Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Stork CM et al. | Elevated International Normalized Ratio associated with long-term azithromycin therapy in a child with cerebral palsy. | 2011 | Am J Health Syst Pharm | pmid:21593229 |
Baker WL and Couch KA | Azithromycin for the secondary prevention of coronary artery disease: a meta-analysis. | 2007 | Am J Health Syst Pharm | pmid:17420199 |
Voytilla KL et al. | Visual compatibility of azithromycin with 24 commonly used drugs during simulated Y-site delivery. | 2002 | Am J Health Syst Pharm | pmid:12004465 |
Goldstein RC et al. | Fluoroquinolone- and ceftriaxone-based therapy of community-acquired pneumonia in hospitalized patients: the risk of subsequent isolation of multidrug-resistant organisms. | 2014 | Am J Infect Control | pmid:24773792 |
Sorvillo F et al. | Incidence and determinants of Pseudomonas aeruginosa infection among persons with HIV: association with hospital exposure. | 2001 | Am J Infect Control | pmid:11287873 |
Lilley LL and Guanci R | Distraction delays a dose. | 1998 | Am J Nurs | pmid:9473978 |
Hashisaki GT | Update on macrolide antibiotics. | 1995 May-Jun | Am J Otolaryngol | pmid:7661309 |
Marple BF et al. | Azithromycin extended release vs amoxicillin/clavulanate: symptom resolution in acute sinusitis. | 2010 Jan-Feb | Am J Otolaryngol | pmid:19944891 |
El Hennawi DED et al. | Management of recurrent tonsillitis in children. | Am J Otolaryngol | pmid:28385329 | |
Klapan I et al. | Azithromycin versus amoxicillin/clavulanate in the treatment of acute sinusitis. | 1999 Jan-Feb | Am J Otolaryngol | pmid:9950107 |
Mvundura E et al. | Good pregnancy outcome with emergent cerclage placed in the presence of intra-amniotic microbial invasion. | 2007 | Am J Perinatol | pmid:17597442 |
Crum NF et al. | Halting a pneumococcal pneumonia outbreak among United States Marine Corps trainees. | 2003 | Am J Prev Med | pmid:12880877 |
Wolter JM et al. | Macrolides in cystic fibrosis: is there a role? | 2002 | Am J Respir Med | pmid:14720043 |
Margaritis VK et al. | Sinus fluid penetration of oral clarithromycin and azithromycin in patients with acute rhinosinusitis. | 2007 Sep-Oct | Am J Rhinol | pmid:17999793 |
Maniakas A and Desrosiers M | Azithromycin add-on therapy in high-risk postendoscopic sinus surgery patients failing corticosteroid irrigations: A clinical practice audit. | Am J Rhinol Allergy | pmid:24598145 | |
Amali A et al. | Long-term postoperative azithromycin in patients with chronic rhinosinusitis: A randomized clinical trial. | Am J Rhinol Allergy | pmid:26637580 | |
Bin Abdulhak AA et al. | Azithromycin and Risk of Cardiovascular Death: A Meta-Analytic Review of Observational Studies. | Am J Ther | pmid:25748818 | |
Sutera L et al. | Azithromycin in an older woman with diabetic gastroparesis. | 2008 Jan-Feb | Am J Ther | pmid:18223358 |
Muhlestein JB | Animal models of chlamydia and atherosclerosis. | 1999 | Am. Heart J. | pmid:10539862 |
Gupta S | Chlamydia pneumoniae, monocyte activation, and azithromycin in coronary heart disease. | 1999 | Am. Heart J. | pmid:10539869 |