Azithramycine

Azithramycine is a lipid of Polyketides (PK) class. Azithramycine is associated with abnormalities such as Respiratory Tract Infections, Pneumonia, Lower respiratory tract infection, Infection and Nonspecific urethritis. The involved functions are known as Lysis, Selection, Genetic, Mutation, Relapse and Adaptation. Azithramycine often locates in Blood, Respiratory System, Genitourinary system, Back and Chest. The associated genes with Azithramycine are Genes, rRNA, Genome, RPL22 gene, OPRM1 gene and tryptic soy broth. The related lipids are Liposomes, Phosphatidylserines, Promega, Lipopolysaccharides and Steroids. The related experimental models are Mouse Model, Knock-out and Tissue Model.

Cross Reference

Introduction

To understand associated biological information of Azithramycine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Azithramycine?

Azithramycine is suspected in Infection, Pneumonia, Trachoma, Respiratory Tract Infections, Gonorrhea, Infectious disease of lung and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Azithramycine

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diarrhea D003967 32 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hearing Loss, Sensorineural D006319 8 associated lipids
Otitis Media D010033 12 associated lipids
Carcinoma, Basal Cell D002280 6 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 276

PubChem Associated disorders and diseases

What pathways are associated with Azithramycine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Azithramycine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Azithramycine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Azithramycine?

Related references are published most in these journals:

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What genes are associated with Azithramycine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Azithramycine?

Mouse Model

Mouse Model are used in the study 'Azithromycin increases in vitro fibronectin production through interactions between macrophages and fibroblasts stimulated with Pseudomonas aeruginosa.' (Cory TJ et al., 2013), Mouse Model are used in the study 'Efficacy of azithromycin, clarithromycin and beta-lactam agents against experimentally induced bronchopneumonia caused by Haemophilus influenzae in mice.' (Miyazaki S et al., 2001), Mouse Model are used in the study 'Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.' (Gross M et al., 2004), Mouse Model are used in the study 'Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections.' (Bala A et al., 2011) and Mouse Model are used in the study 'Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.' (Girard D et al., 2005).

Knock-out

Knock-out are used in the study 'Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.' (Bulman ZP et al., 2017) and Knock-out are used in the study 'Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.' (Mulet X et al., 2009).

Tissue Model

Tissue Model are used in the study 'Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects.' (Zheng S et al., 2014).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Azithramycine

