clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Formanoy E et al. | Tenosynovitis of the right hand. Mycobacterium kansasii. | 2013 | Neth J Med | pmid:24394739 |
Patel AM et al. | Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study. | 2013 | Ann. Intern. Med. | pmid:23778904 |
Morakul B et al. | Precipitation-lyophilization-homogenization (PLH) for preparation of clarithromycin nanocrystals: influencing factors on physicochemical properties and stability. | 2013 | Int J Pharm | pmid:24076396 |
Siamas K and Khachemoune A | Mycobacteria infection in an immunocompetent patient with no risk factors: evaluation and management of non-healing majocchi granuloma-type nodule. | 2013 | Dermatol. Online J. | pmid:24021439 |
Xu Y et al. | Synthesis and antibacterial activity of novel modified 5-O-mycaminose 14-membered ketolides. | 2013 | Eur J Med Chem | pmid:24021890 |
Ranganathan D et al. | Mycobacterium fortuitum peritonitis in a patient receiving continuous ambulatory peritoneal dialysis. | 2013 | Saudi J Kidney Dis Transpl | pmid:24029271 |
Krashias G et al. | Prevalence of Helicobacter pylori cagA and vacA genes in Cypriot patients. | 2013 | J Infect Dev Ctries | pmid:24042099 |
Nguyen L and Taylor-Gjevre RM | An emerging role for clarithromycin in adult-onset still disease? | 2013 | J Clin Rheumatol | pmid:24048102 |
Trespalacios AA et al. | Phenotypic and genotypic analysis of clarithromycin-resistant Helicobacter pylori from Bogotá D.C., Colombia. | 2013 | J. Microbiol. | pmid:23990295 |
Lee YC et al. | The benefit of mass eradication of Helicobacter pylori infection: a community-based study of gastric cancer prevention. | 2013 | Gut | pmid:22698649 |
Saviola G et al. | Clarithromycin in rheumatoid arthritis: the addition to methotrexate and low-dose methylprednisolone induces a significant additive value--a 24-month single-blind pilot study. | 2013 | Rheumatol. Int. | pmid:23864141 |
Amado-RodrÃguez L et al. | Anti-inflammatory effects of clarithromycin in ventilator-induced lung injury. | 2013 | Respir. Res. | pmid:23663489 |
Pereira JM et al. | Interplay of degradation, dissolution and stabilization of clarithromycin and its amorphous solid dispersions. | 2013 | Mol. Pharm. | pmid:24116899 |
Huang J et al. | Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study. | 2013 | Aliment. Pharmacol. Ther. | pmid:24117692 |
Yoon H et al. | Meta-analysis: is sequential therapy superior to standard triple therapy for Helicobacter pylori infection in Asian adults? | 2013 | J. Gastroenterol. Hepatol. | pmid:24118110 |
Chen K et al. | Low dose macrolide administration for long term is effective for otitis media with effusion in children. | 2013 | Auris Nasus Larynx | pmid:22673738 |
Drago F et al. | Acute autoimmune thrombocytopenia and worsening of dermatomyositis after administration of clarithromycin. | 2013 | J. Am. Acad. Dermatol. | pmid:24124859 |
Wang S et al. | A supra-monolayer nanopattern for organic nanoparticle array deposition. | 2013 | ACS Appl Mater Interfaces | pmid:23480527 |
Nykula TD and Furleta VV | [Rationale for improved treatment of ulcerative disease complicated by chronic pyelonephritis]. | 2013 | Lik. Sprava | pmid:25095689 |
Raghunatha K and George JP | Periodontal tissue and serum concentration of clarithromycin after systemic administration in patients affected by chronic periodontitis. | 2013 | J. Periodontol. | pmid:23451987 |
