Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Moon JE et al. | Efficacy of macrolides and telithromycin against leptospirosis in a hamster model. | 2006 | Antimicrob. Agents Chemother. | pmid:16723556 |
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Matsui H et al. | Azithromycin inhibits the formation of flagellar filaments without suppressing flagellin synthesis in Salmonella enterica serovar typhimurium. | 2005 | Antimicrob. Agents Chemother. | pmid:16048953 |
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Zhang Y et al. | Novel Detection Strategy To Rapidly Evaluate the Efficacy of Antichlamydial Agents. | 2017 | Antimicrob. Agents Chemother. | pmid:27855081 |
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D'Ignazio J et al. | Novel, single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired Pneumonia in adults. | 2005 | Antimicrob. Agents Chemother. | pmid:16189077 |
Tissi L et al. | In vivo efficacy of azithromycin in treatment of systemic infection and septic arthritis induced by type IV group B Streptococcus strains in mice: comparative study with erythromycin and penicillin G. | 1995 | Antimicrob. Agents Chemother. | pmid:8540695 |
Jensen JS et al. | In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and -susceptible Mycoplasma genitalium strains. | 2014 | Antimicrob. Agents Chemother. | pmid:24637681 |
Koirala KD et al. | Highly resistant Salmonella enterica serovar Typhi with a novel gyrA mutation raises questions about the long-term efficacy of older fluoroquinolones for treating typhoid fever. | 2012 | Antimicrob. Agents Chemother. | pmid:22371897 |
Binet R et al. | Impact of azithromycin resistance mutations on the virulence and fitness of Chlamydia caviae in guinea pigs. | 2010 | Antimicrob. Agents Chemother. | pmid:20065052 |
Bermudez LE et al. | Activity of moxifloxacin by itself and in combination with ethambutol, rifabutin, and azithromycin in vitro and in vivo against Mycobacterium avium. | 2001 | Antimicrob. Agents Chemother. | pmid:11120969 |
Ohara T et al. | Effects of azithromycin on shiga toxin production by Escherichia coli and subsequent host inflammatory response. | 2002 | Antimicrob. Agents Chemother. | pmid:12384353 |
Bielaszewska M et al. | Effects of antibiotics on Shiga toxin 2 production and bacteriophage induction by epidemic Escherichia coli O104:H4 strain. | 2012 | Antimicrob. Agents Chemother. | pmid:22391549 |
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Cigana C et al. | Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. | 2007 | Antimicrob. Agents Chemother. | pmid:17210769 |
Nahata MC et al. | Pharmacokinetics of azithromycin in pediatric patients with acute otitis media. | 1995 | Antimicrob. Agents Chemother. | pmid:7486938 |
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Nagai K et al. | Susceptibility to telithromycin in 1,011 Streptococcus pyogenes isolates from 10 central and Eastern European countries. | 2002 | Antimicrob. Agents Chemother. | pmid:11796375 |
Vazifeh D et al. | Cellular accumulation of the new ketolide RU 64004 by human neutrophils: comparison with that of azithromycin and roxithromycin. | 1997 | Antimicrob. Agents Chemother. | pmid:9333032 |
Sugimura M et al. | Macrolide antibiotic-mediated downregulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa. | 2008 | Antimicrob. Agents Chemother. | pmid:18676884 |
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Su XH et al. | Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914). | 2015 | Antimicrob. Agents Chemother. | pmid:26482313 |
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Ma Q et al. | A Waterborne Outbreak of Shigella sonnei with Resistance to Azithromycin and Third-Generation Cephalosporins in China in 2015. | 2017 | Antimicrob. Agents Chemother. | pmid:28373192 |
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Pérez-MartÃnez I and Haas D | Azithromycin inhibits expression of the GacA-dependent small RNAs RsmY and RsmZ in Pseudomonas aeruginosa. | 2011 | Antimicrob. Agents Chemother. | pmid:21537014 |
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