clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Eickel V et al. | Emergence of respiratory Streptococcus agalactiae isolates in cystic fibrosis patients. | 2009 | PLoS ONE | pmid:19247473 |
| Yonezawa H et al. | Impact of Helicobacter pylori biofilm formation on clarithromycin susceptibility and generation of resistance mutations. | 2013 | PLoS ONE | pmid:24039906 |
| Jakobsson HE et al. | Short-term antibiotic treatment has differing long-term impacts on the human throat and gut microbiome. | 2010 | PLoS ONE | pmid:20352091 |
| Juste RA et al. | On the prevalence of M. avium subspecies paratuberculosis DNA in the blood of healthy individuals and patients with inflammatory bowel disease. | 2008 | PLoS ONE | pmid:18596984 |
| Kim BJ et al. | Discovery of a novel hsp65 genotype within Mycobacterium massiliense associated with the rough colony morphology. | 2012 | PLoS ONE | pmid:22693637 |
| Shin SH et al. | Helicobacter pylori Eradication Prevents Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia. | 2015 | PLoS ONE | pmid:26580072 |
| Desai S et al. | The Epidemiology of Invasive Haemophilus influenzae Non-Serotype B Disease in Ontario, Canada from 2004 to 2013. | 2015 | PLoS ONE | pmid:26569613 |
| Rubio M et al. | Inducible and Acquired Clarithromycin Resistance in the Mycobacterium abscessus Complex. | 2015 | PLoS ONE | pmid:26448181 |
| Makobongo MO et al. | In vitro characterization of the anti-bacterial activity of SQ109 against Helicobacter pylori. | 2013 | PLoS ONE | pmid:23935905 |
| Chauffour A et al. | Sterilizing Activity of Fully Oral Intermittent Regimens against Mycobacterium Ulcerans Infection in Mice. | 2016 | PLoS Negl Trop Dis | pmid:27755552 |
| Converse PJ et al. | Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease. | 2015 | PLoS Negl Trop Dis | pmid:26042792 |
| Friedman ND et al. | Mycobacterium ulcerans disease: experience with primary oral medical therapy in an Australian cohort. | 2013 | PLoS Negl Trop Dis | pmid:23875050 |
| Cowan R et al. | Mycobacterium ulcerans treatment--can antibiotic duration be reduced in selected patients? | 2015 | PLoS Negl Trop Dis | pmid:25658304 |
| Gopinath K and Singh S | Non-tuberculous mycobacteria in TB-endemic countries: are we neglecting the danger? | 2010 | PLoS Negl Trop Dis | pmid:20436962 |
| Vinh H et al. | A multi-center randomized trial to assess the efficacy of gatifloxacin versus ciprofloxacin for the treatment of shigellosis in Vietnamese children. | 2011 | PLoS Negl Trop Dis | pmid:21829747 |
| Almeida D et al. | Activities of rifampin, Rifapentine and clarithromycin alone and in combination against mycobacterium ulcerans disease in mice. | 2011 | PLoS Negl Trop Dis | pmid:21245920 |
| Hobbie SN et al. | Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma. | 2011 | PLoS Negl Trop Dis | pmid:21629725 |
| Trunck LA et al. | Molecular basis of rare aminoglycoside susceptibility and pathogenesis of Burkholderia pseudomallei clinical isolates from Thailand. | 2009 | PLoS Negl Trop Dis | pmid:19771149 |
| Gordon CL et al. | All-oral antibiotic treatment for buruli ulcer: a report of four patients. | 2010 | PLoS Negl Trop Dis | pmid:21152060 |
| O'Brien DP et al. | Successful outcomes with oral fluoroquinolones combined with rifampicin in the treatment of Mycobacterium ulcerans: an observational cohort study. | 2012 | PLoS Negl Trop Dis | pmid:22272368 |
| Connolly LE et al. | Why is long-term therapy required to cure tuberculosis? | 2007 | PLoS Med. | pmid:17388672 |
| Corrales-Medina VF et al. | Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies. | 2011 | PLoS Med. | pmid:21738449 |
| Skalet AH et al. | Antibiotic selection pressure and macrolide resistance in nasopharyngeal Streptococcus pneumoniae: a cluster-randomized clinical trial. | 2010 | PLoS Med. | pmid:21179434 |
| Letek M et al. | The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions. | 2010 | PLoS Genet. | pmid:20941392 |
