clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zhanel GG et al. | Telithromycin in the treatment of acute bacterial sinusitis, acute exacerbations of chronic bronchitis, and community-acquired pneumonia. | 2006 | Ther Clin Risk Manag | pmid:18360582 |
Nawarskas JJ and Snowden SS | Critical appraisal of ticagrelor in the management of acute coronary syndrome. | 2011 | Ther Clin Risk Manag | pmid:22241944 |
Rafii F et al. | Effects of treatment with antimicrobial agents on the human colonic microflora. | 2008 | Ther Clin Risk Manag | pmid:19337440 |
Zhou S et al. | Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4. | 2005 | Ther Clin Risk Manag | pmid:18360537 |
Pace F et al. | A review of rabeprazole in the treatment of acid-related diseases. | 2007 | Ther Clin Risk Manag | pmid:18488081 |
Oncü S | Treatment of community-acquired pneumonia, with special emphasis on gemifloxacin. | 2007 | Ther Clin Risk Manag | pmid:18488076 |
Duclos AJ et al. | Current treatment options in the management of chronic prostatitis. | 2007 | Ther Clin Risk Manag | pmid:18472971 |
Carrie AG and Marrie TJ | Use of intravenous antibiotics for the treatment of community-acquired pneumonia in the emergency department. | 2005 | Ther Clin Risk Manag | pmid:18360543 |
Goodman JJ and Martin SI | Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections. | 2012 | Ther Clin Risk Manag | pmid:22547933 |
Werth S et al. | Efficacy and safety of venous thromboembolism prophylaxis with apixaban in major orthopedic surgery. | 2012 | Ther Clin Risk Manag | pmid:22547932 |
Neely M and Kovacs A | Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir. | 2009 | Ther Clin Risk Manag | pmid:19707276 |
Niioka T et al. | Identification of a single time-point for plasma lansoprazole measurement that adequately reflects area under the concentration-time curve. | 2006 | Ther Drug Monit | pmid:16778714 |
Kunicki PK and Sobieszczańska-Małek M | Pharmacokinetic interaction between tacrolimus and clarithromycin in a heart transplant patient. | 2005 | Ther Drug Monit | pmid:15665756 |
Zhou SF et al. | Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. | 2007 | Ther Drug Monit | pmid:18043468 |
Krause M | [Resistance problems in gastrointestinal infections]. | 2002 | Ther Umsch | pmid:11851045 |
Bohr UR and Malfertheiner P | Eradication of H. pylori Infection: the Challenge is on if Standard Therapy Fails. | 2009 | Therap Adv Gastroenterol | pmid:21180534 |
Berning M et al. | Should quinolones come first in Helicobacter pylori therapy? | 2011 | Therap Adv Gastroenterol | pmid:21694812 |
Mégraud F | The challenge of Helicobacter pylori resistance to antibiotics: the comeback of bismuth-based quadruple therapy. | 2012 | Therap Adv Gastroenterol | pmid:22423259 |
Gisbert JP | Second-line rescue therapy of helicobacter pylori infection. | 2009 | Therap Adv Gastroenterol | pmid:21180581 |
Pinzani V et al. | [Occurrence of anterior uveitis in a HIV patient treated with rifabutin, ethambutol, clarithromycin]. | 1995 Sep-Oct | Therapie | pmid:8571297 |
van Ingen J et al. | Clinical relevance of non-tuberculous mycobacteria isolated in the Nijmegen-Arnhem region, The Netherlands. | 2009 | Thorax | pmid:19213773 |
Andréjak C et al. | Mycobacterium xenopi pulmonary infections: a multicentric retrospective study of 136 cases in north-east France. | 2009 | Thorax | pmid:19052044 |
Essilfie AT et al. | Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma. | 2015 | Thorax | pmid:25746630 |
Jenkins PA et al. | Clarithromycin vs ciprofloxacin as adjuncts to rifampicin and ethambutol in treating opportunist mycobacterial lung diseases and an assessment of Mycobacterium vaccae immunotherapy. | 2008 | Thorax | pmid:18250184 |
Majoor CJ et al. | Mycobacterium xenopi infection in an immunosuppressed patient with Crohn's disease. | 2004 | Thorax | pmid:15223876 |
