clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shaulov A et al. | Progressive refractory light chain amyloidosis and multiple myeloma patients are responsive to the addition of clarithromycin to IMiD based therapy. | 2017 | Am. J. Hematol. | pmid:27804150 |
| Gaur S et al. | Bronchus-associated lymphoid tissue lymphoma arising in a patient with bronchiectasis and chronic Mycobacterium avium infection. | 2004 | Am. J. Hematol. | pmid:15307101 |
| Rostami N et al. | Effect of eradication of Helicobacter pylori on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura: a controlled trial. | 2008 | Am. J. Hematol. | pmid:18183613 |
| Ghosh N et al. | Clarithromycin overcomes resistance to lenalidomide and dexamethasone in multiple myeloma. | 2014 | Am. J. Hematol. | pmid:24723438 |
| Gay F et al. | Clarithromycin (Biaxin)-lenalidomide-low-dose dexamethasone (BiRd) versus lenalidomide-low-dose dexamethasone (Rd) for newly diagnosed myeloma. | 2010 | Am. J. Hematol. | pmid:20645430 |
| Mirabile A et al. | MALT lymphoma and Kaposi sarcoma in an HIV-negative patient. | 2010 | Am. J. Hematol. | pmid:20721890 |
| Steinman MA and Steinman TI | Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulatory peritoneal dialysis. | 1996 | Am. J. Kidney Dis. | pmid:8546130 |
| Wang YL et al. | Noninvasive stool antigen assay can effectively screen Helicobacter pylori Infection and assess success of eradication therapy in hemodialysis patients. | 2001 | Am. J. Kidney Dis. | pmid:11431188 |
| Mendu ML and Waikar SS | Drug-drug interactions and acute kidney injury: caveat prescriptor. | 2014 | Am. J. Kidney Dis. | pmid:24820318 |
| Okada S et al. | Angiocentric immunoproliferative lesions of the lung associated with diffuse renal involvement. | 2002 | Am. J. Kidney Dis. | pmid:11877592 |
| Mak SK et al. | Efficacy of a 1-week course of proton-pump inhibitor-based triple therapy for eradicating Helicobacter pylori in patients with and without chronic renal failure. | 2002 | Am. J. Kidney Dis. | pmid:12200810 |
| Sekkarie MA | Torsades de pointes in two chronic renal failure patients treated with cisapride and clarithromycin. | 1997 | Am. J. Kidney Dis. | pmid:9292575 |
| Keenan N et al. | Mycobacterium simiae: a previously undescribed pathogen in peritoneal dialysis peritonitis. | 2005 | Am. J. Kidney Dis. | pmid:15861339 |
| Santos MA et al. | Nothing to (S)cough at: Pulmonary Mycobacterium avium Complex Infection. | 2017 | Am. J. Med. | pmid:27984010 |
| Curtis LH et al. | Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients. | 2003 | Am. J. Med. | pmid:12586234 |
| Nayyar E and Taimur S | Sporotrichoid lesions: an age-old conundrum. | 2015 | Am. J. Med. | pmid:26021809 |
| Jaber BL et al. | The serotonin syndrome complicating co-prescription of paroxetine and clarithromycin. | 2006 | Am. J. Med. | pmid:16564762 |
| Cicconi V et al. | Disappearance of antiphospholipid antibodies syndrome after Helicobacter pylori eradication. | 2001 | Am. J. Med. | pmid:11501549 |
| Siddiqui J | Immunomodulatory effects of macrolides: implications for practicing clinicians. | 2004 | Am. J. Med. | pmid:15586561 |
| Tamaoki J et al. | Clinical implications of the immunomodulatory effects of macrolides. | 2004 | Am. J. Med. | pmid:15586558 |
| Abisheganaden JA et al. | Effect of clarithromycin on experimental rhinovirus-16 colds: a randomized, double-blind, controlled trial. | 2000 | Am. J. Med. | pmid:10781777 |
| Gotfried MH | Epidemiology of clinically diagnosed community-acquired pneumonia in the primary care setting: results from the 1999-2000 respiratory surveillance program. | 2001 | Am. J. Med. | pmid:11755440 |
| Sherman PM | Appropriate strategies for testing and treating Helicobacter pylori in children: when and how? | 2004 | Am. J. Med. | pmid:15478850 |
| Sokol W | Epidemiology of sinusitis in the primary care setting: results from the 1999-2000 respiratory surveillance program. | 2001 | Am. J. Med. | pmid:11755439 |
