clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hahn DL et al. | Evidence for Chlamydia pneumoniae infection in steroid-dependent asthma. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9475566 |
Price J and Hamilton W | Pragmatic eradication of H. pylori. | 1997 | Br J Gen Pract | pmid:9474836 |
Tzivras M et al. | One-week therapy with omeprazole, clarithromycin and metronidazole or ornidazole, followed by 3 weeks' treatment with omeprazole, eradicates Helicobacter pylori equally and heals duodenal ulcer. | 1997 | Eur J Gastroenterol Hepatol | pmid:9471024 |
Preston SL et al. | Drug interactions in HIV-positive patients initiated on protease inhibitor therapy. | 1998 | AIDS | pmid:9468380 |
Torresani C et al. | Clarithromycin versus doxycycline in the treatment of rosacea. | 1997 | Int. J. Dermatol. | pmid:9466207 |
Hoffner SE et al. | In-vitro activity of fluorinated quinolones and macrolides against drug-resistant Mycobacterium tuberculosis. | 1997 | J. Antimicrob. Chemother. | pmid:9462443 |
Loo VG et al. | In-vitro susceptibility of Helicobacter pylori to ampicillin, clarithromycin, metronidazole and omeprazole. | 1997 | J. Antimicrob. Chemother. | pmid:9462442 |
Misiewicz JJ et al. | One week triple therapy for Helicobacter pylori: a multicentre comparative study. Lansoprazole Helicobacter Study Group. | 1997 | Gut | pmid:9462204 |
Briant C et al. | Pericarditis as a manifestation of Lyme disease. | 1997 | J Emerg Nurs | pmid:9460386 |
Holmberg SD et al. | Possible effectiveness of clarithromycin and rifabutin for cryptosporidiosis chemoprophylaxis in HIV disease. HIV Outpatient Study (HOPS) Investigators. | 1998 | JAMA | pmid:9459473 |
Thornsberry C et al. | Surveillance of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States in 1996-1997 respiratory season. The Laboratory Investigator Group. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9458982 |
Goujard C et al. | Clarithromycin-resistant Mycobacterium avium strain in a clarithromycin-naive AIDS patient. | 1998 | Clin. Infect. Dis. | pmid:9455532 |
Sax L | Bacterial pharyngitis in children. | 1998 | J Fam Pract | pmid:9451356 |
Bermudez LE et al. | Emergence of Mycobacterium avium populations resistant to macrolides during experimental chemotherapy. | 1998 | Antimicrob. Agents Chemother. | pmid:9449283 |
Forné M et al. | Randomized clinical trial comparing two one-week triple-therapy regimens for the eradication of Helicobacter pylori infection and duodenal ulcer healing. | 1998 | Am. J. Gastroenterol. | pmid:9448170 |
Fennerty MB | Should we abandon metronidazole containing Helicobacter pylori treatment regimens? The clinical relevance of metronidazole resistance. | 1998 | Am. J. Gastroenterol. | pmid:9448162 |
Genné D et al. | Clarithromycin versus amoxicillin-clavulanic acid in the treatment of community-acquired pneumonia. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9447898 |
Prattichizzo FA et al. | [Carditis associated with Mycoplasma pneumoniae infection. Clinical aspects and therapeutic problems]. | 1997 | Minerva Cardioangiol | pmid:9446067 |
Mikamo H et al. | Effects of long-term/low-dose clarithromycin on neutrophil count and interleukin-8 level in pyometra. | 1998 Jan-Feb | Chemotherapy | pmid:9444409 |
Gotoh A et al. | Interaction of drugs for eradication therapy against antibiotic-resistant strains of Helicobacter pylori. | 1997 | Microbiol. Immunol. | pmid:9444328 |
Suzuki K et al. | Activity of KRM 1648 or rifabutin alone or in combination with clarithromycin against Mycobacterium avium complex in human alveolar macrophages. | 1997 | Int. J. Tuberc. Lung Dis. | pmid:9441102 |
