clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Stomach Ulcer D013276 75 associated lipids
Hyperlipidemias D006949 73 associated lipids
Colitis D003092 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Pain D010146 64 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Psoriasis D011565 47 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Tracy TS and Johns M Comment: delirium probably induced by clarithromycin in a patient receiving fluoxetine. 1996 Ann Pharmacother pmid:8893135
Wintermeyer SM et al. Dirithromycin: a new macrolide. 1996 Ann Pharmacother pmid:8893122
Hunt Gerardo S et al. Comparison of Etest to broth microdilution method for testing Streptococcus pneumoniae susceptibility to levofloxacin and three macrolides. 1996 Antimicrob. Agents Chemother. pmid:8891154
Patel KB et al. Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891147
Tateda K et al. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891128
Giacometti A et al. In-vitro activity of macrolides alone and in combination with artemisin, atovaquone, dapsone, minocycline or pyrimethamine against Cryptosporidium parvum. 1996 J. Antimicrob. Chemother. pmid:8889715
Tursi A et al. One-week low-dose triple therapy vs. two-week medium-dose double therapy for H.pylori infection. 1996 Jul-Aug Hepatogastroenterology pmid:8884304
Ji B et al. Bactericidal activity of single dose of clarithromycin plus minocycline, with or without ofloxacin, against Mycobacterium leprae in patients. 1996 Antimicrob. Agents Chemother. pmid:8878595
Pankuch GA et al. MIC and time-kill study of antipneumococcal activities of RPR 106972 (a new oral streptogramin), RP 59500 (quinupristin-dalfopristin), pyostacine (RP 7293), penicillin G, cefotaxime, erythromycin, and clarithromycin against 10 penicillin-susceptible and -resistant pneumococci. 1996 Antimicrob. Agents Chemother. pmid:8878583
Wenisch C et al. Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. 1996 Antimicrob. Agents Chemother. pmid:8878577
McLinn S and Williams D Incidence of antibiotic-resistant Streptococcus pneumoniae and beta-lactamase-positive Haemophilus influenzae in clinical isolates from patients with otitis media. 1996 Pediatr. Infect. Dis. J. pmid:8878239
Thor P et al. Dysfunction in gastric myoelectric and motor activity in Helicobacter pylori positive gastritis patients with non-ulcer dyspesia. 1996 J. Physiol. Pharmacol. pmid:8877902
Tursi A et al. Helicobacter pylori eradication helps resolve pyloric and duodenal stenosis. 1996 J. Clin. Gastroenterol. pmid:8877648
Dhaenens L et al. In-vitro activities of clarithromycin and other antimicrobial agents against Helicobacter pylori isolated from children. 1996 J. Antimicrob. Chemother. pmid:8877551
Fisher M et al. The management of mycobacterial infections in HIV seropositive individuals. Jefferiss Wing Therapeutics and Protocols Group. 1996 Int J STD AIDS pmid:8876354
Yousfi MM et al. Metronidazole, ranitidine and clarithromycin combination for treatment of Helicobacter pylori infection (modified Bazzoli's triple therapy). 1996 Aliment. Pharmacol. Ther. pmid:8871452
Ferguson PJ and Saulsbury FT Successful treatment of chronic Mycobacterium abscessus otitis media with clarithromycin. 1996 Pediatr. Infect. Dis. J. pmid:8866816
Xu G et al. Effect of macrolide antibiotics on macrophage functions. 1996 Microbiol. Immunol. pmid:8865152
Hackelsberger A and Malfertheiner P A risk-benefit assessment of drugs used in the eradication of Helicobacter pylori infection. 1996 Drug Saf pmid:8862962
Chiba N Omeprazole and clarithromycin with and without metronidazole for the eradication of Helicobacter pylori. 1996 Am. J. Gastroenterol. pmid:8855737
Schimkat M et al. Rifabutin-associated anterior uveitis in patients infected with human immunodeficiency virus. 1996 Ger J Ophthalmol pmid:8854102
Yousfi MM et al. One-week triple therapy with omeprazole, amoxycillin and clarithromycin for treatment of Helicobacter pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8853767
