Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kobuchi S et al. | Transport of Azithromycin into Extravascular Space in Rats. | 2016 | Antimicrob. Agents Chemother. | pmid:27600045 |
Rajesh AM and Popat KM | Taste masking of azithromycin by resin complex and sustained release through interpenetrating polymer network with functionalized biopolymers. | 2017 | Drug Dev Ind Pharm | pmid:27600608 |
Thompson DF and Ramos CL | Antibiotic-Induced Rash in Patients With Infectious Mononucleosis. | 2017 | Ann Pharmacother | pmid:27620494 |
Peart JM et al. | Sporotrichoid fluctuant nodules. | 2016 | Cutis | pmid:27622258 |
Dombrowski JC and Batteiger BE | Reconsidering the Use of Azithromycin for Chlamydial Urethritis. | 2016 | Sex Transm Dis | pmid:27626187 |
Mitjà O et al. | Mass Treatment with Single-Dose Azithromycin for Yaws. | 2016 | N. Engl. J. Med. | pmid:27626525 |
Eckhoff G et al. | Mass Treatment with Single-Dose Azithromycin for Yaws. | 2016 | N. Engl. J. Med. | pmid:27626526 |
Tepper M et al. | Mass Treatment with Single-Dose Azithromycin for Yaws. | 2016 | N. Engl. J. Med. | pmid:27626527 |
Kissinger PJ et al. | Azithromycin Treatment Failure for Chlamydia trachomatis Among Heterosexual Men With Nongonococcal Urethritis. | 2016 | Sex Transm Dis | pmid:27631353 |
Regnath T et al. | Antimicrobial resistance of Neisseria gonorrhoeae isolates in south-west Germany, 2004 to 2015: increasing minimal inhibitory concentrations of tetracycline but no resistance to third-generation cephalosporins. | 2016 | Euro Surveill. | pmid:27632642 |
Mosquera RA et al. | Anti-inflammatory effect of prophylactic macrolides on children with chronic lung disease: a protocol for a double-blinded randomised controlled trial. | 2016 | BMJ Open | pmid:27638496 |
Brunner A et al. | Emerging azithromycin-resistance among the Neisseria gonorrhoeae strains isolated in Hungary. | 2016 | Ann. Clin. Microbiol. Antimicrob. | pmid:27646968 |
Johnston SL et al. | Azithromycin for Acute Exacerbations of Asthma : The AZALEA Randomized Clinical Trial. | 2016 | JAMA Intern Med | pmid:27653939 |
Li S et al. | Two case reports: Whole genome sequencing of two clinical macrolide-resistant Mycoplasma pneumoniae isolates with different responses to azithromycin. | 2016 | Medicine (Baltimore) | pmid:27661056 |
Petrelli F et al. | Poly(ADP-ribose) polymerase is not involved in the neuroprotection exerted by azithromycin against ischemic stroke in mice. | 2016 | Eur. J. Pharmacol. | pmid:27663279 |
Lin SJ et al. | Azithromycin modulates immune response of human monocyte-derived dendritic cells and CD4 T cells. | 2016 | Int. Immunopharmacol. | pmid:27664570 |
Narita M et al. | Antimicrobial Susceptibility of Microorganisms Isolated from Periapical Periodontitis Lesions. | 2016 | Bull. Tokyo Dent. Coll. | pmid:27665691 |
Waites KB et al. | In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas. | 2016 | Antimicrob. Agents Chemother. | pmid:27671057 |
Tita AT et al. | Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. | 2016 | N. Engl. J. Med. | pmid:27682034 |
Jover-GarcÃa J et al. | [In-vitro activity of azithromycin in faecal isolates of Aeromonas hydrophila]. | 2017 | An Pediatr (Barc) | pmid:27686393 |
Mougari F et al. | Infections caused by Mycobacterium abscessus: epidemiology, diagnostic tools and treatment. | 2016 | Expert Rev Anti Infect Ther | pmid:27690688 |
Bouklouze A et al. | Azithromycin assay in drug formulations: Validation of a HPTLC method with a quadratic polynomial calibration model using the accuracy profile approach. | 2017 | Ann Pharm Fr | pmid:27692351 |
van den Berg GF et al. | Chlamydia screening and prophylactic treatment in termination of pregnancy clinics in the Netherlands and Great Britain: a qualitative study. | 2016 | Eur J Contracept Reprod Health Care | pmid:27701927 |
Wind CM et al. | Time to clearance of Chlamydia trachomatis RNA and DNA after treatment in patients coinfected with Neisseria gonorrhoeae - a prospective cohort study. | 2016 | BMC Infect. Dis. | pmid:27724878 |
