| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lutgen N et al. | [Prevalence and treatment of Helicobacter pylori in gastro-duodenal ulcers. An experience in Liege]. | 2001 | Rev Med Liege | pmid:11256133 |
| Khor CJ et al. | Recurrence of Helicobacter pylori infection and duodenal ulcer relapse, following successful eradication in an urban east Asian population. | 2000 | Singapore Med J | pmid:11256345 |
| Casal M and Casal MM | Multicenter study of incidence of Mycobacterium marinum in humans in Spain. | 2001 | Int. J. Tuberc. Lung Dis. | pmid:11258515 |
| Hamamoto Y et al. | Fixed drug eruption due to clarithromycin. | 2001 | Clin. Exp. Dermatol. | pmid:11260179 |
| Jang HS et al. | Six cases of confluent and reticulated papillomatosis alleviated by various antibiotics. | 2001 | J. Am. Acad. Dermatol. | pmid:11260541 |
| Peña JA et al. | Molecular resistance testing of Helicobacter pylori in gastric biopsies. | 2001 | Arch. Pathol. Lab. Med. | pmid:11260622 |
| Schaumann R et al. | Pericarditis after allogeneic peripheral blood stem cell transplantation caused by Legionella pneumophila (non-serogroup 1). | 2001 Jan-Feb | Infection | pmid:11261761 |
| Schulz S et al. | Molecular diagnosis of a Mycobacterium chelonae infection. | 2001 | Pathol. Res. Pract. | pmid:11261816 |
| Endo H et al. | Effects of lansoprazole, clarithromycin and pH gradient on uptake of [14C]amoxycillin into rat gastric tissue. | 2001 | J. Antimicrob. Chemother. | pmid:11266411 |
| Kim JJ et al. | Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea. | 2001 | J. Antimicrob. Chemother. | pmid:11266421 |
| Wexler HM et al. | In vitro activity of telithromycin (HMR 3647) against 502 strains of anaerobic bacteria. | 2001 | J. Antimicrob. Chemother. | pmid:11266423 |
| Olivier D | [HIV: a guide on management of seropositive patients]. | 2001 | Presse Med | pmid:11268903 |
| Dogukan A et al. | Acute fatal colchicine intoxication in a patient on continuous ambulatory peritoneal dialysis (CAPD). Possible role of clarithromycin administration. | 2001 | Clin. Nephrol. | pmid:11269688 |
| Rathi P et al. | Comparison of two regimens on eradication of Helicobacter pylori. | 2000 | J Assoc Physicians India | pmid:11273492 |
| Fock KM et al. | A randomised trial of amoxycillin versus clarithromycin in combination with omeprazole for eradication of Helicobacter pylori infection in Singapore. | 2000 | Singapore Med J | pmid:11281438 |
| Ioannidou S et al. | Antibiotic resistance rates and macrolide resistance phenotypes of viridans group streptococci from the oropharynx of healthy Greek children. | 2001 | Int. J. Antimicrob. Agents | pmid:11282264 |
| Chisholm SA et al. | PCR-based diagnosis of Helicobacter pylori infection and real-time determination of clarithromycin resistance directly from human gastric biopsy samples. | 2001 | J. Clin. Microbiol. | pmid:11283030 |
| Broutet N et al. | cagA Status and eradication treatment outcome of anti-Helicobacter pylori triple therapies in patients with nonulcer dyspepsia. | 2001 | J. Clin. Microbiol. | pmid:11283049 |
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| Shuster J | Clarithromycin and CNS disturbances. | 2001 | Nursing | pmid:11288564 |
| Zwolińska-Wcisło M and Palka M | [Principles of managing Helicobacter pylori infections. Guidelines of the European Society of Gastroenterology in Primary Health Care]. | 2000 | Prz. Lek. | pmid:11293204 |
| Jeen YT et al. | Differentiation between reinfection and recrudescence of helicobacter pylori strains using PCR-based restriction fragment length polymorphism analysis. | 2001 | Yonsei Med. J. | pmid:11293500 |