| Pfaller MA et al. | Frequency of pathogen occurrence and antimicrobial susceptibility among community-acquired respiratory tract infections in the respiratory surveillance program study: microbiology from the medical office practice environment. | 2001 | Am. J. Med. | pmid:11755437 |
| Lee KL et al. | QT prolongation and Torsades de Pointes associated with clarithromycin. | 1998 | Am. J. Med. | pmid:9576415 |
| Hunt RH | Eradication of Helicobacter pylori infection. | 1996 | Am. J. Med. | pmid:8644782 |
| Stasi R et al. | Helicobacter pylori eradication in the management of patients with idiopathic thrombocytopenic purpura. | 2005 | Am. J. Med. | pmid:15808140 |
| Gokturk HS et al. | Does long-term aspirin use have any effect on Helicobacter pylori eradication? | 2011 | Am. J. Med. Sci. | pmid:21642817 |
| Brener ZZ et al. | Rhabdomyolysis following clarithromycin monotherapy. | 2009 | Am. J. Med. Sci. | pmid:19474653 |
| Songür Y et al. | Triple or quadruple tetracycline-based therapies versus standard triple treatment for Helicobacter pylori treatment. | 2009 | Am. J. Med. Sci. | pmid:19474657 |
| Demir M et al. | Efficacy of two different Helicobacter pylori eradication regimens in patients with type 2 diabetes and the effect of Helicobacter pylori eradication on dyspeptic symptoms in patients with diabetes: a randomized controlled study. | 2009 | Am. J. Med. Sci. | pmid:19884816 |
| Butt AA | Cervical adenitis due to Mycobacterium fortuitum in patients with acquired immunodeficiency syndrome. | 1998 | Am. J. Med. Sci. | pmid:9427575 |
| Baciewicz AM et al. | Update on rifampin and rifabutin drug interactions. | 2008 | Am. J. Med. Sci. | pmid:18277121 |
| Gascón A et al. | Catheter salvage in a patient on hemodialysis with a catheter-related bacteremia by Pseudomonas aeruginosa. Usefulness of clarithromycin. | 2000 Nov-Dec | Am. J. Nephrol. | pmid:11146320 |
| Witt A et al. | Placental passage of clarithromycin surpasses other macrolide antibiotics. | 2003 | Am. J. Obstet. Gynecol. | pmid:12634663 |
| Lin KJ et al. | Safety of macrolides during pregnancy. | 2013 | Am. J. Obstet. Gynecol. | pmid:23254249 |
| Kuehne JJ et al. | Corneal pharmacokinetics of topically applied azithromycin and clarithromycin. | 2004 | Am. J. Ophthalmol. | pmid:15488779 |
| Helm CJ et al. | Comparison of topical antibiotics for treating Mycobacterium fortuitum keratitis in an animal model. | 1993 | Am. J. Ophthalmol. | pmid:8250072 |
| Chandra NS et al. | Cluster of Mycobacterium chelonae keratitis cases following laser in-situ keratomileusis. | 2001 | Am. J. Ophthalmol. | pmid:11730644 |
| Feldman M et al. | Influence of H. pylori infection on meal-stimulated gastric acid secretion and gastroesophageal acid reflux. | 1999 | Am. J. Physiol. | pmid:10600812 |
| Kaneko Y et al. | Clarithromycin inhibits overproduction of muc5ac core protein in murine model of diffuse panbronchiolitis. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12818892 |
| Shinkai M et al. | Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16085674 |
| Chmura K et al. | Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18487355 |
| Tanabe T et al. | Clarithromycin inhibits interleukin-13-induced goblet cell hyperplasia in human airway cells. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:21642590 |
| Abe S et al. | Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10615065 |
| Oberley-Deegan RE et al. | The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus. | 2009 | Am. J. Respir. Cell Mol. Biol. | pmid:19097985 |
| Yamasawa H et al. | Macrolides inhibit epithelial cell-mediated neutrophil survival by modulating granulocyte macrophage colony-stimulating factor release. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:14551160 |
| Jeon K et al. | Antibiotic treatment of Mycobacterium abscessus lung disease: a retrospective analysis of 65 patients. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19661243 |
| Azuma M et al. | Role of alpha1-acid glycoprotein in therapeutic antifibrotic effects of imatinib with macrolides in mice. | 2007 | Am. J. Respir. Crit. Care Med. | pmid:17717205 |