Weintraub A et al. | In-vitro activity of solithromycin against anaerobic bacteria from the normal intestinal microbiota. | 2016 | Anaerobe | pmid:27725229 |
Sadatsafavi M et al. | The Association Between Rate and Severity of Exacerbations in Chronic Obstructive Pulmonary Disease: An Application of a Joint Frailty-Logistic Model. | 2016 | Am. J. Epidemiol. | pmid:27737842 |
Johnson P | Management of a 16-Year-Old With Axillary Lymphadenopathy: The Cat's in the Bag. | J Pediatr Health Care | pmid:27742481 | |
Daimee UA et al. | A 77-year-old man with fever and night sweats. | 2017 | Eur. J. Intern. Med. | pmid:27765389 |
Gaudreau C et al. | Shigella flexneri with Ciprofloxacin Resistance and Reduced Azithromycin Susceptibility, Canada, 2015. | 2016 | Emerging Infect. Dis. | pmid:27767915 |
Luo Q et al. | Surface plasmon resonance sensor for antibiotics detection based on photo-initiated polymerization molecularly imprinted array. | 2016 | Talanta | pmid:27769483 |
Alcaraz I et al. | [Mycoplasma genitalium]. | 2016 | Ann Dermatol Venereol | pmid:27773499 |
Dupin N et al. | [Chlamydia trachomatis]. | 2016 | Ann Dermatol Venereol | pmid:27773503 |
Caumes E et al. | [Donovanosis (granuloma inguinale)]. | 2016 | Ann Dermatol Venereol | pmid:27773509 |
Mwingira UJ et al. | Progress of Trachoma Mapping in Mainland Tanzania: Results of Baseline Surveys from 2012 to 2014. | 2016 | Ophthalmic Epidemiol | pmid:27775455 |
Gerhardt P et al. | [Male urethritis]. | 2016 | Ann Dermatol Venereol | pmid:27776813 |
Fu L et al. | Toxicity of 13 different antibiotics towards freshwater green algae Pseudokirchneriella subcapitata and their modes of action. | 2017 | Chemosphere | pmid:27783962 |
Gomes C et al. | Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin. | 2017 | Crit. Rev. Microbiol. | pmid:27786586 |
Libois A and De Wit S | Which empiric syndromic treatment for urethritis? | 2016 | Int J STD AIDS | pmid:27794143 |
Ervin AM et al. | Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) Trial: Design and Baseline Characteristics. | 2016 | Ophthalmic Epidemiol | pmid:27820670 |
Serdar Kutuk M et al. | Relationship between maternal c-reactive protein level and neonatal outcome in patients with preterm premature rupture of membranes treated with Ampicillin and Azithromycin. | 2016 | J Obstet Gynaecol | pmid:27825282 |
Paul SP et al. | Spontaneous surgical emphysema: an unusual complication of paediatric asthma. | 2016 | Br J Hosp Med (Lond) | pmid:27828753 |
Yan M et al. | Synthesis and antibacterial activity of novel 3-O-descladinosylazithromycin derivatives. | 2017 | Eur J Med Chem | pmid:27836198 |
Elshafie BE et al. | The Epidemiology of Trachoma in Darfur States and Khartoum State, Sudan: Results of 32 Population-Based Prevalence Surveys. | 2016 | Ophthalmic Epidemiol | pmid:27841721 |
Zhang C et al. | Decreased Susceptibility to Azithromycin Among Clinical Shigella Isolates from China. | 2017 | Microb. Drug Resist. | pmid:27841958 |
Waites KB et al. | In Vitro Activities of Lefamulin and Other Antimicrobial Agents against Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China. | 2017 | Antimicrob. Agents Chemother. | pmid:27855075 |
Zhang Y et al. | Novel Detection Strategy To Rapidly Evaluate the Efficacy of Antichlamydial Agents. | 2017 | Antimicrob. Agents Chemother. | pmid:27855081 |
Phiri K et al. | Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. | 2016 | PLoS ONE | pmid:27861509 |
Babić I et al. | Therapeutic efficacy of azithromycin and acetylcysteine in chronic otitis media with effusion. | 2017 | Eur Arch Otorhinolaryngol | pmid:27873023 |
Brittain C et al. | Gentamicin versus ceftriaxone for the treatment of gonorrhoea (G-TOG trial): study protocol for a randomised trial. | 2016 | Trials | pmid:27881151 |
Requena-Méndez A et al. | Enteric fever in Barcelona: Changing patterns of importation and antibiotic resistance. | Travel Med Infect Dis | pmid:27890811 | |
