Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Currier J | Progress report: prophylaxis and therapy for MAC. | 1996 | AIDS Clin Care | pmid:11363599 |
Old drug approved for MAC prevention. | 1996 | AIDS Alert | pmid:11363659 | |
Torres G | MAC prophylaxis revisited. | 1996 | GMHC Treat Issues | pmid:11363706 |
Antivirals key to MAC prevention regimen. | 1996 | AIDS Alert | pmid:11363722 | |
Marco M | Opportunistic infections in Vancouver. | 1996 | GMHC Treat Issues | pmid:11363841 |
Azithromycin effective in preventing MAC. | 1996 | AIDS Alert | pmid:11363857 | |
D'Amico R | ICAAC update on opportunistic infections. | 1996 Nov-Dec | Posit Aware | pmid:11363974 |
Schouten JT and Whittemore S | Recent development in the treatment and prevention of disseminated Mycobacterium avium complex (MAC). | 1996 | STEP Perspect | pmid:11364267 |
LaCARP opens clinical trials to patients of all primary care providers. | 1998 Mar-Apr | Fac Notes (New Orleans La) | pmid:11365129 | |
Syphilis elimination seen as good HIV prevention. | 1998 | AIDS Alert | pmid:11365457 | |
Azithro once a week for MAC. | 1998 | TreatmentUpdate | pmid:11365625 | |
Eagan L | Data on HIV infection in women expands. | 1999 | Posit Living | pmid:11367336 |
Citterio F et al. | Azithromycin treatment of gingival hyperplasia in kidney transplant recipients is effective and safe. | 2001 | Transplant. Proc. | pmid:11377476 |
Kurdowska A et al. | The effect of azithromycin and clarithromycin on ex vivo interleukin-8 (IL-8) release from whole blood and IL-8 production by human alveolar macrophages. | 2001 | J. Antimicrob. Chemother. | pmid:11389120 |
Gakiya E et al. | [Experimental infection in mice by Plasmodium berghei: an evidence of antiparasitic action of azithromycin]. | 2001 Mar-Apr | Rev. Soc. Bras. Med. Trop. | pmid:11391444 |
Lorenz J et al. | Treatment outcomes in acute exacerbations of chronic bronchitis: comparison of macrolides and moxifloxacin from the patient perspective. | 2001 Mar-Apr | J. Int. Med. Res. | pmid:11393351 |
O'Farrell N | Donovanosis: an update. | 2001 | Int J STD AIDS | pmid:11394976 |
Schmutz JL et al. | [Skin eruptions due to azithromycin (Azadose-Zithromax) and infectious mononucleosis]. | 2001 | Ann Dermatol Venereol | pmid:11395665 |
Kawamura-Sato K et al. | Postantibiotic suppression effect of macrolides on the expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis. | 2001 | J. Infect. Chemother. | pmid:11406758 |
Nilius AM et al. | Comparative in vitro activity of ABT-773, a novel antibacterial ketolide. | 2001 | Antimicrob. Agents Chemother. | pmid:11408246 |
Thompson C et al. | A family cluster of Chlamydia trachomatis infection. | 2001 | BMJ | pmid:11408308 |
Jacobson GF et al. | A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy. | 2001 | Am. J. Obstet. Gynecol. | pmid:11408852 |
Matsunaga T | [Pharmacological and pharmacokinetic properties of azithromycin (Zithromac), a novel 15-membered ring macrolide antibacterial agent]. | 2001 | Nippon Yakurigaku Zasshi | pmid:11411344 |
Krudsood S et al. | A randomized clinical trial of combinations of artesunate and azithromycin for treatment of uncomplicated Plasmodium falciparum malaria in Thailand. | 2000 | Southeast Asian J. Trop. Med. Public Health | pmid:11414432 |
Kain KC et al. | Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens. | 2001 | Clin. Infect. Dis. | pmid:11418883 |
Chetchotisakd P et al. | Maintenance therapy of melioidosis with ciprofloxacin plus azithromycin compared with cotrimoxazole plus doxycycline. | 2001 Jan-Feb | Am. J. Trop. Med. Hyg. | pmid:11425157 |
Tabbara KF | Trachoma: a review. | 2001 | J Chemother | pmid:11434524 |
Lisby G et al. | Bacteremia and meningitis caused by a macrolide-sensitive strain of Streptococcus pneumoniae during treatment with azithromycin. | 2001 | Clin. Infect. Dis. | pmid:11438918 |
Ishimatsu Y et al. | [Effect of macrolide antibiotics on apoptosis induction]. | 2001 | Jpn J Antibiot | pmid:11439895 |
