clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Terashima T et al. | Pulmonary infection due to Mycobacterium xenopi. | 1994 | Intern. Med. | pmid:8000103 |
Fish DN et al. | Penetration of clarithromycin into lung tissues from patients undergoing lung resection. | 1994 | Antimicrob. Agents Chemother. | pmid:8031063 |
Shafran SD et al. | Uveitis and pseudojaundice during a regimen of clarithromycin, rifabutin, and ethambutol. MAC Study Group of the Canadian HIV Trials Network. | 1994 | N. Engl. J. Med. | pmid:8284019 |
Meier A et al. | Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare. | 1994 | Antimicrob. Agents Chemother. | pmid:8192472 |
Jones RN et al. | Validation of NCCLS macrolide (azithromycin, clarithromycin, and erythromycin) interpretive criteria for Haemophilus influenzae tested with the Haemophilus test medium. National Committee for Clinical Laboratory Standards. | 1994 | Diagn. Microbiol. Infect. Dis. | pmid:7924221 |
Olliaro P et al. | In-vitro and in-vivo activity of rifabutin against Toxoplasma gondii. | 1994 | J. Antimicrob. Chemother. | pmid:7706160 |
Kanatani MS and Guglielmo BJ | The new macrolides. Azithromycin and clarithromycin. | 1994 | West. J. Med. | pmid:8128699 |
Tomono K | [Therapeutic efficacy of macrolide in pulmonary nontuberculous mycobacteriosis]. | 1994 | Kekkaku | pmid:7837727 |
Sanchez T et al. | Quantitation of mycobacteria in blood specimens from patients with AIDS. | 1994 | Tuber. Lung Dis. | pmid:7841433 |
Sungur C | Acute rheumatic fever despite clarithromycin treatment of beta-hemolytic streptococcal tonsillitis. | 1994 | Ann Pharmacother | pmid:7841580 |
Maass M and Dalhoff K | [Isolation of Chlamydia pneumoniae in atypical pneumonia]. | 1994 | Dtsch. Med. Wochenschr. | pmid:7956770 |
Tessier MH et al. | Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. | 1994 Dec 24-31 | Lancet | pmid:7997032 |
Mor N et al. | Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. | 1994 Jan-Feb | Pharmacotherapy | pmid:8159593 |
Winter J | Intravenous clarithromycin. | 1994 Mar 16-Apr 5 | Br J Hosp Med | pmid:8032567 |
Gersema LM et al. | Suspected drug interaction between cyclosporine and clarithromycin. | 1994 Mar-Apr | J. Heart Lung Transplant. | pmid:8031821 |
Heifets LB | Quantitative cultures and drug susceptibility testing of Mycobacterium avium clinical isolates before and during the antimicrobial therapy. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809471 |
Dautzenberg B | Clinical trials in Mycobacterium avium therapy: lessons to take home. | 1994 Mar-Apr | Res. Microbiol. | pmid:7809472 |
Scaglione F et al. | Effect of antibiotics on Bordetella pertussis adhering activity: hypothesis regarding mechanism of action. | 1994 May-Jun | Chemotherapy | pmid:7515782 |
O'Connor NK and Fris J | Clarithromycin-carbamazepine interaction in a clinical setting. | 1994 Nov-Dec | J Am Board Fam Pract | pmid:7847111 |
Cama VA et al. | Treatment of acute and chronic Cryptosporidium parvum infections in mice using clarithromycin and 14-OH clarithromycin. | 1994 Sep-Oct | J. Eukaryot. Microbiol. | pmid:7804227 |
FDA approves Biaxin for MAC prophylaxis. Food and Drug Administration. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11363096 | |
Nash KA and Inderlied CB | Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease. | 1995 | Antimicrob. Agents Chemother. | pmid:8592991 |
Adamek RJ et al. | [Short-term triple therapy with pantoprazole, clarithromycin and metronidazole for the healing of Helicobacter pylori infection]. | 1995 | Dtsch. Med. Wochenschr. | pmid:7889816 |
Shimoyama T et al. | Eradication of Helicobacter pylori with lansoprazole and clarithromycin in gastric ulcer patients. | 1995 | J. Clin. Gastroenterol. | pmid:7594328 |
