Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Stout JE and Floto RA | Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:23118083 |
Hayes D et al. | ABCA3 transporter deficiency. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:23071193 |
Albert RK et al. | Azithromycin: We're there! | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25360732 |
Williams TJ and Verleden GM | Azithromycin: a plea for multicenter randomized studies in lung transplantation. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16148194 |
Saiman L et al. | Heterogeneity of treatment response to azithromycin in patients with cystic fibrosis. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16040785 |
Kunisaki KM et al. | Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:22077070 |
Lococo F et al. | Hemoptysis and Progressive Dyspnea in a 67-Year-Old Woman with History of Renal Transplantation. | 2016 | Am. J. Respir. Crit. Care Med. | pmid:26681504 |
Yates B et al. | Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15976371 |
Hodge S et al. | Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease. | 2008 | Am. J. Respir. Crit. Care Med. | pmid:18420960 |
Gerhardt SG et al. | Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study. | 2003 | Am. J. Respir. Crit. Care Med. | pmid:12672648 |
O'Beirne SL et al. | Severe Cavitary, Fistulating Mycobacterium avium-intracellulare Complex Disease in an Immunocompetent Host. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:26244303 |
Albert RK and Schuller JL | Macrolide antibiotics and the risk of cardiac arrhythmias. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24707986 |
Han MK et al. | Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:24779680 |
Mertens V et al. | Bile acids aspiration reduces survival in lung transplant recipients with BOS despite azithromycin. | 2011 | Am. J. Transplant. | pmid:21272237 |
Glanville AR | CLAD: does the Emperor have new clothes? | 2014 | Am. J. Transplant. | pmid:25394597 |
Vos R et al. | Azithromycin and the treatment of lymphocytic airway inflammation after lung transplantation. | 2014 | Am. J. Transplant. | pmid:25394537 |
Verleden SE et al. | Lymphocytic bronchiolitis after lung transplantation is associated with daily changes in air pollution. | 2012 | Am. J. Transplant. | pmid:22682332 |
Vanaudenaerde BM et al. | Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. | 2007 | Am. J. Transplant. | pmid:17061983 |
Greer M et al. | Phenotyping established chronic lung allograft dysfunction predicts extracorporeal photopheresis response in lung transplant patients. | 2013 | Am. J. Transplant. | pmid:23406373 |
Robertson AG et al. | Targeting allograft injury and inflammation in the management of post-lung transplant bronchiolitis obliterans syndrome. | 2009 | Am. J. Transplant. | pmid:19459806 |
Ruttens D et al. | Prophylactic Azithromycin Therapy After Lung Transplantation: Post hoc Analysis of a Randomized Controlled Trial. | 2016 | Am. J. Transplant. | pmid:26372728 |
Amsden GW et al. | Pharmacokinetics of azithromycin and the combination of ivermectin and albendazole when administered alone and concurrently in healthy volunteers. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17556628 |
Bloch EM et al. | Antibiotic Resistance in Young Children in Kilosa District, Tanzania 4 Years after Mass Distribution of Azithromycin for Trachoma Control. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28722638 |
O'Brien KS et al. | Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28722569 |
Stoney RJ et al. | Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28719282 |
Miller RS et al. | Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose-ranging study. | 2006 | Am. J. Trop. Med. Hyg. | pmid:16525097 |
Cook JA et al. | Lack of a pharmacokinetic interaction between azithromycin and chloroquine. | 2006 | Am. J. Trop. Med. Hyg. | pmid:16525098 |