| Ashitani J et al. | Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection. | 2001 | Chest | pmid:11296180 |
| Karia N and Aylward GW | Postoperative proprionibacterium acnes endophthalmitis. | 2001 | Ophthalmology | pmid:11297461 |
| Bhagat N et al. | Rifabutin-associated hypopyon uveitis in human immunodeficiency virus-negative immunocompetent individuals. | 2001 | Ophthalmology | pmid:11297492 |
| Blokh I et al. | A rare case of osteomyelitis of the sternum in an adult with sickle cell disease. | 2001 | Hemoglobin | pmid:11300345 |
| van Doorn LJ et al. | Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene: multicenter validation study. | 2001 | Antimicrob. Agents Chemother. | pmid:11302817 |
| Piccolomini R et al. | In vitro activity of clarithromycin against intracellular Helicobacter pylori. | 2001 | Antimicrob. Agents Chemother. | pmid:11302831 |
| Avidan B et al. | The effect of culture results for Helicobacter pylori on the choice of treatment following failure of initial eradication. | 2001 | Isr. Med. Assoc. J. | pmid:11303370 |
| Lombardi A et al. | Antimicrobial activity of thiamphenicol-glycinate-acetylcysteinate and other drugs against Chlamydia pneumoniae. | 2001 | Arzneimittelforschung | pmid:11304944 |
| Bochud PY et al. | Breakthrough Streptococcus pneumoniae meningitis during clarithromycin therapy for acute otitis media. | 2001 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:11305469 |
| Braga PC et al. | Bacterial adhesiveness: effects of the SH metabolite of erdosteine (mucoactive drug) plus clarithromycin versus clarithromycin alone. | 2001 May-Jun | Chemotherapy | pmid:11306790 |
| Maraki S et al. | Prospective evaluation of the impact of amoxicillin, clarithromycin and their combination on human gastrointestinal colonization by Candida species. | 2001 May-Jun | Chemotherapy | pmid:11306791 |
| Fukuda Y et al. | [The history of Helicobacter pylori]. | 2001 | Rinsho Byori | pmid:11307300 |
| Kodama M and Fujioka T | [Eradication therapy of Helicobacter pylori infection]. | 2001 | Rinsho Byori | pmid:11307304 |
| Karrow NA et al. | Evaluation of the immunomodulatory effects of the macrolide antibiotic, clarithromycin, in female B6C3F1 mice: a 28-day oral gavage study. | 2001 | Drug Chem Toxicol | pmid:11307632 |
| Melo-Cristino J et al. | A multicenter study of the antimicrobial susceptibility of Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis isolated from patients with community-acquired lower respiratory tract infections in 1999 in Portugal. | 2001 | Microb. Drug Resist. | pmid:11310801 |
| Street ME et al. | Antibiotic resistance and antibiotic sensitivity based treatment in Helicobacter pylori infection: advantages and outcome. | 2001 | Arch. Dis. Child. | pmid:11316688 |
| Kurowski K et al. | Clarithromycin-induced alterations in vaginal flora. | 2000 | Am J Ther | pmid:11317173 |
| Songné B et al. | [Buruli ulcer in Togo: 21 cases]. | 2001 | Presse Med | pmid:11317927 |
| Kays MB and Denys GA | In vitro activity and pharmacodynamics of azithromycin and clarithromycin against Streptococcus pneumoniae based on serum and intrapulmonary pharmacokinetics. | 2001 | Clin Ther | pmid:11318076 |
| Ferrara A et al. | Effect of some fractions of alveolar surfactant (phospholipids and SP-A) on the bactericidal activity of different antimicrobials against some respiratory pathogens. | 2001 | Clin. Microbiol. Infect. | pmid:11318808 |
| Domergue Thân Trong E et al. | [Mycobacterium kansasii skin infection at insulin injection sites]. | 2001 | Ann Dermatol Venereol | pmid:11319391 |
| Jokinen MJ et al. | Effect of clarithromycin and itraconazole on the pharmacokinetics of ropivacaine. | 2001 | Pharmacol. Toxicol. | pmid:11322176 |
