clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jaup BH and Norrby A | Low dose, short-term triple therapy for cure of Helicobacter pylori infection and healing of peptic ulcers. | 1995 | Am. J. Gastroenterol. | pmid:7771426 |
| Musher DM | Clarithromycin therapy for Mycobacterium avium complex bacteremia. | 1995 | Ann. Intern. Med. | pmid:7778830 |
| van der Meer JT and Danner SA | Clarithromycin therapy for Mycobacterium avium complex bacteremia. | 1995 | Ann. Intern. Med. | pmid:7778831 |
| Burette A and Glupczynski Y | Helicobacter pylori: the place of the new macrolides in the eradication of the bacteria in peptic ulcer disease. | 1995 | Infection | pmid:7782116 |
| Block S et al. | Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate. | 1995 | Pediatr. Infect. Dis. J. | pmid:7667050 |
| Nash KA and Inderlied CB | Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease. | 1995 | Antimicrob. Agents Chemother. | pmid:8592991 |
| RamÃrez Ramos A | [Treatment of Helicobacter pylori infection: current status]. | 1995 | Rev Gastroenterol Peru | pmid:8520021 |
| Cavalieri SJ et al. | Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis. | 1995 | Antimicrob. Agents Chemother. | pmid:7492101 |
| Englishby VL | Case reports of death associated with pseudomembranous colitis and clarithromycin. | 1995 | Eur J Gastroenterol Hepatol | pmid:7496875 |
| Savarino V et al. | New insight in the mechanism of omeprazole antimicrobial combinations to eradicate Helicobacter pylori. | 1995 | Am. J. Gastroenterol. | pmid:7717343 |
| Saito H et al. | Therapeutic effect of KRM-1648 with various antimicrobials against Mycobacterium avium complex infection in mice. | 1995 | Tuber. Lung Dis. | pmid:7718848 |
| Hedenmo M and Eriksson BM | Liquid chromatographic determination of the macrolide antibiotics roxithromycin and clarithromycin in plasma by automated solid-phase extraction and electrochemical detection. | 1995 | J Chromatogr A | pmid:7719451 |
| Götz JM et al. | Triple therapy with ranitidine, clarithromycin, and metronidazole in the treatment of Helicobacter pylori. | 1995 | Scand. J. Gastroenterol. Suppl. | pmid:8578230 |
| Atkinson BA et al. | Treatment of Mycobacterium haemophilum infection in a murine model with clarithromycin, rifabutin, and ciprofloxacin. | 1995 | Antimicrob. Agents Chemother. | pmid:8619588 |
| Piersimoni C et al. | Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of Mycobacterium avium complex. | 1995 | J. Antimicrob. Chemother. | pmid:8830013 |
| Clarithromycin for MAC. | 1995 | AIDS Patient Care | pmid:11361361 | |
| Cama VA et al. | Treatment of acute and chronic Cryptosporidium parvum infections in mice using clarithromycin and 14-OH clarithromycin. | 1994 Sep-Oct | J. Eukaryot. Microbiol. | pmid:7804227 |
| O'Connor NK and Fris J | Clarithromycin-carbamazepine interaction in a clinical setting. | 1994 Nov-Dec | J Am Board Fam Pract | pmid:7847111 |
| Scaglione F et al. | Effect of antibiotics on Bordetella pertussis adhering activity: hypothesis regarding mechanism of action. | 1994 May-Jun | Chemotherapy | pmid:7515782 |
| Gersema LM et al. | Suspected drug interaction between cyclosporine and clarithromycin. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:8031821 |
| Heifets LB | Quantitative cultures and drug susceptibility testing of Mycobacterium avium clinical isolates before and during the antimicrobial therapy. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809471 |
| Dautzenberg B | Clinical trials in Mycobacterium avium therapy: lessons to take home. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809472 |
| Winter J | Intravenous clarithromycin. | 1994 Mar 16-Apr 5 | Br J Hosp Med | pmid:8032567 |
| Mor N et al. | Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. | 1994 Jan-Feb | Pharmacotherapy | pmid:8159593 |
| Tessier MH et al. | Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. | 1994 Dec 24-31 | Lancet | pmid:7997032 |
