clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Gastritis, Hypertrophic D005758 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Tuberculosis, Spinal D014399 1 associated lipids
Hypoproteinemia D007019 1 associated lipids
Myxoma D009232 1 associated lipids
Granuloma, Plasma Cell D006104 1 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Encephalomyelitis, Acute Disseminated D004673 1 associated lipids
Empyema, Tuberculous D004654 1 associated lipids
Tuberculosis, Ocular D014392 1 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Serositis D012700 1 associated lipids
Euthyroid Sick Syndromes D005067 1 associated lipids
Glossitis, Benign Migratory D005929 1 associated lipids
Parotid Diseases D010305 1 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Sacroiliitis D058566 1 associated lipids
Achlorhydria D000126 1 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Pseudomyxoma Peritonei D011553 1 associated lipids
Eye Infections D015817 1 associated lipids
Tuberculosis, Avian D014379 2 associated lipids
Immunoproliferative Small Intestinal Disease D007161 2 associated lipids
Tooth, Nonvital D019553 2 associated lipids
Cardiovascular Abnormalities D018376 2 associated lipids
Hyperemesis Gravidarum D006939 2 associated lipids
Typhoid Fever D014435 2 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Diphtheria D004165 2 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Empyema, Pleural D016724 2 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Mastoiditis D008417 2 associated lipids
Periodontal Abscess D010508 2 associated lipids
Duodenogastric Reflux D004383 2 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Iritis D007500 2 associated lipids
Parotid Neoplasms D010307 2 associated lipids
Monoclonal Gammopathy of Undetermined Significance D008998 2 associated lipids
IgA Deficiency D017098 2 associated lipids
Still's Disease, Adult-Onset D016706 2 associated lipids
Eye Injuries, Penetrating D015807 2 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
Leprosy, Lepromatous D015440 2 associated lipids
Discitis D015299 2 associated lipids
Iris Diseases D007499 2 associated lipids
Angiomatosis, Bacillary D016917 2 associated lipids
Barrett Esophagus D001471 3 associated lipids
Giardiasis D005873 3 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Eye Infections, Bacterial D015818 3 associated lipids
Conjunctival Neoplasms D003230 3 associated lipids
Empyema D004653 3 associated lipids
alpha 1-Antitrypsin Deficiency D019896 3 associated lipids
Tenosynovitis D013717 3 associated lipids
Pleuropneumonia D011001 3 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Peptic Ulcer Perforation D010439 3 associated lipids
Ureteral Diseases D014515 3 associated lipids
Sporotrichosis D013174 3 associated lipids
Ecchymosis D004438 3 associated lipids
Hernia, Hiatal D006551 3 associated lipids
Fusobacterium Infections D005674 3 associated lipids
Conjunctivitis, Bacterial D003234 3 associated lipids
Keratoconjunctivitis D007637 3 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Bartonella Infections D001474 3 associated lipids
Paronychia D010304 3 associated lipids
Leprosy, Borderline D015439 3 associated lipids
Psychophysiologic Disorders D011602 3 associated lipids
Scrub Typhus D012612 3 associated lipids
Fractures, Open D005597 3 associated lipids
Mycetoma D008271 4 associated lipids
Legionnaires' Disease D007877 4 associated lipids
Mycobacterium avium-intracellulare Infection D015270 4 associated lipids
Duodenitis D004382 4 associated lipids
Cysts D003560 4 associated lipids
Lymphoma, T-Cell, Cutaneous D016410 4 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Gastritis, Atrophic D005757 4 associated lipids
Foot Diseases D005534 4 associated lipids
Chlamydophila Infections D023521 4 associated lipids
Purpura, Thrombocytopenic, Idiopathic D016553 4 associated lipids
Ergotism D004881 4 associated lipids
Actinomycetales Infections D000193 4 associated lipids
