clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kamberoglou D et al. | Comparison of 1-week vs. 2- or 4-week therapy regimens with ranitidine bismuth citrate plus two antibiotics for Helicobacter pylori eradication. | 2001 | Aliment. Pharmacol. Ther. | pmid:11552924 |
Neri M et al. | Omeprazole, bismuth and clarithromycin in the sequential treatment of Helicobacter pylori infection. | 1994 | Aliment. Pharmacol. Ther. | pmid:7986974 |
Zullo A et al. | High eradication rates of Helicobacter pylori with a new sequential treatment. | 2003 | Aliment. Pharmacol. Ther. | pmid:12641522 |
Lane JA et al. | Randomised clinical trial: Helicobacter pylori eradication is associated with a significantly increased body mass index in a placebo-controlled study. | 2011 | Aliment. Pharmacol. Ther. | pmid:21366634 |
Bazzoli F et al. | Low-dose lansoprazole and clarithromycin plus metronidazole vs. full-dose lansoprazole and clarithromycin plus amoxicillin for eradication of Helicobacter pylori infection. | 2002 | Aliment. Pharmacol. Ther. | pmid:11856090 |
Grimley CE et al. | Comparison of two 3-day Helicobacter pylori eradication regimens with a standard 1-week regimen. | 1999 | Aliment. Pharmacol. Ther. | pmid:10383520 |
Houben MH et al. | Randomized trial of omeprazole and clarithromycin combined with either metronidazole or amoxycillin in patients with metronidazole-resistant or -susceptible Helicobacter pylori strains. | 1999 | Aliment. Pharmacol. Ther. | pmid:10383522 |
Bortolotti M et al. | Effects of oral clarithromycin and amoxycillin on interdigestive gastrointestinal motility of patients with functional dyspepsia and Helicobacter pylori gastritis. | 1998 | Aliment. Pharmacol. Ther. | pmid:9798808 |
John Albert M et al. | High prevalence and level of resistance to metronidazole, but lack of resistance to other antimicrobials in Helicobacter pylori, isolated from a multiracial population in Kuwait. | 2006 | Aliment. Pharmacol. Ther. | pmid:17059517 |
Furuta T et al. | Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. | 2007 | Aliment. Pharmacol. Ther. | pmid:17697203 |
Veldhuyzen Van Zanten S et al. | One-week triple therapy with esomeprazole provides effective eradication of Helicobacter pylori in duodenal ulcer disease. | 2000 | Aliment. Pharmacol. Ther. | pmid:11121908 |
Kim YS et al. | Randomised clinical trial: the efficacy of a 10-day sequential therapy vs. a 14-day standard proton pump inhibitor-based triple therapy for Helicobacter pylori in Korea. | 2011 | Aliment. Pharmacol. Ther. | pmid:21923713 |
Gisbert JP et al. | Proton pump inhibitor, clarithromycin and either amoxycillin or nitroimidazole: a meta-analysis of eradication of Helicobacter pylori. | 2000 | Aliment. Pharmacol. Ther. | pmid:11012477 |
Graham DY et al. | Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection. | 1999 | Aliment. Pharmacol. Ther. | pmid:10102946 |
Zanten SJ et al. | The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy. | 1999 | Aliment. Pharmacol. Ther. | pmid:10102960 |
Tankovic J et al. | Impact of Helicobacter pylori resistance to clarithromycin on the efficacy of the omeprazole-amoxicillin-clarithromycin therapy. | 2001 | Aliment. Pharmacol. Ther. | pmid:11328266 |
Feydt-Schmidt A et al. | Fluorescence in situ hybridization vs. epsilometer test for detection of clarithromycin-susceptible and clarithromycin-resistant Helicobacter pylori strains in gastric biopsies from children. | 2002 | Aliment. Pharmacol. Ther. | pmid:12452940 |
Nista EC et al. | Bacillus clausii therapy to reduce side-effects of anti-Helicobacter pylori treatment: randomized, double-blind, placebo controlled trial. | 2004 | Aliment. Pharmacol. Ther. | pmid:15569121 |
Drouet M et al. | [Unusual clinical form of amoxicillin allergy]. | 1996 | Allerg Immunol (Paris) | pmid:9011169 |
Can C et al. | Symmetrical drug-related intertriginous and flexural exanthema induced by two different antibiotics. | Allergol Immunopathol (Madr) | pmid:23253684 | |