Liang X et al. | Efficacy of bismuth-containing quadruple therapies for clarithromycin-, metronidazole-, and fluoroquinolone-resistant Helicobacter pylori infections in a prospective study. | 2013 | Clin. Gastroenterol. Hepatol. | pmid:23376004 |
Calza P et al. | Fate of selected pharmaceuticals in river waters. | 2013 | Environ Sci Pollut Res Int | pmid:22851223 |
Morse AL et al. | A randomized controlled trial comparing sequential with triple therapy for Helicobacter pylori in an Aboriginal community in the Canadian North. | 2013 | Can. J. Gastroenterol. | pmid:24340314 |
Mikamo H et al. | [Infection and host reaction]. | 2013 | Jpn J Antibiot | pmid:24649796 |
Zhen-Hua Z et al. | Characterization of 23S rRNA gene mutation in primary and secondary clarithromycin-resistant Helicobacter pylori strains from East China. | 2013 | Turk J Gastroenterol | pmid:23794337 |
Evdokimova AG et al. | [New approaches to therapy of Helicobacterpylori infection (by the materials of the Maastricht Consensus-IV, Florence, 2010)]. | 2013 | Antibiot. Khimioter. | pmid:24640139 |
Onal IK et al. | What is the impact of Helicobacter pylori density on the success of eradication therapy: a clinico-histopathological study. | 2013 | Clin Res Hepatol Gastroenterol | pmid:23796974 |
de Zeeuw J et al. | Serum levels of neopterin during antimicrobial treatment for Mycobacterium ulcerans infection. | 2013 | Am. J. Trop. Med. Hyg. | pmid:23836576 |
Janković B et al. | Consolidation trend design based on Young's modulus of clarithromycin single crystals. | 2013 | Int J Pharm | pmid:23872226 |
Shinahara W et al. | Immunomodulator clarithromycin enhances mucosal and systemic immune responses and reduces re-infection rate in pediatric patients with influenza treated with antiviral neuraminidase inhibitors: a retrospective analysis. | 2013 | PLoS ONE | pmid:23875018 |
Friedman ND et al. | Mycobacterium ulcerans disease: experience with primary oral medical therapy in an Australian cohort. | 2013 | PLoS Negl Trop Dis | pmid:23875050 |
Suzuki RB et al. | Low Helicobacter pylori primary resistance to clarithromycin in gastric biopsy specimens from dyspeptic patients of a city in the interior of São Paulo, Brazil. | 2013 | BMC Gastroenterol | pmid:24305035 |
Yano K et al. | Clinical outcome of the chronic flexor tenosynovitis in the hand caused by non-tuberculous mycobacterium treated by extensive tenosynovectomy and drugs. | 2013 | J Plast Surg Hand Surg | pmid:23875916 |
Trifan A et al. | Pseudomembranous colitis associated with a triple therapy for Helicobacter pylori eradication. | 2013 | World J. Gastroenterol. | pmid:24259981 |
Laving A et al. | Effectiveness of sequential v. standard triple therapy for treatment of Helicobacter pylori infection in children in Nairobi, Kenya. | 2013 | S. Afr. Med. J. | pmid:24300630 |
Venerito M et al. | Meta-analysis of bismuth quadruple therapy versus clarithromycin triple therapy for empiric primary treatment of Helicobacter pylori infection. | 2013 | Digestion | pmid:23880479 |
Cecchini MP et al. | Might Helicobacter pylori infection be associated with distortion on taste perception? | 2013 | Med. Hypotheses | pmid:23845559 |
Delgado JS et al. | Granulomatous gastritis and Helicobacter pylori infection. | 2013 | Isr. Med. Assoc. J. | pmid:23882902 |
Lee HJ et al. | Eradication of Helicobacter pylori according to 23S ribosomal RNA point mutations associated with clarithromycin resistance. | 2013 | J. Infect. Dis. | pmid:23801607 |
Shallom SJ et al. | New rapid scheme for distinguishing the subspecies of the Mycobacterium abscessus group and identifying Mycobacterium massiliense isolates with inducible clarithromycin resistance. | 2013 | J. Clin. Microbiol. | pmid:23804391 |
