clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

Cross Reference

Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Abnormalities, Drug-Induced D000014 10 associated lipids
Abortion, Spontaneous D000022 12 associated lipids
Abscess D000038 13 associated lipids
Achlorhydria D000126 1 associated lipids
Actinomycetales Infections D000193 4 associated lipids
Adenocarcinoma D000230 166 associated lipids
Angina Pectoris D000787 27 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Infectious D001170 8 associated lipids
Bacterial Infections D001424 21 associated lipids
Bacteriuria D001437 7 associated lipids
Barrett Esophagus D001471 3 associated lipids
Bartonella Infections D001474 3 associated lipids
Body Weight D001835 333 associated lipids
Boutonneuse Fever D001907 5 associated lipids
Bradycardia D001919 13 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bronchiectasis D001987 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Per page 10 20 50 100 | Total 7636
Authors Title Published Journal PubMed Link
Mosdósi B et al. Severe acrocyanosis precipitated by cold agglutinin secondary to infection with Mycoplasma pneumoniae in a pediatric patient. 2017 Croat. Med. J. pmid:29308834
Zhang X and Hu C Selecting optimal columns for clarithromycin impurity analysis according to the quantitative relationship of hydrophobic subtraction model. 2017 J Pharm Biomed Anal pmid:28024686
Addo KK et al. Genotyping and drug susceptibility testing of mycobacterial isolates from population-based tuberculosis prevalence survey in Ghana. 2017 BMC Infect. Dis. pmid:29197331
Liu W et al. Rapid detection of mutations in erm(41) and rrl associated with clarithromycin resistance in Mycobacterium abscessus complex by denaturing gradient gel electrophoresis. 2017 J. Microbiol. Methods pmid:29079298
Koh WJ et al. Mycobacterial Characteristics and Treatment Outcomes in Mycobacterium abscessus Lung Disease. 2017 Clin. Infect. Dis. pmid:28011608
Chang CH et al. Non-Tuberculous Mycobacteria Infection Following Autologous Fat Grafting on the Face. 2017 Aesthet Surg J pmid:29045552
Çekin AH et al. Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance. 2017 Turk J Gastroenterol pmid:28007678
Ikeue T et al. Pleuritis Caused by Mycobacterium kyorinense without Pulmonary Involvement. 2017 Intern. Med. pmid:28924121
Panozzo C et al. Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants. 2017 Biochim. Biophys. Acta pmid:28888990
Geng X et al. The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471. 2017 Antimicrob. Agents Chemother. pmid:28242673
Emmanuel R et al. Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from Justicia glauca against oral pathogens: A nanoantibiotic approach. 2017 Microb. Pathog. pmid:29101061
Larsen EL et al. Clarithromycin, trimethoprim, and penicillin and oxidative nucleic acid modifications in humans: randomised, controlled trials. 2017 Br J Clin Pharmacol pmid:28185274
Ono S et al. Vonoprazan improves the efficacy of Helicobacter pylori eradication therapy with a regimen consisting of clarithromycin and metronidazole in patients allergic to penicillin. 2017 Helicobacter pmid:28098408
Gouin-Thibault I et al. Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin. 2017 J. Thromb. Haemost. pmid:27893182
Park J et al. Progression and Treatment Outcomes of Lung Disease Caused by Mycobacterium abscessus and Mycobacterium massiliense. 2017 Clin. Infect. Dis. pmid:28011609
Park SM et al. Randomized clinical trial comparing 10- or 14-day sequential therapy and 10- or 14-day concomitant therapy for the first line empirical treatment of Helicobacter pylori infection. 2017 J. Gastroenterol. Hepatol. pmid:27505301
Ishiguro N et al. Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae pneumonia in pediatric patients. 2017 PLoS ONE pmid:28288170
Attaran B et al. Effect of biofilm formation by clinical isolates of on the efflux-mediated resistance to commonly used antibiotics. 2017 World J. Gastroenterol. pmid:28275296
Osaki T et al. Usefulness of detection of clarithromycin-resistant Helicobacter pylori from fecal specimens for young adults treated with eradication therapy. 2017 Helicobacter pmid:28544222
Chang CT et al. Antibiotic treatment of zebrafish mycobacteriosis: tolerance and efficacy of treatments with tigecycline and clarithromycin. 2017 J. Fish Dis. pmid:28422304
