Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.
To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Azithramycine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).
Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).
Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Vajpayee S et al. | Scrub typhus causing neonatal hepatitis with acute liver failure-A case series. | 2017 | Indian J Gastroenterol | pmid:28612320 |
Tsubouchi K et al. | Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4. | 2017 | Autophagy | pmid:28613983 |
Sanders AM et al. | Burden of trachoma in five counties of Eastern Equatoria state, South Sudan: Results from population-based surveys. | 2017 | PLoS Negl Trop Dis | pmid:28614375 |
Turner KM et al. | Analysis of the potential for point-of-care test to enable individualised treatment of infections caused by antimicrobial-resistant and susceptible strains of : a modelling study. | 2017 | BMJ Open | pmid:28615273 |
Nozawa H et al. | Pertussis without apparent cough in a disabled girl with a tracheostomy. | 2017 | J. Infect. Chemother. | pmid:28623110 |
Kirk SK et al. | Efficacy of Azithromycin and Compounded Atovaquone for Treatment of Babesia gibsoni in Dogs. | 2017 | J. Vet. Intern. Med. | pmid:28625019 |
Kawamura K et al. | Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study. | 2017 | BMC Pulm Med | pmid:28629448 |
Wang Y et al. | Synthesis and antibacterial activity of novel 4″-O-(1-aralkyl-1,2,3-triazol-4-methyl-carbamoyl) azithromycin analogs. | 2017 | Bioorg. Med. Chem. Lett. | pmid:28655423 |
Lendermon EA et al. | Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation. | 2017 | Respir. Res. | pmid:28659178 |
Yazdanbakhsh AR et al. | Reduction of non-Betalactam Antibiotics COD by Combined Coagulation and Advanced Oxidation Processes. | 2016 | Water Environ. Res. | pmid:28661328 |
West SK et al. | Treating village newcomers and travelers for trachoma: Results from ASANTE cluster randomized trial. | 2017 | PLoS ONE | pmid:28662043 |
Xiao Z et al. | Comparison of the ameliorative effects of Qingfei Tongluo formula and azithromycin on Mycoplasma pneumoniae pneumonia. | 2017 | J Nat Med | pmid:28664473 |
Koetsveld J et al. | Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. | 2017 | Antimicrob. Agents Chemother. | pmid:28674060 |
Molefe NI et al. | Oral administration of azithromycin ameliorates trypanosomosis in Trypanosoma congolense-infected mice. | 2017 | Parasitol. Res. | pmid:28674747 |
Balci O and Gulkilik G | Assessment of efficacy of topical azithromycin 1.5 per cent ophthalmic solution for the treatment of meibomian gland dysfunction. | 2018 | Clin Exp Optom | pmid:28677153 |
Paul P et al. | Capillary electrophoresis with capacitively coupled contactless conductivity detection method development and validation for the determination of azithromycin, clarithromycin, and clindamycin. | 2017 | J Sep Sci | pmid:28683179 |
Fan LC et al. | Macrolides protect against infection via inhibition of inflammasomes. | 2017 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:28684545 |
Brusselle G and Pavord I | Azithromycin in uncontrolled asthma. | 2017 | Lancet | pmid:28687412 |
Gibson PG et al. | Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial. | 2017 | Lancet | pmid:28687413 |
Harper LM et al. | Economic Evaluation of Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. | 2017 | Obstet Gynecol | pmid:28697108 |
Barberá MJ et al. | Mycoplasma genitalium Macrolide and Fluoroquinolone Resistance: Prevalence and Risk Factors Among a 2013-2014 Cohort of Patients in Barcelona, Spain. | 2017 | Sex Transm Dis | pmid:28703723 |
Horner P et al. | Which azithromycin regimen should be used for treating ? A meta-analysis. | 2018 | Sex Transm Infect | pmid:28717050 |
Stoney RJ et al. | Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28719282 |
O'Brien KS et al. | Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28722569 |
Bloch EM et al. | Antibiotic Resistance in Young Children in Kilosa District, Tanzania 4 Years after Mass Distribution of Azithromycin for Trachoma Control. | 2017 | Am. J. Trop. Med. Hyg. | pmid:28722638 |
