Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Skerk V et al. | Azithromycin and doxycycline in the treatment of female patients with acute urethral syndrome caused by Ureaplasma urealyticum: significance of duration of clinical symptoms. | 2001 | Drugs Exp Clin Res | pmid:11822223 |
[Antibiotics in respiratory tract infections. Enormous differences in compliance]. | 2001 | MMW Fortschr Med | pmid:11824169 | |
[Chronic bronchitis. When to use antibiotics?]. | 2001 | MMW Fortschr Med | pmid:11824170 | |
Burton MJ et al. | Azithromycin for the treatment and control of trachoma. | 2002 | Expert Opin Pharmacother | pmid:11829725 |
Biswas S | In-vitro antimalarial activity of azithromycin against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. | 2001 Oct-Dec | J Postgrad Med | pmid:11832638 |
Gaylor AS and Reilly JC | Therapy with macrolides in patients with cystic fibrosis. | 2002 | Pharmacotherapy | pmid:11837560 |
Smith SR et al. | A double-blind placebo-controlled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: clinical results. | 2002 | J. Clin. Periodontol. | pmid:11846850 |
Calvo A et al. | [Activity of different antimicrobial agents against penicillin-resistant Streptococcus pneumoniae]. | 2001 | Rev Esp Quimioter | pmid:11856980 |
Wu ML et al. | Enterocolonic Mycobacterium avium-intracellulare. | 2002 | Arch. Pathol. Lab. Med. | pmid:11860323 |
Duff P | Antibiotic selection in obstetrics: making cost-effective choices. | 2002 | Clin Obstet Gynecol | pmid:11862059 |
Wolter J et al. | Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: a randomised trial. | 2002 | Thorax | pmid:11867823 |
Zhou F et al. | High accuracy mass measurement of peptides with internal calibration using a dual electrospray ionization sprayer system for protein identification. | 2002 | Rapid Commun. Mass Spectrom. | pmid:11870887 |
Martinez SM et al. | Azithromycin prophylaxis during a hospitalwide outbreak of a pertussis-like illness. | 2001 | Infect Control Hosp Epidemiol | pmid:11876458 |
Muirhead GJ et al. | The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers. | 2002 | Br J Clin Pharmacol | pmid:11879258 |
Parchure N et al. | Effect of azithromycin treatment on endothelial function in patients with coronary artery disease and evidence of Chlamydia pneumoniae infection. | 2002 | Circulation | pmid:11901039 |
SoRelle R | Treatment with azithromycin improves endothelial function. | 2002 | Circulation | pmid:11902195 |
Ohara T et al. | [Protective effect of azithromycin against verotoxin]. | 2002 | Kansenshogaku Zasshi | pmid:11905000 |
Salaria M and Singh M | Atypical pneumonia in children. | 2002 | Indian Pediatr | pmid:11910135 |
Desta Z et al. | In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin. | 2002 | J Clin Psychopharmacol | pmid:11910261 |
Kacmar J et al. | A randomized trial of azithromycin versus amoxicillin for the treatment of Chlamydia trachomatis in pregnancy. | 2001 | Infect Dis Obstet Gynecol | pmid:11916175 |
Treadway G et al. | The safety of azithromycin in the treatment of adults with community-acquired respiratory tract infections. | 2002 | Int. J. Antimicrob. Agents | pmid:11932140 |
Nalbanski B and Nalbanski A | [Treatment of Chlamydia trachomatis with azatril]. | 2002 | Akush Ginekol (Sofiia) | pmid:11935692 |
Krumov G et al. | [Treatment of chlamydial cervicitis with azatril]. | 2002 | Akush Ginekol (Sofiia) | pmid:11935693 |
Amsden GW et al. | A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers. | 2002 | J Clin Pharmacol | pmid:11936570 |
Lacroix JS et al. | Symptoms and clinical and radiological signs predicting the presence of pathogenic bacteria in acute rhinosinusitis. | 2002 | Acta Otolaryngol. | pmid:11936912 |
King A et al. | Erythromycin susceptibility of viridans streptococci from the normal throat flora of patients treated with azithromycin or clarithromycin. | 2002 | Clin. Microbiol. Infect. | pmid:11952721 |
Blandizzi C et al. | Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patients. | 2002 | Antimicrob. Agents Chemother. | pmid:11959610 |