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Per page 10 20 50 100 | Total 4404
Authors Title Published Journal PubMed Link
Martin DL et al. Serology for trachoma surveillance after cessation of mass drug administration. 2015 PLoS Negl Trop Dis pmid:25714363
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Euba B et al. Relationship between azithromycin susceptibility and administration efficacy for nontypeable Haemophilus influenzae respiratory infection. 2015 Antimicrob. Agents Chemother. pmid:25712355
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Waag DM Efficacy of postexposure therapy against glanders in mice. 2015 Antimicrob. Agents Chemother. pmid:25645854
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Zheng H et al. Association of the in vitro susceptibility of clinical isolates of chlamydia trachomatis with serovar and duration of antibiotic exposure. 2015 Sex Transm Dis pmid:25668641
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Kong FY et al. The efficacy of azithromycin and doxycycline for the treatment of rectal chlamydia infection: a systematic review and meta-analysis. 2015 J. Antimicrob. Chemother. pmid:25637520
Saini H et al. Azithromycin and ciprofloxacin: a possible synergistic combination against Pseudomonas aeruginosa biofilm-associated urinary tract infections. 2015 Int. J. Antimicrob. Agents pmid:25604277
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Singh N et al. Cat-scratch fever and lymphadenopathy in a rheumatoid arthritis patient on tocilizumab. 2015 J Clin Rheumatol pmid:25539435
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Hocking JS et al. Treatment of rectal chlamydia infection may be more complicated than we originally thought. 2015 J. Antimicrob. Chemother. pmid:25480490
Kadova Z et al. IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats. 2015 Am. J. Physiol. Renal Physiol. pmid:25503728
Lu ZK et al. Cardiac risks associated with antibiotics: azithromycin and levofloxacin. 2015 Expert Opin Drug Saf pmid:25494485
Kapil R et al. Investigating the epidemiology of repeat Chlamydia trachomatis detection after treatment by using C. trachomatis OmpA genotyping. 2015 J. Clin. Microbiol. pmid:25472488
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Beigelman A et al. Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis. 2015 J. Allergy Clin. Immunol. pmid:25458910
Kirkcaldy RD et al. Analysis of Neisseria gonorrhoeae azithromycin susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013. 2015 Antimicrob. Agents Chemother. pmid:25451056
Radhakrishnan SV et al. Preventive azithromycin treatment reduces noninfectious lung injury and acute graft-versus-host disease in a murine model of allogeneic hematopoietic cell transplantation. 2015 Biol. Blood Marrow Transplant. pmid:25445642
Vora GK et al. Conjunctival pseudotumor caused by herpes simplex virus infection. 2015 JAMA Ophthalmol pmid:25232655
Cocco G and Jerie P Torsades de pointes induced by the concomitant use of ivabradine and azithromycin: an unexpected dangerous interaction. 2015 Cardiovasc. Toxicol. pmid:25158669
Keenan JD et al. Evidence for clonal expansion after antibiotic selection pressure: pneumococcal multilocus sequence types before and after mass azithromycin treatments. 2015 J. Infect. Dis. pmid:25293366
Wan YF et al. Azithromycin attenuates pulmonary inflammation and emphysema in smoking-induced COPD model in rats. 2015 Respir Care pmid:25249648
Lai PC et al. Azithromycin enhances phagocytic killing of Aggregatibacter actinomycetemcomitans Y4 by human neutrophils. 2015 J. Periodontol. pmid:25186779
Gardiner SJ et al. Antibiotics for community-acquired lower respiratory tract infections secondary to Mycoplasma pneumoniae in children. 2015 Cochrane Database Syst Rev pmid:25566754
Young PM et al. Multi-breath dry powder inhaler for delivery of cohesive powders in the treatment of bronchiectasis. 2015 Drug Dev Ind Pharm pmid:24811055
Doyle CJ et al. Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro. 2015 Clin Oral Investig pmid:24806810
Young TP Banana fibers masquerading as worms in the stool of a 14-month-old girl. 2015 Clin Pediatr (Phila) pmid:24803631
Willekens J et al. How long should we maintain long-term azithromycin treatment in cystic fibrosis patients? 2015 Pediatr. Pulmonol. pmid:24464958