| Zhanel GG et al. | Review of macrolides and ketolides: focus on respiratory tract infections. | 2001 | Drugs | pmid:11324679 |
| Perry CM and Jarvis B | Linezolid: a review of its use in the management of serious gram-positive infections. | 2001 | Drugs | pmid:11324682 |
| Ryan KA et al. | Evaluation of clarithromycin resistance and cagA and vacA genotyping of Helicobacter pylori strains from the west of Ireland using line probe assays. | 2001 | J. Clin. Microbiol. | pmid:11326028 |
| Janssen MJ et al. | A systematic comparison of triple therapies for treatment of Helicobacter pylori infection with proton pump inhibitor/ ranitidine bismuth citrate plus clarithromycin and either amoxicillin or a nitroimidazole. | 2001 | Aliment. Pharmacol. Ther. | pmid:11328254 |
| Tankovic J et al. | Impact of Helicobacter pylori resistance to clarithromycin on the efficacy of the omeprazole-amoxicillin-clarithromycin therapy. | 2001 | Aliment. Pharmacol. Ther. | pmid:11328266 |
| Shiotani A et al. | Beneficial effect of Helicobacter pylori eradication in dermatologic diseases. | 2001 | Helicobacter | pmid:11328367 |
| Simala-Grant JL et al. | Antibiotic susceptibility of attached and free-floating Helicobacter pylori. | 2001 | J. Antimicrob. Chemother. | pmid:11328765 |
| Martin SJ et al. | The activity of 14-hydroxy clarithromycin, alone and in combination with clarithromycin, against penicillin- and erythromycin-resistant Streptococcus pneumoniae. | 2001 | J. Antimicrob. Chemother. | pmid:11328768 |
| Warburton-Timms VJ and McNulty CA | Role of screening agar plates for in vitro susceptibility testing of Helicobacter pylori in a routine laboratory setting. | 2001 | J. Clin. Pathol. | pmid:11328845 |
| Baffone W et al. | Studies on the development and stability of resistance of Helicobacter pylori to metronidazole and clarithromycin. | 2001 | J Chemother | pmid:11330358 |
| Eltahawy AT | Antimicrobial resistance of Streptococcus pneumoniae at a university hospital in Saudi Arabia. | 2001 | J Chemother | pmid:11330361 |
| Lin Z et al. | Prevalence of gastric myoelectrical abnormalities in patients with nonulcer dyspepsia and H. pylori infection: resolution after H. pylori eradication. | 2001 | Dig. Dis. Sci. | pmid:11330406 |
| Matsuoka M et al. | A Mycobacterium leprae isolate resistant to dapsone, rifampin, ofloxacin and sparfloxacin. | 2000 | Int. J. Lepr. Other Mycobact. Dis. | pmid:11332288 |
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| Stein GE and Schooley S | Comparative serum bactericidal activity of clarithromycin and azithromycin against macrolide-sensitive and resistant strains of Streptococcus pneumoniae. | 2001 | Diagn. Microbiol. Infect. Dis. | pmid:11337186 |
| Alou L et al. | Evaluation of two in vitro pharmacodynamic simulation models: microfiltration versus centrifugation-filtration. | 2001 | Int. J. Antimicrob. Agents | pmid:11337222 |
| Ferrara A et al. | Effect of different antibacterial agents and surfactant protein-A (SP-A) on adherence of some respiratory pathogens to bronchial epithelial cells. | 2001 | Int. J. Antimicrob. Agents | pmid:11337228 |
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| Drinkard CR et al. | Postmarketing surveillance of medications and pregnancy outcomes: clarithromycin and birth malformations. | 2000 | Pharmacoepidemiol Drug Saf | pmid:11338912 |
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| Currier JS et al. | Impact of prophylaxis for Mycobacterium avium complex on bacterial infections in patients with advanced human immunodeficiency virus disease. | 2001 | Clin. Infect. Dis. | pmid:11340534 |
