Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Tracheobronchomalacia D055089 1 associated lipids
Trismus D014313 1 associated lipids
Pneumocystis Infections D016720 1 associated lipids
Reproductive Tract Infections D060737 1 associated lipids
Corneal Endothelial Cell Loss D055954 1 associated lipids
Male Urogenital Diseases D052801 1 associated lipids
Trichiasis D058457 1 associated lipids
Frontal Sinusitis D015522 1 associated lipids
Asymptomatic Infections D058345 1 associated lipids
Hyper-IgM Immunodeficiency Syndrome D053306 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Gupta A and Khanna S Repeat Clostridium difficile Testing. 2016 JAMA pmid:27959982
Misra R and Prasad KN Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India. 2016 J. Med. Microbiol. pmid:27902389
Espadas D et al. Lack of effect of azithromycin on QT interval in children: a cohort study. 2016 Arch. Dis. Child. pmid:27515186
Hanssens L et al. The clinical benefits of long-term supplementation with omega-3 fatty acids in cystic fibrosis patients - A pilot study. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27154364
Zhou Y et al. Azithromycin therapy during respiratory syncytial virus bronchiolitis: Upper airway microbiome alterations and subsequent recurrent wheeze. 2016 J. Allergy Clin. Immunol. pmid:27339392
Rosenthal PJ Azithromycin for Malaria? 2016 Am. J. Trop. Med. Hyg. pmid:27215296
Mosquera RA et al. Anti-inflammatory effect of prophylactic macrolides on children with chronic lung disease: a protocol for a double-blinded randomised controlled trial. 2016 BMJ Open pmid:27638496
Kissinger PJ et al. Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. 2016 Sex Transm Dis pmid:27631353
Nielsen HL et al. Azithromycin vs. Placebo for the Clinical Outcome in Campylobacter concisus Diarrhoea in Adults: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. 2016 PLoS ONE pmid:27893820
Tepper M et al. Mass Treatment with Single-Dose Azithromycin for Yaws. 2016 N. Engl. J. Med. pmid:27626527
Phiri K et al. Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. 2016 PLoS ONE pmid:27861509
Eckhoff G et al. Mass Treatment with Single-Dose Azithromycin for Yaws. 2016 N. Engl. J. Med. pmid:27626526
Peart JM et al. Sporotrichoid fluctuant nodules. 2016 Cutis pmid:27622258
Elshafie BE et al. The Epidemiology of Trachoma in Darfur States and Khartoum State, Sudan: Results of 32 Population-Based Prevalence Surveys. 2016 Ophthalmic Epidemiol pmid:27841721
Sadatsafavi M et al. The Association Between Rate and Severity of Exacerbations in Chronic Obstructive Pulmonary Disease: An Application of a Joint Frailty-Logistic Model. 2016 Am. J. Epidemiol. pmid:27737842
Nair S et al. WGS for surveillance of antimicrobial resistance: a pilot study to detect the prevalence and mechanism of resistance to azithromycin in a UK population of non-typhoidal Salmonella. 2016 J. Antimicrob. Chemother. pmid:27585964
Mwingira UJ et al. Progress of Trachoma Mapping in Mainland Tanzania: Results of Baseline Surveys from 2012 to 2014. 2016 Ophthalmic Epidemiol pmid:27775455
Wind CM et al. Time to clearance of Chlamydia trachomatis RNA and DNA after treatment in patients coinfected with Neisseria gonorrhoeae - a prospective cohort study. 2016 BMC Infect. Dis. pmid:27724878
Yasuda M et al. Remarkable increase of Neisseria gonorrhoeae with decreased susceptibility of azithromycin and increase in the failure of azithromycin therapy in male gonococcal urethritis in Sendai in 2015. 2016 J. Infect. Chemother. pmid:27578029
Tita AT et al. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2016 N. Engl. J. Med. pmid:27682034
Committee Opinion No. 645: Dual Therapy for Gonococcal Infections. 2016 Obstet Gynecol pmid:27548425
Waites KB et al. In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas. 2016 Antimicrob. Agents Chemother. pmid:27671057