Oldenburg CE et al. | Comparison of Mass Azithromycin Coverage Targets of Children in Niger: A Cluster-Randomized Trachoma Trial. | 2018 | Am. J. Trop. Med. Hyg. | pmid:29260659 |
Chetchotisakd P et al. | Maintenance therapy of melioidosis with ciprofloxacin plus azithromycin compared with cotrimoxazole plus doxycycline. | 2001 Jan-Feb | Am. J. Trop. Med. Hyg. | pmid:11425157 |
Pan H and Ba-Thein W | Diagnostic Accuracy of Global Pharma Health Fund Minilabâ„¢ in Assessing Pharmacopoeial Quality of Antimicrobials. | 2018 | Am. J. Trop. Med. Hyg. | pmid:29141717 |
González-Beiras C et al. | Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28193743 |
Wittner M et al. | Atovaquone in the treatment of Babesia microti infections in hamsters. | 1996 | Am. J. Trop. Med. Hyg. | pmid:8780464 |
Chi KH et al. | Molecular differentiation of Treponema pallidum subspecies in skin ulceration clinically suspected as yaws in Vanuatu using real-time multiplex PCR and serological methods. | 2015 | Am. J. Trop. Med. Hyg. | pmid:25404075 |
Heppner DG et al. | Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. | 2005 | Am. J. Trop. Med. Hyg. | pmid:16282291 |
Gingras BA and Jensen JB | Activity of azithromycin (CP-62,993) and erythromycin against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro. | 1992 | Am. J. Trop. Med. Hyg. | pmid:1326232 |
Gao D et al. | Optimal seasonal timing of oral azithromycin for malaria. | 2014 | Am. J. Trop. Med. Hyg. | pmid:25223942 |
Ginouvès M et al. | In Vitro Sensitivity of Cutaneous Leishmania Promastigote Isolates Circulating in French Guiana to a Set of Drugs. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28167598 |
Rosenthal PJ | Azithromycin for Malaria? | 2016 | Am. J. Trop. Med. Hyg. | pmid:27215296 |
Layegh P et al. | Efficacy of azithromycin versus systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17620637 |
Mikals K et al. | Campylobacter fetus bacteremia in an immunocompetent traveler. | 2014 | Am. J. Trop. Med. Hyg. | pmid:25071002 |
Katanami Y et al. | Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27352874 |
Kumaresan JA and Mecaskey JW | The global elimination of blinding trachoma: progress and promise. | 2003 | Am. J. Trop. Med. Hyg. | pmid:14692677 |
Phong NC et al. | In Vivo Efficacy and Tolerability of Artesunate-Azithromycin for the Treatment of Falciparum Malaria in Vietnam. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27215294 |
Yelenich-Huss MJ et al. | Ozena in Immigrants of Differing Backgrounds. | 2016 | Am. J. Trop. Med. Hyg. | pmid:27114295 |
Krolewiecki A et al. | Activity of azithromycin against Leishmania major in vitro and in vivo. | 2002 | Am. J. Trop. Med. Hyg. | pmid:12408666 |
Andersen SL et al. | Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo. | 1995 | Am. J. Trop. Med. Hyg. | pmid:7872444 |
Luntamo M et al. | Effect of repeated treatment of pregnant women with sulfadoxine-pyrimethamine and azithromycin on preterm delivery in Malawi: a randomized controlled trial. | 2010 | Am. J. Trop. Med. Hyg. | pmid:21118924 |
de Oliveira-Silva F et al. | Antileishmanial activity of azithromycin against Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis, and Leishmania (Leishmania) chagasi. | 2008 | Am. J. Trop. Med. Hyg. | pmid:18458308 |
Haile M et al. | The association between latrine use and trachoma: a secondary cohort analysis from a randomized clinical trial. | 2013 | Am. J. Trop. Med. Hyg. | pmid:24002488 |
See CW et al. | The Effect of Mass Azithromycin Distribution on Childhood Mortality: Beliefs and Estimates of Efficacy. | 2015 | Am. J. Trop. Med. Hyg. | pmid:26392160 |
Ayele B et al. | Adverse events after mass azithromycin treatments for trachoma in Ethiopia. | 2011 | Am. J. Trop. Med. Hyg. | pmid:21813850 |
Gaynor BD et al. | Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. | 2014 | Am. J. Trop. Med. Hyg. | pmid:24615132 |