Edelstein PH et al. | In vitro activity of gemifloxacin (SB-265805, LB20304a) against Legionella pneumophila and its pharmacokinetics in guinea pigs with L. pneumophila pneumonia. | 2001 | Antimicrob. Agents Chemother. | pmid:11451675 |
Arellano-Rodrigo E et al. | [Torsade de pointes and cardiorespiratory arrest induced by azithromycin in a patient with congenital long QT syndrome]. | 2001 | Med Clin (Barc) | pmid:11459586 |
Fraser-Hurt N et al. | Efficacy of oral azithromycin versus topical tetracycline in mass treatment of endemic trachoma. | 2001 | Bull. World Health Organ. | pmid:11477966 |
Gray GC and Ryan MA | Azithromycin chemoprophylaxis. | 2001 | J. Infect. Dis. | pmid:11494171 |
Noedl H et al. | Antimalarial activity of azithromycin, artemisinin and dihydroartemisinin in fresh isolates of Plasmodium falciparum in Thailand. | 2001 | Acta Trop. | pmid:11495642 |
Gómez J et al. | [Prospective, comparative study (1994-1998) of the influence of short-term prophylactic treatment with azithromycin on patients with advanced COPD]. | 2000 | Rev Esp Quimioter | pmid:11498704 |
Tyteca D et al. | Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts. | 2001 | Eur. J. Cell Biol. | pmid:11499789 |
Dillon JA et al. | Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from three Caribbean countries: Trinidad, Guyana, and St. Vincent. | 2001 | Sex Transm Dis | pmid:11518867 |
Dillon JA et al. | Reduced susceptibility to azithromycin and high percentages of penicillin and tetracycline resistance in Neisseria gonorrhoeae isolates from Manaus, Brazil, 1998. | 2001 | Sex Transm Dis | pmid:11518869 |
Damianov L et al. | [Treatment of genital chlamydia infections with Sumamed]. | 2001 | Akush Ginekol (Sofiia) | pmid:11519320 |
González de Aledo Linos A and GarcÃa Merino J | [Control of a school outbreak of serogroup B meningococcal disease by chemoprophylaxis with azithromycin and ciprofloxacin]. | 2000 | An. Esp. Pediatr. | pmid:11521657 |
Doern GV | Antimicrobial use and the emergence of antimicrobial resistance with Streptococcus pneumoniae in the United States. | 2001 | Clin. Infect. Dis. | pmid:11524718 |
Gray GC et al. | Randomized, placebo-controlled clinical trial of oral azithromycin prophylaxis against respiratory infections in a high-risk, young adult population. | 2001 | Clin. Infect. Dis. | pmid:11528569 |
Schlegel L et al. | In vitro activity of midecamycin diacetate, a 16-membered macrolide, against Streptococcus pyogenes isolated in France, 1995-1999. | 2001 | Clin. Microbiol. Infect. | pmid:11531981 |
Urbano F and Urbano P | Azithromycin in healthy adults? | 2001 | Clin. Microbiol. Infect. | pmid:11531993 |
Miyazaki S et al. | Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice. | 2001 | J. Antimicrob. Chemother. | pmid:11533011 |
Milkovic-Kraus S and Kanceljak-Macan B | Occupational airborne allergic contact dermatitis from azithromycin. | 2001 | Contact Derm. | pmid:11553158 |
Kaiser L et al. | Role of nasopharyngeal culture in antibiotic prescription for patients with common cold or acute sinusitis. | 2001 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:11561799 |
Amsden GW | Advanced-generation macrolides: tissue-directed antibiotics. | 2001 | Int. J. Antimicrob. Agents | pmid:11574189 |
Rubinstein E | Comparative safety of the different macrolides. | 2001 | Int. J. Antimicrob. Agents | pmid:11574199 |
Malizia T et al. | Interaction between piroxicam and azithromycin during distribution to human periodontal tissues. | 2001 | J. Periodontol. | pmid:11577945 |
Schilling F and Kessler S | [Chronic recurrent multifocal osteomyelitis-- I. Review]. | 2001 Sep-Oct | Klin Padiatr | pmid:11582525 |
Schilling F et al. | [Pelvic type of chronic recurrent multifocal osteomyelitis]. | 2001 Sep-Oct | Klin Padiatr | pmid:11582526 |
Kent JR et al. | Azithromycin: an assessment of its pharmacokinetics and therapeutic potential in CAPD. | 2001 Jul-Aug | Perit Dial Int | pmid:11587400 |
