Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Legionnaires' Disease D007877 4 associated lipids
Sexually Transmitted Diseases D012749 4 associated lipids
Cat-Scratch Disease D002372 4 associated lipids
Tick Infestations D013984 4 associated lipids
Lymphogranuloma Venereum D008219 4 associated lipids
Respiratory Tract Infections D012141 4 associated lipids
Elephantiasis, Filarial D004605 4 associated lipids
Retinitis D012173 4 associated lipids
Agammaglobulinemia D000361 4 associated lipids
Otitis Media, Suppurative D010035 4 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
Yaws D015001 4 associated lipids
Psittacosis D009956 4 associated lipids
Lymphangitis D008205 4 associated lipids
Syphilis, Latent D013592 4 associated lipids
Conjunctivitis, Inclusion D003235 4 associated lipids
Purpura, Thrombocytopenic, Idiopathic D016553 4 associated lipids
Fetal Membranes, Premature Rupture D005322 4 associated lipids
Acinetobacter Infections D000151 4 associated lipids
Mycobacterium avium-intracellulare Infection D015270 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

Download all related citations
Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Bosch-Driessen LH et al. A prospective, randomized trial of pyrimethamine and azithromycin vs pyrimethamine and sulfadiazine for the treatment of ocular toxoplasmosis. 2002 Am. J. Ophthalmol. pmid:12095805
Katusic D et al. Azithromycin vs doxycycline in the treatment of inclusion conjunctivitis. 2003 Am. J. Ophthalmol. pmid:12654359
Fan LC et al. Macrolides protect against infection via inhibition of inflammasomes. 2017 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:28684545
Shinkai M et al. Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16085674
Blau H et al. Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1/2, JNK, and NF-kappaB activation in a cystic fibrosis epithelial cell line. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17012372
Tarran R et al. Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. 2013 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:23542952
Kadova Z et al. IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats. 2015 Am. J. Physiol. Renal Physiol. pmid:25503728
Meyer M et al. Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis. 2009 Am. J. Respir. Cell Mol. Biol. pmid:19244203
Halldorsson S et al. Azithromycin maintains airway epithelial integrity during Pseudomonas aeruginosa infection. 2010 Am. J. Respir. Cell Mol. Biol. pmid:19372247
Bergamini G et al. Effects of azithromycin on glutathione S-transferases in cystic fibrosis airway cells. 2009 Am. J. Respir. Cell Mol. Biol. pmid:19097986
Kanazawa S et al. Azithromycin and bronchiolitis obliterans. 2004 Am. J. Respir. Crit. Care Med. pmid:14982826
Tsai WC et al. Azithromycin blocks neutrophil recruitment in Pseudomonas endobronchial infection. 2004 Am. J. Respir. Crit. Care Med. pmid:15361366
Jeong BH et al. Intermittent antibiotic therapy for nodular bronchiectatic Mycobacterium avium complex lung disease. 2015 Am. J. Respir. Crit. Care Med. pmid:25393520
Restrepo MI and Anzueto A Reply: Azithromycin: We're there! 2014 Am. J. Respir. Crit. Care Med. pmid:25360733
Albert RK et al. Azithromycin: We're there! 2014 Am. J. Respir. Crit. Care Med. pmid:25360732
Verleden GM et al. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. 2006 Am. J. Respir. Crit. Care Med. pmid:16741151
Barker PM et al. Effect of macrolides on in vivo ion transport across cystic fibrosis nasal epithelium. 2005 Am. J. Respir. Crit. Care Med. pmid:15657462
Choi GE et al. Macrolide treatment for Mycobacterium abscessus and Mycobacterium massiliense infection and inducible resistance. 2012 Am. J. Respir. Crit. Care Med. pmid:22878281
Binder AM et al. Epidemiology of nontuberculous mycobacterial infections and associated chronic macrolide use among persons with cystic fibrosis. 2013 Am. J. Respir. Crit. Care Med. pmid:23927602
Angel LF et al. Azithromycin in bronchiolitis obliterans: is the evidence strong enough? 2006 Am. J. Respir. Crit. Care Med. pmid:16467178