Ghaffar F et al. | Effects of large dosages of amoxicillin/clavulanate or azithromycin on nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, nonpneumococcal alpha-hemolytic streptococci, and Staphylococcus aureus in children with acute otitis media. | 2002 | Clin. Infect. Dis. | pmid:11981724 |
Edelstein PH | Predicting the emergence of antimicrobial resistance. | 2002 | Clin. Infect. Dis. | pmid:11981741 |
Ekici A et al. | Effect of azithromycin on the severity of bronchial hyperresponsiveness in patients with mild asthma. | 2002 | J Asthma | pmid:11990233 |
Mohler AM | Treatment of streptococcal pharyngitis. | 2002 | Am Fam Physician | pmid:11996411 |
Davis JL et al. | Pharmacokinetics of azithromycin in foals after i.v. and oral dose and disposition into phagocytes. | 2002 | J. Vet. Pharmacol. Ther. | pmid:12000529 |
Champney WS and Miller M | Inhibition of 50S ribosomal subunit assembly in Haemophilus influenzae cells by azithromycin and erythromycin. | 2002 | Curr. Microbiol. | pmid:12000992 |
Mandell GL and Coleman EJ | Effect of antipyretic agents on uptake, transport, and release of antimicrobial agents by human polymorphonuclear leukocytes. | 2002 | J. Infect. Dis. | pmid:12001049 |
Kutlin A et al. | Effect of gemifloxacin on viability of Chlamydia pneumoniae (Chlamydophila pneumoniae) in an in vitro continuous infection model. | 2002 | J. Antimicrob. Chemother. | pmid:12003969 |
Jung R et al. | Intracellular activity of ABT-773 and other antimicrobial agents against Legionella pneumophila. | 2002 | J. Antimicrob. Chemother. | pmid:12003984 |
Rustomjee R et al. | A randomized controlled trial of azithromycin versus doxycycline/ciprofloxacin for the syndromic management of sexually transmitted infections in a resource-poor setting. | 2002 | J. Antimicrob. Chemother. | pmid:12003988 |
Voytilla KL et al. | Visual compatibility of azithromycin with 24 commonly used drugs during simulated Y-site delivery. | 2002 | Am J Health Syst Pharm | pmid:12004465 |
[Unfortunately without effectiveness: chlamydia eradication after infarct]. | 2002 | MMW Fortschr Med | pmid:12014269 | |
Suriawinata A and Min AD | A 33-year-old woman with jaundice after azithromycin use. | 2002 | Semin. Liver Dis. | pmid:12016551 |
Valleala H et al. | [The unknown SAPHO]. | 2000 | Duodecim | pmid:12017613 |
Evans AT et al. | Azithromycin for acute bronchitis: a randomised, double-blind, controlled trial. | 2002 | Lancet | pmid:12020525 |
Campos-Outcalt D et al. | Use of directly observed azithromycin treatment for syphilis in a homeless woman. | 2002 | Sex Transm Dis | pmid:12035029 |
Ortega E et al. | In vitro and ex vivo effects of erythromycin A, azithromycin and josamycin on the splenic response to specific antigens and mitogens. | 2002 | J. Antimicrob. Chemother. | pmid:12039899 |
Chokephaibulkit K et al. | Intestinal parasitic infections among human immunodeficiency virus-infected and -uninfected children hospitalized with diarrhea in Bangkok, Thailand. | 2001 | Southeast Asian J. Trop. Med. Public Health | pmid:12041552 |
Lisby JG et al. | [Bacteremia and meningitis caused by Streptococcus pneumoniae during treatment with azithromycin]. | 2002 | Ugeskr. Laeg. | pmid:12043408 |
Nishikawa T | [Comment on the contribution by Weigl CB et al. "Papillomatosis confluens et reticularis"]. | 2002 | Hautarzt | pmid:12063751 |
Batieha A et al. | No advantage of treating acute respiratory tract infections with azithromycin in a placebo-controlled study. | 2002 | Scand. J. Infect. Dis. | pmid:12064684 |
Carryn S et al. | Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations. | 2002 | Antimicrob. Agents Chemother. | pmid:12069960 |
Babl FE et al. | Experimental acute otitis media due to nontypeable Haemophilus influenzae: comparison of high and low azithromycin doses with placebo. | 2002 | Antimicrob. Agents Chemother. | pmid:12069974 |
Chimura T | [Changes of antibody titers during antimicrobial therapy including levofloxacin for Chlamydia infections in the obstetrics and gynecology field]. | 2002 | Jpn J Antibiot | pmid:12071097 |