| Ploy MC et al. | [Antibacterial activity of clarithromycin and its hydroxylated derivative and two other macrolides against thirty strains of Streptococcus pneumoniae]. | 1994 | Pathol. Biol. | pmid:7824300 |
| Gevaudan MJ et al. | [Evaluation of the extra- and intracellular activity of clarithromycin against Mycobacterium chelonae]. | 1994 | Pathol. Biol. | pmid:7824305 |
| Rolinson GN | A clarithromycin sensitivity survey. | 1994 | J. Antimicrob. Chemother. | pmid:7829420 |
| Durodie J and Slocombe B | A clarithromycin sensitivity survey. | 1994 | J. Antimicrob. Chemother. | pmid:7829421 |
| Sano M et al. | [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]. | 1994 | Kansenshogaku Zasshi | pmid:7829898 |
| Sieber CC et al. | [Helicobacter pylori resistance against metronidazole in Switzerland: implications for eradication therapy?]. | 1994 | Schweiz Med Wochenschr | pmid:8091165 |
| Terashima T et al. | Pulmonary infection due to Mycobacterium xenopi. | 1994 | Intern. Med. | pmid:8000103 |
| Fish DN et al. | Penetration of clarithromycin into lung tissues from patients undergoing lung resection. | 1994 | Antimicrob. Agents Chemother. | pmid:8031063 |
| Bonnet E et al. | Clarithromycin: a potent agent against infections due to Mycobacterium marinum. | 1994 | Clin. Infect. Dis. | pmid:8038339 |
| Lemmen SW et al. | Bactericidal activity of clarithromycin and cefaclor against Streptococcus pneumoniae and Moraxella catarrhalis in healthy volunteers. | 1994 | J. Antimicrob. Chemother. | pmid:8040139 |
| Dautzenberg B et al. | [Treatment with clarithromycin of 173 HIV+ patients with disseminated Mycobacterium avium intracellulare infection]. | 1994 | Rev Mal Respir | pmid:8041990 |
| Ishida K et al. | In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. | 1994 | Antimicrob. Agents Chemother. | pmid:8031048 |
| al-Assi MT et al. | Clarithromycin, tetracycline, and bismuth: a new non-metronidazole therapy for Helicobacter pylori infection. | 1994 | Am. J. Gastroenterol. | pmid:8053435 |
| Guelar A et al. | [Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. | 1994 | Enferm. Infecc. Microbiol. Clin. | pmid:8011719 |
| Aspin MM et al. | Comparative study of the safety and efficacy of clarithromycin and amoxicillin-clavulanate in the treatment of acute otitis media in children. | 1994 | J. Pediatr. | pmid:8021763 |
| Chaisson RE et al. | Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. AIDS Clinical Trials Group Protocol 157 Study Team. | 1994 | Ann. Intern. Med. | pmid:7978715 |
| Goldberger M and Masur H | Clarithromycin therapy for Mycobacterium avium complex disease in patients with AIDS: potential and problems. | 1994 | Ann. Intern. Med. | pmid:7978725 |
| Thijs JC et al. | Short report: clarithromycin, an alternative to metronidazole in the triple therapy of Helicobacter pylori infection. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186339 |
| Gelber RH et al. | Minimal bactericidal concentration of clarithromycin against M. leprae. | 1994 | Int. J. Lepr. Other Mycobact. Dis. | pmid:8189083 |
| Xiong JH et al. | Further study of the effectiveness of single doses of clarithromycin and minocycline against Mycobacterium leprae in mice. | 1994 | Int. J. Lepr. Other Mycobact. Dis. | pmid:8189087 |
| Paffetti A et al. | [Clarithromycin in pediatric age. Personal experience]. | 1994 | Minerva Pediatr. | pmid:8084327 |
| Saran BR et al. | Hypopyon uveitis in patients with acquired immunodeficiency syndrome treated for systemic Mycobacterium avium complex infection with rifabutin. | 1994 | Arch. Ophthalmol. | pmid:8085960 |
| Ohgaki N | Bacterial biofilm in chronic airway infection. | 1994 | Kansenshogaku Zasshi | pmid:8138670 |
| Yew WW et al. | Cholestatic hepatitis in a patient who received clarithromycin therapy for a Mycobacterium chelonae lung infection. | 1994 | Clin. Infect. Dis. | pmid:8086541 |
| Yasuda H et al. | Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis. | 1994 | Antimicrob. Agents Chemother. | pmid:8141568 |