Joloba ML et al. | Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media. | 2001 | Clin. Infect. Dis. | pmid:11588694 |
Chahine C et al. | Ultrashort regimen of lansoprazole-amoxicillin-azithromycin for eradicating Helicobacter pylori. | 2001 | Am J Health Syst Pharm | pmid:11596697 |
Dreses-Werringloer U et al. | Effects of azithromycin and rifampin on Chlamydia trachomatis infection in vitro. | 2001 | Antimicrob. Agents Chemother. | pmid:11600348 |
Nagai K et al. | Activities of a new fluoroketolide, HMR 3787, and its (des)-fluor derivative RU 64399 compared to those of telithromycin, erythromycin A, azithromycin, clarithromycin, and clindamycin against macrolide-susceptible or -resistant Streptococcus pneumoniae and S. pyogenes. | 2001 | Antimicrob. Agents Chemother. | pmid:11600391 |
Ioannidis JP et al. | Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for upper respiratory tract infections. | 2001 | J. Antimicrob. Chemother. | pmid:11679557 |
Contopoulos-Ioannidis DG et al. | Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for lower respiratory tract infections. | 2001 | J. Antimicrob. Chemother. | pmid:11679558 |
Laurent J et al. | A randomized comparison of four omeprazole-based triple therapy regimens for the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia. | 2001 | Aliment. Pharmacol. Ther. | pmid:11683693 |
Dubois J and St-Pierre C | In vitro susceptibility study of BMS-284756 against Legionella species. | 2001 Sep-Oct | Diagn. Microbiol. Infect. Dis. | pmid:11687318 |
Kastner U and Guggenbichler JP | Influence of macrolide antibiotics on promotion of resistance in the oral flora of children. | 2001 | Infection | pmid:11688901 |
Golledge CL and Riley TV | The efficacy of an antibiotic protocol for community-acquired pneumonia. | 2001 | Med. J. Aust. | pmid:11700844 |
Toro C et al. | [Prevalence of primary Helicobacter pylori resistance to eight antimicrobial agents in a hospital in Madrid]. | 2001 | Rev Esp Quimioter | pmid:11704771 |
Postma MJ et al. | Cost-effectiveness of partner pharmacotherapy in screening women for asymptomatic infection with Chlamydia Trachomatis. | 2001 May-Jun | Value Health | pmid:11705188 |
Pukrittayakamee S et al. | Therapeutic responses to antibacterial drugs in vivax malaria. | 2001 Sep-Oct | Trans. R. Soc. Trop. Med. Hyg. | pmid:11706666 |
Samarendra P et al. | QT prolongation associated with azithromycin/amiodarone combination. | 2001 | Pacing Clin Electrophysiol | pmid:11707055 |
Hand WL and Hand DL | Characteristics and mechanisms of azithromycin accumulation and efflux in human polymorphonuclear leukocytes. | 2001 | Int. J. Antimicrob. Agents | pmid:11711255 |
Treadway G and Reisman A | Tolerability of 3-day, once-daily azithromycin suspension versus standard treatments for community-acquired paediatric infectious diseases. | 2001 | Int. J. Antimicrob. Agents | pmid:11711256 |
Page RL et al. | Possible interaction between intravenous azithromycin and oral cyclosporine. | 2001 | Pharmacotherapy | pmid:11714218 |
Weigl LB et al. | [Confluent and reticulate papillomatosis. Successful therapy with azithromycin]. | 2001 | Hautarzt | pmid:11715390 |
Gray RH et al. | Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. | 2001 | Am. J. Obstet. Gynecol. | pmid:11717659 |
Intrauterine devices: antibiotic prophylaxis not necessary during insertion. | 2001 | Prescrire Int | pmid:11718174 | |
Salopek-Rabatić J | Chlamydial conjunctivitis in contact lens wearers: successful treatment with single dose azithromycin. | 2001 | CLAO J | pmid:11725983 |
Butler T | Effect of increased inoculum of Salmonella typhi on MIC of azithromycin and resultant growth characteristics. | 2001 | J. Antimicrob. Chemother. | pmid:11733476 |
Cascio A et al. | Clarithromycin versus azithromycin in the treatment of Mediterranean spotted fever in children: a randomized controlled trial. | 2002 | Clin. Infect. Dis. | pmid:11740701 |
Bain DL et al. | Chlamydial genovar distribution after community wide antibiotic treatment. | 2001 | J. Infect. Dis. | pmid:11740734 |
