Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bayoumi AM and Redelmeier DA | Decision analysis with cumulative prospect theory. | 2000 Oct-Dec | Med Decis Making | pmid:11059473 |
Boccazzi A et al. | Short course therapy with cefitbuten versus azithromycin in pediatric streptococcal pharyngitis. | 2000 | Pediatr. Infect. Dis. J. | pmid:11055597 |
Renz CL and Ashraf T | Comment: cost-effectiveness of macrolides in lower respiratory tract infections. | 2000 | Ann Pharmacother | pmid:11054992 |
See S | Is azithromycin monotherapy as efficacious as cefuroxime plus erythromycin for the treatment of community-acquired pneumonia in hospitalized patients? | 2000 | J Fam Pract | pmid:11052155 |
Adachi JA et al. | Empirical antimicrobial therapy for traveler's diarrhea. | 2000 | Clin. Infect. Dis. | pmid:11049792 |
Kelley MA et al. | Breakthrough pneumococcal bacteremia in patients being treated with azithromycin and clarithromycin. | 2000 | Clin. Infect. Dis. | pmid:11049784 |
Ghaffar F et al. | Effects of amoxicillin/clavulanate or azithromycin on nasopharyngeal carriage of Streptococcus pneumoniae and Haemophilus influenzae in children with acute otitis media. | 2000 | Clin. Infect. Dis. | pmid:11049764 |
Miller JM and Martin DH | Treatment of Chlamydia trachomatis infections in pregnant women. | 2000 | Drugs | pmid:11030469 |
Semaan HB et al. | The effect of chronic azithromycin therapy on soluble endothelium-derived adhesion molecules in patients with coronary artery disease. | 2000 | J. Cardiovasc. Pharmacol. | pmid:11026657 |
Granowitz EV et al. | Potentially fatal interaction between azithromycin and disopyramide. | 2000 | Pacing Clin Electrophysiol | pmid:11025903 |
Muhlestein JB et al. | Randomized secondary prevention trial of azithromycin in patients with coronary artery disease: primary clinical results of the ACADEMIC study. | 2000 | Circulation | pmid:11023928 |
Grayston JT | Secondary prevention antibiotic treatment trials for coronary artery disease. | 2000 | Circulation | pmid:11023925 |
Kuper JI and D'Aprile M | Drug-Drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. | 2000 | Clin Pharmacokinet | pmid:11020135 |
Schneider CA et al. | In vivo uptake of azithromycin in human coronary plaques. | 2000 | Am. J. Cardiol. | pmid:11018204 |
Currier JS et al. | Discontinuation of Mycobacterium avium complex prophylaxis in patients with antiretroviral therapy-induced increases in CD4+ cell count. A randomized, double-blind, placebo-controlled trial. AIDS Clinical Trials Group 362 Study Team. | 2000 | Ann. Intern. Med. | pmid:11015162 |
Westphal JF | Macrolide - induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin. | 2000 | Br J Clin Pharmacol | pmid:11012550 |
Erhardt W et al. | Establishing criteria for assessment of efficacy of antimicrobial agents in acute otitis media. | 2000 | Antimicrob. Agents Chemother. | pmid:11012390 |
Fluoroquinolone-resistance in Neisseria gonorrhoeae, Hawaii, 1999, and decreased susceptibility to azithromycin in N. gonorrhoeae, Missouri, 1999. | 2000 | MMWR Morb. Mortal. Wkly. Rep. | pmid:11012233 | |
Flores S et al. | [Triple therapy of short-term with azithromycin, amoxycillin and omeprazole for the eradication of Helicobacter pylori]. | 2000 | Rev Med Chil | pmid:11008354 |
Beckey NP et al. | Retrospective evaluation of a potential interaction between azithromycine and warfarin in patients stabilized on warfarin. | 2000 | Pharmacotherapy | pmid:10999497 |
Ohtani H et al. | Comparative pharmacodynamic analysis of Q-T interval prolongation induced by the macrolides clarithromycin, roxithromycin, and azithromycin in rats. | 2000 | Antimicrob. Agents Chemother. | pmid:10991836 |
Fogarty C et al. | Bacteremic pneumonia due to multidrug-resistant pneumococci in 3 patients treated unsuccessfully with azithromycin and successfully with levofloxacin. | 2000 | Clin. Infect. Dis. | pmid:10987733 |
Schouenborg P et al. | Azithromycin versus pivampicillin in the treatment of acute exacerbations of chronic bronchitis: a single-blind, double-dummy, multicentre study. | 2000 May-Jun | J. Int. Med. Res. | pmid:10983860 |