Nielsen HL et al. | Azithromycin vs. Placebo for the Clinical Outcome in Campylobacter concisus Diarrhoea in Adults: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. | 2016 | PLoS ONE | pmid:27893820 |
Manesh A et al. | A case of clinical and microbiological failure of azithromycin therapy in Salmonella enterica serotype Typhi despite low azithromycin MIC. | 2017 | Int. J. Infect. Dis. | pmid:27894983 |
Bornstein M et al. | Factors Associated With Primary Care Physician Knowledge of the Recommended Regimen for Treating Gonorrhea. | 2017 | Sex Transm Dis | pmid:27898574 |
Misra R and Prasad KN | Antimicrobial susceptibility to azithromycin among Salmonella enterica Typhi and Paratyphi A isolates from India. | 2016 | J. Med. Microbiol. | pmid:27902389 |
Zhao X et al. | Sensitive and Simplified Detection of Antibiotic Influence on the Dynamic and Versatile Changes of Fecal Short-Chain Fatty Acids. | 2016 | PLoS ONE | pmid:27907030 |
Retallack H et al. | Zika virus cell tropism in the developing human brain and inhibition by azithromycin. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:27911847 |
Valdés SO et al. | Cardiac Arrest in Pediatric Patients Receiving Azithromycin. | 2017 | J. Pediatr. | pmid:27912925 |
Liu Y et al. | Azithromycin ameliorates airway remodeling via inhibiting airway epithelium apoptosis. | 2017 | Life Sci. | pmid:27916734 |
Arora N et al. | Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. | 2016 | Nat Microbiol | pmid:27918528 |
Collins SA et al. | Cephalosporin-3'-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms. | 2017 | Antimicrob. Agents Chemother. | pmid:27919896 |
EmiralioÄŸlu N et al. | Long term azithromycin therapy in patients with cystic fibrosis. | 2016 | Turk. J. Pediatr. | pmid:27922234 |
Amza A et al. | A Cluster-Randomized Trial to Assess the Efficacy of Targeting Trachoma Treatment to Children. | 2017 | Clin. Infect. Dis. | pmid:27956455 |
Gupta A and Khanna S | Repeat Clostridium difficile Testing. | 2016 | JAMA | pmid:27959982 |
Hirasawa K et al. | Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. | 2016 | PLoS ONE | pmid:27977675 |
Nenoff P et al. | [Non-viral sexually transmitted infections - Epidemiology, clinical manifestations, diagnostics and therapy : Part 1: Gonococci]. | 2017 | Hautarzt | pmid:27981386 |
Marks M et al. | Mathematical Modeling of Programmatic Requirements for Yaws Eradication. | 2017 | Emerging Infect. Dis. | pmid:27983500 |
Seyama S et al. | Emergence and molecular characterization of Haemophilus influenzae harbouring mef(A). | 2017 | J. Antimicrob. Chemother. | pmid:27999037 |
Shapiro ED and Wormser GP | Prophylaxis with topical azithromycin against Lyme borreliosis. | 2017 | Lancet Infect Dis | pmid:28007427 |
Schwameis M et al. | Topical azithromycin for the prevention of Lyme borreliosis: a randomised, placebo-controlled, phase 3 efficacy trial. | 2017 | Lancet Infect Dis | pmid:28007428 |
Liu X et al. | Novel antimicrobial peptide-modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus. | 2016 | Int J Nanomedicine | pmid:28008253 |
Read TR et al. | Azithromycin 1.5g Over 5 Days Compared to 1g Single Dose in Urethral Mycoplasma genitalium: Impact on Treatment Outcome and Resistance. | 2017 | Clin. Infect. Dis. | pmid:28011607 |
Park J et al. | Progression and Treatment Outcomes of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense. | 2017 | Clin. Infect. Dis. | pmid:28011609 |
Nichols DP et al. | Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis. | 2017 | J. Cyst. Fibros. | pmid:28025037 |
Saini H et al. | Azithromycin-Ciprofloxacin-Impregnated Urinary Catheters Avert Bacterial Colonization, Biofilm Formation, and Inflammation in a Murine Model of Foreign-Body-Associated Urinary Tract Infections Caused by Pseudomonas aeruginosa. | 2017 | Antimicrob. Agents Chemother. | pmid:28031194 |
