Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Periodontitis D010518 22 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Vomiting D014839 21 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Pregnancy Complications, Infectious D011251 11 associated lipids
Toxoplasmosis D014123 9 associated lipids
Toxoplasmosis, Congenital D014125 2 associated lipids
Otitis Media with Effusion D010034 9 associated lipids
Shock, Septic D012772 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Authors Title Published Journal PubMed Link
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Vandepitte J et al. High prevalence of ciprofloxacin-resistant gonorrhea among female sex workers in Kampala, Uganda (2008-2009). 2014 Sex Transm Dis pmid:24622633
Takayama Y et al. Characterization of azithromycin-resistant Neisseria gonorrhoeae isolated in Tokyo in 2005-2011. 2014 J. Infect. Chemother. pmid:24571786
Choi EY et al. Effect of azithromycin on Prevotella intermedia lipopolysaccharide-induced production of interleukin-6 in murine macrophages. 2014 Eur. J. Pharmacol. pmid:24534490
Zasowski E et al. Relationship between time to clinical response and outcomes among Pneumonia Outcomes Research Team (PORT) risk class III and IV hospitalized patients with community-acquired pneumonia who received ceftriaxone and azithromycin. 2014 Antimicrob. Agents Chemother. pmid:24752270
Wong MH et al. Emergence of clinical Salmonella enterica serovar Typhimurium isolates with concurrent resistance to ciprofloxacin, ceftriaxone, and azithromycin. 2014 Antimicrob. Agents Chemother. pmid:24752251
Gaudreau C et al. Shigella spp. with reduced azithromycin susceptibility, Quebec, Canada, 2012-2013. 2014 Emerging Infect. Dis. pmid:24750584
Gaubert A et al. Preliminary pharmaceutical development of antimalarial-antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas. 2014 Int J Pharm pmid:24726300
Fan L et al. Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin-pretreated Pseudomonas aeruginosa in vitro. 2014 FEMS Microbiol. Lett. pmid:24716633
Barbee LA Preparing for an era of untreatable gonorrhea. 2014 Curr. Opin. Infect. Dis. pmid:24685549
Seidman JC et al. Increased carriage of macrolide-resistant fecal E. coli following mass distribution of azithromycin for trachoma control. 2014 Int J Epidemiol pmid:24659584
Belibasakis GN and Thurnheer T Validation of antibiotic efficacy on in vitro subgingival biofilms. 2014 J. Periodontol. pmid:23659420
Hassing RJ et al. Salmonella subtypes with increased MICs for azithromycin in travelers returned to The Netherlands. 2014 Emerging Infect. Dis. pmid:24655478
Luo Z et al. Effects of prednisolone on refractory mycoplasma pneumoniae pneumonia in children. 2014 Pediatr. Pulmonol. pmid:23401275
Lösch B and Wank R Life-threatening angioedema of the tongue: the detection of the RNA of B henselae in the saliva of a male patient and his dog as well as of the DNA of three Bartonella species in the blood of the patient. 2014 BMJ Case Rep pmid:24654245
Jensen JS et al. In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and -susceptible Mycoplasma genitalium strains. 2014 Antimicrob. Agents Chemother. pmid:24637681
Kakeya H et al. Efficacy of combination therapy with oseltamivir phosphate and azithromycin for influenza: a multicenter, open-label, randomized study. 2014 PLoS ONE pmid:24632748
Anstead M et al. Pulmonary exacerbations in CF patients with early lung disease. 2014 J. Cyst. Fibros. pmid:24029220
Abera B and Kibret M Azithromycin, fluoroquinolone and chloramphenicol resistance of non-chlamydia conjunctival bacteria in rural community of Ethiopia. 2014 Indian J Ophthalmol pmid:23571246
Panduranga V and Kumar A Severe babesiosis presenting as acute respiratory distress syndrome in an immunocompetent patient. 2014 Conn Med pmid:24974563
