Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 276

PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

Download all related citations
Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Hong BK et al. "MAC" attack. 2009 Am. J. Med. pmid:19958886
Moellering RC Introduction: revolutionary changes in the macrolide and azalide antibiotics. 1991 Am. J. Med. pmid:1656735
Hooton TM A comparison of azithromycin and penicillin V for the treatment of streptococcal pharyngitis. 1991 Am. J. Med. pmid:1656738
Casiano RR Azithromycin and amoxicillin in the treatment of acute maxillary sinusitis. 1991 Am. J. Med. pmid:1656739
Dark D Multicenter evaluation of azithromycin and cefaclor in acute lower respiratory tract infections. 1991 Am. J. Med. pmid:1656740
Mallory SB Azithromycin compared with cephalexin in the treatment of skin and skin structure infections. 1991 Am. J. Med. pmid:1656741
Hopkins S Clinical toleration and safety of azithromycin. 1991 Am. J. Med. pmid:1656742
Schentag JJ and Ballow CH Tissue-directed pharmacokinetics. 1991 Am. J. Med. pmid:1656743
Winton JC and Twilla JD Sudden cardiac arrest in a patient on chronic methadone after the addition of azithromycin. 2013 Am. J. Med. Sci. pmid:23103438
Devasia RA et al. Compliance with azithromycin versus erythromycin in the setting of a pertussis outbreak. 2009 Am. J. Med. Sci. pmid:19301451
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Andrews WW et al. Interconceptional antibiotics to prevent spontaneous preterm birth: a randomized clinical trial. 2006 Am. J. Obstet. Gynecol. pmid:16522388
Jacobson GF et al. A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy. 2001 Am. J. Obstet. Gynecol. pmid:11408852
Tita AT et al. Impact of interconception antibiotics on the endometrial microbial flora. 2007 Am. J. Obstet. Gynecol. pmid:17346530
Grigsby PL et al. Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model. 2012 Am. J. Obstet. Gynecol. pmid:23111115
Ward E and Duff P A comparison of 3 antibiotic regimens for prevention of postcesarean endometritis: an historical cohort study. 2016 Am. J. Obstet. Gynecol. pmid:26901276
Gray RH et al. Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. 2001 Am. J. Obstet. Gynecol. pmid:11717659
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Lin KJ et al. Safety of macrolides during pregnancy. 2013 Am. J. Obstet. Gynecol. pmid:23254249
Tita AT et al. Impact of extended-spectrum antibiotic prophylaxis on incidence of postcesarean surgical wound infection. 2008 Am. J. Obstet. Gynecol. pmid:18771992
Johnson RB The role of azalide antibiotics in the treatment of Chlamydia. 1991 Am. J. Obstet. Gynecol. pmid:1645503
Kelsey JJ et al. Presence of azithromycin breast milk concentrations: a case report. 1994 Am. J. Obstet. Gynecol. pmid:8178871
Keelan JA et al. Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep. 2011 Am. J. Obstet. Gynecol. pmid:21481833
Tita AT et al. Clinical trial of interconceptional antibiotics to prevent preterm birth: subgroup analyses and possible adverse antibiotic-microbial interaction. 2007 Am. J. Obstet. Gynecol. pmid:17904962
Uy HS et al. Infectious crystalline keratopathy and endophthalmitis secondary to Mycobacterium abscessus in a monocular patient with Stevens-Johnson syndrome. 1999 Am. J. Ophthalmol. pmid:10030567
Kuehne JJ et al. Corneal pharmacokinetics of topically applied azithromycin and clarithromycin. 2004 Am. J. Ophthalmol. pmid:15488779
Bosch-Driessen LH et al. A prospective, randomized trial of pyrimethamine and azithromycin vs pyrimethamine and sulfadiazine for the treatment of ocular toxoplasmosis. 2002 Am. J. Ophthalmol. pmid:12095805
Stewart WC et al. Pharmacokinetics of azithromycin and moxifloxacin in human conjunctiva and aqueous humor during and after the approved dosing regimens. 2010 Am. J. Ophthalmol. pmid:20813346
Wolle MA et al. Impact of Trichiasis surgery on physical functioning in Ethiopian patients: STAR trial. 2011 Am. J. Ophthalmol. pmid:21333268
Katusic D et al. Azithromycin vs doxycycline in the treatment of inclusion conjunctivitis. 2003 Am. J. Ophthalmol. pmid:12654359
Abelson MB et al. Clinical cure of bacterial conjunctivitis with azithromycin 1%: vehicle-controlled, double-masked clinical trial. 2008 Am. J. Ophthalmol. pmid:18374301
Ness PJ et al. An anterior chamber toxicity study evaluating Besivance, AzaSite, and Ciprofloxacin. 2010 Am. J. Ophthalmol. pmid:20678751
Fan LC et al. Macrolides protect against infection via inhibition of inflammasomes. 2017 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:28684545
Shinkai M et al. Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16085674
Blau H et al. Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1/2, JNK, and NF-kappaB activation in a cystic fibrosis epithelial cell line. 2007 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:17012372
Tarran R et al. Nonantibiotic macrolides prevent human neutrophil elastase-induced mucus stasis and airway surface liquid volume depletion. 2013 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:23542952
Kadova Z et al. IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats. 2015 Am. J. Physiol. Renal Physiol. pmid:25503728
Meyer M et al. Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis. 2009 Am. J. Respir. Cell Mol. Biol. pmid:19244203
Halldorsson S et al. Azithromycin maintains airway epithelial integrity during Pseudomonas aeruginosa infection. 2010 Am. J. Respir. Cell Mol. Biol. pmid:19372247
Bergamini G et al. Effects of azithromycin on glutathione S-transferases in cystic fibrosis airway cells. 2009 Am. J. Respir. Cell Mol. Biol. pmid:19097986
Verleden GM et al. Azithromycin reduces airway neutrophilia and interleukin-8 in patients with bronchiolitis obliterans syndrome. 2006 Am. J. Respir. Crit. Care Med. pmid:16741151
Williams TJ and Verleden GM Azithromycin: a plea for multicenter randomized studies in lung transplantation. 2005 Am. J. Respir. Crit. Care Med. pmid:16148194
Barker PM et al. Effect of macrolides on in vivo ion transport across cystic fibrosis nasal epithelium. 2005 Am. J. Respir. Crit. Care Med. pmid:15657462
Kunisaki KM et al. Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study. 2012 Am. J. Respir. Crit. Care Med. pmid:22077070
Restrepo MI and Anzueto A Macrolide antibiotics for prevention of chronic obstructive pulmonary disease exacerbations: are we there yet? 2014 Am. J. Respir. Crit. Care Med. pmid:24983214
Lococo F et al. Hemoptysis and Progressive Dyspnea in a 67-Year-Old Woman with History of Renal Transplantation. 2016 Am. J. Respir. Crit. Care Med. pmid:26681504
Yates B et al. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. 2005 Am. J. Respir. Crit. Care Med. pmid:15976371
Gerhardt SG et al. Maintenance azithromycin therapy for bronchiolitis obliterans syndrome: results of a pilot study. 2003 Am. J. Respir. Crit. Care Med. pmid:12672648
Albert RK and Schuller JL Macrolide antibiotics and the risk of cardiac arrhythmias. 2014 Am. J. Respir. Crit. Care Med. pmid:24707986
Han MK et al. Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. 2014 Am. J. Respir. Crit. Care Med. pmid:24779680