Furuya H et al. SAPHO syndrome-like presentation of disseminated nontuberculous mycobacterial infection in a case with neutralizing anti-IFNγ autoantibody. 2017 Rheumatology (Oxford) pmid:28371927
Ye JF et al. Evaluation of first-line bismuth-containing 7-day concomitant quintuple therapy for Helicobacter pylori eradication. 2017 J Dig Dis pmid:29119724
Chang KH et al. Comparison of antibiotic regimens in preterm premature rupture of membranes: neonatal morbidity and 2-year follow-up of neurologic outcome. 2017 J. Matern. Fetal. Neonatal. Med. pmid:27687157
Sotto RB et al. Sub-lethal pharmaceutical hazard tracking in adult zebrafish using untargeted LC-MS environmental metabolomics. 2017 J. Hazard. Mater. pmid:28623724
Liatsos C and Leontiadis GII The "report card" to grade H. Pylori treatment regimens: is it achievable in real-world in areas with high clarithromycin resistance? 2017 J Gastrointestin Liver Dis pmid:28617893
Chew CA et al. The diagnosis and management of H. pylori infection in Singapore. 2017 Singapore Med J pmid:28536725
Gunnarsdottir AI et al. Antibiotic susceptibility of Helicobacter pylori in Iceland. 2017 Infect Dis (Lond) pmid:28440099
Carneiro MDS et al. Lack of association between rrl and erm(41) mutations and clarithromycin resistance in Mycobacterium abscessus complex. 2017 Mem. Inst. Oswaldo Cruz pmid:29091138
Oikawa R et al. Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing. 2017 Tumour Biol. pmid:28990461
Radzikowska E et al. Cryptogenic organizing pneumonia-Results of treatment with clarithromycin versus corticosteroids-Observational study. 2017 PLoS ONE pmid:28945804
Chew KL et al. Predominance of clarithromycin-susceptible Mycobacterium massiliense subspecies: Characterization of the Mycobacterium abscessus complex at a tertiary acute care hospital. 2017 J. Med. Microbiol. pmid:28874233
Mougari F et al. Evaluation of the new GenoType NTM-DR kit for the molecular detection of antimicrobial resistance in non-tuberculous mycobacteria. 2017 J. Antimicrob. Chemother. pmid:28333340
Anwar HF et al. Synthesis of clarithromycin ketolides chemically modified at the unreactive C10-methyl group. 2017 Bioorg. Med. Chem. pmid:28302508
Turvey SL et al. Mycobacterium branderi infection: Case report and literature review of an unusual and difficult-to-treat non-tuberculous mycobacterium. 2017 Int. J. Infect. Dis. pmid:28268125
Kadota JI et al. The clinical efficacy of a clarithromycin-based regimen for Mycobacterium avium complex disease: A nationwide post-marketing study. 2017 J. Infect. Chemother. pmid:28254517
Quinn KL et al. Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. 2017 Drug Saf pmid:28421551
Huang CC et al. In vitro activity of aminoglycosides, clofazimine, d-cycloserine and dapsone against 83 Mycobacterium avium complex clinical isolates. 2018 J Microbiol Immunol Infect pmid:28705770
Kelly C et al. Macrolide antibiotics for bronchiectasis. 2018 Cochrane Database Syst Rev pmid:29543980
Yeo YH et al. First-line eradication therapies in countries with high and low clarithromycin resistance: a systematic review and network meta-analysis. 2018 Gut pmid:27670375
Suzuki R et al. Sinobronchial syndrome treated as intractable asthma. 2018 Pediatr Int pmid:30320426
Mégraud F Antibiotic Resistance Is the Key Element in Treatment of Helicobacter pylori Infection. 2018 Gastroenterology pmid:30308190
Mieras LF et al. An enhanced regimen as post-exposure chemoprophylaxis for leprosy: PEP+. 2018 BMC Infect. Dis. pmid:30290790
Liou JM et al. Toward population specific and personalized treatment of Helicobacter pylori infection. 2018 J. Biomed. Sci. pmid:30285834
Liu HY et al. Bilateral Non-tuberculous Mycobacterial Keratitis After Small Incision Lenticule Extraction. 2018 J Refract Surg pmid:30199569
Kabakambira JD et al. Efficacy of Helicobacter pylori eradication regimens in Rwanda: a randomized controlled trial. 2018 BMC Gastroenterol pmid:30165823
Yotsu RR et al. Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease). 2018 Cochrane Database Syst Rev pmid:30136733
Tang D et al. [Efficacy of bismuth containing quadruple therapies on Helicobacter pylori eradication in patients with history of antibiotic treatment]. 2018 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:30124214
Byeon JY et al. Effects of genetic polymorphisms of CYP2C19 on the pharmacokinetics of zolpidem. 2018 Arch. Pharm. Res. pmid:30117082