| Balcan D et al. | Modeling the critical care demand and antibiotics resources needed during the Fall 2009 wave of influenza A(H1N1) pandemic. | 2009 | PLoS Curr | pmid:20029670 |
| Fouts DE et al. | Major structural differences and novel potential virulence mechanisms from the genomes of multiple campylobacter species. | 2005 | PLoS Biol. | pmid:15660156 |
| Matsukawa Y et al. | Long term changes in platelet counts after H. pylori eradication in non-ITP patients. | 2010 | Platelets | pmid:20849211 |
| Matsukawa Y et al. | Helicobacter pylori eradication reduces platelet count in patients without idiopathic thrombocytopenic purpura. | 2007 | Platelets | pmid:17365854 |
| Lee D et al. | Localized Mycobacterium avium-intracellulare mastitis in an immunocompetent woman with silicone breast implants. | 1995 | Plast. Reconstr. Surg. | pmid:7809228 |
| Hess CL et al. | Mycobacterium marinum infections of the upper extremity. | 2005 | Plast. Reconstr. Surg. | pmid:15731663 |
| Dantas da Silva LL et al. | Antibacterial activity of a stearic acid derivative from Stemodia foliosa. | 2002 | Planta Med. | pmid:12494347 |
| Kwak HM et al. | The efficacy of cefazolin plus macrolide (erythromycin or clarithromycin) versus cefazolin alone in neonatal morbidity and placental inflammation for women with preterm premature rupture of membranes. | 2013 | Placenta | pmid:23465535 |
| MAC management. | 1996 | PI Perspect | pmid:11363967 | |
| Cheng B | Preventing opportunistic infections. | 1995 | PI Perspect | pmid:11362422 |
| Liu WH et al. | In vitro anti-Helicobacter pylori activity of diallyl sulphides and protocatechuic acid. | 2008 | Phytother Res | pmid:17705145 |
| Nostro A et al. | Effects of combining extracts (from propolis or Zingiber officinale) with clarithromycin on Helicobacter pylori. | 2006 | Phytother Res | pmid:16521108 |
| Lawal TO et al. | Combination studies of Eucalyptus torelliana F. Muell. leaf extracts and clarithromycin on Helicobacter pylori. | 2012 | Phytother Res | pmid:22318891 |
| Safak B et al. | In vitro anti-Helicobacter pylori activity of usnic acid. | 2009 | Phytother Res | pmid:19367654 |
| Stege PW et al. | Antimicrobial activity of aqueous extracts of Larrea divaricata Cav (jarilla) against Helicobacter pylori. | 2006 | Phytomedicine | pmid:17085295 |
| Dabos KJ et al. | The effect of mastic gum on Helicobacter pylori: a randomized pilot study. | 2010 | Phytomedicine | pmid:19879118 |
| Celik H and Ayar A | Clarithromycin inhibits myometrial contractions in isolated human myometrium independent of stimulus. | 2002 | Physiol Res | pmid:12234115 |
| Kim PK and Dorshimer GW | Case report: peptic ulcer disease in a professional athlete. | 2009 | Phys Sportsmed | pmid:20048520 |
| Guo D et al. | The cardiotoxicity of macrolides: a systematic review. | 2010 | Pharmazie | pmid:21038838 |
| Valizadeh H et al. | Antibacterial activity of clarithromycin loaded PLGA nanoparticles. | 2012 | Pharmazie | pmid:22393833 |
| Togami K et al. | Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells. | 2012 | Pharmazie | pmid:22764569 |
| Hamdan II | Comparative in vitro investigations of the interaction between some macrolides and Cu(II), Zn(II) and Fe(II). | 2003 | Pharmazie | pmid:12685822 |
| Lohitnavy M et al. | Pharmacokinetic and bloequivalence studies of generic clarithromycin tablets in healthy male volunteers. | 2003 | Pharmazie | pmid:12622260 |
| Chadha R et al. | Quantitative analysis of in vitro compatibility of binary and ternary mixtures of nitroimidazole and macrolides in combination with omeprazole using a calorimetric technique. | 2007 | Pharmazie | pmid:17557738 |
| Najib MM et al. | Cost-effectiveness of sparfloxacin compared with other oral antimicrobials in outpatient treatment of community-acquired pneumonia. | 2000 | Pharmacotherapy | pmid:10772376 |
| Mertl SL | The role of clarithromycin in the prophylaxis of disseminated Mycobacterium avium-intracellulare infection in patients with AIDS. | 1996 May-Jun | Pharmacotherapy | pmid:8726597 |