Kim SG et al. | [Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition]. | 2013 | Korean J Gastroenterol | pmid:23954956 |
Yoshida S et al. | Further isolation of Mycobacterium abscessus subsp. abscessus and subsp. bolletii in different regions of Japan and susceptibility of these isolates to antimicrobial agents. | 2013 | Int. J. Antimicrob. Agents | pmid:23850022 |
Dib J et al. | Efficacy of PPI, levofloxacin and amoxicillin in the eradication of Helicobacter pylori compared to conventional triple therapy at a Venezuelan hospital. | 2013 | Arab J Gastroenterol | pmid:24206741 |
Gibbins NE et al. | Time to reconsider guidelines on clarithromycin in chronic rhinosinusitis? | 2013 | BMJ | pmid:23635541 |
Pilcer G et al. | Carrier-free combination for dry powder inhalation of antibiotics in the treatment of lung infections in cystic fibrosis. | 2013 | Int J Pharm | pmid:23643509 |
Rimbara E et al. | Helicobacter cinaedi and Helicobacter fennelliae transmission in a hospital from 2008 to 2012. | 2013 | J. Clin. Microbiol. | pmid:23658263 |
Bismuth + metronidazole + tetracycline. Why risk adding bismuth? | 2013 | Prescrire Int | pmid:23662315 | |
Zhuo FL et al. | Clinical isolates of Mycobacterium abscessus in Guangzhou area most possibly from the environmental infection showed variable susceptibility. | 2013 | Chin. Med. J. | pmid:23673103 |
Seck A et al. | Primary antibiotic resistance and associated mechanisms in Helicobacter pylori isolates from Senegalese patients. | 2013 | Ann. Clin. Microbiol. Antimicrob. | pmid:23298145 |
Rossi A et al. | BiRd (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma. | 2013 | Blood | pmid:23299315 |
Andersen JT et al. | Clarithromycin in early pregnancy and the risk of miscarriage and malformation: a register based nationwide cohort study. | 2013 | PLoS ONE | pmid:23301061 |
Kwak HM et al. | The efficacy of cefazolin plus macrolide (erythromycin or clarithromycin) versus cefazolin alone in neonatal morbidity and placental inflammation for women with preterm premature rupture of membranes. | 2013 | Placenta | pmid:23465535 |
Huang HC et al. | Primary central nervous system diffuse large B cell lymphoma transformed from orbital mucosa-associated lymphoid tissue lymphoma: complete response to combined intrathecal and systemic rituximab. | 2013 | Ann. Hematol. | pmid:23242476 |
Ang TL et al. | Is there still a role for empiric first-line triple therapy using proton pump inhibitor, amoxicillin and clarithromycin for Helicobacter pylori infection in Singapore? Results of a time trend analysis. | 2013 | J Dig Dis | pmid:23253473 |
Danilko L et al. | [Clarithromycin therapy of a B cell MALT lymphoma]. | 2013 | Ophthalmologe | pmid:23224128 |
Singh RP et al. | Antimicrobial prophylaxis in open reduction and internal fixation of compound mandibular fractures: a collaborative regional audit of outcome. | 2013 | Br J Oral Maxillofac Surg | pmid:23369782 |
Prasertpetmanee S et al. | Improved efficacy of proton pump inhibitor - amoxicillin - clarithromycin triple therapy for Helicobacter pylori eradication in low clarithromycin resistance areas or for tailored therapy. | 2013 | Helicobacter | pmid:23356886 |
Nakamura Y et al. | Optimal duration of macrolide treatment for chronic sinusitis after endoscopic sinus surgery. | 2013 | Auris Nasus Larynx | pmid:23107100 |
Kazama I and Maruyama Y | Differential effects of clarithromycin and azithromycin on delayed rectifier K(+)-channel currents in murine thymocytes. | 2013 | Pharm Biol | pmid:23527897 |