Cone LA et al. Mania due to clarithromycin therapy in a patient who was not infected with human immunodeficiency virus. 1996 Clin. Infect. Dis. pmid:8853002
Dammann HG [Helicobacter pylori eradication: triple therapy versus dual therapy]. 1996 Fortschr. Med. pmid:8852685
Vermot D et al. Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis. 1996 Antimicrob. Agents Chemother. pmid:8851620
Amsden GW Erythromycin, clarithromycin, and azithromycin: are the differences real? 1996 Jan-Feb Clin Ther pmid:8851453
O'Hara K and Yamamoto K Reaction of roxithromycin and clarithromycin with macrolide-inactivating enzymes from highly erythromycin-resistant Escherichia coli. 1996 Antimicrob. Agents Chemother. pmid:8849224
Liviu L et al. Pancreatitis induced by clarithromycin. 1996 Ann. Intern. Med. pmid:8849171
Ednie LM et al. Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci. 1996 Antimicrob. Agents Chemother. pmid:8843313
Rana KZ et al. Clarithromycin does not affect phosphorylation of zidovudine in vitro. 1996 Antimicrob. Agents Chemother. pmid:8843311
Alper CM et al. Efficacy of clarithromycin treatment of acute otitis media caused by infection with penicillin-susceptible, -intermediate, and -resistant Streptococcus pneumoniae in the chinchilla. 1996 Antimicrob. Agents Chemother. pmid:8843299
Heifets L Susceptibility testing of Mycobacterium avium complex isolates. 1996 Antimicrob. Agents Chemother. pmid:8843278
Yousfi MM et al. Resolution of a metaplastic duodenal polyp after cure of Helicobacter pylori infection. 1996 J. Clin. Gastroenterol. pmid:8835902
Versalovic J et al. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. 1996 Antimicrob. Agents Chemother. pmid:8834903
Dattwyler RJ et al. Clarithromycin in treatment of early Lyme disease: a pilot study. 1996 Antimicrob. Agents Chemother. pmid:8834900
Ji B et al. How effective is KRM-1648 in treatment of disseminated Mycobacterium avium complex infections in beige mice? 1996 Antimicrob. Agents Chemother. pmid:8834894
Yamamoto T et al. Activity of KRM-1648 alone or in combination with both ethambutol and kanamycin or clarithromycin against Mycobacterium intracellulare infections in beige mice. 1996 Antimicrob. Agents Chemother. pmid:8834892
Ji B et al. Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice. 1996 Antimicrob. Agents Chemother. pmid:8834886
Vangala R and Cernek PK Hypersensitivity reaction to clarithromycin. 1996 Ann Pharmacother pmid:8833572
Erah PO et al. Ion-pair high-performance liquid chromatographic assay method for the assessment of clarithromycin stability in aqueous solution and in gastric juice. 1996 J. Chromatogr. B, Biomed. Appl. pmid:8832427
Piersimoni C et al. Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of Mycobacterium avium complex. 1995 J. Antimicrob. Chemother. pmid:8830013
Webb DD Practice guidelines for treatment of peptic ulcer disease. 1996 JAMA pmid:8827959
Pijpers E et al. A clarithromycin-induced myasthenic syndrome. 1996 Clin. Infect. Dis. pmid:8824993
Xu G et al. [Effect of clarithromycin on cytocidal activity against Pseudomonas aeruginosa in mice peritoneal cavity]. 1996 Kansenshogaku Zasshi pmid:8822058
Nishi K et al. [Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome]. 1995 Nihon Kyobu Shikkan Gakkai Zasshi pmid:8821993
Sketris IS et al. Possible role of the intestinal P-450 enzyme system in a cyclosporine-clarithromycin interaction. 1996 Mar-Apr Pharmacotherapy pmid:8820476
Nash KA and Inderlied CB Rapid detection of mutations associated with macrolide resistance in Mycobacterium avium complex. 1996 Antimicrob. Agents Chemother. pmid:8807078
Gillum JG et al. Effect of combination therapy with ciprofloxacin and clarithromycin on theophylline pharmacokinetics in healthy volunteers. 1996 Antimicrob. Agents Chemother. pmid:8807068
Wallace RJ et al. Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. 1996 Antimicrob. Agents Chemother. pmid:8807061