Wang X et al. Increased therapeutic efficacy of combination of azithromycin and ceftazidime on Pseudomonas aeruginosa biofilm in an animal model of ureteral stent infection. 2016 BMC Microbiol. pmid:27341798
Das S et al. Revisit of fluoroquinolone and azithromycin susceptibility breakpoints for Salmonella enterica serovar Typhi. 2016 J. Med. Microbiol. pmid:27221661
Fifer H et al. Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea. 2016 N. Engl. J. Med. pmid:27332921
Bacharier LB et al. Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children--Reply. 2016 JAMA pmid:27187309
Gesink D et al. Mycoplasma genitalium in Toronto, Ont: Estimates of prevalence and macrolide resistance. 2016 Can Fam Physician pmid:27331225
Fleming-Dutra KE et al. Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children. 2016 JAMA pmid:27187308
Kimani J et al. Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial. 2016 PLoS ONE pmid:27326859
Morgan R et al. Unusual cause of lymphangitis in a 2-year-old boy. 2016 BMJ Case Rep pmid:27181743
Weckmann M et al. Treatment with rhDNase in patients with cystic fibrosis alters in-vitro CHIT-1 activity of isolated leucocytes. 2016 Clin. Exp. Immunol. pmid:27324468
Kong FY et al. Higher organism load associated with failure of azithromycin to treat rectal chlamydia. 2016 Epidemiol. Infect. pmid:27180823
Oliveira GN et al. Congenital dacryocystocoele with prenatal diagnosis. 2016 BMJ Case Rep pmid:27166005
Falay D et al. Microbiological, clinical and molecular findings of non-typhoidal Salmonella bloodstream infections associated with malaria, Oriental Province, Democratic Republic of the Congo. 2016 BMC Infect. Dis. pmid:27286886
Horner PJ et al. 2016 European guideline on the management of non-gonococcal urethritis. 2016 Int J STD AIDS pmid:27147267
El-Shitany NA and El-Desoky K Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression. 2016 Oxid Med Cell Longev pmid:27274777
Kreuter A and Wieland U Azithromycin versus Doxycycline for Chlamydia. 2016 N. Engl. J. Med. pmid:27144858
García-Quintanilla M et al. Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii. 2016 Antimicrob. Agents Chemother. pmid:27270288
Schachter J Azithromycin versus Doxycycline for Chlamydia. 2016 N. Engl. J. Med. pmid:27144857
Oey M and Malhotra P Azithromycin and ceftriaxone combination treatment for relapsed Salmonella Paratyphi A bacteraemia. 2016 J Travel Med pmid:26858276
DeCoster B et al. Expedited Partner Therapy: Clinical Considerations and Public Health Explorations. 2016 AMA J Ethics pmid:27002992
Zhou T et al. Determination of azithromycin residue in pork using a molecularly imprinted monolithic microcolumn coupled to liquid chromatography with tandem mass spectrometry. 2016 J Sep Sci pmid:26854282
Das MC et al. Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. 2016 Sci Rep pmid:27000525
Saleh A et al. Comparison of adjunctive azithromycin and amoxicillin/metronidazole for patients with chronic periodontitis: preliminary randomized control trial. 2016 Aust Dent J pmid:26836781
Maeda M et al. Study on rectal administration of azithromycin by suppository for pediatric use. 2016 Int J Clin Pharmacol Ther pmid:26833461
Jost C et al. Susceptibility of enterohaemorrhagic Escherichia coli to azithromycin in France and analysis of resistance mechanisms. 2016 J. Antimicrob. Chemother. pmid:26832755
Demczuk W et al. Genomic Epidemiology and Molecular Resistance Mechanisms of Azithromycin-Resistant Neisseria gonorrhoeae in Canada from 1997 to 2014. 2016 J. Clin. Microbiol. pmid:26935729
Mohotti JE et al. A case of bilateral endogenous bacterial endophthalmitis from Streptococcus pneumoniae bacteraemia. 2016 Med. J. Aust. pmid:26821111
Trac MH et al. Macrolide antibiotics and the risk of ventricular arrhythmia in older adults. 2016 CMAJ pmid:26903359
Marks M et al. Mass drug administration of azithromycin for trachoma reduces the prevalence of genital Chlamydia trachomatis infection in the Solomon Islands. 2016 Sex Transm Infect pmid:26888658