Restrepo MI and Anzueto A Macrolide antibiotics for prevention of chronic obstructive pulmonary disease exacerbations: are we there yet? 2014 Am. J. Respir. Crit. Care Med. pmid:24983214
Oud EV et al. Pitfalls in the diagnosis and management of inguinal lymphogranuloma venereum: important lessons from a case series. 2014 Sex Transm Infect pmid:24787368
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Liu Y et al. Effect of azithromycin on lipid accumulation in immortalized human meibomian gland epithelial cells. 2014 JAMA Ophthalmol pmid:24357250
Heiman KE et al. Notes from the field: Shigella with decreased susceptibility to azithromycin among men who have sex with men - United States, 2002-2013. 2014 MMWR Morb. Mortal. Wkly. Rep. pmid:24522098
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Zhao Q et al. Population pharmacokinetics of azithromycin and chloroquine in healthy adults and paediatric malaria subjects following oral administration of fixed-dose azithromycin and chloroquine combination tablets. 2014 Malar. J. pmid:24472224
Liu Y et al. One man's poison is another man's meat: using azithromycin-induced phospholipidosis to promote ocular surface health. 2014 Toxicology pmid:24613571
Gaynor BD et al. Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. 2014 Am. J. Trop. Med. Hyg. pmid:24615132
Kaiser C A coughing spell. 2014 JEMS pmid:24724329
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Toledo Junior A et al. Poor response to azithromycin in cutaneous leishmaniasis leading to a premature interruption of a multicentric phase III clinical trial in Brazil. 2014 Nov-Dec Rev. Soc. Bras. Med. Trop. pmid:25626655
Rai S Azithromycin zone interpretation for Salmonella: time to adopt BSAC's zone diameters? 2014 Oct-Dec Indian J Med Microbiol pmid:25297045
He X et al. Synergistic combination of marine oligosaccharides and azithromycin against Pseudomonas aeruginosa. 2014 Sep-Oct Microbiol. Res. pmid:24529598
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Luo H et al. Identification of ribosomal RNA methyltransferase gene ermF in Riemerella anatipestifer. 2015 Avian Pathol. pmid:25690020
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Fonseca DC et al. Clinical and Microbiologic Evaluation of Scaling and Root Planing per Quadrant and One-Stage Full-Mouth Disinfection Associated With Azithromycin or Chlorhexidine: A Clinical Randomized Controlled Trial. 2015 J. Periodontol. pmid:26252751
Medina AM et al. Comparative analysis of antimicrobial resistance in enterotoxigenic Escherichia coli isolates from two paediatric cohort studies in Lima, Peru. 2015 Trans. R. Soc. Trop. Med. Hyg. pmid:26175267
West SK et al. Risk of Infection with Chlamydia trachomatis from Migrants to Communities Undergoing Mass Drug Administration for Trachoma Control. 2015 Ophthalmic Epidemiol pmid:26158574
Bérard A et al. Use of macrolides during pregnancy and the risk of birth defects: a population-based study. 2015 Pharmacoepidemiol Drug Saf pmid:26513406
Barve A et al. The effects of CYP3A4 induction and inhibition on the pharmacokinetics of alisporivir in humans. 2015 Clin Pharmacol Drug Dev pmid:27128001
Gomi K et al. Full-mouth scaling and root planing combined with azithromycin to treat peri-implantitis. 2015 Aust Dent J pmid:25439282
Zhi D et al. The enhancement of cardiac toxicity by concomitant administration of Berberine and macrolides. 2015 Eur J Pharm Sci pmid:25976224
Jimenez V et al. Mass drug administration for trachoma: how long is not long enough? 2015 PLoS Negl Trop Dis pmid:25799168
Kitsiouli E et al. Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells. 2015 Biochim. Biophys. Acta pmid:25791017
Prohl A et al. Enrofloxacin and macrolides alone or in combination with rifampicin as antimicrobial treatment in a bovine model of acute Chlamydia psittaci infection. 2015 PLoS ONE pmid:25768665