Park CG et al. Clinical relevance of point mutations in the 23S rRNA gene in Helicobacter pylori eradication: A prospective, observational study. 2018 Medicine (Baltimore) pmid:30113472
Morgene MF et al. HaCaT epithelial cells as an innovative novel model of rhinovirus infection and impact of clarithromycin treatment on infection kinetics. 2018 Virology pmid:30077071
Abu-Khalaf N et al. The Taste of Commercially Available Clarithromycin Oral Pharmaceutical Suspensions in the Palestinian Market: Electronic Tongue and In Vivo Evaluation. 2018 Sensors (Basel) pmid:29401675
Gonzalez-Hormazabal P et al. Prevalence of clarithromycin resistance in Helicobacter pylori in Santiago, Chile, estimated by real-time PCR directly from gastric mucosa. 2018 BMC Gastroenterol pmid:29925321
Clarithromycin in patients with coronary artery disease. 2018 Med Lett Drugs Ther pmid:29913468
Li M et al. Systematic review with meta-analysis: Vonoprazan, a potent acid blocker, is superior to proton-pump inhibitors for eradication of clarithromycin-resistant strains of Helicobacter pylori. 2018 Helicobacter pmid:29873436
Blümel B et al. Retrospective study on outcome of salvage Helicobacter pylori eradication therapies based on molecular genetic susceptibility testing. 2018 Helicobacter pmid:29873430
Ito M et al. Phase transitions of antibiotic clarithromycin forms I, IV and new form VII crystals. 2018 Int J Pharm pmid:29864514
Jin BH et al. Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study. 2018 Eur. J. Clin. Pharmacol. pmid:29846770
Auesomwang C et al. Ten-day high-dose proton pump inhibitor triple therapy versus sequential therapy for Helicobacter pylori eradication. 2018 J. Gastroenterol. Hepatol. pmid:29804294
Chai KY et al. Roxithromycin monotherapy inducing a partial response in a patient with myeloma: a case report. 2018 J Med Case Rep pmid:29743095
Strouvalis I et al. Early increase of VEGF-A is associated with resolution of ventilator-associated pneumonia: Clinical and experimental evidence. 2018 Respirology pmid:29741298
Long X et al. Bismuth improves efficacy of proton-pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance. 2018 Helicobacter pmid:29696736
Fiorini G et al. Antibiotic resistance pattern of Helicobacter pylori strains isolated in Italy during 2010-2016. 2018 Scand. J. Gastroenterol. pmid:29688095
Matta AJ et al. Punctual mutations in gene of clarithromycin-resistant in Colombian populations. 2018 World J. Gastroenterol. pmid:29662291
Rodríguez-Sevilla G et al. Influence of three-dimensional lung epithelial cells and interspecies interactions on antibiotic efficacy against Mycobacterium abscessus and Pseudomonas aeruginosa. 2018 Pathog Dis pmid:29648588
Namkoong H et al. Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia. 2018 PLoS Pathog. pmid:29621339
Berende A et al. Cost-effectiveness of longer-term versus shorter-term provision of antibiotics in patients with persistent symptoms attributed to Lyme disease. 2018 PLoS ONE pmid:29608590
Mabe K et al. Randomized controlled trial: PPI-based triple therapy containing metronidazole versus clarithromycin as first-line treatment for Helicobacter pylori in adolescents and young adults in Japan. 2018 J. Infect. Chemother. pmid:29605555
Chen SA et al. HLA-A*02:07 Allele Associates with Clarithromycin-Induced Cutaneous Adverse Drug Reactions in Chinese Patients. 2018 Basic Clin. Pharmacol. Toxicol. pmid:29575644
van Dyk M et al. Assessment of inter-racial variability in CYP3A4 activity and inducibility among healthy adult males of Caucasian and South Asian ancestries. 2018 Eur. J. Clin. Pharmacol. pmid:29572563
Tsutsui A et al. Trends and patterns of national antimicrobial consumption in Japan from 2004 to 2016. 2018 J. Infect. Chemother. pmid:29428566
Tarhini M et al. First-line treatment of Helicobacter pylori in Lebanon: Comparison of bismuth-containing quadruple therapy versus 14-days sequential therapy. 2018 Microb. Pathog. pmid:29428426
Kobayashi T et al. The potential role of clarithromycin addition to lenalidomide and dexamethasone therapy (BiRd) in multiple myeloma. 2018 Ann. Hematol. pmid:29427183
Wang S et al. Enhanced adsorption of ionizable antibiotics on activated carbon fiber under electrochemical assistance in continuous-flow modes. 2018 Water Res. pmid:29426033
Yagbasan A et al. A Prospective, randomized study comparing 7-day and 14-day quadruple therapies as first-line treatments for helicobacter pylori infection in patients with functional dyspepsia. 2018 Niger J Clin Pract pmid:29411724