Gebre T et al. | Latrine promotion for trachoma: assessment of mortality from a cluster-randomized trial in Ethiopia. | 2011 | Am. J. Trop. Med. Hyg. | pmid:21896815 |
Gingras BA and Jensen JB | Antimalarial activity of azithromycin and erythromycin against Plasmodium berghei. | 1993 | Am. J. Trop. Med. Hyg. | pmid:8394660 |
Å majs D et al. | Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains? | 2015 | Am. J. Trop. Med. Hyg. | pmid:26217043 |
Shih CM and Wang CC | Ability of azithromycin in combination with quinine for the elimination of babesial infection in humans. | 1998 | Am. J. Trop. Med. Hyg. | pmid:9790419 |
Amza A et al. | A cluster-randomized controlled trial evaluating the effects of mass azithromycin treatment on growth and nutrition in Niger. | 2013 | Am. J. Trop. Med. Hyg. | pmid:23208876 |
Krolewiecki AJ et al. | A randomized clinical trial comparing oral azithromycin and meglumine antimoniate for the treatment of American cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17978064 |
Richards FO et al. | No depletion of Wolbachia from Onchocerca volvulus after a short course of rifampin and/or azithromycin. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17984346 |
Fossa AA et al. | Azithromycin/chloroquine combination does not increase cardiac instability despite an increase in monophasic action potential duration in the anesthetized guinea pig. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17984356 |
Keenan JD et al. | Clinical activity and polymerase chain reaction evidence of chlamydial infection after repeated mass antibiotic treatments for trachoma. | 2010 | Am. J. Trop. Med. Hyg. | pmid:20207878 |
Coles CL et al. | Association of mass treatment with azithromycin in trachoma-endemic communities with short-term reduced risk of diarrhea in young children. | 2011 | Am. J. Trop. Med. Hyg. | pmid:21976574 |
Dunne MW et al. | A double-blind, randomized study of azithromycin compared to chloroquine for the treatment of Plasmodium vivax malaria in India. | 2005 | Am. J. Trop. Med. Hyg. | pmid:16354821 |
Lee S et al. | Chlamydia on children and flies after mass antibiotic treatment for trachoma. | 2007 | Am. J. Trop. Med. Hyg. | pmid:17255240 |
Jacks S et al. | Pharmacokinetics of azithromycin and concentration in body fluids and bronchoalveolar cells in foals. | 2001 | Am. J. Vet. Res. | pmid:11763173 |
Westfall DS et al. | Inoculation of two genotypes of Hemobartonella felis (California and Ohio variants) to induce infection in cats and the response to treatment with azithromycin. | 2001 | Am. J. Vet. Res. | pmid:11341386 |
Neiger R et al. | Use of a urea breath test to evaluate short-term treatments for cats naturally infected with Helicobacter heilmannii. | 1999 | Am. J. Vet. Res. | pmid:10407483 |
Coke RL et al. | Pharmacokinetics and tissue concentrations of azithromycin in ball pythons (Python regius). | 2003 | Am. J. Vet. Res. | pmid:12602593 |
DeCoster B et al. | Expedited Partner Therapy: Clinical Considerations and Public Health Explorations. | 2016 | AMA J Ethics | pmid:27002992 |
Diniz LM et al. | Bacillary angiomatosis with bone invasion. | 2016 Nov-Dec | An Bras Dermatol | pmid:28099606 |
Sampaio RN et al. | The use of azythromycin and N-methyl glucamine for the treatment of cutaneous Leishmaniasis caused by Leishmania (Leishmania) amazonensis in C57BL6 mice. | 2009 Mar-Apr | An Bras Dermatol | pmid:19503979 |
Iglesias Caamaño M et al. | [Mycoplasma pneumoniae pneumonia and adult respiratory distress syndrome]. | 2007 | An Med Interna | pmid:17907893 |
Pino Rivero V et al. | [Facial palsy caused by otitis media with effusion in a 9-year old child]. | 2004 | An Otorrinolaringol Ibero Am | pmid:15663088 |
Vázquez Fernández ME et al. | [Variability in antibiotic prescription in the pediatric population of Castile and Leon (Spain) from 2001 to 2005 in relation to urban or rural setting]. | 2007 | An Pediatr (Barc) | pmid:17692259 |