Conte JE et al. Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects. 1996 Antimicrob. Agents Chemother. pmid:8807050
Goh KL et al. Helicobacter pylori eradication with short-term therapy leads to duodenal ulcer healing without the need for continued acid suppression therapy. 1996 Eur J Gastroenterol Hepatol pmid:8804868
Papp J et al. Efficacy of nizatidine, clarithromycin and bismuth subcitrate therapy for Helicobacter pylori eradication in duodenal ulcer patients--a preliminary report. 1996 Jul-Aug Br J Clin Pract pmid:8794601
Tursi A et al. Low-dose omeprazole plus clarithromycin and either tinidazole or amoxycillin for Helicobacter pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8791952
Weldon MJ et al. A seven-day Helicobacter pylori treatment regimen using clarithromycin, omeprazole and tripotassium dicitrato bismuthate. 1996 Aliment. Pharmacol. Ther. pmid:8791951
Jaup BH and Norrby A Comparison of two low-dose one-week triple therapy regimens with and without metronidazole for cure of H. pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8791950
Delchier JC et al. Omeprazole-amoxycillin versus omeprazole-amoxycillin-clarithromycin in the eradication of Helicobacter pylori. 1996 Aliment. Pharmacol. Ther. pmid:8791948
Peterson WL et al. Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence. RBC H. pylori Study Group. 1996 Aliment. Pharmacol. Ther. pmid:8791947
Gross U and Pohl F Influence of antimicrobial agents on replication and stage conversion of Toxoplasma gondii. 1996 Curr. Top. Microbiol. Immunol. pmid:8791704
Mehaffey PC et al. Evaluation of in vitro spectra of activity of azithromycin, clarithromycin, and erythromycin tested against strains of Neisseria gonorrhoeae by reference agar dilution, disk diffusion, and Etest methods. 1996 J. Clin. Microbiol. pmid:8789046
Welsh L et al. In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. 1996 Antimicrob. Agents Chemother. pmid:8787907
Reid R et al. Pneumococcal meningitis during therapy of otitis media with clarithromycin. 1995 Pediatr. Infect. Dis. J. pmid:8786899
Bagarazzi ML et al. Pulmonary Mycobacterium gordonae infection in a two-year-old child: case report. 1996 Clin. Infect. Dis. pmid:8783736
Plemmons RM et al. Otitis media and mastoiditis due to Mycobacterium fortuitum: case report, review of four cases, and a cautionary note. 1996 Clin. Infect. Dis. pmid:8783722
Apseloff G et al. Severe neutropenia caused by recommended prophylactic doses of rifabutin. 1996 Lancet pmid:8782773
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Deltenre M et al. Strategies for Helicobacter pylori eradication in 1995: a review of international and Belgian experience. 1996 J. Physiol. Pharmacol. pmid:8777308
Gabryelewicz A Critical evaluation of the treatment of peptic ulcer diseases associated with Helicobacter pylori infection. 1996 J. Physiol. Pharmacol. pmid:8777307
Sito E et al. One week treatment with omeprazole, clarithromycin and tinidazole or lansoprazole, amoxicillin and metronidazole for cure of Helicobacter pylori infection in duodenal ulcer patients. 1996 J. Physiol. Pharmacol. pmid:8777303
Berger C et al. Treatment of nontuberculous mycobacterial lymphadenitis with clarithromycin plus rifabutin. 1996 J. Pediatr. pmid:8774511
Jordan WC Clarithromycin prophylaxis against Cryptosporidium enteritis in patients with AIDS. 1996 J Natl Med Assoc pmid:8764523
Géhanno P et al. [Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults]. 1996 Pathol. Biol. pmid:8763594
Sander P et al. Ribosomal drug resistance in mycobacteria. 1996 Jan-Feb Res. Microbiol. pmid:8761724
Debets-Ossenkopp YJ et al. Mechanism of clarithromycin resistance in clinical isolates of Helicobacter pylori. 1996 FEMS Microbiol. Lett. pmid:8759787
Tursi A et al. Short-term low-dose triple therapy with lansoprazole plus amoxycillin and clarithromycin for Helicobacter pylori eradication. 1996 Am. J. Gastroenterol. pmid:8759696