Gangemi S et al. | Immediate reaction to clarithromycin. | 2001 Jan-Feb | Allergol Immunopathol (Madr) | pmid:11449533 |
Gaig P et al. | Efficacy of the eradication of Helicobacter pylori infection in patients with chronic urticaria. A placebo-controlled double blind study. | 2002 Sep-Oct | Allergol Immunopathol (Madr) | pmid:12396958 |
Karakaya G et al. | Determining safe antibiotics for drug hypersensitive patients with the alternative method of double-triple test. | Allergol Immunopathol (Madr) | pmid:19080798 | |
Malheiro D et al. | Nimesulide-induced fixed drug eruption. | 2005 Sep-Oct | Allergol Immunopathol (Madr) | pmid:16287549 |
Seitz CS et al. | Suspicion of macrolide allergy after treatment of infectious diseases including Helicobacter pylori: results of allergological testing. | Allergol Immunopathol (Madr) | pmid:21269750 | |
Moreira A et al. | Is Helicobacter pylori infection associated with chronic idiopathic urticaria? | Allergol Immunopathol (Madr) | pmid:12890412 | |
Brož P et al. | Nonirritant intradermal skin test concentrations of ciprofloxacin, clarithromycin, and rifampicin. | 2012 | Allergy | pmid:22435670 |
Igea JM and Lázaro M | Hypersensitivity reaction to clarithromycin. | 1998 | Allergy | pmid:9491242 |
Ben-Shoshan M et al. | Anaphylactic reaction to clarithromycin in a child. | 2009 | Allergy | pmid:19222423 |
Siddiqui S and Brightling CE | Airways disease: phenotyping heterogeneity using measures of airway inflammation. | 2007 | Allergy Asthma Clin Immunol | pmid:20525145 |
Xepapadaki P et al. | Atypical bacteria and macrolides in asthma. | 2008 | Allergy Asthma Clin Immunol | pmid:20525132 |
Desrosiers M et al. | Canadian clinical practice guidelines for acute and chronic rhinosinusitis. | 2011 | Allergy Asthma Clin Immunol | pmid:21310056 |
Wedi B et al. | Urticaria and infections. | 2009 | Allergy Asthma Clin Immunol | pmid:20066173 |
Thong BY | Update on the management of antibiotic allergy. | 2010 | Allergy Asthma Immunol Res | pmid:20358021 |
Park SJ et al. | Fulminant and Fatal Multiple Organ Failure in a 12-Year-Old Boy With Mycoplasma pneumoniae Infection. | 2012 | Allergy Asthma Immunol Res | pmid:22211173 |
Kim MH et al. | A case of chlorpheniramine maleate-induced hypersensitivity with aspirin intolerance. | 2011 | Allergy Asthma Immunol Res | pmid:21217928 |
Hong SJ | The Role of Mycoplasma pneumoniae Infection in Asthma. | 2012 | Allergy Asthma Immunol Res | pmid:22379599 |
Kariyawasam HH and Scadding GK | Chronic rhinosinusitis: therapeutic efficacy of anti-inflammatory and antibiotic approaches. | 2011 | Allergy Asthma Immunol Res | pmid:21966602 |
Damianos AJ and McGarrity TJ | Treatment strategies for Helicobacter pylori infection. | 1997 | Am Fam Physician | pmid:9191460 |
Karlstadt RG and Walker K | Update on prescribing information for pantoprazole. | 2003 | Am Fam Physician | pmid:12674447 |
Gregory DS | Pertussis: a disease affecting all ages. | 2006 | Am Fam Physician | pmid:16913160 |
Chaisson R | Clarithromycin is effective against M. avium complex in AIDS. | 1992 | Am Fam Physician | pmid:1456199 |
Elston D | Nontuberculous mycobacterial skin infections: recognition and management. | 2009 | Am J Clin Dermatol | pmid:19658440 |
Rebora A | The management of rosacea. | 2002 | Am J Clin Dermatol | pmid:12180896 |
Scheinfeld N | Confluent and reticulated papillomatosis : a review of the literature. | 2006 | Am J Clin Dermatol | pmid:17007541 |
Zeegelaar JE and Faber WR | Imported tropical infectious ulcers in travelers. | 2008 | Am J Clin Dermatol | pmid:18572973 |
Chang SL et al. | Bilateral sporotrichoid lymphocutaneous dermatosis in a drug abuser: case report and review of the literature. | 2008 | Am J Clin Dermatol | pmid:18973406 |
Wedi B and Kapp A | Helicobacter pylori infection in skin diseases: a critical appraisal. | 2002 | Am J Clin Dermatol | pmid:12010072 |
