Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
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Hirasawa K et al. Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. 2016 PLoS ONE pmid:27977675
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Zhao X et al. Sensitive and Simplified Detection of Antibiotic Influence on the Dynamic and Versatile Changes of Fecal Short-Chain Fatty Acids. 2016 PLoS ONE pmid:27907030
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Phiri K et al. Parasitological Clearance Rates and Drug Concentrations of a Fixed Dose Combination of Azithromycin-Chloroquine in Asymptomatic Pregnant Women with Plasmodium Falciparum Parasitemia: An Open-Label, Non-Comparative Study in Sub-Saharan Africa. 2016 PLoS ONE pmid:27861509
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Jeong BH et al. Peak Plasma Concentration of Azithromycin and Treatment Responses in Mycobacterium avium Complex Lung Disease. 2016 Antimicrob. Agents Chemother. pmid:27480854
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Lockington D Oral azithromycin and blepharitis: symptoms and signs improve, so where are the publications? 2016 Clin. Experiment. Ophthalmol. pmid:27356302
Zhu B et al. High Resistance to Azithromycin in Clinical Samples from Patients with Sexually Transmitted Diseases in Guangxi Zhuang Autonomous Region, China. 2016 PLoS ONE pmid:27467164
Miyake H et al. Meibomian Gland Dysfunction Model in Hairless Mice Fed a Special Diet With Limited Lipid Content. 2016 Invest. Ophthalmol. Vis. Sci. pmid:27327582
Kobbernagel HE et al. Study protocol, rationale and recruitment in a European multi-centre randomized controlled trial to determine the efficacy and safety of azithromycin maintenance therapy for 6 months in primary ciliary dyskinesia. 2016 BMC Pulm Med pmid:27450411
Sacks HS In older adults, macrolide antibiotics were not linked to increased risk for ventricular arrhythmia. 2016 Ann. Intern. Med. pmid:27323264
Goh YS et al. Neutralizing Antibodies against Plasmodium falciparum Associated with Successful Cure after Drug Therapy. 2016 PLoS ONE pmid:27427762
Shah SA et al. Meibomian gland dysfunction: azithromycin and objective improvement in outcomes in posterior blepharitis. 2016 Clin. Experiment. Ophthalmol. pmid:27314917
Davido B et al. Why should 1 gram of ceftriaxone monotherapy be considered as a therapeutic option in gonococcal sexually transmitted diseases? 2016 Clin. Microbiol. Infect. pmid:27404364
Belkacem A et al. Molecular epidemiology and mechanisms of resistance of azithromycin-resistant Neisseria gonorrhoeae isolated in France during 2013-14. 2016 J. Antimicrob. Chemother. pmid:27301565
Malhotra S et al. Prevalence of Trachoma in Car-Nicobar Island, India after Three Annual Rounds of Mass Drug Administration with Azithromycin. 2016 PLoS ONE pmid:27391274
Marks M Yaws: towards the WHO eradication target. 2016 Trans. R. Soc. Trop. Med. Hyg. pmid:27268712
Liu B et al. Relationship between Community Drug Administration Strategy and Changes in Trachoma Prevalence, 2007 to 2013. 2016 PLoS Negl Trop Dis pmid:27385309
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Katanami Y et al. Six Cases of Paratyphoid Fever Due to Salmonella Paratyphi A in Travelers Returning from Myanmar Between July 2014 and August 2015. 2016 Am. J. Trop. Med. Hyg. pmid:27352874
Mertens TC et al. Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells. 2016 Pulm Pharmacol Ther pmid:27246785
Wang X et al. Increased therapeutic efficacy of combination of azithromycin and ceftazidime on Pseudomonas aeruginosa biofilm in an animal model of ureteral stent infection. 2016 BMC Microbiol. pmid:27341798
Das S et al. Revisit of fluoroquinolone and azithromycin susceptibility breakpoints for Salmonella enterica serovar Typhi. 2016 J. Med. Microbiol. pmid:27221661
Fifer H et al. Failure of Dual Antimicrobial Therapy in Treatment of Gonorrhea. 2016 N. Engl. J. Med. pmid:27332921
Bacharier LB et al. Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children--Reply. 2016 JAMA pmid:27187309