| Osato MS et al. | Pattern of primary resistance of Helicobacter pylori to metronidazole or clarithromycin in the United States. | 2001 | Arch. Intern. Med. | pmid:11343444 |
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| Neville PM et al. | Randomised study of the efficacy of omeprazole and clarithromycin with either amoxycillin or metronidazole in the eradication of Helicobacter pylori in screened primary care patients. | 2001 | Dig Liver Dis | pmid:11346140 |
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| Dresser LD et al. | Cost-effectiveness of gatifloxacin vs ceftriaxone with a macrolide for the treatment of community-acquired pneumonia. | 2001 | Chest | pmid:11348951 |
| Akritopoulou-Zanze I and Sowin TJ | Solid-phase synthesis of macrolide analogues. | 2001 May-Jun | J Comb Chem | pmid:11350254 |
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| Nash KA | Effect of drug concentration on emergence of macrolide resistance in Mycobacterium avium. | 2001 | Antimicrob. Agents Chemother. | pmid:11353601 |
| Guay DR et al. | Pharmacokinetics and tolerability of extended-release clarithromycin. | 2001 | Clin Ther | pmid:11354390 |
| Adam D et al. | Comparative efficacy of clarithromycin modified-release and clarithromycin immediate-release formulations in the treatment of lower respiratory tract infection. | 2001 | Clin Ther | pmid:11354392 |
| Capella GL et al. | A randomized trial of leukotriene receptor antagonist montelukast in moderate-to-severe atopic dermatitis of adults. | 2001 May-Jun | Eur J Dermatol | pmid:11358726 |
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| Clarithromycin for MAC. | 1995 | AIDS Patient Care | pmid:11361361 | |
| NIAID study rules out high-dose clarithromycin for AIDS-related MAC. | 1996 | AIDS Patient Care STDS | pmid:11361534 | |
| New data suggest antibiotic clarithromycin is effective in prolonging life of AIDS patients. | 1996 | AIDS Patient Care STDS | pmid:11361575 | |
| Clarithromycin and MAC. | 1996 | AIDS Patient Care STDS | pmid:11361673 | |
| Different clarithromycin doses affect mortality. | 1997 | AIDS Patient Care STDS | pmid:11361754 | |
| Cheng B | Preventing opportunistic infections. | 1995 | PI Perspect | pmid:11362422 |
| Abbott files SNDA for MAC prophylaxis. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362606 | |
| Pierce M | Another perspective on MAC prophylaxis. Interview by Gordon Nary. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362746 |
| Archange YR et al. | Clarithromycin prophylaxis against disseminated Mycobacterium avium complex in patients with AIDS. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11362747 |
| Physician's aggressive preventive therapy differs. | 1995 | AIDS Alert | pmid:11362774 | |
| New drug applications sought. | 1995 | AIDS Alert | pmid:11362777 | |
| Smart T | Cryptosporidiosis at ICAAC. | 1995 | GMHC Treat Issues | pmid:11362913 |
| Researchers find new drugs to fight MAC. | 1995 | AIDS Alert | pmid:11362925 | |
| FDA approves Biaxin for MAC prophylaxis. Food and Drug Administration. | 1995 | J Int Assoc Physicians AIDS Care | pmid:11363096 | |
| Prescott LM | Clarithromycin for MAC prevention offers additional benefits. | 1996 May-Jun | Posit Aware | pmid:11363431 |
| Young A | Hold the big MAC. | 1996 | Notes Undergr | pmid:11363450 |
| High-dose clarithromycin should be avoided. | 1996 | AIDS Alert | pmid:11363723 | |
| Pot shots. | 1996 | Notes Undergr | pmid:11363915 | |
| Bowersox J | CPCRA researchers present OI studies at Vancouver. | 1996 | NIAID AIDS Agenda | pmid:11363924 |
| MAC management. | 1996 | PI Perspect | pmid:11363967 |