Salcedo Posadas A et al. | [Complementary therapies in cystic fibrosis: evidence of therapeutic benefits and treatment recommendations]. | 2003 | An Pediatr (Barc) | pmid:12628117 |
Jover-GarcÃa J et al. | [In-vitro activity of azithromycin in faecal isolates of Aeromonas hydrophila]. | 2017 | An Pediatr (Barc) | pmid:27686393 |
Pérez-Doñate V et al. | [Is azithromycin really a therapeutic option in intestinal salmonellosis?]. | 2015 | An Pediatr (Barc) | pmid:26006271 |
González de Aledo Linos A and GarcÃa Merino J | [Control of a school outbreak of serogroup B meningococcal disease by chemoprophylaxis with azithromycin and ciprofloxacin]. | 2000 | An. Esp. Pediatr. | pmid:11521657 |
Obando Santaella I et al. | [Cat scratch disease. Diagnostic and therapeutic considerations]. | 1997 | An. Esp. Pediatr. | pmid:9382360 |
RodrÃguez Núñez A et al. | [Chemoprophylaxis of meningococcal disease with azithromycin and ciprofloxacin]. | 2001 | An. Esp. Pediatr. | pmid:11333489 |
Weintraub A et al. | In-vitro activity of solithromycin against anaerobic bacteria from the normal intestinal microbiota. | 2016 | Anaerobe | pmid:27725229 |
Barrett B et al. | Validated HPLC-MS-MS method for determination of azithromycin in human plasma. | 2005 | Anal Bioanal Chem | pmid:16091946 |
Rufino JL et al. | Flow-injection spectrophotometric determination of azithromycin in pharmaceutical formulations using p-chloranil in the presence of hydrogen peroxide. | 2008 | Anal Sci | pmid:18614828 |
Galvidis I et al. | Group determination of 14-membered macrolide antibiotics and azithromycin using antibodies against common epitopes. | 2015 | Anal. Biochem. | pmid:25256165 |
Hemmateenejad B et al. | Spectrophotometric study of complex formation equilibria in the presence of interference using hard-soft net analyte signal method: application to drug-metal complexation. | 2011 | Anal. Chim. Acta | pmid:21167968 |
Zhang K et al. | Facile synthesis of the necklace-like graphene oxide-multi-walled carbon nanotube nanohybrid and its application in electrochemical sensing of azithromycin. | 2013 | Anal. Chim. Acta | pmid:23830420 |
Magri V et al. | Eradication of Chlamydia trachomatis parallels symptom regression in chronic bacterial prostatitis patients treated with a fluoroquinolone-macrolide combination. | 2010 | Andrologia | pmid:21105887 |
Kim HC and Kang SH | Total synthesis of azithromycin. | 2009 | Angew. Chem. Int. Ed. Engl. | pmid:19173267 |
O'Beirne SL et al. | Trust Your Instincts. Surgical Lung Biopsy with Normal Chest Imaging in a 49-Year-Old Man with Progressive Dyspnea. | 2016 | Ann Am Thorac Soc | pmid:27144798 |
McColley SA | Practice guidelines, clinical trials, and unexpected results in cystic fibrosis. | 2014 | Ann Am Thorac Soc | pmid:24673695 |
Cheng GS et al. | Lung Function Trajectory in Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Cell Transplant. | 2016 | Ann Am Thorac Soc | pmid:27513368 |
Lee G et al. | Nodular bronchiectatic Mycobacterium avium complex pulmonary disease. Natural course on serial computed tomographic scans. | 2013 | Ann Am Thorac Soc | pmid:23952847 |
Nick JA et al. | Azithromycin may antagonize inhaled tobramycin when targeting Pseudomonas aeruginosa in cystic fibrosis. | 2014 | Ann Am Thorac Soc | pmid:24476418 |
Schmutz JL et al. | [Azithromycin and Stevens-Johnson syndrome]. | 2005 Aug-Sep | Ann Dermatol Venereol | pmid:16230934 |
Clyti E et al. | [Short treatment of donovanosis with azithromycin]. | 2004 | Ann Dermatol Venereol | pmid:15235534 |
Gerhardt P et al. | [Male urethritis]. | 2016 | Ann Dermatol Venereol | pmid:27776813 |
Dupin N et al. | [Chlamydia trachomatis]. | 2016 | Ann Dermatol Venereol | pmid:27773503 |
Alcaraz I et al. | [Mycoplasma genitalium]. | 2016 | Ann Dermatol Venereol | pmid:27773499 |
Caumes E et al. | [Donovanosis (granuloma inguinale)]. | 2016 | Ann Dermatol Venereol | pmid:27773509 |
Schmutz JL and Trechot P | [DRESS associated with azithromycin in a child]. | 2013 | Ann Dermatol Venereol | pmid:23328369 |