Jonas D et al. | The effect of azithromycin on intracellular Legionella pneumophila in the Mono Mac 6 cell line at serum concentrations attainable in vivo. | 2000 | J. Antimicrob. Chemother. | pmid:10980164 |
Guzey M et al. | Three-day course of oral azithromycin vs topical oxytetracycline/polymyxin in treatment of active endemic trachoma. | 2000 Jul-Aug | Jpn. J. Ophthalmol. | pmid:10974295 |
Scaglione F et al. | In vitro comparative dynamics of modified-release clarithromycin and of azithromycin. | 2000 Sep-Oct | Chemotherapy | pmid:10965100 |
Thompson C | Azithromycin v oxytetracycline for the treatment of non-specific urethritis. | 2000 | Sex Transm Infect | pmid:10961211 |
Mandell GL and Coleman EJ | Activities of antimicrobial agents against intracellular pneumococci. | 2000 | Antimicrob. Agents Chemother. | pmid:10952618 |
Dean D et al. | Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping. | 2000 | J. Infect. Dis. | pmid:10950788 |
Vranes J | Effect of subminimal inhibitory concentrations of azithromycin on adherence of Pseudomonas aeruginosa to polystyrene. | 2000 | J Chemother | pmid:10949976 |
Ng DK et al. | A randomized controlled trial of azithromycin and amoxycillin/clavulanate in the management of subacute childhood rhinosinusitis. | 2000 | J Paediatr Child Health | pmid:10940175 |
Rekart M et al. | Mass treatment/prophylaxis during an outbreak of infectious syphilis in Vancouver, British Columbia. | 2000 | Can. Commun. Dis. Rep. | pmid:10932390 |
Hammerschlag MR | Treatment of Chlamydia pneumoniae. | 2000 | Int. J. Antimicrob. Agents | pmid:10926449 |
Gomperts BN and White LK | Gonococcal hand abscess. | 2000 | Pediatr. Infect. Dis. J. | pmid:10917235 |
Drugs for sexually transmitted infections. | 1999 | Med Lett Drugs Ther | pmid:10906932 | |
McBroom JW | Medical management of interstitial pregnancy with a retained IUD. A case report. | 2000 | J Reprod Med | pmid:10900583 |
Herrera D et al. | The periodontal abscess (II). Short-term clinical and microbiological efficacy of 2 systemic antibiotic regimes. | 2000 | J. Clin. Periodontol. | pmid:10883868 |
Koch CC et al. | Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae. | 2000 | J. Antimicrob. Chemother. | pmid:10882684 |
Barsic B et al. | Comparison of azithromycin and doxycycline in the treatment of erythema migrans. | 2000 May-Jun | Infection | pmid:10879639 |
Gruber F et al. | Treatment of early syphilis with azithromycin. | 2000 | J Chemother | pmid:10877520 |
Scharfstein JA et al. | The cost-effectiveness of prophylaxis for Mycobacterium avium complex in AIDS. | 1999 | Int J Technol Assess Health Care | pmid:10874380 |
SendaÄŸ F et al. | Single dose oral azithromycin versus seven day doxycycline in the treatment of non-gonococcal mucopurulent endocervicitis. | 2000 | Aust N Z J Obstet Gynaecol | pmid:10870778 |
Miltner EC and Bermudez LE | Mycobacterium avium grown in Acanthamoeba castellanii is protected from the effects of antimicrobials. | 2000 | Antimicrob. Agents Chemother. | pmid:10858369 |
Chinh NT et al. | A randomized controlled comparison of azithromycin and ofloxacin for treatment of multidrug-resistant or nalidixic acid-resistant enteric fever. | 2000 | Antimicrob. Agents Chemother. | pmid:10858343 |
Plouffe J et al. | Clinical efficacy of intravenous followed by oral azithromycin monotherapy in hospitalized patients with community-acquired pneumonia. The Azithromycin Intravenous Clinical Trials Group. | 2000 | Antimicrob. Agents Chemother. | pmid:10858333 |
Criqui GI et al. | Effects of azithromycin on ozone-induced airway neutrophilia and cytokine release. | 2000 | Eur. Respir. J. | pmid:10853849 |
Ernst EJ et al. | Comparison of the serum and intracellular pharmacokinetics of azithromycin in healthy and diabetic volunteers. | 2000 | Pharmacotherapy | pmid:10853621 |
Raja Babu KK et al. | Confluent and reticulate papillomatosis: successful treatment with azithromycin. | 2000 | Br. J. Dermatol. | pmid:10848767 |
Heikkinen T et al. | The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin. | 2000 | BJOG | pmid:10847234 |
Jackson LA | Description and status of the azithromycin and coronary events study (ACES). | 2000 | J. Infect. Dis. | pmid:10839763 |