| Zahid MA et al. | Mycobacterium chelonae (M. chelonae subspecies chelonae): report of a patient with a sporotrichoid presentation who was successfully treated with clarithromycin and ciprofloxacin. | 1994 | Clin. Infect. Dis. | pmid:8086568 |
| Uveitis associated with rifabutin therapy. | 1994 | MMWR Morb. Mortal. Wkly. Rep. | pmid:8072478 | |
| Sano M et al. | [Adaptation study for biofilm of the urinary tract via highly complicated bladder model (biofilm model of the urinary tract)--experimental study using automatic simulator of the urinary antimicrobial agent concentration]. | 1994 | Kansenshogaku Zasshi | pmid:8089557 |
| AIDS patients have a new weapon against MAC infection. | 1994 | RN | pmid:8128150 | |
| Fujii K et al. | In vitro and in vivo antibacterial activities of KRM-1648 and KRM-1657, new rifamycin derivatives. | 1994 | Antimicrob. Agents Chemother. | pmid:8067748 |
| Honeybourne D et al. | The levels of clarithromycin and its 14-hydroxy metabolite in the lung. | 1994 | Eur. Respir. J. | pmid:7925906 |
| Gad A and Unge P | Antibacterial therapy of Helicobacter pylori-associated peptic ulcer disease: a new strategy. The Swedes go for it. | 1994 | J. Clin. Gastroenterol. | pmid:7930437 |
| Braegger CP and Nadal D | Clarithromycin and pseudomembranous enterocolitis. | 1994 | Lancet | pmid:7904702 |
| Nishimura M et al. | [Therapeutic study on biofilm of the urinary tract using a severely complicated bladder model (biofilm model of the urinary tract)--experimental study using an automatic simulator of urinary antimicrobial agent concentration, and clinical study]. | 1994 | Kansenshogaku Zasshi | pmid:7909830 |
| Morikawa K et al. | Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. | 1994 | Antimicrob. Agents Chemother. | pmid:7532933 |
| Labenz J | [Helicobacter pylori therapy with omeprazole and clarithromycin: current status]. | 1994 | Leber Magen Darm | pmid:7968179 |
| Oteo JA et al. | Clarithromycin-induced thrombocytopenic purpura. | 1994 | Clin. Infect. Dis. | pmid:7888564 |
| Goldman RC et al. | Tight binding of clarithromycin, its 14-(R)-hydroxy metabolite, and erythromycin to Helicobacter pylori ribosomes. | 1994 | Antimicrob. Agents Chemother. | pmid:7979278 |
| Lazard T et al. | Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages. | 1994 | Tuber. Lung Dis. | pmid:7949074 |
| Shafran SD et al. | Uveitis and pseudojaundice during a regimen of clarithromycin, rifabutin, and ethambutol. MAC Study Group of the Canadian HIV Trials Network. | 1994 | N. Engl. J. Med. | pmid:8284019 |
| Roblin PM et al. | Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia. | 1994 | Antimicrob. Agents Chemother. | pmid:7979292 |
| Inderlied CB et al. | Activities of the benzoxazinorifamycin KRM 1648 and ethambutol against Mycobacterium avium complex in vitro and in macrophages. | 1994 | Antimicrob. Agents Chemother. | pmid:7986017 |
| Bermudez LE et al. | Activity of KRM 1648 alone or in combination with ethambutol or clarithromycin against Mycobacterium avium in beige mouse model of disseminated infection. | 1994 | Antimicrob. Agents Chemother. | pmid:7986018 |
| Meier A et al. | Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare. | 1994 | Antimicrob. Agents Chemother. | pmid:8192472 |
| Labenz J et al. | [Omeprazole modified antibiotic therapy of Helicobacter pylori infection: can clarithromycin be replaced by roxithromycin?]. | 1994 | Leber Magen Darm | pmid:8196468 |
| Chan GP et al. | Clinical trial of clarithromycin for lepromatous leprosy. | 1994 | Antimicrob. Agents Chemother. | pmid:8203847 |
| Onyeji CO et al. | Efficacies of liposome-encapsulated clarithromycin and ofloxacin against Mycobacterium avium-M. intracellulare complex in human macrophages. | 1994 | Antimicrob. Agents Chemother. | pmid:8203849 |
| Wallace RJ et al. | Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8173775 |
| Husson RN et al. | Orally administered clarithromycin for the treatment of systemic Mycobacterium avium complex infection in children with acquired immunodeficiency syndrome. | 1994 | J. Pediatr. | pmid:8176574 |