Gesink D et al. Mycoplasma genitalium in Toronto, Ont: Estimates of prevalence and macrolide resistance. 2016 Can Fam Physician pmid:27331225
Fleming-Dutra KE et al. Early Azithromycin Treatment to Prevent Severe Lower Respiratory Tract Illnesses in Children. 2016 JAMA pmid:27187308
Guo Y et al. Chlamydiaphage φCPG1 Capsid Protein Vp1 Inhibits Chlamydia trachomatis Growth via the Mitogen-Activated Protein Kinase Pathway. 2016 Viruses pmid:27089359
Gülses A and Ayna M Re: Comparison of Azithromycin and Amoxicillin Before Dental Implant Placement: An Exploratory Study of Bioavailability and Resolution of Postoperative Inflammation. 2016 J. Periodontol. pmid:26962889
Hu J et al. Streptococcus pneumoniae and Haemophilus influenzae type b carriage in Chinese children aged 12-18 months in Shanghai, China: a cross-sectional study. 2016 BMC Infect. Dis. pmid:27080523
McClure KS and Cameron ST An audit of expedited treatment for uncomplicated Chlamydia trachomatis index cases at the community pharmacy. 2016 Int J STD AIDS pmid:26945591
Liang JY et al. Azithromycin-resistant Neisseria gonorrhoeae isolates in Guangzhou, China (2009-2013): coevolution with decreased susceptibilities to ceftriaxone and genetic characteristics. 2016 BMC Infect. Dis. pmid:27080231
McCarthy M No link between macrolide antibiotics and ventricular arrhythmias, study finds. 2016 BMJ pmid:26905692
Lahra MM and Enriquez RP Australian Gonococcal Surveillance Programme, 1 July to 30 September 2015. 2016 Commun Dis Intell Q Rep pmid:27080026
Ward E and Duff P A comparison of 3 antibiotic regimens for prevention of postcesarean endometritis: an historical cohort study. 2016 Am. J. Obstet. Gynecol. pmid:26901276
Yuan Z et al. Randomized controlled clinical trial on the efficacy of fosfomycin trometamol for uncomplicated gonococcal urethritis in men. 2016 Clin. Microbiol. Infect. pmid:27064136
Hathorn E et al. What is the most appropriate treatment for rectal Chlamydia trachomatis infection? 2016 Sex Transm Infect pmid:26892930
Farrell DJ et al. Results from the Solithromycin International Surveillance Program (2014). 2016 Antimicrob. Agents Chemother. pmid:27044551
Moore BR et al. Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women. 2016 Br J Clin Pharmacol pmid:26889763
Mathew JL et al. Oral Azithromycin for Acute Episodic Airway Symptoms in Young Children: Evidence-based Medicine Viewpoint. 2016 Indian Pediatr pmid:27029689
Pavlović D and Mutak S Synthesis and antibacterial evaluation of novel 4″-glycyl linked quinolyl-azithromycins with potent activity against macrolide-resistant pathogens. 2016 Bioorg. Med. Chem. pmid:26860929
Roca A et al. Oral azithromycin given during labour decreases bacterial carriage in the mothers and their offspring: a double-blind randomized trial. 2016 Clin. Microbiol. Infect. pmid:27026482
Oey M and Malhotra P Azithromycin and ceftriaxone combination treatment for relapsed Salmonella Paratyphi A bacteraemia. 2016 J Travel Med pmid:26858276
DeCoster B et al. Expedited Partner Therapy: Clinical Considerations and Public Health Explorations. 2016 AMA J Ethics pmid:27002992
Zhou T et al. Determination of azithromycin residue in pork using a molecularly imprinted monolithic microcolumn coupled to liquid chromatography with tandem mass spectrometry. 2016 J Sep Sci pmid:26854282
Das MC et al. Attenuation of Pseudomonas aeruginosa biofilm formation by Vitexin: A combinatorial study with azithromycin and gentamicin. 2016 Sci Rep pmid:27000525
Saleh A et al. Comparison of adjunctive azithromycin and amoxicillin/metronidazole for patients with chronic periodontitis: preliminary randomized control trial. 2016 Aust Dent J pmid:26836781
Topp E et al. Reduced persistence of the macrolide antibiotics erythromycin, clarithromycin and azithromycin in agricultural soil following several years of exposure in the field. 2016 Sci. Total Environ. pmid:27096634
Li X et al. Macrolides use and the risk of sudden cardiac death. 2016 Expert Rev Anti Infect Ther pmid:27086751