Galvidis I et al. Group determination of 14-membered macrolide antibiotics and azithromycin using antibodies against common epitopes. 2015 Anal. Biochem. pmid:25256165
Siekmeier R et al. Inhalation of macrolides: a novel approach to treatment of pulmonary infections. 2015 Adv. Exp. Med. Biol. pmid:25252902
Méndez Abad P et al. Idiopathic plastic bronchitis as an uncommon cause of massive pulmonary atelectasis. 2015 Arch. Bronconeumol. pmid:24495947
Quinn TC and Gaydos CA Treatment for Chlamydia Infection--Doxycycline versus Azithromycin. 2015 N. Engl. J. Med. pmid:26699174
Lahra MM and Enriquez RP Australian Gonococcal Surveillance Programme, 1 April to 30 June 2015. 2015 Commun Dis Intell Q Rep pmid:26779739
Azzam O et al. Rhodococcus equi peritonitis in continuous ambulatory peritoneal dialysis: a first in Australia. 2015 BMJ Case Rep pmid:26438670
ACOG Committee Opinion No. 645: Dual Therapy for Gonococcal Infections. 2015 Obstet Gynecol pmid:26488526
Shibahara D et al. Falciparum Malaria Incidentally Pretreated with Azithromycin. 2015 Intern. Med. pmid:26424314
ACOG Committee Opinion No. 645 Summary: Dual Therapy for Gonococcal Infections. 2015 Obstet Gynecol pmid:26488518
Wei HX et al. A Systematic Review and Meta-Analysis of the Efficacy of Anti-Toxoplasma gondii Medicines in Humans. 2015 PLoS ONE pmid:26394212
Babics A and Roussellier P Gardnerella vaginalis: An overlooked pathogen in male patients? 2015 Med Mal Infect pmid:26472061
See CW et al. The Effect of Mass Azithromycin Distribution on Childhood Mortality: Beliefs and Estimates of Efficacy. 2015 Am. J. Trop. Med. Hyg. pmid:26392160
Kalonji LM et al. Invasive Salmonella Infections at Multiple Surveillance Sites in the Democratic Republic of the Congo, 2011-2014. 2015 Clin. Infect. Dis. pmid:26449951
Winters N et al. Efficacy and safety of World Health Organization group 5 drugs for multidrug-resistant tuberculosis treatment. 2015 Eur. Respir. J. pmid:26381514
Yan M et al. Synthesis and antibacterial activity of 4″-O-(trans-β-arylacrylamido)carbamoyl azithromycin analogs. 2015 Eur J Med Chem pmid:26402728
Marks M et al. Challenges and key research questions for yaws eradication. 2015 Lancet Infect Dis pmid:26362174
García-Quintanilla M et al. Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii. 2015 Int. J. Antimicrob. Agents pmid:26391380
Muralidharan V and Striepen B Teaching old drugs new tricks to stop malaria invasion in its tracks. 2015 BMC Biol. pmid:26349580
Hare KM et al. Nasopharyngeal carriage and macrolide resistance in Indigenous children with bronchiectasis randomized to long-term azithromycin or placebo. 2015 Eur. J. Clin. Microbiol. Infect. Dis. pmid:26363637
Phoon YW et al. Isolation of multidrug-resistant Salmonella in Singapore. 2015 Singapore Med J pmid:26311915
Unemo M Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge. 2015 BMC Infect. Dis. pmid:26293005
Lin L et al. Azithromycin Synergizes with Cationic Antimicrobial Peptides to Exert Bactericidal and Therapeutic Activity Against Highly Multidrug-Resistant Gram-Negative Bacterial Pathogens. 2015 EBioMedicine pmid:26288841
Hancock RE Rethinking the Antibiotic Discovery Paradigm. 2015 EBioMedicine pmid:26288830
Zhanel GG et al. Clinical cure rates in subjects treated with azithromycin for community-acquired respiratory tract infections caused by azithromycin-susceptible or azithromycin-resistant Streptococcus pneumoniae: analysis of Phase 3 clinical trial data-authors' response. 2015 J. Antimicrob. Chemother. pmid:26242414
Horner PJ Editorial Commentary: Mycoplasma genitalium and Declining Treatment Efficacy of Azithromycin 1 g: What Can We Do? 2015 Clin. Infect. Dis. pmid:26240204
Lau A et al. The Efficacy of Azithromycin for the Treatment of Genital Mycoplasma genitalium: A Systematic Review and Meta-analysis. 2015 Clin. Infect. Dis. pmid:26240201
Goldstein LH et al. Azithromycin is not associated with QT prolongation in hospitalized patients with community-acquired pneumonia. 2015 Pharmacoepidemiol Drug Saf pmid:26238864
Gualdoni GA et al. Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation. 2015 Sci Rep pmid:26152605
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Unemo M et al. High in vitro susceptibility to the novel spiropyrimidinetrione ETX0914 (AZD0914) among 873 contemporary clinical Neisseria gonorrhoeae isolates from 21 European countries from 2012 to 2014. 2015 Antimicrob. Agents Chemother. pmid:26077246