Zhao L et al. | Trends in antimicrobial resistance in Neisseria gonorrhoeae and molecular characteristics of N. gonorrhoeae with decreased susceptibility to ceftriaxone in Shandong, China, 2007 to 2014. | 2018 | Int. J. Antimicrob. Agents | pmid:28729124 |
McConnell K and Shields M | Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years. | 2017 | Arch Dis Child Educ Pract Ed | pmid:28735295 |
Subedi Y | Around Manaslu Ultramarathon: Diarrhea Is Still the King. | 2017 | Wilderness Environ Med | pmid:28735656 |
Li Y et al. | Synergistic Activity of Berberine with Azithromycin against Pseudomonas Aeruginosa Isolated from Patients with Cystic Fibrosis of Lung In Vitro and In Vivo. | 2017 | Cell. Physiol. Biochem. | pmid:28738346 |
Li R et al. | Effects of oral florfenicol and azithromycin on gut microbiota and adipogenesis in mice. | 2017 | PLoS ONE | pmid:28742883 |
Fleming-Dutra KE et al. | Variations in Antibiotic and Azithromycin Prescribing for Children by Geography and Specialty-United States, 2013. | 2018 | Pediatr. Infect. Dis. J. | pmid:28746259 |
Tada H et al. | The effects of Lactobacillus reuteri probiotics combined with azithromycin on peri-implantitis: A randomized placebo-controlled study. | 2018 | J Prosthodont Res | pmid:28756115 |
Casas-Maldonado F | Bronchiectasis and Azithromycin. | 2018 | Arch. Bronconeumol. | pmid:28757281 |
Upadhyay K et al. | Combination therapy with ampicillin and azithromycin improved outcomes in a mouse model of group B streptococcal sepsis. | 2017 | PLoS ONE | pmid:28759625 |
Gifford J et al. | Decision support during electronic prescription to stem antibiotic overuse for acute respiratory infections: a long-term, quasi-experimental study. | 2017 | BMC Infect. Dis. | pmid:28760143 |
Mandhane PJ et al. | Treatment of preschool children presenting to the emergency department with wheeze with azithromycin: A placebo-controlled randomized trial. | 2017 | PLoS ONE | pmid:28771627 |
Hoogewoud F et al. | Prognostic Factors in Syphilitic Uveitis. | 2017 | Ophthalmology | pmid:28779905 |
Bergeron A et al. | Effect of Azithromycin on Airflow Decline-Free Survival After Allogeneic Hematopoietic Stem Cell Transplant: The ALLOZITHRO Randomized Clinical Trial. | 2017 | JAMA | pmid:28787506 |
Fage C et al. | The combination of oseltamivir with azithromycin does not show additional benefits over oseltamivir monotherapy in mice infected with influenza A(H1N1)pdm2009 virus. | 2017 | J. Med. Virol. | pmid:28792077 |
Benn K et al. | Bradycardia and Hypothermia Complicating Azithromycin Treatment. | 2017 | Am J Case Rep | pmid:28798290 |
Ribeiro M et al. | Azithromycin treatment is able to control the infection by two genotypes of Toxoplasma gondii in human trophoblast BeWo cells. | 2017 | Exp. Parasitol. | pmid:28803905 |
Whiley DM et al. | Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia. | 2017 | Emerging Infect. Dis. | pmid:28820128 |
Yoon HY et al. | Clinical significance of QT-prolonging drug use in patients with MDR-TB or NTM disease. | 2017 | Int. J. Tuberc. Lung Dis. | pmid:28826448 |
Hallström H et al. | Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: A randomized clinical trial. | 2017 | J. Clin. Periodontol. | pmid:28836279 |
Gaydos CA | Mycoplasma genitalium: Accurate Diagnosis Is Necessary for Adequate Treatment. | 2017 | J. Infect. Dis. | pmid:28838072 |
Bradshaw CS et al. | New Horizons in Mycoplasma genitalium Treatment. | 2017 | J. Infect. Dis. | pmid:28838073 |
Horner PJ and Martin DH | Mycoplasma genitalium Infection in Men. | 2017 | J. Infect. Dis. | pmid:28838074 |
Iannetta M et al. | Azithromycin Shows Anti-Zika Virus Activity in Human Glial Cells. | 2017 | Antimicrob. Agents Chemother. | pmid:28839081 |
Saiz JC and MartÃn-Acebes MA | Reply to Iannetta et al., "Azithromycin Shows Anti-Zika Virus Activity in Human Glial Cells". | 2017 | Antimicrob. Agents Chemother. | pmid:28839084 |
Seyama S et al. | Amino Acid Substitution in the Major Multidrug Efflux Transporter Protein AcrB Contributes to Low Susceptibility to Azithromycin in Haemophilus influenzae. | 2017 | Antimicrob. Agents Chemother. | pmid:28848006 |
