Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 276

PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Thapa A et al. Typhoid fever with isolated left lateral rectus palsy. 2018 BMJ Case Rep pmid:30181402
Afghani T et al. Preventing Long-Term Ocular Complications of Trachoma With Topical Azithromycin: A 3-Year Follow-up Study. 2017 Jan-Feb Asia Pac J Ophthalmol (Phila) pmid:28161923
González-Beiras C et al. Single-Dose Azithromycin for the Treatment of Haemophilus ducreyi Skin Ulcers in Papua New Guinea. 2017 Clin. Infect. Dis. pmid:29020192
Lu Y et al. Antibiotics Promote Escherichia coli-Pseudomonas aeruginosa Conjugation through Inhibiting Quorum Sensing. 2017 Antimicrob. Agents Chemother. pmid:28993333
Agarwal P et al. susceptibility of Indian isolates to different antimalarial drugs & antibiotics. 2017 Indian J. Med. Res. pmid:29512604
Paul P et al. Capillary electrophoresis with capacitively coupled contactless conductivity detection method development and validation for the determination of azithromycin, clarithromycin, and clindamycin. 2017 J Sep Sci pmid:28683179
Volgers C et al. Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection. 2017 Inflammopharmacology pmid:28528362
O'Brien KS et al. Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. 2017 Am. J. Trop. Med. Hyg. pmid:28722569
Stoney RJ et al. Travelers' Diarrhea and Other Gastrointestinal Symptoms Among Boston-Area International Travelers. 2017 Am. J. Trop. Med. Hyg. pmid:28719282
Stieger N et al. Solution-mediated crystallization of amorphous azithromycin. 2017 Pharmazie pmid:29441902
Harper LM et al. Economic Evaluation of Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 Obstet Gynecol pmid:28697108
Feng X and Liu J A combination of irsogladine maleate and azithromycin exhibits addictive protective effects in LPS-induced human gingival epithelial cells. 2017 Pharmazie pmid:29441859
Fan LC et al. Macrolides protect against infection via inhibition of inflammasomes. 2017 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:28684545
Wang Y et al. Synthesis and antibacterial activity of novel 4″-O-(1-aralkyl-1,2,3-triazol-4-methyl-carbamoyl) azithromycin analogs. 2017 Bioorg. Med. Chem. Lett. pmid:28655423
Kirk SK et al. Efficacy of Azithromycin and Compounded Atovaquone for Treatment of Babesia gibsoni in Dogs. 2017 J. Vet. Intern. Med. pmid:28625019
Vajpayee S et al. Scrub typhus causing neonatal hepatitis with acute liver failure-A case series. 2017 Indian J Gastroenterol pmid:28612320
Kimura S et al. Azithromycin Modulates 3',5'-cyclic Diguanylic Acid Signaling in Pseudomonas aeruginosa. 2017 J. Infect. Chemother. pmid:28579350
Dixit S et al. Carbamoylated azithromycin incorporated zirconia hybrid monolith for enantioseparation of acidic chiral drugs using non-aqueous capillary electrochromatography. 2017 J Chromatogr A pmid:28558906
Jordan SJ et al. Lower Levels of Cervicovaginal Tryptophan Are Associated With Natural Clearance of Chlamydia in Women. 2017 J. Infect. Dis. pmid:28520912
Lopes Dos Santos Santiago G et al. Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma. 2017 BMC Microbiol. pmid:28486933
Savaris RF et al. Antibiotic therapy for pelvic inflammatory disease. 2017 Cochrane Database Syst Rev pmid:28436019
Snelling PJ et al. Rhabdomyolysis Complicating Typhoid Fever in A Child and Review of the Literature. 2017 Pediatr. Infect. Dis. J. pmid:28430751
Riddle MS et al. Trial Evaluating Ambulatory Therapy of Travelers' Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide. 2017 Clin. Infect. Dis. pmid:29029033
Alchakaki A et al. Which patients with respiratory disease need long-term azithromycin? 2017 Cleve Clin J Med pmid:28985171
Senilă S et al. Infliximab-induced acne and acute localized exanthematous pustulosis: Case report. 2017 Dermatol Ther pmid:28976720