Dunne MW | Rationale and design of a secondary prevention trial of antibiotic use in patients after myocardial infarction: the WIZARD (weekly intervention with zithromax [azithromycin] for atherosclerosis and its related disorders) trial. | 2000 | J. Infect. Dis. | pmid:10839762 |
Anderson JL and Muhlestein JB | The ACADEMIC study in perspective (Azithromycin in coronary artery disease: elimination of myocardial infection with Chlamydia). | 2000 | J. Infect. Dis. | pmid:10839761 |
Matute AJ et al. | Is a 5 day course of azithromycin enough for infections caused by Legionella pneumophila? | 2000 | J. Antimicrob. Chemother. | pmid:10837459 |
Moshkani SK and Dalimi A | Evaluation of the efficacy of atovaquone alone or in combination with azithromycin against acute murine toxoplasmosis. | 2000 | Vet. Res. Commun. | pmid:10836275 |
Straubinger RK | PCR-Based quantification of Borrelia burgdorferi organisms in canine tissues over a 500-Day postinfection period. | 2000 | J. Clin. Microbiol. | pmid:10834975 |
Mirmiran R et al. | Disseminated gonococcal infection: a case of beta-lactamase-producing Neisseria gonorrhoeae. | 2000 | J Am Podiatr Med Assoc | pmid:10833879 |
Zuckerman JM | The newer macrolides: azithromycin and clarithromycin. | 2000 | Infect. Dis. Clin. North Am. | pmid:10829265 |
Bin XX et al. | Effect of azithromycin plus rifampin versus amoxicillin alone on eradication and inflammation in the chronic course of Chlamydia pneumoniae pneumonitis in mice. | 2000 | Antimicrob. Agents Chemother. | pmid:10817751 |
Tsitsika A et al. | Single-oral-dose azithromycin prophylaxis against experimental streptococcal or staphylococcal aortic valve endocarditis. | 2000 | Antimicrob. Agents Chemother. | pmid:10817749 |
Turcinov D et al. | Failure of azithromycin in treatment of Brill-Zinsser disease. | 2000 | Antimicrob. Agents Chemother. | pmid:10817744 |
Vergis EN et al. | Azithromycin vs cefuroxime plus erythromycin for empirical treatment of community-acquired pneumonia in hospitalized patients: a prospective, randomized, multicenter trial. | 2000 | Arch. Intern. Med. | pmid:10809032 |
Sasaki TY and Sumida KN | Angioimmunoblastic T-cell lymphoma (AIL-TCL) following macrolide administration. | 2000 | Hawaii Med J | pmid:10800250 |
Kozyrskyj AL et al. | Short course antibiotics for acute otitis media. | 2000 | Cochrane Database Syst Rev | pmid:10796591 |
Skerk V et al. | Comparative analysis of azithromycin and doxycycline efficacy in the treatment of female patients with acute urethral syndrome caused by Ureaplasma urealyticum. | 2000 | J Chemother | pmid:10789560 |
Miller SA et al. | Chlamydia pneumoniae activates nuclear factor kappaB and activator protein 1 in human vascular smooth muscle and induces cellular proliferation. | 2000 | J. Surg. Res. | pmid:10781378 |
Ress BD and Gross EM | Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity. A case report. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10778901 |
Bujanda L et al. | Ranitidine bismuth citrate plus azithromycin for Helicobacter pylori eradication. | 2000 | J. Clin. Gastroenterol. | pmid:10777206 |
Donders GG | Treatment of sexually transmitted bacterial diseases in pregnant women. | 2000 | Drugs | pmid:10776830 |
Laming AC et al. | A targeted, single-dose azithromycin strategy for trachoma. | 2000 | Med. J. Aust. | pmid:10772587 |
Najib MM et al. | Cost-effectiveness of sparfloxacin compared with other oral antimicrobials in outpatient treatment of community-acquired pneumonia. | 2000 | Pharmacotherapy | pmid:10772376 |
Brieland JK et al. | Efficacy of SCH27899 in an animal model of Legionnaires' disease using immunocompromised A/J mice. | 2000 | Antimicrob. Agents Chemother. | pmid:10770771 |
El-Sadr WM et al. | Discontinuation of prophylaxis for Mycobacterium avium complex disease in HIV-infected patients who have a response to antiretroviral therapy. Terry Beirn Community Programs for Clinical Research on AIDS. | 2000 | N. Engl. J. Med. | pmid:10766581 |
Somani J et al. | Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure. | 2000 | J. Infect. Dis. | pmid:10762573 |
Diculencu D et al. | [The postantibiotic effect of azithromycin on respiratory pathogens]. | 1998 Jul-Dec | Rev Med Chir Soc Med Nat Iasi | pmid:10756861 |