Spencer S and Jones PW | Time course of recovery of health status following an infective exacerbation of chronic bronchitis. | 2003 | Thorax | pmid:12832673 |
Brusselle GG | Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? | 2015 | Thorax | pmid:25870311 |
Schweeger I et al. | Successful eradication of Helicobacter pylori as determined by ((13))C-urea breath test does not alter fibrinogen and acute phase response markers. | 2000 | Thromb. Res. | pmid:10704650 |
Lygren I et al. | [Treatment of Helicobacter pylori infection]. | 1998 | Tidsskr. Nor. Laegeforen. | pmid:9889634 |
Farup PG | [Treatment of Helicobacter pylori infection--results and experiences with an Internet-based collaboration trial]. | 2003 | Tidsskr. Nor. Laegeforen. | pmid:14714012 |
Walrave TR et al. | [Mania induced by antibiotic therapy]. | Tijdschr Psychiatr | pmid:27527887 | |
Mukae H et al. | Low expression of T-cell co-stimulatory molecules in bone marrow-derived dendritic cells in a mouse model of chronic respiratory infection with Pseudomonas aeruginosa. | 2010 | Tohoku J. Exp. Med. | pmid:20046053 |
Kaji C et al. | Antimicrobial effect of fluoroquinolones for the eradication of nontypeable Haemophilus influenzae isolates within biofilms. | 2008 | Tohoku J. Exp. Med. | pmid:18285669 |
De Lorenzi G et al. | Mycobacterium genavense Infection in a Domestic Ferret (Mustela putorius furo). | 2018 | Top Companion Anim Med | pmid:30502861 |
Peters TS | Do preclinical testing strategies help predict human hepatotoxic potentials? | 2005 | Toxicol Pathol | pmid:15805066 |
Cosgrove BD et al. | Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. | 2009 | Toxicol. Appl. Pharmacol. | pmid:19362101 |
Liu CN and Somps CJ | Telithromycin blocks neuromuscular transmission and inhibits nAChR currents in vitro. | 2010 | Toxicol. Lett. | pmid:20153815 |
Pedersen JM et al. | Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). | 2013 | Toxicol. Sci. | pmid:24014644 |
Guo L et al. | Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. | 2013 | Toxicol. Sci. | pmid:24052561 |
Sawada H et al. | A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. | 2005 | Toxicol. Sci. | pmid:15342952 |
Lin Z and Will Y | Evaluation of drugs with specific organ toxicities in organ-specific cell lines. | 2012 | Toxicol. Sci. | pmid:22166485 |
Jiang H et al. | MLVA typing and antibiotic susceptibility of Brucella human isolates from Liaoning, China. | 2010 | Trans. R. Soc. Trop. Med. Hyg. | pmid:20832094 |
Ani AE et al. | Antimicrobial susceptibility test of Helicobacter pylori isolated from Jos, Nigeria. | 1999 Nov-Dec | Trans. R. Soc. Trop. Med. Hyg. | pmid:10717760 |
Baron BW et al. | Thrombotic thrombocytopenic purpura after cephalosporin administration: a possible relationship. | 2003 | Transfusion | pmid:12919436 |
Ivetic Tkalcevic V et al. | Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories. | 2012 | Transl Res | pmid:22677362 |
Korres DS et al. | Multifocal spinal and extra-spinal Mycobacterium chelonae osteomyelitis in a renal transplant recipient. | 2007 | Transpl Infect Dis | pmid:17313477 |
Chan A et al. | A case of wrist tenosynovitis caused by Mycobacterium kansasii in a renal transplant recipient. | 2012 | Transpl Infect Dis | pmid:22822725 |
Silva JT et al. | Mycobacterium abscessus pulmonary infection complicated with vertebral osteomyelitis in a heart transplant recipient: case report and literature review. | 2015 | Transpl Infect Dis | pmid:25816889 |
den Broeder AA et al. | Disseminated Mycobacterium gordonae infection in a renal transplant recipient. | 2003 | Transpl Infect Dis | pmid:14617305 |
Kim JE et al. | Synchronous infection with Mycobacterium chelonae and Paecilomyces in a heart transplant patient. | 2011 | Transpl Infect Dis | pmid:20412536 |