Cohen R et al. | Comparison of two dosages of azithromycin for three days versus penicillin V for ten days in acute group A streptococcal tonsillopharyngitis. | 2002 | Pediatr. Infect. Dis. J. | pmid:12075760 |
Schaad UB et al. | Azithromycin versus penicillin V for treatment of acute group A streptococcal pharyngitis. | 2002 | Pediatr. Infect. Dis. J. | pmid:12075761 |
Domeika M et al. | Chlamydia trachomatis infections in eastern Europe: legal aspects, epidemiology, diagnosis, and treatment. | 2002 | Sex Transm Infect | pmid:12081171 |
Patrick DM et al. | Heterosexual outbreak of infectious syphilis: epidemiological and ethnographic analysis and implications for control. | 2002 | Sex Transm Infect | pmid:12083438 |
Reshetniak VI et al. | [Eradication of Helicobacter pylori in patients with duodenal ulcer following the short course of treatment with azitromycin and amoxycillin]. | 2002 | Antibiot. Khimioter. | pmid:12087718 |
Kays MB et al. | Azithromycin treatment failure in community-acquired pneumonia caused by Streptococcus pneumoniae resistant to macrolides by a 23S rRNA mutation. | 2002 | Diagn. Microbiol. Infect. Dis. | pmid:12088625 |
Breier AR et al. | Microbiological assay for azithromycin in pharmaceutical formulations. | 2002 | J Pharm Biomed Anal | pmid:12093530 |
Bosch-Driessen LH et al. | A prospective, randomized trial of pyrimethamine and azithromycin vs pyrimethamine and sulfadiazine for the treatment of ocular toxoplasmosis. | 2002 | Am. J. Ophthalmol. | pmid:12095805 |
Butler T | Reduction of MIC of azithromycin for Salmonella typhi and Staphylococcus aureus in broth exposed to previous growth of Salmonella typhi. | 2002 | J. Antimicrob. Chemother. | pmid:12096025 |
White RL et al. | Comparative activity of gatifloxacin and other antibiotics against 4009 clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000. | 2002 | Diagn. Microbiol. Infect. Dis. | pmid:12106954 |
Matute AJ et al. | Double-blind, placebo-controlled study comparing the effect of azithromycin with clarithromycin on oropharyngeal and bowel microflora in volunteers. | 2002 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:12111597 |
Williams ES and Miller JM | Results from late-breaking clinical trial sessions at the American College of Cardiology 51st Annual Scientific Session. | 2002 | J. Am. Coll. Cardiol. | pmid:12113263 |
Ohrt C et al. | Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro. | 2002 | Antimicrob. Agents Chemother. | pmid:12121927 |
Gandhi R et al. | Characterization of azithromycin hydrates. | 2002 | Eur J Pharm Sci | pmid:12128172 |
Fulcher SF et al. | Delayed-onset mycobacterial keratitis after LASIK. | 2002 | Cornea | pmid:12131028 |
Infection fighters. MAC prevention takes a holiday. | 2000 | TreatmentUpdate | pmid:12132450 | |
House D et al. | Cytokine release by lipopolysaccharide-stimulated whole blood from patients with typhoid fever. | 2002 | J. Infect. Dis. | pmid:12134261 |
Wallace Jr RJ et al. | Repeat positive cultures in Mycobacterium intracellulare lung disease after macrolide therapy represent new infections in patients with nodular bronchiectasis. | 2002 | J. Infect. Dis. | pmid:12134265 |
Fry AM et al. | Adverse and beneficial secondary effects of mass treatment with azithromycin to eliminate blindness due to trachoma in Nepal. | 2002 | Clin. Infect. Dis. | pmid:12145722 |
Shelby-James TM et al. | Impact of single dose azithromycin on group A streptococci in the upper respiratory tract and skin of Aboriginal children. | 2002 | Pediatr. Infect. Dis. J. | pmid:12150171 |
Weiss LM | Babesiosis in humans: a treatment review. | 2002 | Expert Opin Pharmacother | pmid:12150690 |
Blondeau JM | The evolution and role of macrolides in infectious diseases. | 2002 | Expert Opin Pharmacother | pmid:12150692 |
Cheng H et al. | Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent Gram-positive and Gram-negative antibacterial agents. | 2002 | Bioorg. Med. Chem. Lett. | pmid:12161150 |
