Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Corneal Edema D015715 3 associated lipids
Frontal Sinusitis D015522 1 associated lipids
Ethmoid Sinusitis D015521 2 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Dry Eye Syndromes D015352 10 associated lipids
Mycobacterium avium-intracellulare Infection D015270 4 associated lipids
Sexually Transmitted Diseases, Bacterial D015231 5 associated lipids
Superinfection D015163 3 associated lipids
Yaws D015001 4 associated lipids
Per page 10 20 50 100 | Total 276

PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Lu Y et al. Antibiotics Promote Escherichia coli-Pseudomonas aeruginosa Conjugation through Inhibiting Quorum Sensing. 2017 Antimicrob. Agents Chemother. pmid:28993333
Paul P et al. Capillary electrophoresis with capacitively coupled contactless conductivity detection method development and validation for the determination of azithromycin, clarithromycin, and clindamycin. 2017 J Sep Sci pmid:28683179
Volgers C et al. Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection. 2017 Inflammopharmacology pmid:28528362
Stieger N et al. Solution-mediated crystallization of amorphous azithromycin. 2017 Pharmazie pmid:29441902
Feng X and Liu J A combination of irsogladine maleate and azithromycin exhibits addictive protective effects in LPS-induced human gingival epithelial cells. 2017 Pharmazie pmid:29441859
Dixit S et al. Carbamoylated azithromycin incorporated zirconia hybrid monolith for enantioseparation of acidic chiral drugs using non-aqueous capillary electrochromatography. 2017 J Chromatogr A pmid:28558906
Jordan SJ et al. Lower Levels of Cervicovaginal Tryptophan Are Associated With Natural Clearance of Chlamydia in Women. 2017 J. Infect. Dis. pmid:28520912
Lopes Dos Santos Santiago G et al. Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma. 2017 BMC Microbiol. pmid:28486933
Savaris RF et al. Antibiotic therapy for pelvic inflammatory disease. 2017 Cochrane Database Syst Rev pmid:28436019
Snelling PJ et al. Rhabdomyolysis Complicating Typhoid Fever in A Child and Review of the Literature. 2017 Pediatr. Infect. Dis. J. pmid:28430751
Koštrun S et al. Around the macrolide - Impact of 3D structure of macrocycles on lipophilicity and cellular accumulation. 2017 Eur J Med Chem pmid:28410508
Koeva M et al. An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections. 2017 Antimicrob. Agents Chemother. pmid:28923873
Ito A et al. A Case of Community-Acquired Pneumonia Due to Legionella pneumophila Serogroup 9 Wherein Initial Treatment with Single-Dose Oral Azithromycin Appeared Useful. 2017 Jpn. J. Infect. Dis. pmid:28890505
Saiz JC and Martín-Acebes MA Reply to Iannetta et al., "Azithromycin Shows Anti-Zika Virus Activity in Human Glial Cells". 2017 Antimicrob. Agents Chemother. pmid:28839084
Iannetta M et al. Azithromycin Shows Anti-Zika Virus Activity in Human Glial Cells. 2017 Antimicrob. Agents Chemother. pmid:28839081
Hallström H et al. Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: A randomized clinical trial. 2017 J. Clin. Periodontol. pmid:28836279
Liu D et al. Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2. 2017 PLoS ONE pmid:28976984
Lee S et al. The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis. 2017 PLoS ONE pmid:28973041
Lee SC et al. Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis. 2017 Medicine (Baltimore) pmid:28885357
Mandhane PJ et al. Treatment of preschool children presenting to the emergency department with wheeze with azithromycin: A placebo-controlled randomized trial. 2017 PLoS ONE pmid:28771627
Okah E et al. Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. 2017 Sex Transm Dis pmid:28079746
Gifford J et al. Decision support during electronic prescription to stem antibiotic overuse for acute respiratory infections: a long-term, quasi-experimental study. 2017 BMC Infect. Dis. pmid:28760143
Ragusa A and Svelato A Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28079335
Upadhyay K et al. Combination therapy with ampicillin and azithromycin improved outcomes in a mouse model of group B streptococcal sepsis. 2017 PLoS ONE pmid:28759625
Greig JR and Jones L Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28079334