Curth HM et al. | Effects of Helicobacter pylori Eradication in Chronic Spontaneous Urticaria: Results from a Retrospective Cohort Study. | 2015 | Am J Clin Dermatol | pmid:26334425 |
Parsad D et al. | A guide to selection and appropriate use of macrolides in skin infections. | 2003 | Am J Clin Dermatol | pmid:12762831 |
Yeh I et al. | Cutaneous mycobacterial spindle cell pseudotumor: a potential mimic of soft tissue neoplasms. | 2011 | Am J Dermatopathol | pmid:21712686 |
Song H et al. | Cutaneous nontuberculous mycobacterial infection: a clinicopathological study of 7 cases. | 2009 | Am J Dermatopathol | pmid:19384062 |
Lai J et al. | Epithelioid histiocytic infiltrate caused by Mycobacterium scrofulaceum infection: a potential mimic of various neoplastic entities. | 2013 | Am J Dermatopathol | pmid:22935892 |
Sketris IS et al. | Comparison of anti-infective drug use in elderly persons in Manitoba, Nova Scotia, and Saskatchewan, Canada: relationship to drug insurance reimbursement policies. | 2004 | Am J Geriatr Pharmacother | pmid:15555476 |
Hsu O et al. | Decreased plasma efavirenz concentrations in a patient receiving rifabutin. | 2010 | Am J Health Syst Pharm | pmid:20852162 |
Johnson TJ and Hedge DD | Esomeprazole: a clinical review. | 2002 | Am J Health Syst Pharm | pmid:12132559 |
Halpern MT et al. | Cost-effectiveness of gemifloxacin: results from the GLOBE study. | 2002 | Am J Health Syst Pharm | pmid:12132563 |
Chahine C et al. | Ultrashort regimen of lansoprazole-amoxicillin-azithromycin for eradicating Helicobacter pylori. | 2001 | Am J Health Syst Pharm | pmid:11596697 |
Henneman A and Thornby KA | Risk of hypotension with concomitant use of calcium-channel blockers and macrolide antibiotics. | 2012 | Am J Health Syst Pharm | pmid:22644980 |
Kaeser YA et al. | Severe hypotension and bradycardia associated with verapamil and clarithromycin. | 1998 | Am J Health Syst Pharm | pmid:9825040 |
Three new studies expand understanding of MAC therapy. | 1996 | Am J Health Syst Pharm | pmid:8899122 | |
Peloquin CA and Berning SE | Advice on treatment of Mycobacterium avium complex infection. | 1997 | Am J Health Syst Pharm | pmid:9161632 |
H. pylori treatment recognized by FDA. | 1996 | Am J Health Syst Pharm | pmid:8725200 | |
Sonnenberg A et al. | Antibiotic therapy of Helicobacter pylori infection reduces healthcare expenditures related to duodenal ulcer. | 1999 | Am J Manag Care | pmid:10345967 |
Lilley LL and Guanci R | A dangerous combination. | 1998 | Am J Nurs | pmid:9612423 |
Antibiotic gets FDA nod for MAC treatment. | 1994 | Am J Nurs | pmid:8304386 | |
Evans AK and Cunningham MJ | Atypical mycobacterial cervicofacial lymphadenitis in children: a disease as old as mankind, yet a persistent challenge. | 2005 Sep-Oct | Am J Otolaryngol | pmid:16137534 |
Hashisaki GT | Update on macrolide antibiotics. | 1995 May-Jun | Am J Otolaryngol | pmid:7661309 |
Einarson A et al. | A prospective controlled multicentre study of clarithromycin in pregnancy. | 1998 | Am J Perinatol | pmid:9890248 |
Jacoby EB and Porter KB | Helicobacter pylori infection and persistent hyperemesis gravidarum. | 1999 | Am J Perinatol | pmid:10355915 |
Abouesh A and Hobbs WR | Clarithromycin-induced mania. | 1998 | Am J Psychiatry | pmid:9812131 |
Brooks JO and Hoblyn JC | Secondary mania in older adults. | 2005 | Am J Psychiatry | pmid:16263839 |
Keicho N and Kudoh S | Diffuse panbronchiolitis: role of macrolides in therapy. | 2002 | Am J Respir Med | pmid:14720066 |
Darkes MJ and Perry CM | Clarithromycin extended-release tablet: a review of its use in the management of respiratory tract infections. | 2003 | Am J Respir Med | pmid:14720016 |
Tohnai A et al. | Clarithromycin suppresses proliferation of rat nasal epithelium exposed to endotoxin. | 1998 Nov-Dec | Am J Rhinol | pmid:9883303 |
Zeng M et al. | Comparison of efficacy of mometasone furoate versus clarithromycin in the treatment of chronic rhinosinusitis without nasal polyps in Chinese adults. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185725 |