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Koeva M et al. An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections. 2017 Antimicrob. Agents Chemother. pmid:28923873
Ullah S et al. Creatinine-based non-phospholipid vesicular carrier for improved oral bioavailability of Azithromycin. 2017 Drug Dev Ind Pharm pmid:28157445
Mohammed H et al. First line dual therapy for gonorrhoea to limit the spread of antimicrobial resistance. 2017 BMJ pmid:28153820
Ito A et al. A Case of Community-Acquired Pneumonia Due to Legionella pneumophila Serogroup 9 Wherein Initial Treatment with Single-Dose Oral Azithromycin Appeared Useful. 2017 Jpn. J. Infect. Dis. pmid:28890505
Oluwalana C et al. Azithromycin in Labor Lowers Clinical Infections in Mothers and Newborns: A Double-Blind Trial. 2017 Pediatrics pmid:28130432
Saiz JC and Martín-Acebes MA Reply to Iannetta et al., "Azithromycin Shows Anti-Zika Virus Activity in Human Glial Cells". 2017 Antimicrob. Agents Chemother. pmid:28839084
Gerber JS and Zaoutis TE Azithromycin Prophylaxis for Laboring Mothers. 2017 Pediatrics pmid:28130431
Iannetta M et al. Azithromycin Shows Anti-Zika Virus Activity in Human Glial Cells. 2017 Antimicrob. Agents Chemother. pmid:28839081
Cogen JD et al. Characterization of Inpatient Cystic Fibrosis Pulmonary Exacerbations. 2017 Pediatrics pmid:28126911
Hallström H et al. Open flap debridement of peri-implantitis with or without adjunctive systemic antibiotics: A randomized clinical trial. 2017 J. Clin. Periodontol. pmid:28836279
Cramer CL et al. Immunomodulatory indications of azithromycin in respiratory disease: a concise review for the clinician. 2017 Postgrad Med pmid:28116959
Liu D et al. Mycoplasma-associated multidrug resistance of hepatocarcinoma cells requires the interaction of P37 and Annexin A2. 2017 PLoS ONE pmid:28976984
Lee S et al. The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis. 2017 PLoS ONE pmid:28973041
Kibuule D et al. An analysis of policies for cotrimoxazole, amoxicillin and azithromycin use in Namibia's public sector: Findings and therapeutic implications. 2017 Int. J. Clin. Pract. pmid:28090718
Lee SC et al. Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis. 2017 Medicine (Baltimore) pmid:28885357
Mandhane PJ et al. Treatment of preschool children presenting to the emergency department with wheeze with azithromycin: A placebo-controlled randomized trial. 2017 PLoS ONE pmid:28771627
Okah E et al. Sentinel Surveillance for Expedited Partner Therapy Prescriptions Using Pharmacy Data, in 2 New York City Neighborhoods, 2015. 2017 Sex Transm Dis pmid:28079746
Gifford J et al. Decision support during electronic prescription to stem antibiotic overuse for acute respiratory infections: a long-term, quasi-experimental study. 2017 BMC Infect. Dis. pmid:28760143
Ragusa A and Svelato A Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28079335
Upadhyay K et al. Combination therapy with ampicillin and azithromycin improved outcomes in a mouse model of group B streptococcal sepsis. 2017 PLoS ONE pmid:28759625
Greig JR and Jones L Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28079334
Bellon H et al. Interleukin-1α induced release of interleukin-8 by human bronchial epithelial cells in vitro: assessing mechanisms and possible treatment options. 2017 Transpl. Int. pmid:28078769
Varano GP et al. Post-ischemic treatment with azithromycin protects ganglion cells against retinal ischemia/reperfusion injury in the rat. 2017 Mol. Vis. pmid:29296071
Pokharel S et al. Co-trimoxazole versus azithromycin for the treatment of undifferentiated febrile illness in Nepal: study protocol for a randomized controlled trial. 2017 Trials pmid:28969659
Brown JD et al. Shigella species epidemiology and antimicrobial susceptibility: the implications of emerging azithromycin resistance for guiding treatment, guidelines and breakpoints. 2017 J. Antimicrob. Chemother. pmid:28961759