Li R et al. Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice. 2017 PLoS ONE pmid:28742883
Bellon H et al. Interleukin-1α induced release of interleukin-8 by human bronchial epithelial cells in vitro: assessing mechanisms and possible treatment options. 2017 Transpl. Int. pmid:28078769
Tribble DR Antibiotic Therapy for Acute Watery Diarrhea and Dysentery. 2017 Mil Med pmid:28885920
Pavlova A et al. Toward the rational design of macrolide antibiotics to combat resistance. 2017 Chem Biol Drug Des pmid:28419786
Asano N et al. Limited Azithromycin Localization to Rabbit Meibomian Glands Revealed by LC-MS-Based Bioanalysis and DESI Imaging. 2017 Biol. Pharm. Bull. pmid:28867744
Seyama S et al. Amino Acid Substitution in the Major Multidrug Efflux Transporter Protein AcrB Contributes to Low Susceptibility to Azithromycin in Haemophilus influenzae. 2017 Antimicrob. Agents Chemother. pmid:28848006
Yoon HY et al. Clinical significance of QT-prolonging drug use in patients with MDR-TB or NTM disease. 2017 Int. J. Tuberc. Lung Dis. pmid:28826448
Whiley DM et al. Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia. 2017 Emerging Infect. Dis. pmid:28820128
Fage C et al. The combination of oseltamivir with azithromycin does not show additional benefits over oseltamivir monotherapy in mice infected with influenza A(H1N1)pdm2009 virus. 2017 J. Med. Virol. pmid:28792077
Koetsveld J et al. Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. 2017 Antimicrob. Agents Chemother. pmid:28674060
Chavada VD et al. Surface plasmon resonance based selective and sensitive colorimetric determination of azithromycin using unmodified silver nanoparticles in pharmaceuticals and human plasma. 2017 Spectrochim Acta A Mol Biomol Spectrosc pmid:27419643
Agarwal E et al. Locally Delivered 0.5% Azithromycin as an Adjunct to Non-Surgical Treatment in Patients With Chronic Periodontitis With Type 2 Diabetes: A Randomized Controlled Clinical Trial. 2017 J. Periodontol. pmid:22655911
Lau A et al. Treatment efficacy of azithromycin 1 g single dose versus doxycycline 100 mg twice daily for 7 days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. 2017 BMC Infect. Dis. pmid:28061753
Saini H et al. Azithromycin-Ciprofloxacin-Impregnated Urinary Catheters Avert Bacterial Colonization, Biofilm Formation, and Inflammation in a Murine Model of Foreign-Body-Associated Urinary Tract Infections Caused by Pseudomonas aeruginosa. 2017 Antimicrob. Agents Chemother. pmid:28031194
Bouklouze A et al. Azithromycin assay in drug formulations: Validation of a HPTLC method with a quadratic polynomial calibration model using the accuracy profile approach. 2017 Ann Pharm Fr pmid:27692351
Collins SA et al. Cephalosporin-3'-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms. 2017 Antimicrob. Agents Chemother. pmid:27919896
Han B et al. Intrahepatic cholestasis of pregnancy or azithromycin-induced intrahepatic cholestasis: A case report. 2017 Medicine (Baltimore) pmid:29384912
Katz AR et al. Cluster of Neisseria gonorrhoeae Isolates With High-level Azithromycin Resistance and Decreased Ceftriaxone Susceptibility, Hawaii, 2016. 2017 Clin. Infect. Dis. pmid:28549097
Lee N et al. Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: A randomized controlled trial. 2017 Antiviral Res. pmid:28535933
Allen GP and Harris KA Resistance Selection in Shigella flexneri by Azithromycin, Ceftriaxone, Ciprofloxacin, Levofloxacin, and Moxifloxacin. 2017 Antimicrob. Agents Chemother. pmid:28483960
Waetzig V et al. Neurodegenerative effects of azithromycin in differentiated PC12 cells. 2017 Eur. J. Pharmacol. pmid:28479141
Park HS et al. Subantibiotic dose of azithromycin attenuates alveolar bone destruction and improves trabecular microarchitectures in a rat model of experimental periodontitis: A study using micro-computed tomography. 2017 Int. Immunopharmacol. pmid:28432937
Horner P and Saunders J Should azithromycin 1 g be abandoned as a treatment for bacterial STIs? The case for and against. 2017 Sex Transm Infect pmid:27418572
Quinn KL et al. Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. 2017 Drug Saf pmid:28421551
Bergeron A et al. Azithromycin and Survival After Hematopoietic Stem Cell Transplant-Reply. 2017 JAMA pmid:29279924