Gupta AK and Moorman CT | Nocardia nova infection after primary anterior cruciate ligament reconstruction with tibialis anterior allograft. | 2010 | Am J Sports Med | pmid:20375367 |
Yang X et al. | Comparison Between Sequential Therapy and Modified Bismuth-Included Quadruple Therapy for Helicobacter pylori Eradication in Chinese Patients. | Am J Ther | pmid:25923229 | |
Feng L et al. | Sequential Therapy or Standard Triple Therapy for Helicobacter pylori Infection: An Updated Systematic Review. | Am J Ther | pmid:25569598 | |
McCarthy DM et al. | Impact of cotherapy with some proton pump inhibitors on medical claims among HMO patients already using other common drugs also cleared by cytochrome P450. | 2003 Sep-Oct | Am J Ther | pmid:12975717 |
Chang NL et al. | Clarithromycin-Induced Torsades de Pointes. | Am J Ther | pmid:25057773 | |
Kurowski K et al. | Clarithromycin-induced alterations in vaginal flora. | 2000 | Am J Ther | pmid:11317173 |
Alkim H et al. | Role of Bismuth in the Eradication of Helicobacter pylori. | Am J Ther | pmid:26808355 | |
Jacobson TA | Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors. | 2004 | Am. J. Cardiol. | pmid:15518608 |
Hsu CH et al. | The lesson of supplementary treatment with Chinese medicine on severe laboratory-confirmed SARS patients. | 2006 | Am. J. Chin. Med. | pmid:17163582 |
Wang YC et al. | In vitro activity of Impatiens balsamina L. against multiple antibiotic-resistant Helicobacter pylori. | 2009 | Am. J. Chin. Med. | pmid:19655409 |
Sauter C and Blum S | Regression of lung lesions in Hodgkin's disease by antibiotics: case report and hypothesis on the etiology of Hodgkin's disease. | 2003 | Am. J. Clin. Oncol. | pmid:12576932 |
Kapadia M et al. | Invasive Streptomyces infections: six cases and literature review. | 2007 | Am. J. Clin. Pathol. | pmid:17369139 |
Buchanan Keller K and Lemberg L | Torsade. | 2008 | Am. J. Crit. Care | pmid:18158394 |
Jaup BH and Norrby A | Low dose, short-term triple therapy for cure of Helicobacter pylori infection and healing of peptic ulcers. | 1995 | Am. J. Gastroenterol. | pmid:7771426 |
de Bortoli N et al. | Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics. | 2007 | Am. J. Gastroenterol. | pmid:17313499 |
Sullivan B et al. | Comparison of azithromycin and clarithromycin in triple therapy regimens for the eradication of Helicobacter pylori. | 2002 | Am. J. Gastroenterol. | pmid:12385435 |
Ozmen MM and Johnson CD | Is short-term triple therapy with lansoprazole, clarithromycin, and metronidazole a definitive answer for Helicobacter pylori eradication? | 1995 | Am. J. Gastroenterol. | pmid:7661197 |
Savarino V et al. | New insight in the mechanism of omeprazole antimicrobial combinations to eradicate Helicobacter pylori. | 1995 | Am. J. Gastroenterol. | pmid:7717343 |
Zullo A et al. | Omeprazole plus clarithromycin and either tinidazole or tetracycline for Helicobacter pylori infection: a randomized prospective study. | 1997 | Am. J. Gastroenterol. | pmid:9362185 |
Sirimontaporn N et al. | Ten-day sequential therapy of Helicobacter pylori infection in Thailand. | 2010 | Am. J. Gastroenterol. | pmid:20010919 |
Basu PP et al. | A randomized study comparing levofloxacin, omeprazole, nitazoxanide, and doxycycline versus triple therapy for the eradication of Helicobacter pylori. | 2011 | Am. J. Gastroenterol. | pmid:21989146 |
Jarbol DE et al. | Proton pump inhibitor or testing for Helicobacter pylori as the first step for patients presenting with dyspepsia? A cluster-randomized trial. | 2006 | Am. J. Gastroenterol. | pmid:16771937 |
Nakao K et al. | Relation of lactoferrin levels in gastric mucosa with Helicobacter pylori infection and with the degree of gastric inflammation. | 1997 | Am. J. Gastroenterol. | pmid:9177520 |
Maconi G et al. | Do some patients with Helicobacter pylori infection benefit from an extension to 2 weeks of a proton pump inhibitor-based triple eradication therapy? | 2001 | Am. J. Gastroenterol. | pmid:11232676 |