clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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De Wit S et al. | Acquired resistance to clarithromycin as combined therapy in Mycobacterium avium intracellulare infection. | 1993 | Lancet | pmid:8093299 |
Tomioka H et al. | [In vitro antimycobacterial activity of clarithromycin and its therapeutic efficacy against Mycobacterium intracellulare infection induced in mice]. | 1993 | Kekkaku | pmid:8497119 |
Monteforte JS and Wood CA | Pneumonia caused by Nocardia nova and Aspergillus fumigatus after cardiac transplantation. | 1993 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:8500477 |
Hakkarinen WD | Clarithromycin vs penicillin. | 1993 | J Fam Pract | pmid:8482929 |
Luger SW | Clarithromycin vs penicillin. | 1993 | J Fam Pract | pmid:8482930 |
Lazard T et al. | Clarithromycin, minocycline, and rifabutin treatments before and after infection of C57BL/6 mice with Mycobacterium avium. | 1993 | Antimicrob. Agents Chemother. | pmid:8215285 |
Pialoux G et al. | Combination antibiotic treatment with clarithromycin for human immunodeficiency virus-associated Rhodococcus equi infection. | 1993 | Clin. Infect. Dis. | pmid:8218702 |
Fraschini F et al. | Clarithromycin clinical pharmacokinetics. | 1993 | Clin Pharmacokinet | pmid:8222460 |
Neu HC and Chick TW | Efficacy and safety of clarithromycin compared to cefixime as outpatient treatment of lower respiratory tract infections. | 1993 | Chest | pmid:8222794 |
Sedlmayr T et al. | [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]. | 1993 | Geburtshilfe Frauenheilkd | pmid:8370491 |
Kodama R et al. | [Eradication therapy of Helicobacter pylori in gastroduodenal ulcer and its long-term course]. | 1993 | Nippon Rinsho | pmid:8283646 |
Hoffner SE et al. | Susceptibility of Mycobacterium malmoense to antibacterial drugs and drug combinations. | 1993 | Antimicrob. Agents Chemother. | pmid:8392308 |
Gevaudan MJ et al. | In-vitro evaluation of clarithromycin, temafloxacin, and ethambutol in combination against Mycobacterium avium complex. | 1993 | J. Antimicrob. Chemother. | pmid:8392998 |
Wallace RJ et al. | Clinical trial of clarithromycin for cutaneous (disseminated) infection due to Mycobacterium chelonae. | 1993 | Ann. Intern. Med. | pmid:8357113 |
Wettengel R et al. | Clarithromycin versus cefaclor for the treatment of mild-to-moderate acute bacterial bronchitis. | 1993 | J. Antimicrob. Chemother. | pmid:8360133 |
Nakashio S et al. | [Antimicrobial activity of clarithromycin and its effect on bacterial adherence to medical material]. | 1993 | Jpn J Antibiot | pmid:8360978 |
Guay DR et al. | Overview of the tolerability profile of clarithromycin in preclinical and clinical trials. | 1993 | Drug Saf | pmid:8504017 |
Mazzei T et al. | Chemistry and mode of action of macrolides. | 1993 | J. Antimicrob. Chemother. | pmid:7683018 |
Lazard T et al. | Efficacy of granulocyte colony-stimulating factor and RU-40555 in combination with clarithromycin against Mycobacterium avium complex infection in C57BL/6 mice. | 1993 | Antimicrob. Agents Chemother. | pmid:7684213 |
Emori M et al. | Therapeutic efficacy of the benzoxazinorifamycin KRM-1648 against experimental Mycobacterium avium infection induced in rabbits. | 1993 | Antimicrob. Agents Chemother. | pmid:7684214 |