Peptic Ulcer Hemorrhage D010438 4 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Pleural Diseases D010995 4 associated lipids
Rodent Diseases D012376 4 associated lipids
Parotitis D010309 4 associated lipids
Psittacosis D009956 4 associated lipids
Prurigo D011536 4 associated lipids
Confusion D003221 4 associated lipids
Lymphangitis D008205 4 associated lipids
Dyspepsia D004415 5 associated lipids
Erythema Nodosum D004893 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

Download all related citations
Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Svensson M et al. Pharmacodynamic effects of nitroimidazoles alone and in combination with clarithromycin on Helicobacter pylori. 2002 Antimicrob. Agents Chemother. pmid:12069981
Gibreel A et al. Contribution of the CmeABC efflux pump to macrolide and tetracycline resistance in Campylobacter jejuni. 2007 Antimicrob. Agents Chemother. pmid:17606685
Comley JC and Sterling AM Effect of atovaquone and atovaquone drug combinations on prophylaxis of Pneumocystis carinii pneumonia in SCID mice. 1995 Antimicrob. Agents Chemother. pmid:7785975
Struillou L et al. Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. 1995 Antimicrob. Agents Chemother. pmid:7785988
Endo H et al. Effects of lansoprazole and amoxicillin on uptake of [(14)C]clarithromycin into gastric tissue in rats. 2001 Antimicrob. Agents Chemother. pmid:11709323
Goswami S et al. Anti-Helicobacter pylori potential of artemisinin and its derivatives. 2012 Antimicrob. Agents Chemother. pmid:22687518
Taylor DE et al. Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations. 1997 Antimicrob. Agents Chemother. pmid:9420030
Nash KA and Inderlied CB Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease. 1995 Antimicrob. Agents Chemother. pmid:8592991
Alder J et al. Clarithromycin therapy of experimental Treponema pallidum infections in hamsters. 1993 Antimicrob. Agents Chemother. pmid:8494384
Cho SH et al. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. 2007 Antimicrob. Agents Chemother. pmid:17210775
Ji B et al. Orally administered combined regimens for treatment of Mycobacterium ulcerans infection in mice. 2007 Antimicrob. Agents Chemother. pmid:17664316
Yasuda H et al. Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis. 1994 Antimicrob. Agents Chemother. pmid:8141568
Vaara M Outer membrane permeability barrier to azithromycin, clarithromycin, and roxithromycin in gram-negative enteric bacteria. 1993 Antimicrob. Agents Chemother. pmid:8383945
Fujii K et al. In vitro and in vivo antibacterial activities of KRM-1648 and KRM-1657, new rifamycin derivatives. 1994 Antimicrob. Agents Chemother. pmid:8067748
Bakker-Woudenberg IA et al. Antimycobacterial agents differ with respect to their bacteriostatic versus bactericidal activities in relation to time of exposure, mycobacterial growth phase, and their use in combination. 2005 Antimicrob. Agents Chemother. pmid:15917538
Traunmüller F et al. Pharmacokinetics of single- and multiple-dose oral clarithromycin in soft tissues determined by microdialysis. 2007 Antimicrob. Agents Chemother. pmid:17606673
Kim YC et al. Effect of CYP3A1(23) induction on clarithromycin pharmacokinetics in rats with diabetes mellitus. 2005 Antimicrob. Agents Chemother. pmid:15917564
Romand S et al. In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. 1993 Antimicrob. Agents Chemother. pmid:8285620
Yasuda H et al. Interaction between biofilms formed by Pseudomonas aeruginosa and clarithromycin. 1993 Antimicrob. Agents Chemother. pmid:8239580
Kalach N et al. Clarithromycin resistance and eradication of Helicobacter pylori in children. 2001 Antimicrob. Agents Chemother. pmid:11408237
Alder J et al. Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo. 1993 Antimicrob. Agents Chemother. pmid:8328782
Mor N and Heifets L Inhibition of intracellular growth of Mycobacterium avium by one pulsed exposure of infected macrophages to clarithromycin. 1993 Antimicrob. Agents Chemother. pmid:8328792