Burman WJ et al. | A retrospective comparison of clarithromycin versus rifampin in combination treatment for disseminated Mycobacterium avium complex disease in AIDS: clarithromycin decreases transfusion requirements. | 1997 | Int. J. Tuberc. Lung Dis. | pmid:9441082 |
Yatsunami J et al. | Clarithromycin is a potent inhibitor of tumor-induced angiogenesis. | 1997 | Res Exp Med (Berl) | pmid:9440137 |
Dixon JS et al. | Ranitidine bismuth citrate plus clarithromycin for the eradication of H. pylori. | 1997 | J. Physiol. Pharmacol. | pmid:9440055 |
Bazzoli F and Pozzato P | Therapy of H. pylori infection. | 1997 | J. Physiol. Pharmacol. | pmid:9440054 |
Akiyama H et al. | Biofilm formation of Staphylococcus aureus strains isolated from impetigo and furuncle: role of fibrinogen and fibrin. | 1997 | J. Dermatol. Sci. | pmid:9438901 |
Lerang F et al. | Highly effective second-line anti-Helicobacter pylori therapy in patients with previously failed metronidazole-based therapy. | 1997 | Scand. J. Gastroenterol. | pmid:9438318 |
Reisner BS et al. | Electron microscopic analysis of Mycobacterium avium complex isolates exposed to ciprofloxacin, rifabutin, ethambutol and clarithromycin. | 1997 | Int. J. Tuberc. Lung Dis. | pmid:9432376 |
Pounder RE et al. | Ranitidine bismuth citrate with clarithromycin for the eradication of Helicobacter pylori and for ulcer healing. | 1997 | Helicobacter | pmid:9432341 |
Pieramico O et al. | Omeprazole-based dual and triple therapy for the treatment of Helicobacter pylori infection in peptic ulcer disease: a randomized trial. | 1997 | Helicobacter | pmid:9432335 |
Takimoto T et al. | The efficacy and safety of one-week triple therapy with lansoprazole, clarithromycin, and metronidazole for the treatment of Helicobacter pylori infection in Japanese patients. | 1997 | Helicobacter | pmid:9432334 |
Bardhan KD et al. | Effects of smoking on cure of Helicobacter pylori infection and duodenal ulcer recurrence in patients treated with clarithromycin and omeprazole. | 1997 | Helicobacter | pmid:9432318 |
McLaren A et al. | The role of ranitidine bismuth citrate in significantly reducing the emergence of Helicobacter pylori strains resistant to antibiotics. | 1997 | Helicobacter | pmid:9432317 |
Stone GG et al. | Identification of a 23S rRNA gene mutation in clarithromycin-resistant Helicobacter pylori. | 1996 | Helicobacter | pmid:9432314 |
Feldman C et al. | Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects of bioactive phospholipids on human respiratory epithelium in vitro. | 1997 | Inflammation | pmid:9429912 |
Butt AA | Cervical adenitis due to Mycobacterium fortuitum in patients with acquired immunodeficiency syndrome. | 1998 | Am. J. Med. Sci. | pmid:9427575 |
Midolo PD et al. | Antimicrobial resistance testing of Helicobacter pylori: a comparison of Etest and disk diffusion methods. | 1997 | Pathology | pmid:9423225 |
Matsunaga K et al. | [Successful eradication of H. pylori in an elderly patient with gastric cancer after effective UFT-E therapy]. | 1997 | Gan To Kagaku Ryoho | pmid:9422074 |
O'Connor HJ et al. | One week triple therapy for Helicobacter pylori: does high-dose clarithromycin confer additional benefit? | 1997 | Helicobacter | pmid:9421124 |
Hultén K et al. | Combination treatment with ranitidine is highly efficient against Helicobacter pylori despite negative impact of macrolide resistance. | 1997 | Helicobacter | pmid:9421122 |
Tompkins DS et al. | Failed treatment of Helicobacter pylori infection associated with resistance to clarithromycin. | 1997 | Helicobacter | pmid:9421121 |