Cowling CS et al. National trachoma surveillance annual report, 2012. 2015 Commun Dis Intell Q Rep pmid:26063088
Arnež M and Ružić-Sabljić E Azithromycin Is Equally Effective as Amoxicillin in Children with Solitary Erythema Migrans. 2015 Pediatr. Infect. Dis. J. pmid:26186104
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Patterson L et al. Outbreak of invasive pneumococcal disease at a Belfast shipyard in men exposed to welding fumes, Northern Ireland, April-May 2015: preliminary report. 2015 Euro Surveill. pmid:26062559
Bowen A et al. Notes from the Field: Outbreaks of Shigella sonnei Infection with Decreased Susceptibility to Azithromycin Among Men Who Have Sex with Men - Chicago and Metropolitan Minneapolis-St. Paul, 2014. 2015 MMWR Morb. Mortal. Wkly. Rep. pmid:26042652
Vandermeulen E et al. BAL neutrophilia in azithromycin-treated lung transplant recipients: Clinical significance. 2015 Transpl. Immunol. pmid:26168736
Lu H et al. High frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis. 2015 Emerg Microbes Infect pmid:26038763
Llata E et al. Management of Pelvic Inflammatory Disease in Selected U.S. Sexually Transmitted Disease Clinics: Sexually Transmitted Disease Surveillance Network, January 2010-December 2011. 2015 Sex Transm Dis pmid:26165434
Washington AZ et al. Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel. 2015 Bioorg. Med. Chem. pmid:26037612
Tabidze IL et al. Adherence to Centers for Disease Control and Prevention Gonococcal Treatment Guidelines Among Chicago Health Care Providers, 2011-2012. 2015 Sex Transm Dis pmid:26165433
Schreeg ME et al. Rapid High-Resolution Melt Analysis of Cytauxzoon felis Cytochrome b To Aid in the Prognosis of Cytauxzoonosis. 2015 J. Clin. Microbiol. pmid:26019197
Pérez-Doñate V et al. [Is azithromycin really a therapeutic option in intestinal salmonellosis?]. 2015 An Pediatr (Barc) pmid:26006271
Teo A et al. Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission. 2015 Malar. J. pmid:26006260
Chazan B et al. Susceptibility of Group A Streptococcus to Antimicrobial Agents in Northern Israel: A Surveillance Study. 2015 Microb. Drug Resist. pmid:26430943
Barni S et al. Azithromycin is more allergenic than clarithromycin in children with suspected hypersensitivity reaction to macrolides. 2015 J Investig Allergol Clin Immunol pmid:25997306
Earl CS et al. Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance. 2015 EMBO Mol Med pmid:25995336
Baker KS et al. Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study. 2015 Lancet Infect Dis pmid:25936611
Agaisse H Shigella flexneri serotype 3a: the rise of a superbug. 2015 Lancet Infect Dis pmid:25936610
Rice LB Will use of combination cephalosporin/azithromycin therapy forestall resistance to cephalosporins in Neisseria gonorrhoeae? 2015 Sex Transm Infect pmid:25926405
Lynagh Y et al. Detailed characterization of the first high-level azithromycin-resistant Neisseria gonorrhoeae cases in Ireland. 2015 J. Antimicrob. Chemother. pmid:25907073
Choi AH et al. Clinicocytopathologic correlation in an atypical presentation of lymphadenopathy with review of literature. 2015 Am. J. Clin. Pathol. pmid:25873511
Coolen N et al. Reduced risk of nontuberculous mycobacteria in cystic fibrosis adults receiving long-term azithromycin. 2015 J. Cyst. Fibros. pmid:25735458
Riesselman A and El-Mallakh RS Akathisia with azithromycin. 2015 Ann Pharmacother pmid:25870444
Soares GM et al. Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model. 2015 Antimicrob. Agents Chemother. pmid:25733510
Brusselle GG Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? 2015 Thorax pmid:25870311
Parry CM et al. Clinically and microbiologically derived azithromycin susceptibility breakpoints for Salmonella enterica serovars Typhi and Paratyphi A. 2015 Antimicrob. Agents Chemother. pmid:25733500
Gose SO et al. Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California. 2015 Sex Transm Dis pmid:25868141
Shoaib A et al. Determining the role of a probiotic in the restoration of intestinal microbial balance by molecular and cultural techniques. 2015 Genet. Mol. Res. pmid:25730092
Franco M et al. Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy. 2015 Transpl Infect Dis pmid:25846671
Corris PA et al. A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation. 2015 Thorax pmid:25714615
Hung AM and Hakim RM Dialysate and serum potassium in hemodialysis. 2015 Am. J. Kidney Dis. pmid:25828570