Kawai Y et al. | Therapeutic efficacy of macrolides, minocycline, and tosufloxacin against macrolide-resistant Mycoplasma pneumoniae pneumonia in pediatric patients. | 2013 | Antimicrob. Agents Chemother. | pmid:23459497 |
Sardarian H et al. | Comparison of hybrid and sequential therapies for Helicobacter pylori eradication in Iran: a prospective randomized trial. | 2013 | Helicobacter | pmid:23121338 |
Liou JM et al. | Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial. | 2013 | Lancet | pmid:23158886 |
Sarkeshikian SS et al. | Azithromycin based triple therapy versus standard clarithromycin based triple therapy in eradication of Helicobacter pylori infection in Iran: a randomized controlled clinical trial. | 2013 | Turk J Gastroenterol | pmid:23794338 |
Uthman MM et al. | Interventions for the prevention of mycobacterium avium complex in adults and children with HIV. | 2013 | Cochrane Database Syst Rev | pmid:23633339 |
Kupcinskas L et al. | Evolution of Helicobacter pylori susceptibility to antibiotics during a 10-year period in Lithuania. | 2013 | APMIS | pmid:23078193 |
Wu Y et al. | Overexpression of YKL-40 predicts plaque instability in carotid atherosclerosis with CagA-positive Helicobacter pylori infection. | 2013 | PLoS ONE | pmid:23573226 |
Koh WJ et al. | Reply: drug concentration monitoring in Mycobacterium avium lung disease: problems with methods and conclusions. | 2013 | Am. J. Respir. Crit. Care Med. | pmid:23577353 |
Schmitt BH et al. | PCR detection of clarithromycin-susceptible and -resistant Helicobacter pylori from formalin-fixed, paraffin-embedded gastric biopsies. | 2013 | Mod. Pathol. | pmid:23579617 |
Lai J et al. | Epithelioid histiocytic infiltrate caused by Mycobacterium scrofulaceum infection: a potential mimic of various neoplastic entities. | 2013 | Am J Dermatopathol | pmid:22935892 |
Boyanova L et al. | Living in Sofia is associated with a risk for antibiotic resistance in Helicobacter pylori: a Bulgarian study. | 2013 | Folia Microbiol. (Praha) | pmid:23580173 |
Bradbeer L et al. | Childhood headache and H. pylori--a possible association. | 2013 | Aust Fam Physician | pmid:23529524 |
Yula E et al. | Detection of primary clarithromycin resistance of Helicobacter pylori and association between cagA (+) status and clinical outcome. | 2013 | Folia Microbiol. (Praha) | pmid:22956464 |
Zhou L et al. | Cutaneous Mycobacterium intracellulare infection in an immuno-competent person. | 2013 | Acta Derm. Venereol. | pmid:23532357 |
Marin AC et al. | A review of rescue regimens after clarithromycin-containing triple therapy failure (for Helicobacter pylori eradication). | 2013 | Expert Opin Pharmacother | pmid:23537368 |
Phunpruch S et al. | A role for 16S rRNA dimethyltransferase (ksgA) in intrinsic clarithromycin resistance in Mycobacterium tuberculosis. | 2013 | Int. J. Antimicrob. Agents | pmid:23541074 |
Alhajlan M et al. | Efficacy and safety of liposomal clarithromycin and its effect on Pseudomonas aeruginosa virulence factors. | 2013 | Antimicrob. Agents Chemother. | pmid:23545534 |
Goh IX et al. | Cytochrome P450 drug interactions with statin therapy. | 2013 | Singapore Med J | pmid:23546024 |
Georgopoulos S et al. | Nonbismuth quadruple "concomitant" therapy versus standard triple therapy, both of the duration of 10 days, for first-line H. pylori eradication: a randomized trial. | 2013 | J. Clin. Gastroenterol. | pmid:22858517 |