Jacobsson S et al. Activity of the Novel Pleuromutilin Lefamulin (BC-3781) and Effect of Efflux Pump Inactivation on Multidrug-Resistant and Extensively Drug-Resistant Neisseria gonorrhoeae. 2017 Antimicrob. Agents Chemother. pmid:28893785
Tribble DR Antibiotic Therapy for Acute Watery Diarrhea and Dysentery. 2017 Mil Med pmid:28885920
Braam JF et al. High prevalence of the A2058T macrolide resistance-associated mutation in Mycoplasma genitalium strains from the Netherlands. 2017 J. Antimicrob. Chemother. pmid:28158595
Pavlova A et al. Toward the rational design of macrolide antibiotics to combat resistance. 2017 Chem Biol Drug Des pmid:28419786
Asano N et al. Limited Azithromycin Localization to Rabbit Meibomian Glands Revealed by LC-MS-Based Bioanalysis and DESI Imaging. 2017 Biol. Pharm. Bull. pmid:28867744
Gensel JC et al. Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment. 2017 Sci Rep pmid:28057928
Seyama S et al. Amino Acid Substitution in the Major Multidrug Efflux Transporter Protein AcrB Contributes to Low Susceptibility to Azithromycin in Haemophilus influenzae. 2017 Antimicrob. Agents Chemother. pmid:28848006
Sutton SS Is cardiovascular risk a concern when prescribing azithromycin? 2017 JAAPA pmid:28033168
Yoon HY et al. Clinical significance of QT-prolonging drug use in patients with MDR-TB or NTM disease. 2017 Int. J. Tuberc. Lung Dis. pmid:28826448
Shapiro ED and Wormser GP Prophylaxis with topical azithromycin against Lyme borreliosis. 2017 Lancet Infect Dis pmid:28007427
Whiley DM et al. Molecular Antimicrobial Resistance Surveillance for Neisseria gonorrhoeae, Northern Territory, Australia. 2017 Emerging Infect. Dis. pmid:28820128
Seyama S et al. Emergence and molecular characterization of Haemophilus influenzae harbouring mef(A). 2017 J. Antimicrob. Chemother. pmid:27999037
Fage C et al. The combination of oseltamivir with azithromycin does not show additional benefits over oseltamivir monotherapy in mice infected with influenza A(H1N1)pdm2009 virus. 2017 J. Med. Virol. pmid:28792077
Haque F et al. Evaluation of a Smartphone Decision-Support Tool for Diarrheal Disease Management in a Resource-Limited Setting. 2017 PLoS Negl Trop Dis pmid:28103233
Chavada VD et al. Surface plasmon resonance based selective and sensitive colorimetric determination of azithromycin using unmodified silver nanoparticles in pharmaceuticals and human plasma. 2017 Spectrochim Acta A Mol Biomol Spectrosc pmid:27419643
Bulman ZP et al. Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin. 2017 Antimicrob. Agents Chemother. pmid:28096154
Wind CM et al. Trends in antimicrobial susceptibility for azithromycin and ceftriaxone in Neisseria gonorrhoeae isolates in Amsterdam, the Netherlands, between 2012 and 2015. 2017 Euro Surveill. pmid:28079519
Agarwal E et al. Locally Delivered 0.5% Azithromycin as an Adjunct to Non-Surgical Treatment in Patients With Chronic Periodontitis With Type 2 Diabetes: A Randomized Controlled Clinical Trial. 2017 J. Periodontol. pmid:22655911
Tita ATN et al. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. 2017 N. Engl. J. Med. pmid:28076707
Idkaidek N et al. Saliva Versus Plasma Bioequivalence of Azithromycin in Humans: Validation of Class I Drugs of the Salivary Excretion Classification System. 2017 Drugs R D pmid:28074334
Gomes C et al. Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin. 2017 Crit. Rev. Microbiol. pmid:27786586
Kwakye-Maclean C et al. A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. 2017 PLoS Negl Trop Dis pmid:28072863
Fu L et al. Toxicity of 13 different antibiotics towards freshwater green algae Pseudokirchneriella subcapitata and their modes of action. 2017 Chemosphere pmid:27783962
Descours G et al. Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila. 2017 Antimicrob. Agents Chemother. pmid:28069647