Economopoulos KP et al. Prevention of antibiotic-associated metabolic syndrome in mice by intestinal alkaline phosphatase. 2016 Diabetes Obes Metab pmid:26876427
Kang JY et al. Long-term azithromycin ameliorates not only airway inflammation but also remodeling in a murine model of chronic asthma. 2016 Pulm Pharmacol Ther pmid:26778828
Sridhar S et al. High recurrence rate supports need for secondary prophylaxis in non-HIV patients with disseminated mycobacterium avium complex infection: a multi-center observational study. 2016 BMC Infect. Dis. pmid:26861696
Peters RP et al. Gonococcal Conjunctivitis Despite Successful Treatment of Male Urethritis Syndrome. 2016 Sex Transm Dis pmid:26760182
Hodgson D et al. The Effects of Azithromycin in Treatment-Resistant Cough: A Randomized, Double-Blind, Placebo-Controlled Trial. 2016 Chest pmid:26836927
Zheng Z et al. Synthesis and antibacterial activity of novel 11-[3-[(arylcarbamoyl)oxy]propylamino]-11-deoxy-6-O-methyl-3-oxoerythromycin A 11-N,12-O-cyclic carbamate derivatives. 2016 J. Antibiot. pmid:27118243
Gratrix J et al. A Retrospective Review of Treatment Failures Using Azithromycin and Doxycycline in the Treatment of Rectal Chlamydia Infections in Women and Men Who Have Sex With Men. 2016 Sex Transm Dis pmid:26760180
Topp E et al. Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. 2016 Sci. Total Environ. pmid:27096634
Li X et al. Macrolides use and the risk of sudden cardiac death. 2016 Expert Rev Anti Infect Ther pmid:27086751
Arnold FW et al. Macrolide Use and Neutrophil Function/Cytokine Levels in Hospitalized Patients with Community-Acquired Pneumonia: A Pilot Study. 2016 Lung pmid:26553025
Olszewska-Sosińska O et al. Persistence of non-typeable Haemophilus Influenzae in the pharynx of children with adenotonsillar hypertrophy after treatment with azithromycin. 2016 Pathog Dis pmid:26546328
Wakiguchi H et al. Multiple Renal and Splenic Lesions in Cat Scratch Disease. 2016 Jpn. J. Infect. Dis. pmid:26567841
So W et al. Poor outcomes of empiric ceftriaxone ± azithromycin for community-acquired pneumonia caused by methicillin-susceptible Staphylococcus aureus. 2016 Intern Emerg Med pmid:26531307
Amantea D et al. Azithromycin protects mice against ischemic stroke injury by promoting macrophage transition towards M2 phenotype. 2016 Exp. Neurol. pmid:26518285
Manavi K et al. Comparison of doxycycline with azithromycin in treatment of pharyngeal chlamydia infection. 2016 Int J STD AIDS pmid:26511655
Williams KM et al. Fluticasone, Azithromycin, and Montelukast Treatment for New-Onset Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation. 2016 Biol. Blood Marrow Transplant. pmid:26475726
Nicholson TT et al. Assessing potential risks of treatment with long-term azithromycin in COPD patients: long-term oxygen users beware? 2016 Ir J Med Sci pmid:26502012
Deguchi T et al. Multidrug-Resistant Mycoplasma genitalium Is Increasing. 2016 Clin. Infect. Dis. pmid:26494825
Kong FY et al. Reply to Deguchi et al. 2016 Clin. Infect. Dis. pmid:26494824
Kasten G et al. Development of low density azithromycin-loaded polycaprolactone microparticles for pulmonary delivery. 2016 Drug Dev Ind Pharm pmid:26289002
Lee RA et al. Evaluation of baseline corrected QT interval and azithromycin prescriptions in an academic medical center. 2016 J Hosp Med pmid:26287278
Kasten G et al. Development of low density azithromycin-loaded polycaprolactone microparticles for pulmonary delivery. 2016 Drug Dev Ind Pharm pmid:26266961
Osborne LG et al. Enteric fever in a British soldier from Sierra Leone. 2016 J R Army Med Corps pmid:26243802
Keenan JD et al. Nasopharyngeal Pneumococcal Serotypes Before and After Mass Azithromycin Distributions for Trachoma. 2016 J Pediatric Infect Dis Soc pmid:27199475
Tous Romero F et al. Acute Infection by Staphylococcus simulans in the Hand of a Man. 2016 JAMA Dermatol pmid:27144675