| Mor N et al. | Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. | 1994 Jan-Feb | Pharmacotherapy | pmid:8159593 |
| Auclair B et al. | Potential interaction between itraconazole and clarithromycin. | 1999 | Pharmacotherapy | pmid:10600094 |
| Khamaisi M and Leitersdorf E | Severe hypoglycemia from clarithromycin-repaglinide drug interaction. | 2008 | Pharmacotherapy | pmid:18447665 |
| Otsuka SH | Severe hypoglycemia from Helicobacter pylori triple-drug therapy and insulin detemir drug interaction. | 2013 | Pharmacotherapy | pmid:23471710 |
| Nicholson SC et al. | Antimicrobial-associated acute hepatitis. | 2002 | Pharmacotherapy | pmid:12066973 |
| Gaylor AS and Reilly JC | Therapy with macrolides in patients with cystic fibrosis. | 2002 | Pharmacotherapy | pmid:11837560 |
| Adelglass J et al. | A multicenter, investigator-blinded, randomized comparison of oral levofloxacin and oral clarithromycin in the treatment of acute bacterial sinusitis. | 1998 Nov-Dec | Pharmacotherapy | pmid:9855324 |
| Kang-Birken SL and Prichard JG | Mycobacterium szulgai in a patient with advanced acquired immunodeficiency syndrome: an unusual pathogen with unusual multidrug resistance. | 2006 | Pharmacotherapy | pmid:17064210 |
| Guerriero SE et al. | Two cases of clarithromycin-induced digoxin toxicity. | 1997 Sep-Oct | Pharmacotherapy | pmid:9324195 |
| McConnell SA and Amsden GW | Review and comparison of advanced-generation macrolides clarithromycin and dirithromycin. | 1999 | Pharmacotherapy | pmid:10212011 |
| Molden E and Andersson KS | Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients. | 2007 | Pharmacotherapy | pmid:17381388 |
| Oberg KC | Delayed elevation of international normalized ratio with concurrent clarithromycin and warfarin therapy. | 1998 Mar-Apr | Pharmacotherapy | pmid:9545160 |
| Shin J et al. | Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin. | 2011 | Pharmacotherapy | pmid:21950641 |
| Stein GE et al. | A preliminary study of clarithromycin versus doxycycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis. | 1995 Nov-Dec | Pharmacotherapy | pmid:8602379 |
| Stein GE and Schooley S | Serum bactericidal activity of extended-release clarithromycin against macrolide-resistant strains of Streptococcus pneumoniae. | 2002 | Pharmacotherapy | pmid:12013358 |
| Sketris IS et al. | Possible role of the intestinal P-450 enzyme system in a cyclosporine-clarithromycin interaction. | 1996 Mar-Apr | Pharmacotherapy | pmid:8820476 |
| Legendre DP et al. | Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. | 2012 | Pharmacotherapy | pmid:22392826 |
| Schulz-Du Bois C et al. | Major increase of quetiapine steady-state plasma concentration following co-administration of clarithromycin: confirmation of the pharmacokinetic interaction potential of quetiapine. | 2008 | Pharmacopsychiatry | pmid:19067264 |
| Kitano M et al. | Effects of clarithromycin and dexamethasone on mucus production in isografted rat trachea. | 2011 | Pharmacology | pmid:21228611 |
| Jokinen MJ et al. | Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine. | 2001 | Pharmacol. Toxicol. | pmid:11322176 |
| Yamamoto K et al. | Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3. | 2016 | Pharmacol. Res. | pmid:27468646 |
| Calabresi L et al. | Pharmacokinetic interactions between omeprazole/pantoprazole and clarithromycin in health volunteers. | 2004 | Pharmacol. Res. | pmid:14998561 |
| Pauwels O | Factors contributing to carbamazepine-macrolide interactions. | 2002 | Pharmacol. Res. | pmid:12030792 |
| Woo PC et al. | Clarithromycin attenuates cyclophosphamide-induced mucositis in mice. | 2000 | Pharmacol. Res. | pmid:10753551 |
| Marjanović N et al. | Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro. | 2011 | Pharmacol. Res. | pmid:21315154 |
| Woo PC et al. | Clarithromycin attenuates the inflammatory response induced by surgical trauma in a guinea pig model. | 1999 | Pharmacol. Res. | pmid:10051377 |