Lee SJ et al. Maternal azithromycin administration eradicates intra-amniotic Ureaplasma infection: The first human case report. 2016 J Obstet Gynaecol pmid:26634623
Martin I et al. Decline in Decreased Cephalosporin Susceptibility and Increase in Azithromycin Resistance in Neisseria gonorrhoeae, Canada. 2016 Emerging Infect. Dis. pmid:26689114
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Yang CJ et al. Comparison of serological responses to single-dose azithromycin (2 g) versus benzathine penicillin G in the treatment of early syphilis in HIV-infected patients in an area of low prevalence of macrolide-resistant Treponema pallidum infection. 2016 J. Antimicrob. Chemother. pmid:26604241
Chisholm SA et al. An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England. 2016 Sex Transm Infect pmid:26601852
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Olszewska-Sosińska O et al. Persistence of non-typeable Haemophilus Influenzae in the pharynx of children with adenotonsillar hypertrophy after treatment with azithromycin. 2016 Pathog Dis pmid:26546328
Wakiguchi H et al. Multiple Renal and Splenic Lesions in Cat Scratch Disease. 2016 Jpn. J. Infect. Dis. pmid:26567841
Luo Q et al. Surface plasmon resonance sensor for antibiotics detection based on photo-initiated polymerization molecularly imprinted array. 2016 Talanta pmid:27769483
Chang Y et al. Factors Influencing the HPLC Determination for Related Substances of Azithromycin. 2016 J Chromatogr Sci pmid:26324196
Shunmugaperumal T and Kaur V In Vitro Anti-inflammatory and Antimicrobial Activities of Azithromycin After Loaded in Chitosan- and Tween 20-Based Oil-in-Water Macroemulsion for Acne Management. 2016 AAPS PharmSciTech pmid:26314246
Víchová B et al. First molecular identification of Babesia gibsoni in dogs from Slovakia, central Europe. 2016 Ticks Tick Borne Dis pmid:26304014
Bhargava A et al. Scrub typhus in Uttarakhand & adjoining Uttar Pradesh: Seasonality, clinical presentations & predictors of mortality. 2016 Indian J. Med. Res. pmid:28474627
Fegan D et al. Tropical leg ulcers in children: more than yaws. 2016 Trop Doct pmid:26289420
Caspi M et al. A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents. 2016 J. Mol. Med. pmid:26620677
Kasten G et al. Development of low density azithromycin-loaded polycaprolactone microparticles for pulmonary delivery. 2016 Drug Dev Ind Pharm pmid:26289002
Libois A and De Wit S Which empiric syndromic treatment for urethritis? 2016 Int J STD AIDS pmid:27794143
Gaudreau C et al. Shigella flexneri with Ciprofloxacin Resistance and Reduced Azithromycin Susceptibility, Canada, 2015. 2016 Emerging Infect. Dis. pmid:27767915
Narita M et al. Antimicrobial Susceptibility of Microorganisms Isolated from Periapical Periodontitis Lesions. 2016 Bull. Tokyo Dent. Coll. pmid:27665691
Dombrowski JC and Batteiger BE Reconsidering the Use of Azithromycin for Chlamydial Urethritis. 2016 Sex Transm Dis pmid:27626187
Yadav H et al. Azithromycin for the Treatment of Obliterative Bronchiolitis after Hematopoietic Stem Cell Transplantation: A Systematic Review and Meta-Analysis. 2016 Biol. Blood Marrow Transplant. pmid:27575542
Lemieux JE et al. A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse. 2016 Nat Microbiol pmid:27572973
Narayanasamy DK et al. Clinico - Laboratory Profile of Scrub Typhus - An Emerging Rickettsiosis in India. 2016 Indian J Pediatr pmid:27352842
Keenan JD et al. Nasopharyngeal Pneumococcal Serotypes Before and After Mass Azithromycin Distributions for Trachoma. 2016 J Pediatric Infect Dis Soc pmid:27199475
Tous Romero F et al. Acute Infection by Staphylococcus simulans in the Hand of a Man. 2016 JAMA Dermatol pmid:27144675
Horner P et al. 2015 UK National Guideline on the management of non-gonococcal urethritis. 2016 Int J STD AIDS pmid:26002319
Ni C et al. High prevalence of Neisseria gonorrhoeae with high-level resistance to azithromycin in Hangzhou, China. 2016 J. Antimicrob. Chemother. pmid:27090631
Garnier C et al. Intra-nodal injection of gentamicin for the treatment of suppurated cat scratch disease's lymphadenitis. 2016 Infection pmid:26001741