Pipkin GA et al. | Clarithromycin dual therapy regimens for eradication of Helicobacter pylori: a review. | 1997 | Helicobacter | pmid:9421117 |
Taylor DE et al. | Cloning and sequence analysis of two copies of a 23S rRNA gene from Helicobacter pylori and association of clarithromycin resistance with 23S rRNA mutations. | 1997 | Antimicrob. Agents Chemother. | pmid:9420030 |
Shafran SD et al. | Determinants of rifabutin-associated uveitis in patients treated with rifabutin, clarithromycin, and ethambutol for Mycobacterium avium complex bacteremia: a multivariate analysis. Canadian HIV Trials Network Protocol 010 Study Group. | 1998 | J. Infect. Dis. | pmid:9419201 |
Greco S et al. | Glossitis, stomatitis, and black tongue with lansoprazole plus clarithromycin and other antibiotics. | 1997 | Ann Pharmacother | pmid:9416400 |
Barry AL et al. | In vitro activity of the new ketolide HMR 3004 compared to an azalide and macrolides against Streptococcus pneumoniae and Haemophilus influenzae. | 1997 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:9405952 |
Sander P et al. | The role of ribosomal RNAs in macrolide resistance. | 1997 | Mol. Microbiol. | pmid:9402018 |
Martin SJ et al. | In vitro activity of clarithromycin alone and in combination with ciprofloxacin or levofloxacin against Legionella spp.: enhanced effect by the addition of the metabolite 14-hydroxy clarithromycin. | 1997 | Diagn. Microbiol. Infect. Dis. | pmid:9401809 |
Srinivasan R and Minocha A | Cure of Helicobacter pylori: a hidden curse? | 1997 | Am. J. Gastroenterol. | pmid:9399784 |
Laine L et al. | Randomized comparison of ranitidine bismuth citrate-based triple therapies for Helicobacter pylori. | 1997 | Am. J. Gastroenterol. | pmid:9399755 |
van der Hulst RW et al. | Treatment of Helicobacter pylori infection: a review of the world literature. | 1996 | Helicobacter | pmid:9398908 |
Lind T et al. | Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study. | 1996 | Helicobacter | pmid:9398894 |
O'Morain C et al. | Double-blind, multicenter, placebo-controlled evaluation of clarithromycin and omeprazole for Helicobacter pylori-associated duodenal ulcer. | 1996 | Helicobacter | pmid:9398893 |
Mégraud F and Malfertheiner P | Treatment of Helicobacter pylori infection: summary of a meeting at the Fourth United European Gastroenterology Week, September 20, 1995. | 1996 | Helicobacter | pmid:9398889 |
Moayyedi P et al. | Comparison of one or two weeks of lansoprazole, amoxicillin, and clarithromycin in the treatment of Helicobacter pylori. | 1996 | Helicobacter | pmid:9398880 |
Jaup BK | Duodenal ulcer healing after 7-day treatment: a pilot study with lansoprazole, amoxicillin, and clarithromycin. | 1996 | Helicobacter | pmid:9398878 |
Schwartz H et al. | Seven-day triple therapy with lansoprazole, clarithromycin, and metronidazole for the cure of Helicobacter pylori infection: a short report. | 1996 | Helicobacter | pmid:9398876 |
Harford W et al. | Double-blind, multicenter evaluation of lansoprazole and amoxicillin dual therapy for the cure of Helicobacter pylori infection. | 1996 | Helicobacter | pmid:9398875 |
Riff DS et al. | Triple therapy with lansoprazole, clarithromycin, and amoxicillin for the cure of Helicobacter pylori infection: a short report. | 1996 | Helicobacter | pmid:9398874 |
Ando H et al. | [Changes in serum anti-Helicobacter pylori IgG antibody, pepsinogen I, and pepsinogen II after eradication therapy of Helicobacter pylori]. | 1997 | Nihon Shokakibyo Gakkai Zasshi | pmid:9396326 |