Santander C et al. Antimicrobial therapy for Helicobacter pylori infection versus long-term maintenance antisecretion treatment in the prevention of recurrent hemorrhage from peptic ulcer: prospective nonrandomized trial on 125 patients. 1996 Am. J. Gastroenterol. pmid:8759659
Sternon J et al. Azithromycin compared with clarithromycin in the treatment of adult patients with acute purulent tracheobronchitis: a cost of illness study. 1995 Nov-Dec J. Int. Med. Res. pmid:8746608
Markham A and McTavish D Clarithromycin and omeprazole as helicobacter pylori eradication therapy in patients with H. pylori-associated gastric disorders. 1996 Drugs pmid:8741237
Akamatsu H et al. Enhanced effect of clarithromycin on neutrophil function in vitro. 1996 Mar-Apr J. Int. Med. Res. pmid:8737228
Lebrun L et al. Evaluation of the Etest for rapid susceptibility testing of Mycobacterium avium to clarithromycin. 1996 J. Antimicrob. Chemother. pmid:8737150
Koga T et al. In-vitro and in-vivo antibacterial activity of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori. 1996 J. Antimicrob. Chemother. pmid:8737142
Cayla R [How to eradicate Helicobacter pylori?]. 1996 Gastroenterol. Clin. Biol. pmid:8734380
Deltenre M et al. [How to eradicate Helicobacter pylori in 1995? Critical review of available treatments]. 1996 Gastroenterol. Clin. Biol. pmid:8734370
Heifets LB Clarithromycin against Mycobacterium avium complex infections. 1996 Tuber. Lung Dis. pmid:8733409
Bachelez H et al. Disseminated varioliform pustular eruption due to Mycobacterium avium intracellulare in an HIV-infected patient. 1996 Br. J. Dermatol. pmid:8733397
Labenz J et al. One-week triple therapy with omeprazole, amoxycillin and either clarithromycin or metronidazole for cure of Helicobacter pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8730252
Dalla Libera M et al. High effectiveness and safety of one-week antibiotic regimen in Helicobacter pylori eradication. 1996 Aliment. Pharmacol. Ther. pmid:8730251
Gillum JG et al. Effect of clarithromycin on the pharmacokinetics of 2',3'-dideoxyinosine in patients who are seropositive for human immunodeficiency virus. 1996 Clin. Infect. Dis. pmid:8729217
Darouiche RO et al. Recurrent disseminated infection with Mycobacterium avium complex identified in tissues by molecular analysis. 1996 Clin. Infect. Dis. pmid:8729215
Vasquez A et al. Metronidazole and clarithromycin resistance in Helicobacter pylori determined by measuring MICs of antimicrobial agents in color indicator egg yolk agar in a miniwell format. The Gastrointestinal Physiology Working Group of Universidad Peruana Cayetano Heredia and the Johns Hopkins University. 1996 J. Clin. Microbiol. pmid:8727909
Mertl SL The role of clarithromycin in the prophylaxis of disseminated Mycobacterium avium-intracellulare infection in patients with AIDS. 1996 May-Jun Pharmacotherapy pmid:8726597
Arain TM et al. Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery. 1996 Antimicrob. Agents Chemother. pmid:8726034
Morikawa K et al. Modulatory effect of antibiotics on cytokine production by human monocytes in vitro. 1996 Antimicrob. Agents Chemother. pmid:8726002
H. pylori treatment recognized by FDA. 1996 Am J Health Syst Pharm pmid:8725200
Barry AL et al. Reassessment of methods for testing the susceptibility of Haemophilus influenzae to clarithromycin. 1996 J. Antimicrob. Chemother. pmid:8722555
Goddard AF and Logan RP Antimicrobial resistance and Helicobacter pylori. 1996 J. Antimicrob. Chemother. pmid:8722530
Bazzoli F Italian omeprazole triple therapy--a 1-week regimen. 1996 Scand. J. Gastroenterol. Suppl. pmid:8722395
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Lowe SH et al. Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol. 1996 Neth J Med pmid:8710040
Araki J et al. [A case of Mounier-Kuhn syndrome]. 1996 Nippon Naika Gakkai Zasshi pmid:8708483
Meier A et al. Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population. 1996 J. Infect. Dis. pmid:8699066