Rastogi N et al. Antimycobacterial spectrum of sparfloxacin and its activities alone and in association with other drugs against Mycobacterium avium complex growing extracellularly and intracellularly in murine and human macrophages. 1991 Antimicrob. Agents Chemother. pmid:1667250
Koh WJ et al. Response to Switch from Intermittent Therapy to Daily Therapy for Refractory Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease. 2015 Antimicrob. Agents Chemother. pmid:25987622
Hultén K et al. New pharmacokinetic in vitro model for studies of antibiotic activity against intracellular microorganisms. 1996 Antimicrob. Agents Chemother. pmid:9124830
Cynamon MH and Klemens SP Activity of azithromycin against Mycobacterium avium infection in beige mice. 1992 Antimicrob. Agents Chemother. pmid:1329622
Bermudez LE et al. Activity of KRM 1648 alone or in combination with ethambutol or clarithromycin against Mycobacterium avium in beige mouse model of disseminated infection. 1994 Antimicrob. Agents Chemother. pmid:7986018
Khan AA et al. Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis. 1997 Antimicrob. Agents Chemother. pmid:9145840
Collins L and Franzblau SG Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. 1997 Antimicrob. Agents Chemother. pmid:9145860
Lounis N et al. Comparative activities of amikacin against Mycobacterium avium complex in nude and beige mice. 1997 Antimicrob. Agents Chemother. pmid:9145892
Osborne CS et al. In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models. 2009 Antimicrob. Agents Chemother. pmid:19596876
Cavalieri SJ et al. Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis. 1995 Antimicrob. Agents Chemother. pmid:7492101
Bosnar M et al. Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin. 2005 Antimicrob. Agents Chemother. pmid:15917536
Subramanian S et al. Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. 2008 Antimicrob. Agents Chemother. pmid:18070962
Moon JE et al. Efficacy of macrolides and telithromycin against leptospirosis in a hamster model. 2006 Antimicrob. Agents Chemother. pmid:16723556
Burton AJ et al. Activity of clarithromycin or rifampin alone or in combination against experimental Rhodococcus equi infection in mice. 2015 Antimicrob. Agents Chemother. pmid:25824218
Leuthner KD et al. Pulsatile delivery of clarithromycin alone or in combination with amoxicillin against Streptococcus pneumoniae. 2006 Antimicrob. Agents Chemother. pmid:16436754
Kohyama T et al. Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. 1999 Antimicrob. Agents Chemother. pmid:10103198
Walzer PD et al. Clinically used antimicrobial drugs against experimental pneumocystosis, singly and in combination: analysis of drug interactions and efficacies. 1997 Antimicrob. Agents Chemother. pmid:9021174
Banerjee DK et al. Experimental evaluation of possible new short-term drug regimens for treatment of multibacillary leprosy. 1997 Antimicrob. Agents Chemother. pmid:9021187
Schuster S et al. Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB. 2016 Antimicrob. Agents Chemother. pmid:27161641
Cirioni O et al. Efficacy of the combination of tachyplesin III and clarithromycin in rat models of Escherichia coli sepsis. 2008 Antimicrob. Agents Chemother. pmid:18779356
Lonks JR and Medeiros AA High rate of erythromycin and clarithromycin resistance among Streptococcus pneumoniae isolates from blood cultures from Providence, R.I. 1993 Antimicrob. Agents Chemother. pmid:8239578
Klopman G et al. Anti-Mycobacterium avium activity of quinolones: in vitro activities. 1993 Antimicrob. Agents Chemother. pmid:8239587
Abduljalil K et al. Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration. 2009 Antimicrob. Agents Chemother. pmid:19414584
Hoppe JE and Bryskier A In vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to two ketolides (HMR 3004 and HMR 3647), four macrolides (azithromycin, clarithromycin, erythromycin A, and roxithromycin), and two ansamycins (rifampin and rifapentine). 1998 Antimicrob. Agents Chemother. pmid:9559823