Xue Y et al. | An in vitro model of azithromycin-induced persistent Chlamydia trachomatis infection. | 2017 | FEMS Microbiol. Lett. | pmid:28854672 |
Asano N et al. | Limited Azithromycin Localization to Rabbit Meibomian Glands Revealed by LC-MS-Based Bioanalysis and DESI Imaging. | 2017 | Biol. Pharm. Bull. | pmid:28867744 |
Lee SC et al. | Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis. | 2017 | Medicine (Baltimore) | pmid:28885357 |
Tribble DR | Antibiotic Therapy for Acute Watery Diarrhea and Dysentery. | 2017 | Mil Med | pmid:28885920 |
Ito A et al. | A Case of Community-Acquired Pneumonia Due to Legionella pneumophila Serogroup 9 Wherein Initial Treatment with Single-Dose Oral Azithromycin Appeared Useful. | 2017 | Jpn. J. Infect. Dis. | pmid:28890505 |
Cole MJ et al. | Overall Low Extended-Spectrum Cephalosporin Resistance but high Azithromycin Resistance in Neisseria gonorrhoeae in 24 European Countries, 2015. | 2017 | BMC Infect. Dis. | pmid:28893203 |
Trembizki E et al. | High levels of macrolide-resistant Mycoplasma genitalium in Queensland, Australia. | 2017 | J. Med. Microbiol. | pmid:28893363 |
Jacobsson S et al. | Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae. | 2017 | Antimicrob. Agents Chemother. | pmid:28893785 |
Wang R et al. | IncA/C plasmids conferring high azithromycin resistance in vibrio cholerae. | 2018 | Int. J. Antimicrob. Agents | pmid:28919196 |
Srivastava S et al. | Failure of the azithromycin and ethambutol combination regimen in the hollow-fibre system model of pulmonary Mycobacterium avium infection is due to acquired resistance. | 2017 | J. Antimicrob. Chemother. | pmid:28922805 |
Srivastava S et al. | A 'shock and awe' thioridazine and moxifloxacin combination-based regimen for pulmonary Mycobacterium avium-intracellulare complex disease. | 2017 | J. Antimicrob. Chemother. | pmid:28922810 |
Koeva M et al. | An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections. | 2017 | Antimicrob. Agents Chemother. | pmid:28923873 |
Cluver C et al. | Interventions for treating genital Chlamydia trachomatis infection in pregnancy. | 2017 | Cochrane Database Syst Rev | pmid:28937705 |
Glanternik JR et al. | A Cluster of Cases of Babesia microti Among Neonates Traced to a Single Unit of Donor Blood. | 2018 | Pediatr. Infect. Dis. J. | pmid:28945680 |
Bogdan M et al. | In vitro effect of subminimal inhibitory concentrations of antibiotics on the biofilm formation ability of Acinetobacter baumannii clinical isolates. | 2018 | J Chemother | pmid:28956494 |
Brown JD et al. | Shigella species epidemiology and antimicrobial susceptibility: the implications of emerging azithromycin resistance for guiding treatment, guidelines and breakpoints. | 2017 | J. Antimicrob. Chemother. | pmid:28961759 |
Atkinson CT et al. | Expression of acquired macrolide resistance genes in Haemophilus influenzae. | 2017 | J. Antimicrob. Chemother. | pmid:28961896 |
Li B et al. | The efficacy of azithromycin and doxycycline treatment for rectal chlamydial infection: a retrospective cohort study in South Australia. | 2018 | Intern Med J | pmid:28967178 |
Tuite AR et al. | Impact of Rapid Susceptibility Testing and Antibiotic Selection Strategy on the Emergence and Spread of Antibiotic Resistance in Gonorrhea. | 2017 | J. Infect. Dis. | pmid:28968710 |
Pokharel S et al. | Co-trimoxazole versus azithromycin for the treatment of undifferentiated febrile illness in Nepal: study protocol for a randomized controlled trial. | 2017 | Trials | pmid:28969659 |
Lee S et al. | The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis. | 2017 | PLoS ONE | pmid:28973041 |
Senilă S et al. | Infliximab-induced acne and acute localized exanthematous pustulosis: Case report. | 2017 | Dermatol Ther | pmid:28976720 |
Liu D et al. | Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2. | 2017 | PLoS ONE | pmid:28976984 |
Alchakaki A et al. | Which patients with respiratory disease need long-term azithromycin? | 2017 | Cleve Clin J Med | pmid:28985171 |