Lau A et al. Treatment efficacy of azithromycin 1 g single dose versus doxycycline 100 mg twice daily for 7 days for the treatment of rectal chlamydia among men who have sex with men - a double-blind randomised controlled trial protocol. 2017 BMC Infect. Dis. pmid:28061753
Saini H et al. Azithromycin-Ciprofloxacin-Impregnated Urinary Catheters Avert Bacterial Colonization, Biofilm Formation, and Inflammation in a Murine Model of Foreign-Body-Associated Urinary Tract Infections Caused by Pseudomonas aeruginosa. 2017 Antimicrob. Agents Chemother. pmid:28031194
Bouklouze A et al. Azithromycin assay in drug formulations: Validation of a HPTLC method with a quadratic polynomial calibration model using the accuracy profile approach. 2017 Ann Pharm Fr pmid:27692351
Björnelius E et al. macrolide resistance in Stockholm, Sweden. 2017 Sex Transm Infect pmid:27502694
O'Rourke VJ Azithromycin as an adjunct to non-surgical periodontal therapy: a systematic review. 2017 Aust Dent J pmid:27492140
Xue Y et al. An in vitro model of azithromycin-induced persistent Chlamydia trachomatis infection. 2017 FEMS Microbiol. Lett. pmid:28854672
Barberá MJ et al. Mycoplasma genitalium Macrolide and Fluoroquinolone Resistance: Prevalence and Risk Factors Among a 2013-2014 Cohort of Patients in Barcelona, Spain. 2017 Sex Transm Dis pmid:28703723
Brusselle G and Pavord I Azithromycin in uncontrolled asthma. 2017 Lancet pmid:28687412
Xiao Z et al. Comparison of the ameliorative effects of Qingfei Tongluo formula and azithromycin on Mycoplasma pneumoniae pneumonia. 2017 J Nat Med pmid:28664473
Atkinson CT et al. Expression of acquired macrolide resistance genes in Haemophilus influenzae. 2017 J. Antimicrob. Chemother. pmid:28961896
Lendermon EA et al. Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation. 2017 Respir. Res. pmid:28659178
Turner KM et al. Analysis of the potential for point-of-care test to enable individualised treatment of infections caused by antimicrobial-resistant and susceptible strains of : a modelling study. 2017 BMJ Open pmid:28615273
Katz AR et al. Cluster of Neisseria gonorrhoeae Isolates With High-level Azithromycin Resistance and Decreased Ceftriaxone Susceptibility, Hawaii, 2016. 2017 Clin. Infect. Dis. pmid:28549097
Lee N et al. Anti-inflammatory effects of adjunctive macrolide treatment in adults hospitalized with influenza: A randomized controlled trial. 2017 Antiviral Res. pmid:28535933
Allen GP and Harris KA Resistance Selection in Shigella flexneri by Azithromycin, Ceftriaxone, Ciprofloxacin, Levofloxacin, and Moxifloxacin. 2017 Antimicrob. Agents Chemother. pmid:28483960
Waetzig V et al. Neurodegenerative effects of azithromycin in differentiated PC12 cells. 2017 Eur. J. Pharmacol. pmid:28479141
Fohner AE et al. PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics. 2017 Pharmacogenet. Genomics pmid:28146011
Murray K et al. Increasing Antibiotic Resistance in Shigella spp. from Infected New York City Residents, New York, USA. 2017 Emerging Infect. Dis. pmid:28098543
Nichols DP et al. Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis. 2017 J. Cyst. Fibros. pmid:28025037
Marks M et al. Mathematical Modeling of Programmatic Requirements for Yaws Eradication. 2017 Emerging Infect. Dis. pmid:27983500
Zhang C et al. Decreased Susceptibility to Azithromycin Among Clinical Shigella Isolates from China. 2017 Microb. Drug Resist. pmid:27841958
Segal LN et al. Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung. 2017 Thorax pmid:27486204
Horner P and Saunders J Should azithromycin 1 g be abandoned as a treatment for bacterial STIs? The case for and against. 2017 Sex Transm Infect pmid:27418572
Quinn KL et al. Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. 2017 Drug Saf pmid:28421551
Bergeron A et al. Azithromycin and Survival After Hematopoietic Stem Cell Transplant-Reply. 2017 JAMA pmid:29279924