Sutton SS | Is cardiovascular risk a concern when prescribing azithromycin? | 2017 | JAAPA | pmid:28033168 |
Allen G | Evidence appraisal of Tita ATN, Szychowski JM, Boggess K, et al. Adjunctive azithromycin prophylaxis for cesarean delivery.: N Engl J Med. 2016;375:1231-1241. | 2017 | AORN J | pmid:28034388 |
Johnson SR et al. | Use of whole-genome sequencing data to analyze 23S rRNA-mediated azithromycin resistance. | 2017 | Int. J. Antimicrob. Agents | pmid:28038960 |
Gong L et al. | Clinical effect of treating secondary asthma attacks of children Mycoplasma pneumoniae with combined therapy of montelukast and azithromycin. | 2016 | Eur Rev Med Pharmacol Sci | pmid:28051240 |
Gensel JC et al. | Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment. | 2017 | Sci Rep | pmid:28057928 |
Lau A et al. | Treatment efficacy of azithromycin 1Â g single dose versus doxycycline 100Â mg twice daily for 7Â days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. | 2017 | BMC Infect. Dis. | pmid:28061753 |
Llop CJ et al. | Antibiotic treatment patterns, costs, and resource utilization among patients with community acquired pneumonia: a US cohort study. | 2017 | Hosp Pract (1995) | pmid:28064542 |
Descours G et al. | Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila. | 2017 | Antimicrob. Agents Chemother. | pmid:28069647 |
Kwakye-Maclean C et al. | A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. | 2017 | PLoS Negl Trop Dis | pmid:28072863 |
Idkaidek N et al. | Saliva Versus Plasma Bioequivalence of Azithromycin in Humans: Validation of Class I Drugs of the Salivary Excretion Classification System. | 2017 | Drugs R D | pmid:28074334 |
Tita ATN et al. | Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. | 2017 | N. Engl. J. Med. | pmid:28076707 |
Bellon H et al. | Interleukin-1α induced release of interleukin-8 by human bronchial epithelial cells in vitro: assessing mechanisms and possible treatment options. | 2017 | Transpl. Int. | pmid:28078769 |
Greig JR and Jones L | Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. | 2017 | N. Engl. J. Med. | pmid:28079334 |
Ragusa A and Svelato A | Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. | 2017 | N. Engl. J. Med. | pmid:28079335 |
Wind CM et al. | Trends in antimicrobial susceptibility for azithromycin and ceftriaxone in Neisseria gonorrhoeae isolates in Amsterdam, the Netherlands, between 2012 and 2015. | 2017 | Euro Surveill. | pmid:28079519 |
Okah E et al. | Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. | 2017 | Sex Transm Dis | pmid:28079746 |
Gawin A et al. | Mildly pruritic palmar rash. | 2016 | J Fam Pract | pmid:28087868 |
Kibuule D et al. | An analysis of policies for cotrimoxazole, amoxicillin and azithromycin use in Namibia's public sector: Findings and therapeutic implications. | 2017 | Int. J. Clin. Pract. | pmid:28090718 |
Bulman ZP et al. | Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin. | 2017 | Antimicrob. Agents Chemother. | pmid:28096154 |
Liao YS et al. | Azithromycin-Nonsusceptible Shigella flexneri 3a in Men Who Have Sex with Men, Taiwan, 2015-2016. | 2016 | Emerging Infect. Dis. | pmid:28098533 |
Murray K et al. | Increasing Antibiotic Resistance in Shigella spp. from Infected New York City Residents, New York, USA. | 2017 | Emerging Infect. Dis. | pmid:28098543 |
Diniz LM et al. | Bacillary angiomatosis with bone invasion. | 2016 Nov-Dec | An Bras Dermatol | pmid:28099606 |
Haque F et al. | Evaluation of a Smartphone Decision-Support Tool for Diarrheal Disease Management in a Resource-Limited Setting. | 2017 | PLoS Negl Trop Dis | pmid:28103233 |
Koop AH et al. | 56-Year-Old Woman With Cough and Fatigue for 1 Week. | 2017 | Mayo Clin. Proc. | pmid:28110893 |
Cramer CL et al. | Immunomodulatory indications of azithromycin in respiratory disease: a concise review for the clinician. | 2017 | Postgrad Med | pmid:28116959 |
Cogen JD et al. | Characterization of Inpatient Cystic Fibrosis Pulmonary Exacerbations. | 2017 | Pediatrics | pmid:28126911 |