| Karczewska E et al. | Primary and secondary clarithromycin, metronidazole, amoxicillin and levofloxacin resistance to Helicobacter pylori in southern Poland. | 2011 | Pharmacol Rep | pmid:21857091 |
| Szałek E et al. | Sunitinib in combination with clarithromycin or azithromycin - is there a risk of interaction or not? | 2012 | Pharmacol Rep | pmid:23406766 |
| Fohner AE et al. | PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics. | 2017 | Pharmacogenet. Genomics | pmid:28146011 |
| Allen LaPointe NM et al. | Frequency of high-risk use of QT-prolonging medications. | 2006 | Pharmacoepidemiol Drug Saf | pmid:16178046 |
| Quach C et al. | Effectiveness of amoxicillin, azithromycin, cefprozil and clarithromycin in the treatment of acute otitis media in children: a population-based study. | 2005 | Pharmacoepidemiol Drug Saf | pmid:15386697 |
| Galatti L et al. | Co-prescriptions with itraconazole and fluconazole as a signal for possible risk of drug-drug interactions: a four-year analysis from Italian general practice. | 2007 | Pharmacoepidemiol Drug Saf | pmid:17323404 |
| Corrao G et al. | Generating signals of drug-adverse effects from prescription databases and application to the risk of arrhythmia associated with antibacterials. | 2005 | Pharmacoepidemiol Drug Saf | pmid:15390219 |
| Drinkard CR et al. | Postmarketing surveillance of medications and pregnancy outcomes: clarithromycin and birth malformations. | 2000 | Pharmacoepidemiol Drug Saf | pmid:11338912 |
| Bérard A et al. | Use of macrolides during pregnancy and the risk of birth defects: a population-based study. | 2015 | Pharmacoepidemiol Drug Saf | pmid:26513406 |
| Craig AM et al. | Decision analysis of Helicobacter pylori eradication therapy using omeprazole with either clarithromycin or amoxicillin. | 1996 | Pharmacoeconomics | pmid:10160472 |
| Agro K et al. | Cost effectiveness in Canada of a multidrug prepackaged regimen (Hp-PAC)+ for Helicobacter pylori eradication. | 2001 | Pharmacoeconomics | pmid:11596835 |
| Plosker GL and Figgitt DP | Repaglinide : a pharmacoeconomic review of its use in type 2 diabetes mellitus. | 2004 | Pharmacoeconomics | pmid:15099124 |
| Ufuk A et al. | In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383. | 2015 | Pharm. Res. | pmid:26224396 |
| Dimer F et al. | Inhalable Clarithromycin Microparticles for Treatment of Respiratory Infections. | 2015 | Pharm. Res. | pmid:26113237 |
| Vehring R | Pharmaceutical particle engineering via spray drying. | 2008 | Pharm. Res. | pmid:18040761 |
| Kita T et al. | CYP2C19 genotype related effect of omeprazole on intragastric pH and antimicrobial stability. | 2001 | Pharm. Res. | pmid:11465416 |
| Haghi M et al. | Immunomodulatory effects of a low-dose clarithromycin-based macrolide solution pressurised metered dose inhaler. | 2015 | Pharm. Res. | pmid:25537341 |
| Lu MY et al. | A polymer carrier system for taste masking of macrolide antibiotics. | 1991 | Pharm. Res. | pmid:1829521 |
| Rotsch TD et al. | Determination of clarithromycin as a contaminant on surfaces by high-performance liquid chromatography using electrochemical detection. | 1991 | Pharm. Res. | pmid:1833731 |
| Meng Y et al. | Multi-functional Liposomes Enhancing Target and Antibacterial Immunity for Antimicrobial and Anti-Biofilm Against Methicillin-Resistant Staphylococcus aureus. | 2016 | Pharm. Res. | pmid:26666773 |
| Takeuchi T et al. | Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1. | 2006 | Pharm. Res. | pmid:16779700 |
| Rose WE et al. | Prevention of biofilm formation by methacrylate-based copolymer films loaded with rifampin, clarithromycin, doxycycline alone or in combination. | 2015 | Pharm. Res. | pmid:24934663 |
| Becker ML et al. | Determinants of potential drug-drug interaction associated dispensing in community pharmacies in the Netherlands. | 2007 | Pharm World Sci | pmid:17187223 |
| Sancar M et al. | Pharmacoeconomic comparison of Helicobacter pylori eradication regimens. | 2006 | Pharm World Sci | pmid:17066247 |