Suzuki Y et al. | [Antimicrobial activities of clarithromycin against recent obtained clinical isolates]. | 1997 | Jpn J Antibiot | pmid:9394238 |
Anzueto A et al. | Efficacy of ciprofloxacin and clarithromycin in acute bacterial exacerbations of complicated chronic bronchitis: interim analysis. Bronchitis Study Group. | 1997 Sep-Oct | Clin Ther | pmid:9385486 |
Stephenson GA et al. | Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity. | 1997 | J Pharm Sci | pmid:9383733 |
Adamek RJ et al. | Pantoprazole versus omeprazole in one-week low-dose triple therapy for curve of H. pylori infection. | 1997 | Am. J. Gastroenterol. | pmid:9382084 |
Kawasaki M et al. | Ménétrièr's disease associated with Helicobacter pylori infection: resolution of enlarged gastric folds and hypoproteinemia after antibacterial treatment. | 1997 | Am. J. Gastroenterol. | pmid:9382064 |
Tartaglione T | Treatment of nontuberculous mycobacterial infections: role of clarithromycin and azithromycin. | 1997 Jul-Aug | Clin Ther | pmid:9377608 |
Hultén K et al. | Macrolide resistance in Helicobacter pylori: mechanism and stability in strains from clarithromycin-treated patients. | 1997 | Antimicrob. Agents Chemother. | pmid:9371366 |
Buckley MJ et al. | Metronidazole resistance reduces efficacy of triple therapy and leads to secondary clarithromycin resistance. | 1997 | Dig. Dis. Sci. | pmid:9365144 |
Ramirez Mayans JA et al. | [Elimination of Helicobacter pylori in patients with recurrent abdominal pain with simultaneous administration of ranitidine, bismuth subsalicylate and clarithromycin]. | 1996 | Acta Gastroenterol. Latinoam. | pmid:9363265 |
Zullo A et al. | Omeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori infection: a randomized prospective study. | 1997 | Am. J. Gastroenterol. | pmid:9362185 |
Zuberi BF et al. | Low dose, short-term, triple therapy for helicobacter pylori associated peptic ulcer. | 1997 | J Pak Med Assoc | pmid:9361485 |
Dubé MP et al. | A randomized evaluation of ethambutol for prevention of relapse and drug resistance during treatment of Mycobacterium avium complex bacteremia with clarithromycin-based combination therapy. California Collaborative Treatment Group. | 1997 | J. Infect. Dis. | pmid:9359722 |
Grosset J and Ji B | Prevention of the selection of clarithromycin-resistant Mycobacterium avium-intracellulare complex. | 1997 | Drugs | pmid:9358197 |
Jablonowski H et al. | Ancillary benefits of Mycobacterium avium-intracellulare complex prophylaxis with clarithromycin in HIV-infected patients. | 1997 | Drugs | pmid:9358196 |
Cohn DL | Prevention strategies for Mycobacterium avium-intracellulare complex (MAC) infection. A review of recent studies in patients with AIDS. | 1997 | Drugs | pmid:9358195 |
Dautzenberg B | Rationale for the prevention of disseminated Mycobacterium avium-intracellulare complex disease. | 1997 | Drugs | pmid:9358194 |
Harris A | H. pylori eradication by LAC. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354216 |
Wurzer H et al. | Short-course therapy with amoxycillin-clarithromycin triple therapy for 10 days (ACT-10) eradicates Helicobacter pylori and heals duodenal ulcer. ACT-10 Study Group. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354205 |
Breuer T et al. | Clarithromycin, amoxycillin and H2-receptor antagonist therapy for Helicobacter pylori peptic ulcer disease in Korea. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354204 |
Rinaldi V et al. | The management of failed dual or triple therapy for Helicobacter pylori eradication. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354202 |