| Bermudez LE et al. | Clarithromycin, dapsone, and a combination of both used to treat or prevent disseminated Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7695252 |
| Mor N et al. | Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium. | 1994 | Antimicrob. Agents Chemother. | pmid:7695255 |
| Calì G et al. | [Clarithromycin in the treatment of oral infections]. | 1994 | Minerva Stomatol | pmid:7700226 |
| Reed PI | The ECP-IM intervention study. | 1994 | Eur. J. Cancer Prev. | pmid:7735056 |
| Kodama R et al. | Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori. | 1994 | Eur J Gastroenterol Hepatol | pmid:7735929 |
| Klemens SP and Cynamon MH | Intermittent azithromycin for treatment of Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7986001 |
| Spangler SK et al. | Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. | 1994 | Antimicrob. Agents Chemother. | pmid:8192445 |
| Jones RN et al. | Validation of NCCLS macrolide (azithromycin, clarithromycin, and erythromycin) interpretive criteria for Haemophilus influenzae tested with the Haemophilus test medium. National Committee for Clinical Laboratory Standards. | 1994 | Diagn. Microbiol. Infect. Dis. | pmid:7924221 |
| Olliaro P et al. | In-vitro and in-vivo activity of rifabutin against Toxoplasma gondii. | 1994 | J. Antimicrob. Chemother. | pmid:7706160 |
| Wolinsky E | Mycobacterium avium strains resistant to clarithromycin and azithromycin. | 1994 | Antimicrob. Agents Chemother. | pmid:8031406 |
| Cynamon MH et al. | Comparative activities of azithromycin and clarithromycin against Mycobacterium avium infection in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7979270 |
| Klemens SP and Cynamon MH | Activities of azithromycin and clarithromycin against nontuberculous mycobacteria in beige mice. | 1994 | Antimicrob. Agents Chemother. | pmid:7979271 |
| Kanatani MS and Guglielmo BJ | The new macrolides. Azithromycin and clarithromycin. | 1994 | West. J. Med. | pmid:8128699 |
| Marco ML et al. | [Rhodococcus equi pneumonia in patients with AIDS]. | 1994 | Arch. Bronconeumol. | pmid:7827773 |
| Rapp RP et al. | New macrolide antibiotics: usefulness in infections caused by mycobacteria other than Mycobacterium tuberculosis. | 1994 | Ann Pharmacother | pmid:7849341 |
| Alder J et al. | Treatment of experimental Toxoplasma gondii infection by clarithromycin-based combination therapy with minocycline or pyrimethamine. | 1994 | J. Acquir. Immune Defic. Syndr. | pmid:7932081 |
| Ferrari SL et al. | The interaction between clarithromycin and cyclosporine in kidney transplant recipients. | 1994 | Transplantation | pmid:7940695 |
| Tomono K | [Therapeutic efficacy of macrolide in pulmonary nontuberculous mycobacteriosis]. | 1994 | Kekkaku | pmid:7837727 |
| Sanchez T et al. | Quantitation of mycobacteria in blood specimens from patients with AIDS. | 1994 | Tuber. Lung Dis. | pmid:7841433 |
| Sungur C | Acute rheumatic fever despite clarithromycin treatment of beta-hemolytic streptococcal tonsillitis. | 1994 | Ann Pharmacother | pmid:7841580 |
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| Verbist L and Dhoore F | In vitro susceptibility of recently isolated respiratory tract pathogens to minocycline and comparable antibiotics. A multicentre study. | 1994 | Acta Clin Belg | pmid:7871933 |
| Ji B et al. | Effectiveness of various antimicrobial agents against Mycobacterium avium complex in the beige mouse model. | 1994 | Antimicrob. Agents Chemother. | pmid:7872741 |
| Skinner PS et al. | A bone marrow-derived murine macrophage model for evaluating efficacy of antimycobacterial drugs under relevant physiological conditions. | 1994 | Antimicrob. Agents Chemother. | pmid:7872747 |
| Valero G et al. | Activities of clarithromycin, ofloxacin, and clarithromycin plus ethambutol against Mycobacterium simiae in murine model of disseminated infection. | 1994 | Antimicrob. Agents Chemother. | pmid:7872769 |
| Yamada S et al. | [A child with iritis due to Chlamydia pneumoniae infection]. | 1994 | Kansenshogaku Zasshi | pmid:7876679 |