Fukuda Y et al. | Combination therapies with a proton pump inhibitor for Helicobacter pylori-infected gastric ulcer patients. | 1995 | J. Clin. Gastroenterol. | pmid:7594330 |
Xu G et al. | [Effect of clarithromycin on macrophage functions]. | 1995 | Kansenshogaku Zasshi | pmid:7594777 |
Gelber RH et al. | Activity of combinations of dapsone, rifampin, minocycline, clarithromycin, and sparfloxacin against M. leprae-infected mice. | 1995 | Int. J. Lepr. Other Mycobact. Dis. | pmid:7602221 |
Milde P et al. | Cutaneous bacillary angiomatosis in a patient with chronic lymphocytic leukemia. | 1995 | Arch Dermatol | pmid:7543264 |
Nightingale SD et al. | Clarithromycin-induced mania in two patients with AIDS. | 1995 | Clin. Infect. Dis. | pmid:7548513 |
Matsiota-Bernard P et al. | Mycobacterium genavense infection in a patient with AIDS who was successfully treated with clarithromycin. | 1995 | Clin. Infect. Dis. | pmid:7548515 |
Citron DM et al. | Activity of ampicillin/sulbactam, ticarcillin/clavulanate, clarithromycin, and eleven other antimicrobial agents against anaerobic bacteria isolated from infections in children. | 1995 | Clin. Infect. Dis. | pmid:7548597 |
Ishii K et al. | A new pharmacokinetic model including in vivo dissolution and gastrointestinal transit parameters. | 1995 | Biol. Pharm. Bull. | pmid:7550125 |
Ellis LC et al. | Postantibiotic effect of clarithromycin alone and combined with ethambutol against Mycobacterium avium complex. | 1995 | Antimicrob. Agents Chemother. | pmid:8593025 |
Truffot-Pernot C et al. | Clarithromycin is inactive against Mycobacterium tuberculosis. | 1995 | Antimicrob. Agents Chemother. | pmid:8593032 |
Schütze K and Hentschel E | Duodenal ulcer healing after 7-day treatment: a pilot study with lansoprazole, amoxicillin and clarithromycin. | 1995 | Z Gastroenterol | pmid:8600661 |
Tseng AL and Walmsley SL | Rifabutin-associated uveitis. | 1995 | Ann Pharmacother | pmid:8573961 |
Moayyedi P et al. | Efficacy and optimum dose of omeprazole in a new 1-week triple therapy regimen to eradicate Helicobacter pylori. | 1995 | Eur J Gastroenterol Hepatol | pmid:8574714 |
Parasakthi N and Goh KL | Primary and acquired resistance to clarithromycin among Helicobacter pylori strains in Malaysia. | 1995 | Am. J. Gastroenterol. | pmid:7872306 |
Kadayifçi A et al. | Low dose clarithromycin plus omeprazole eradicates Helicobacter pylori in duodenal ulcer disease. | 1995 | Am. J. Gastroenterol. | pmid:7872307 |
Wallace RJ et al. | Reduced serum levels of clarithromycin in patients treated with multidrug regimens including rifampin or rifabutin for Mycobacterium avium-M. intracellulare infection. | 1995 | J. Infect. Dis. | pmid:7876634 |
Moorthy RS and Rao NA | Atypical mycobacterial wound infection after blepharoplasty. | 1995 | Br J Ophthalmol | pmid:7880802 |
Yoshizawa A et al. | [Legionella pneumonia diagnosed by urinary antigen detection]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:7791279 |
Cheng B | Preventing opportunistic infections. | 1995 | PI Perspect | pmid:11362422 |
Abbott files SNDA for MAC prophylaxis. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362606 | |
Pierce M | Another perspective on MAC prophylaxis. Interview by Gordon Nary. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362746 |
Archange YR et al. | Clarithromycin prophylaxis against disseminated Mycobacterium avium complex in patients with AIDS. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362747 |
Physician's aggressive preventive therapy differs. | 1995 | AIDS Alert | pmid:11362774 | |
New drug applications sought. | 1995 | AIDS Alert | pmid:11362777 | |
Smart T | Cryptosporidiosis at ICAAC. | 1995 | GMHC Treat Issues | pmid:11362913 |
Researchers find new drugs to fight MAC. | 1995 | AIDS Alert | pmid:11362925 |