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance. | 2015 | EMBO Mol Med | pmid:25995336 |
Koepke R et al. | Widespread Bordetella parapertussis Infections-Wisconsin, 2011-2012: Clinical and Epidemiologic Features and Antibiotic Use for Treatment and Prevention. | 2015 | Clin. Infect. Dis. | pmid:26113655 |
Hoffmann K et al. | Prevalence and resistance patterns of commensal S. aureus in community-dwelling GP patients and socio-demographic associations. A cross-sectional study in the framework of the APRES-project in Austria. | 2015 | BMC Infect. Dis. | pmid:25981559 |
Qin YH et al. | Transdermal application of azithromycin-amlodipine-heparin gel enhances survival of infected random ischaemic flap. | 2015 | J Plast Surg Hand Surg | pmid:26083309 |
Lietman TM et al. | The distribution of the prevalence of ocular chlamydial infection in communities where trachoma is disappearing. | 2015 | Epidemics | pmid:25979286 |
Hauser G et al. | Probiotics for standard triple Helicobacter pylori eradication: a randomized, double-blind, placebo-controlled trial. | 2015 | Medicine (Baltimore) | pmid:25929897 |
Craig AP et al. | Is it time to switch to doxycycline from azithromycin for treating genital chlamydial infections in women? Modelling the impact of autoinoculation from the gastrointestinal tract to the genital tract. | 2015 | BMC Infect. Dis. | pmid:25925662 |
Cusini M | Therapy for Gonococcal and Non-gonococcal Genital Infections is a Major Problem for Clinicians. | 2015 | Acta Derm. Venereol. | pmid:25917593 |
Harding-Esch E et al. | Costs of testing for ocular Chlamydia trachomatis infection compared to mass drug administration for trachoma in the Gambia: application of results from the PRET study. | 2015 | PLoS Negl Trop Dis | pmid:25901349 |
Choi AH et al. | Clinicocytopathologic correlation in an atypical presentation of lymphadenopathy with review of literature. | 2015 | Am. J. Clin. Pathol. | pmid:25873511 |
Riesselman A and El-Mallakh RS | Akathisia with azithromycin. | 2015 | Ann Pharmacother | pmid:25870444 |
Brusselle GG | Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? | 2015 | Thorax | pmid:25870311 |
Gose SO et al. | Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California. | 2015 | Sex Transm Dis | pmid:25868141 |
Franco M et al. | Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy. | 2015 | Transpl Infect Dis | pmid:25846671 |
Hung AM and Hakim RM | Dialysate and serum potassium in hemodialysis. | 2015 | Am. J. Kidney Dis. | pmid:25828570 |