Silva FM et al. | Low efficacy of an ultra-short term, once-daily dose triple therapy with omeprazole, azithromycin, and secnidazole for Helicobacter pylori eradication in peptic ulcer. | 2002 Jan-Feb | Rev Hosp Clin Fac Med Sao Paulo | pmid:12170343 |
Hook EW et al. | A randomized, comparative pilot study of azithromycin versus benzathine penicillin G for treatment of early syphilis. | 2002 | Sex Transm Dis | pmid:12172535 |
Kawashima M et al. | Inhibitory effects of 14-membered ring macrolide antibiotics on bleomycin-induced acute lung injury. | 2002 | Lung | pmid:12182159 |
Yee CL et al. | Tendon or joint disorders in children after treatment with fluoroquinolones or azithromycin. | 2002 | Pediatr. Infect. Dis. J. | pmid:12182376 |
Clark C et al. | In vitro selection of resistance in Haemophilus influenzae by amoxicillin-clavulanate, cefpodoxime, cefprozil, azithromycin, and clarithromycin. | 2002 | Antimicrob. Agents Chemother. | pmid:12183253 |
Ng LK et al. | Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae. | 2002 | Antimicrob. Agents Chemother. | pmid:12183262 |
Prunier AL et al. | Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolides. | 2002 | Antimicrob. Agents Chemother. | pmid:12183270 |
Gaynor BD et al. | Rationale for mass antibiotic distribution for trachoma elimination. | 2002 | Int Ophthalmol Clin | pmid:12189619 |
Maizumi N et al. | Quantitative comparison of the cytocidal effect of seven macrolide antibiotics on human periodontal ligament fibroblasts. | 2002 | J. Periodont. Res. | pmid:12200967 |
Kopjar B | Azithromycin is effective in patients with chronic bronchitis. | 2002 | J. Antimicrob. Chemother. | pmid:12205072 |
Baschiera F et al. | Improved tonsillar disposition of azithromycin following a 3-day oral treatment with 20 mg kg(-1) in paediatric patients. | 2002 | Pharmacol. Res. | pmid:12208127 |
Culić O et al. | Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects. | 2002 | Eur. J. Pharmacol. | pmid:12208321 |
Stone AF et al. | Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: South Thames Trial of Antibiotics in Myocardial Infarction and Unstable Angina (STAMINA). | 2002 | Circulation | pmid:12208796 |
Sirois F | [Delirium associated with azithromycin administration]. | 2002 | Can J Psychiatry | pmid:12211892 |
Lau CY and Qureshi AK | Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials. | 2002 | Sex Transm Dis | pmid:12218839 |
Sieper J and Braun J | [Diagnosis and antibiotic treatment of reactive arthritis]. | 2002 | Dtsch. Med. Wochenschr. | pmid:12226789 |
Fraser-Hurt N and Mabey D | Trachoma. | 2002 | Clin Evid | pmid:12230687 |
Kim MK et al. | Bactericidal effect and pharmacodynamics of cethromycin (ABT-773) in a murine pneumococcal pneumonia model. | 2002 | Antimicrob. Agents Chemother. | pmid:12234843 |
Milberg P et al. | Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235254 |
Frank E et al. | A multicenter, open-label, randomized comparison of levofloxacin and azithromycin plus ceftriaxone in hospitalized adults with moderate to severe community-acquired pneumonia. | 2002 | Clin Ther | pmid:12240780 |
Rao RU et al. | Brugia malayi: effects of antibacterial agents on larval viability and development in vitro. | 2002 | Exp. Parasitol. | pmid:12243742 |
Adimora AA | Treatment of uncomplicated genital Chlamydia trachomatis infections in adults. | 2002 | Clin. Infect. Dis. | pmid:12353204 |
Augenbraun MH | Treatment of syphilis 2001: nonpregnant adults. | 2002 | Clin. Infect. Dis. | pmid:12353205 |
Steinberg JM and Srugo I | Reoccurrence of culture-positive pertussis in an infant initially treated with azithromycin and steroids. | 2002 | Arch Pediatr Adolesc Med | pmid:12361458 |
Gomberg MA | [Combined treatment of persisting urogenital chlamydia infection with sumamed and interferon alfa]. | 2002 | Antibiot. Khimioter. | pmid:12365322 |
Hammerschlag MR | Effect of azithromycin on endothelial function of patients with coronary artery disease and evidence of Chlamydia pneumoniae infection. | 2002 | Circulation | pmid:12370232 |