Laine L et al. | A United States multicentre trial of dual and proton pump inhibitor-based triple therapies for Helicobacter pylori. | 1997 | Aliment. Pharmacol. Ther. | pmid:9354200 |
Lévy M et al. | Endoscopic ultrasonography for the initial staging and follow-up in patients with low-grade gastric lymphoma of mucosa-associated lymphoid tissue treated medically. | 1997 | Gastrointest. Endosc. | pmid:9351036 |
Pendland SL et al. | Comparison of charcoal- and starch-based media for testing susceptibilities of Legionella species to macrolides, azalides, and fluoroquinolones. | 1997 | J. Clin. Microbiol. | pmid:9350781 |
Yasui N et al. | Carbamazepine toxicity induced by clarithromycin coadministration in psychiatric patients. | 1997 | Int Clin Psychopharmacol | pmid:9347384 |
Rodrigues AD and Wong SL | Application of human liver microsomes in metabolism-based drug-drug interactions: in vitro-in vivo correlations and the Abbott Laboratories experience. | 1997 | Adv. Pharmacol. | pmid:9342173 |
Szántó D et al. | [Could Helicobacter pylori cause reactive arthro-osteitis?]. | 1997 | Orv Hetil | pmid:9340585 |
Jingu K et al. | [A case of fluminant Mycoplasma pneumonia and bronchiolitis managed by artificial respiration]. | 1997 | Nippon Naika Gakkai Zasshi | pmid:9340346 |
Brancato R et al. | Mycobacterium chelonae keratitis after excimer laser photorefractive keratectomy. | 1997 | Arch. Ophthalmol. | pmid:9338681 |
Mitsuyama T et al. | Neutrophil-induced endothelial cell damage: inhibition by a 14-membered ring macrolide through the action of nitric oxide. | 1997 | Int. Arch. Allergy Immunol. | pmid:9338603 |
Kundu S et al. | Clarithromycin-induced ventricular tachycardia. | 1997 | Ann Emerg Med | pmid:9326871 |
Guerriero SE et al. | Two cases of clarithromycin-induced digoxin toxicity. | 1997 Sep-Oct | Pharmacotherapy | pmid:9324195 |
Chey WD et al. | Bismuth subsalicylate instead of metronidazole with lansoprazole and clarithromycin for Helicobacter pylori infection: a randomized trial. | 1997 | Am. J. Gastroenterol. | pmid:9317068 |
Picardeau M et al. | Use of different molecular typing techniques for bacteriological follow-up in a clinical trial with AIDS patients with Mycobacterium avium bacteremia. | 1997 | J. Clin. Microbiol. | pmid:9316897 |
Wright DH | Regression of mucosa-associated lymphoid-tissue lymphoma after eradication of Helicobacter pylori. | 1997 | Lancet | pmid:9314895 |
May T et al. | Comparison of combination therapy regimens for treatment of human immunodeficiency virus-infected patients with disseminated bacteremia due to Mycobacterium avium. ANRS Trial 033 Curavium Group. Agence Nationale de Recherche sur le Sida. | 1997 | Clin. Infect. Dis. | pmid:9314450 |
Finkenbine R and Gill HS | Case of mania due to prednisone-clarithromycin interaction. | 1997 | Can J Psychiatry | pmid:9307841 |
Sánchez-Nuñez ML et al. | Clarithromycin in the treatment of cyclosporin-associated gingival hyperplasia. | 1997 | Nephrol. Dial. Transplant. | pmid:9306384 |
Williams MP et al. | Seven-day treatment for Helicobacter pylori infection: ranitidine bismuth citrate plus clarithromycin and tetracycline hydrochloride. | 1997 | Aliment. Pharmacol. Ther. | pmid:9305479 |
Savarino V et al. | A new 1-week therapy for Helicobacter pylori eradication: ranitidine bismuth citrate plus two antibiotics. | 1997 | Aliment. Pharmacol. Ther. | pmid:9305478 |
Mor N and Esfandiari A | Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages. | 1997 | Antimicrob. Agents Chemother. | pmid:9303411 |