Malfertheiner P | [Is sequential eradication of Helicobacter pylori effective? Sequential treatment more effective than triple therapy in patients with clarithromycin resistance]. | 2013 | Dtsch. Med. Wochenschr. | pmid:23512360 |
Seneviratne K and Herieka E | A rifampicin-resistant Mycobacterium marinum infection in a newly diagnosed HIV-1 individual. | 2013 | Int J STD AIDS | pmid:23512514 |
Liu MK et al. | Randomized trial comparing rabeprazole- versus lansoprazole-based Helicobacter pylori eradication regimens. | 2013 | Kaohsiung J. Med. Sci. | pmid:23768702 |
Li XM et al. | Telithromycin versus clarithromycin for the treatment of community-acquired respiratory tract infections: a meta-analysis of randomized controlled trials. | 2013 | Chin. Med. J. | pmid:23769580 |
Asaoka D et al. | Trends of second-line eradication therapy for Helicobacter pylori in Japan: a multicenter study in the Tokyo metropolitan area. | 2013 | Helicobacter | pmid:23773231 |
Al-Haj A et al. | Method development, validation and bioequivalence of varenicline in human plasma by liquid chromatography tandem mass spectrometry. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23774248 |
Quinney SK et al. | Rate of onset of inhibition of gut-wall and hepatic CYP3A by clarithromycin. | 2013 | Eur. J. Clin. Pharmacol. | pmid:22777148 |
Kim T et al. | [Clarithromycin-resistant Helicobacter pylori associated with 23S rRNA point mutations in Jeju Island]. | 2013 | Korean J Gastroenterol | pmid:23756666 |
Howard ST | Recent progress towards understanding genetic variation in the Mycobacterium abscessus complex. | 2013 | Tuberculosis (Edinb) | pmid:24388643 |
Georgopoulos SD et al. | Clinical evaluation of a ten-day regimen with esomeprazole, metronidazole, amoxicillin, and clarithromycin for the eradication of Helicobacter pylori in a high clarithromycin resistance area. | 2013 | Helicobacter | pmid:23714140 |
Koh WJ et al. | Successful treatment of Mycobacterium massiliense lung disease with oral antibiotics only. | 2013 | Antimicrob. Agents Chemother. | pmid:23183432 |
Cerqueira RM et al. | Cumulative Helicobacter pylori eradication therapy in obese patients undergoing gastric bypass surgery. | 2013 | Obes Surg | pmid:23054570 |
Zendedel A et al. | Antibiotic resistance of Helicobacter pylori in Mashhad, Iran. | 2013 | J Pak Med Assoc | pmid:23914633 |
Maggi P et al. | Fatal fulminant hepatitis following administration of clarithromycin in a patient chronically treated with antipsycotic drugs. | 2013 | Immunopharmacol Immunotoxicol | pmid:22804484 |
Haider M et al. | Post-operative sinus formation due to Mycobacterium abscessus: a case report. | 2013 | Indian J Tuberc | pmid:24000496 |
Hong SK et al. | First case of Mycobacterium longobardum infection. | 2013 | Ann Lab Med | pmid:24003427 |
Labenz J | [Fewer stomach cancers after Helicobacter pylori eradication]. | 2013 | MMW Fortschr Med | pmid:24006589 |
Miyauchi R et al. | Clarithromycin-induced haemorrhagic colitis. | 2013 | BMJ Case Rep | pmid:23964038 |
Gandhi S et al. | Calcium-channel blocker-clarithromycin drug interactions and acute kidney injury. | 2013 | JAMA | pmid:24346990 |
Nagaoka K et al. | Macrolides inhibit Fusobacterium nucleatum-induced MUC5AC production in human airway epithelial cells. | 2013 | Antimicrob. Agents Chemother. | pmid:23380724 |
Moriya S et al. | Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells. | 2013 | Int. J. Oncol. | pmid:23546223 |
Akiyoshi T et al. | Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants. | 2013 | Drug Metab. Pharmacokinet. | pmid:23514827 |