Maiolino G et al. Macrolides for KCNJ5-mutated aldosterone-producing adenoma (MAPA): design of a study for personalized diagnosis of primary aldosteronism. 2018 Blood Press. pmid:29409357
Takahashi E et al. Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus. 2018 Comp. Immunol. Microbiol. Infect. Dis. pmid:29406285
Wang YH et al. A systematic review and meta-analysis of genotypic methods for detecting antibiotic resistance in Helicobacter pylori. 2018 Helicobacter pmid:29405526
Tso S et al. Clarithromycin as a steroid sparing agent for the management of infantile bullous pemphigoid. 2018 BMJ Case Rep pmid:29374651
Sahara S et al. Efficacy of Reduced Dosage of Amoxicillin in an Eradication Therapy for Helicobacter pylori Infection in Patients on Hemodialysis: A Randomized Controlled Trial. 2018 Digestion pmid:29310119
Aderemi AO et al. Oxidative stress responses and cellular energy allocation changes in microalgae following exposure to widely used human antibiotics. 2018 Aquat. Toxicol. pmid:30125766
Sue S et al. Vonoprazan- vs proton-pump inhibitor-based first-line 7-day triple therapy for clarithromycin-susceptible Helicobacter pylori: A multicenter, prospective, randomized trial. 2018 Helicobacter pmid:29271026
Nakase K et al. Long-term administration of oral macrolides for acne treatment increases macrolide-resistant Propionibacterium acnes. 2018 J. Dermatol. pmid:29235673
Cho EH et al. Differences in drug susceptibility pattern between Mycobacterium avium and Mycobacterium intracellulare isolated in respiratory specimens. 2018 J. Infect. Chemother. pmid:29223615
Compain F et al. In vitro activity of tedizolid against the Mycobacterium abscessus complex. 2018 Diagn. Microbiol. Infect. Dis. pmid:29217419
Li H et al. Inappropriate treatment in Helicobacter pylori eradication failure: a retrospective study. 2018 Scand. J. Gastroenterol. pmid:29214879
Jung JH et al. Clinical Outcomes of Standard Triple Therapy Plus Probiotics or Concomitant Therapy for Infection. 2018 Gut Liver pmid:29212313
Ersoy B et al. The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs. 2018 J Laryngol Otol pmid:29888693
Inagaki Y et al. Disseminated Cutaneous Infection of Mycobacterium colombiense in a Patient with Myelodysplastic Syndrome. 2018 Intern. Med. pmid:29093379
De Francesco V et al. Quadruple, sequential, and concomitant first-line therapies for H. pylori eradication: a prospective, randomized study. 2018 Dig Liver Dis pmid:29089267
Cerqueira RM et al. Cumulative Helicobacter Pylori Eradication Rates by Adopting First- and Second- Line Regimens Proposed by the Maastricht IV Consensus in Obese Patients Undergoing Gastric Bypass Surgery. 2018 Obes Surg pmid:29076008
Haj Yahia S et al. Colchicine intoxication in familial Mediterranean fever patients using clarithromycin for the treatment of Helicobacter pylori: a series of six patients. 2018 Rheumatol. Int. pmid:28975396
Shaharir SS et al. Non-tuberculous mycobacterium bacteraemia in a pregnant systemic lupus erythematosus (SLE) patient: a case review and pooled case analysis. 2018 Clin. Rheumatol. pmid:28971307
Marsousi N et al. Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software. 2018 Biopharm Drug Dispos pmid:28960401
De Lorenzi G et al. Mycobacterium genavense Infection in a Domestic Ferret (Mustela putorius furo). 2018 Top Companion Anim Med pmid:30502861
Popovic V et al. Mycobacterium shimoidei-cavitary pulmonary disease with favorable outcome. 2018 Folia Microbiol. (Praha) pmid:28913757
Mahachai V et al. Helicobacter pylori management in ASEAN: The Bangkok consensus report. 2018 J. Gastroenterol. Hepatol. pmid:28762251
Hosono Y et al. The association between erythromycin monotherapy for Mycobacterium avium complex lung disease and cross-resistance to clarithromycin: A retrospective case-series study. 2018 J. Infect. Chemother. pmid:29361415
Sancak S et al. A pioneering study: oral clarithromycin treatment for feeding intolerance in very low birth weight preterm infants. 2018 J. Matern. Fetal. Neonatal. Med. pmid:28279123
Alenezi A et al. Controlled release of clarithromycin from PLGA microspheres enhances bone regeneration in rabbit calvaria defects. 2018 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:28067984
Choi IJ et al. Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer. 2018 N. Engl. J. Med. pmid:29562147