Wenisch C | [Pharmacokinetic effects of antibiotics on the development of bacterial resistance particularly in reference to azithromycin]. | 2000 | Wien Med Wochenschr | pmid:10756595 |
Nishi Y et al. | [Effect of macrolide antibiotics on adhesion by cancer cells]. | 2000 | Jpn J Antibiot | pmid:10756450 |
Giacometti A et al. | Activity of nitazoxanide alone and in combination with azithromycin and rifabutin against Cryptosporidium parvum in cell culture. | 2000 | J. Antimicrob. Chemother. | pmid:10747821 |
Schissel DJ et al. | Azithromycin eruption in infectious mononucleosis: a proposed mechanism of interaction. | 2000 | Cutis | pmid:10738636 |
Ouchi K | Chlamydia pneumoniae and atherosclerosis. | 1999 | Jpn. J. Infect. Dis. | pmid:10738358 |
Potts JM et al. | Association of chronic urinary symptoms in women and Ureaplasma urealyticum. | 2000 | Urology | pmid:10736488 |
Canut Blasco A et al. | [A randomized, prospective and comparative study is a clinical trial]. | 2000 | Med Clin (Barc) | pmid:10734631 |
Rino BE et al. | Azithromycin in the treatment of plasmodium falciparum gametocytes: a preliminary observation. | 2000 | J. Trop. Pediatr. | pmid:10730047 |
Angelilli ML et al. | Palatability of oral antibiotics among children in an urban primary care center. | 2000 | Arch Pediatr Adolesc Med | pmid:10710025 |
Slavinsky J et al. | Factors associated with the decline in sexually transmitted infections among HIV-positive women. | 2000 | J. Acquir. Immune Defic. Syndr. | pmid:10708065 |
Giacometti A et al. | Anticryptosporidial activity of ranalexin, lasalocid and azithromycin alone and in combination in cell lines. | 2000 | J. Antimicrob. Chemother. | pmid:10702561 |
Bowden FJ et al. | Donovanosis causing cervical lymphadenopathy in a five-month-old boy. | 2000 | Pediatr. Infect. Dis. J. | pmid:10694010 |
Dagan R et al. | Bacteriologic and clinical efficacy of amoxicillin/clavulanate vs. azithromycin in acute otitis media. | 2000 | Pediatr. Infect. Dis. J. | pmid:10693993 |
Giacometti A et al. | Efficacy of treatment with paromomycin, azithromycin, and nitazoxanide in a patient with disseminated cryptosporidiosis. | 1999 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:10691200 |
Lo SH et al. | Azithromycin-induced hearing loss. | 1999 | Am J Health Syst Pharm | pmid:10690220 |
Steen R et al. | Evidence of declining STD prevalence in a South African mining community following a core-group intervention. | 2000 | Sex Transm Dis | pmid:10654860 |
Fernandez-Obregon AC | Azithromycin for the treatment of acne. | 2000 | Int. J. Dermatol. | pmid:10651967 |
Morita JY et al. | Impact of azithromycin on oropharyngeal carriage of group A Streptococcus and nasopharyngeal carriage of macrolide-resistant Streptococcus pneumoniae. | 2000 | Pediatr. Infect. Dis. J. | pmid:10643849 |
Karpov OI | [The clinical and economic efficacies of short courses of azithromycin in acute sinusitis]. | 1999 | Antibiot. Khimioter. | pmid:10635419 |
Vcev A et al. | Pantoprazole, amoxycillin and either azithromycin or clarithromycin for eradication of Helicobacter pylori in duodenal ulcer. | 2000 | Aliment. Pharmacol. Ther. | pmid:10632647 |
Puri SK and Singh N | Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys. | 2000 | Exp. Parasitol. | pmid:10631075 |
Burgess DS et al. | A time-kill evaluation of clarithromycin and azithromycin against two extracellular pathogens and the development of resistance. | 1999 | Ann Pharmacother | pmid:10630825 |
National guideline for the management of donovanosis (granuloma inguinale). Clinical Effectiveness Group (Association of Genitourinary Medicine and the Medical Society for the Study of Venereal Diseases). | 1999 | Sex Transm Infect | pmid:10616381 | |
Bowden FJ and Skov SJ | Treating donovanosis. | 1999 | Aust Fam Physician | pmid:10615749 |
Ianaro A et al. | Anti-inflammatory activity of macrolide antibiotics. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10604943 |
Dagan R et al. | Bacteriologic efficacies of oral azithromycin and oral cefaclor in treatment of acute otitis media in infants and young children. | 2000 | Antimicrob. Agents Chemother. | pmid:10602721 |