Dever LL et al. Comparative in vitro activities of clarithromycin, azithromycin, and erythromycin against Borrelia burgdorferi. 1993 Antimicrob. Agents Chemother. pmid:8215288
Kashuba AD and Amsden GW Bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. 1998 Antimicrob. Agents Chemother. pmid:9527816
Clark CL et al. Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. 2007 Antimicrob. Agents Chemother. pmid:17876003
Amsden GW et al. Oral cimetidine prolongs clarithromycin absorption. 1998 Antimicrob. Agents Chemother. pmid:9660986
Liou JM et al. Genotypic resistance in Helicobacter pylori strains correlates with susceptibility test and treatment outcomes after levofloxacin- and clarithromycin-based therapies. 2011 Antimicrob. Agents Chemother. pmid:21189342
Kosowska K et al. Activities of two novel macrolides, GW 773546 and GW 708408, compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin against Haemophilus influenzae. 2004 Antimicrob. Agents Chemother. pmid:15504829
Bae S et al. Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. 2010 Antimicrob. Agents Chemother. pmid:19884366
Klemens SP and Cynamon MH Intermittent azithromycin for treatment of Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7986001
Spyridaki A et al. Effect of clarithromycin in inflammatory markers of patients with ventilator-associated pneumonia and sepsis caused by Gram-negative bacteria: results from a randomized clinical study. 2012 Antimicrob. Agents Chemother. pmid:22564837
Stone GG et al. A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori. 1997 Antimicrob. Agents Chemother. pmid:9056021
Furuie H et al. Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. 2010 Antimicrob. Agents Chemother. pmid:19933801
Tessier PR et al. Pharmacodynamic assessment of clarithromycin in a murine model of pneumococcal pneumonia. 2002 Antimicrob. Agents Chemother. pmid:11959578
Ichiyama T et al. Clarithromycin inhibits NF-kappaB activation in human peripheral blood mononuclear cells and pulmonary epithelial cells. 2001 Antimicrob. Agents Chemother. pmid:11120942
Bohnert JA et al. Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay. 2016 Antimicrob. Agents Chemother. pmid:26824939
Ji B et al. Effectiveness of clarithromycin and minocycline alone and in combination against experimental Mycobacterium leprae infection in mice. 1991 Antimicrob. Agents Chemother. pmid:1828136
Heifets L et al. Mycobacterium avium strains resistant to clarithromycin and azithromycin. 1993 Antimicrob. Agents Chemother. pmid:8031351
Miltner EC and Bermudez LE Mycobacterium avium grown in Acanthamoeba castellanii is protected from the effects of antimicrobials. 2000 Antimicrob. Agents Chemother. pmid:10858369
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Nakamura S et al. Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice. 2010 Antimicrob. Agents Chemother. pmid:19949056
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Cynamon MH et al. Comparative activities of azithromycin and clarithromycin against Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7979270
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Fernandez-Martin J et al. Pyrimethamine-clarithromycin combination for therapy of acute Toxoplasma encephalitis in patients with AIDS. 1991 Antimicrob. Agents Chemother. pmid:1836943
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Andini N and Nash KA Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible. 2006 Antimicrob. Agents Chemother. pmid:16801446
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Renvoisé A et al. Assessing primary and secondary resistance to clarithromycin and amikacin in infections due to Mycobacterium avium complex. 2015 Antimicrob. Agents Chemother. pmid:26324275
Nash KA Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38). 2003 Antimicrob. Agents Chemother. pmid:14506008
Best LM et al. Multilaboratory comparison of proficiencies in susceptibility testing of Helicobacter pylori and correlation between agar dilution and E test methods. 2003 Antimicrob. Agents Chemother. pmid:14506021