Lu Y et al. | Antibiotics Promote Escherichia coli-Pseudomonas aeruginosa Conjugation through Inhibiting Quorum Sensing. | 2017 | Antimicrob. Agents Chemother. | pmid:28993333 |
González-Beiras C et al. | Single-Dose Azithromycin for the Treatment of Haemophilus ducreyi Skin Ulcers in Papua New Guinea. | 2017 | Clin. Infect. Dis. | pmid:29020192 |
Riddle MS et al. | Trial Evaluating Ambulatory Therapy of Travelers' Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide. | 2017 | Clin. Infect. Dis. | pmid:29029033 |
Thakur SD et al. | High levels of susceptibility to new and older antibiotics in Neisseria gonorrhoeae isolates from Saskatchewan (2003-15): time to consider point-of-care or molecular testing for precision treatment? | 2018 | J. Antimicrob. Chemother. | pmid:29029217 |
Vermillion Maier ML and Tjeerdema RS | Azithromycin sorption and biodegradation in a simulated California river system. | 2018 | Chemosphere | pmid:29031188 |
Karhu E et al. | Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy. | 2017 | J. Nat. Prod. | pmid:29043803 |
Stanbrook MB | Azithromycin reduced exacerbations and improved QoL in symptomatic asthma despite inhaled maintenance therapy. | 2017 | Ann. Intern. Med. | pmid:29049761 |
Giguère S et al. | Antimicrobial Resistance in . | 2017 | Microbiol Spectr | pmid:29052538 |
Terkelsen D et al. | Multidrug-resistant infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017. | 2017 | Euro Surveill. | pmid:29067905 |
Chatterjee S and Agrawal D | Azithromycin in the Management of Pythium insidiosum Keratitis. | 2018 | Cornea | pmid:29095755 |
Emmanuel R et al. | Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from Justicia glauca against oral pathogens: A nanoantibiotic approach. | 2017 | Microb. Pathog. | pmid:29101061 |
Mitjà O et al. | Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study. | 2017 | Lancet Glob Health | pmid:29107621 |
Marks M and Mabey D | Single-dose azithromycin to treat latent yaws. | 2017 | Lancet Glob Health | pmid:29107622 |
Skeith AE et al. | Adding Azithromycin to Cephalosporin for Cesarean Delivery Infection Prophylaxis: A Cost-Effectiveness Analysis. | 2017 | Obstet Gynecol | pmid:29112658 |
Pan H and Ba-Thein W | Diagnostic Accuracy of Global Pharma Health Fund Minilabâ„¢ in Assessing Pharmacopoeial Quality of Antimicrobials. | 2018 | Am. J. Trop. Med. Hyg. | pmid:29141717 |
Rasmussen LD et al. | Follicular bronchiolitis in an HIV-infected individual on combination antiretroviral therapy with low CD4+ cell count but sustained viral suppression. | 2017 | BMJ Case Rep | pmid:29191821 |
Castelli G et al. | PURLs: Does azithromycin have a role in cesarean sections? | 2017 | J Fam Pract | pmid:29202146 |
Wang CM et al. | Synthesis and Antibacterial Evaluation of a Series of 11,12-Cyclic Carbonate Azithromycin-3-O-descladinosyl-3-O-carbamoyl Glycosyl Derivatives. | 2017 | Molecules | pmid:29207567 |
Dolezelova E et al. | Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. | 2017 | World J. Gastroenterol. | pmid:29209109 |
Medeiros PHQS et al. | Molecular characterization of virulence and antimicrobial resistance profile of Shigella species isolated from children with moderate to severe diarrhea in northeastern Brazil. | 2018 | Diagn. Microbiol. Infect. Dis. | pmid:29217418 |
Papp JR et al. | Accuracy and reproducibility of the Etest to detect drug-resistant Neisseria gonorrhoeae to contemporary treatment. | 2018 | J. Med. Microbiol. | pmid:29219803 |
Romero L et al. | Macrolides for treatment of Haemophilus ducreyi infection in sexually active adults. | 2017 | Cochrane Database Syst Rev | pmid:29226307 |
Sanchez Garcia D et al. | Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs. | 2018 | Chem. Biol. Interact. | pmid:29248446 |
Oldenburg CE et al. | Comparison of Mass Azithromycin Coverage Targets of Children in Niger: A Cluster-Randomized Trachoma Trial. | 2018 | Am. J. Trop. Med. Hyg. | pmid:29260659 |
Mascarenhas TR et al. | Tick-borne illness after transplantation: Case and review. | 2018 | Transpl Infect Dis | pmid:29277955 |
Fuji S | Azithromycin and Survival After Hematopoietic Stem Cell Transplant. | 2017 | JAMA | pmid:29279920 |