Horner P et al. 2015 UK National Guideline on the management of non-gonococcal urethritis. 2016 Int J STD AIDS pmid:26002319
Ni C et al. High prevalence of Neisseria gonorrhoeae with high-level resistance to azithromycin in Hangzhou, China. 2016 J. Antimicrob. Chemother. pmid:27090631
Garnier C et al. Intra-nodal injection of gentamicin for the treatment of suppurated cat scratch disease's lymphadenitis. 2016 Infection pmid:26001741
Wright H et al. Evaluating Guideline-Recommended Antibiotic Practices for Childhood Respiratory Infections: Is It Time to Consider Case-Based Formats? 2016 Clin Pediatr (Phila) pmid:25986442
Chang CC et al. Disseminated cat-scratch disease: case report and review of the literature. 2016 Paediatr Int Child Health pmid:25940800
Dey SK et al. Comparative evaluation of 2 g single dose versus conventional dose azithromycin in uncomplicated skin and skin structure infections. 2015 Jul-Aug Indian J Pharmacol pmid:26288467
Ercan E et al. Effects of azithromycin versus metronidazole-amoxicillin combination as an adjunct to nonsurgical periodontal therapy of generalized aggressive periodontitis. 2015 Jul-Aug Niger J Clin Pract pmid:25966723
Walicka-Serzysko K and Sands D The clinical presentations of pulmonary aspergillosis in children with cystic fibrosis - preliminary report. 2015 Jan-Mar Dev Period Med pmid:26003072
Pandhi D et al. Author's Response--The efficacy of azithromycin in pityriasis rosea: a randomized, double-blind, placebo-controlled trial. 2015 Jan-Feb Indian J Dermatol Venereol Leprol pmid:25566901
Drago F et al. The efficacy of macrolides and acyclovir in pityriasis rosea. 2015 Jan-Feb Indian J Dermatol Venereol Leprol pmid:25566900
Lu ZK et al. Cardiac risks associated with antibiotics: azithromycin and levofloxacin. 2015 Expert Opin Drug Saf pmid:25494485
Kasai A et al. Prevalence and molecular analysis of macrolide-resistant Moraxella catarrhalis clinical isolates in Japan, following emergence of the highly macrolide-resistant strain NSH1 in 2011. 2015 J. Med. Microbiol. pmid:25934551
Keenan JD et al. Evidence for clonal expansion after antibiotic selection pressure: pneumococcal multilocus sequence types before and after mass azithromycin treatments. 2015 J. Infect. Dis. pmid:25293366
Young PM et al. Multi-breath dry powder inhaler for delivery of cohesive powders in the treatment of bronchiectasis. 2015 Drug Dev Ind Pharm pmid:24811055
Willekens J et al. How long should we maintain long-term azithromycin treatment in cystic fibrosis patients? 2015 Pediatr. Pulmonol. pmid:24464958
ACOG Committee Opinion No. 645 Summary: Dual Therapy for Gonococcal Infections. 2015 Obstet Gynecol pmid:26488518
Babics A and Roussellier P Gardnerella vaginalis: An overlooked pathogen in male patients? 2015 Med Mal Infect pmid:26472061
See CW et al. The Effect of Mass Azithromycin Distribution on Childhood Mortality: Beliefs and Estimates of Efficacy. 2015 Am. J. Trop. Med. Hyg. pmid:26392160
Winters N et al. Efficacy and safety of World Health Organization group 5 drugs for multidrug-resistant tuberculosis treatment. 2015 Eur. Respir. J. pmid:26381514
Lau A et al. The Efficacy of Azithromycin for the Treatment of Genital Mycoplasma genitalium: A Systematic Review and Meta-analysis. 2015 Clin. Infect. Dis. pmid:26240201
Lahra MM Australian Gonococcal Surveillance Programme annual report, 2013. 2015 Commun Dis Intell Q Rep pmid:26063087
Patterson L et al. Outbreak of invasive pneumococcal disease at a Belfast shipyard in men exposed to welding fumes, Northern Ireland, April-May 2015: preliminary report. 2015 Euro Surveill. pmid:26062559
Agaisse H Shigella flexneri serotype 3a: the rise of a superbug. 2015 Lancet Infect Dis pmid:25936610
Shoaib A et al. Determining the role of a probiotic in the restoration of intestinal microbial balance by molecular and cultural techniques. 2015 Genet. Mol. Res. pmid:25730092
Corris PA et al. A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation. 2015 Thorax pmid:25714615