Aberg JA et al. | Presence of macrolide resistance in respiratory flora of HIV-Infected patients receiving either clarithromycin or azithromycin for Mycobacterium avium complex prophylaxis. | 2001 Nov-Dec | HIV Clin Trials | pmid:11742432 |
Najib NM et al. | Bioequivalence assessment of Azomycin (Julphar, UAE) as compared to Zithromax (Pfizer, USA)--two brands of azithromycin--in healthy human volunteers. | 2001 | Biopharm Drug Dispos | pmid:11745903 |
Firsov AA et al. | Comparative pharmacodynamics of azithromycin and roxithromycin with S. pyogenes and S. pneumoniae in a model that simulates in vitro pharmacokinetics in human tonsils. | 2002 | J. Antimicrob. Chemother. | pmid:11751774 |
Chodorowska M et al. | [Susceptibility to macrolide antibiotics of Bordetella pertussis and Bordetella parapertussis strains isolated from whooping cough patients in 1968 and in 1997-99]. | 2001 | Med Dosw Mikrobiol | pmid:11757403 |
Jacks S et al. | Pharmacokinetics of azithromycin and concentration in body fluids and bronchoalveolar cells in foals. | 2001 | Am. J. Vet. Res. | pmid:11763173 |
Bragina EY et al. | Electron microscopic evidence of persistent chlamydial infection following treatment. | 2001 | J Eur Acad Dermatol Venereol | pmid:11763379 |
Swanston WH et al. | Single dose (direct observed) azithromycin therapy for Neisseria gonorrhoeae and Chlamydia trachomatis in STD clinic attenders with genital discharge in Trinidad and Tobago. | 2001 | West Indian Med J | pmid:11769023 |
Phillips P et al. | Azithromycin prophylaxis for Mycobacterium avium complex during the era of highly active antiretroviral therapy: evaluation of a provincial program. | 2002 | Clin. Infect. Dis. | pmid:11774085 |
Mendes CM et al. | In vitro susceptibility of gram-positive cocci isolated from skin and respiratory tract to azithromycin and twelve other antimicrobial agents. | 2001 | Braz J Infect Dis | pmid:11779453 |
Castor D et al. | Antibiotic resistant N. gonorrhoeae in Trinidad and Tobago. | 2001 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:11785665 |
Oksi J | [Diagnostics and treatment of Lyme borreliosis]. | 2000 | Duodecim | pmid:11787113 |
van der Griend B et al. | An uncommon cause of a destructive vulval lesion. | 2001 | Aust N Z J Obstet Gynaecol | pmid:11787928 |
Kutlin A et al. | Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection Model. | 2002 | Antimicrob. Agents Chemother. | pmid:11796350 |
Nagai K et al. | Susceptibility to telithromycin in 1,011 Streptococcus pyogenes isolates from 10 central and Eastern European countries. | 2002 | Antimicrob. Agents Chemother. | pmid:11796375 |
Skerk V et al. | Azithromycin in the treatment of chronic prostatitis caused by Chlamydia trachomatis. | 2001 | J Chemother | pmid:11806631 |
Stiefelhagen P | [Treatment refractory fever... und then also the kidneys fail]. | 2001 | MMW Fortschr Med | pmid:11808449 |
Tateda K et al. | Potential of macrolide antibiotics to inhibit protein synthesis of Pseudomonas aeruginosa: suppression of virulence factors and stress response. | 2000 | J. Infect. Chemother. | pmid:11810524 |
Andersen SE et al. | [Failed azithromycin treatment of Chlamydia trachomatis infection]. | 2001 | Ugeskr. Laeg. | pmid:11810790 |
Dawson CR and Schachter J | Should trachoma be treated with antibiotics? | 2002 | Lancet | pmid:11812548 |
Safak MA et al. | A comparative study of azithromycin and pseudoephedrine hydrochloride for otitis media with effusion in children. | 2001 | Acta Otolaryngol. | pmid:11813896 |
Zubata P et al. | A new HPLC method for azithromycin quantitation. | 2002 | J Pharm Biomed Anal | pmid:11814725 |
Lentino JR and Krasnicka B | Association between initial empirical therapy and decreased length of stay among veteran patients hospitalized with community acquired pneumonia. | 2002 | Int. J. Antimicrob. Agents | pmid:11814769 |
Vorbach H et al. | Endothelial cell compatibility of azithromycin and erythromycin. | 2002 | J. Antimicrob. Chemother. | pmid:11815590 |