clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kim SY et al. | Comparative study of Helicobacter pylori eradication rates with 5-day quadruple "concomitant" therapy and 7-day standard triple therapy. | 2013 | J. Clin. Gastroenterol. | pmid:22647826 |
Fagoonee S et al. | Efficacy of cefixime-based triple therapy for Helicobacter pylori eradication: a retrospective study. | 2013 | Panminerva Med | pmid:24088806 |
Gisbert JP et al. | Second-line therapy with levofloxacin after failure of treatment to eradicate helicobacter pylori infection: time trends in a Spanish Multicenter Study of 1000 patients. | 2013 | J. Clin. Gastroenterol. | pmid:22647827 |
Schmidt BJ and Hermansen MN | [Late debut of neonatal pneumonia caused by Chlamydia trachomatis]. | 2013 | Ugeskr. Laeg. | pmid:23428270 |
Yu Q et al. | Treatment of pulmonary mucosa-associated lymphoid tissue lymphoma with clarithromycin. | 2013 | Chin. Med. J. | pmid:23786961 |
Duman DG et al. | Saccharomyces boulardii ameliorates clarithromycin- and methotrexate-induced intestinal and hepatic injury in rats. | 2013 | Br. J. Nutr. | pmid:23279717 |
Lahbabi M et al. | Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: result of the HPFEZ randomised study. | 2013 | Clin Res Hepatol Gastroenterol | pmid:23168228 |
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Mueck W et al. | Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects. | 2013 | Br J Clin Pharmacol | pmid:23305158 |
Karmakar S et al. | Hypokalemia: a potent risk for QTc prolongation in clarithromycin treated rats. | 2013 | Eur. J. Pharmacol. | pmid:23567068 |
Benajah DA et al. | Prevalence of Helicobacter pylori and its recurrence after successful eradication in a developing nation (Morocco). | 2013 | Clin Res Hepatol Gastroenterol | pmid:23567104 |
Abenavoli L et al. | Association between non-alcoholic fatty liver disease, insulin resistance and Helicobacter pylori. | 2013 | Med. Hypotheses | pmid:24011768 |
Faraji F et al. | The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial. | 2012 Nov-Dec | Pain Physician | pmid:23159967 |
Eremenko AA et al. | [Effect of clarithromycin on the systemic inflammatory response syndrome severity in patients after myocardial revascularization surgery]. | 2012 May-Jun | Anesteziol Reanimatol | pmid:22993930 |
Singh V et al. | Vesicular palmoplantar pityriasis rosea. | 2012 Mar-Apr | Skinmed | pmid:22545332 |
Gutiérrez-Castrellón P et al. | Efficacy and safety of clarithromycin in pediatric patients with upper respiratory infections: a systematic review with meta-analysis. | 2012 Mar-Apr | Rev. Invest. Clin. | pmid:22991774 |
Rajendiran S et al. | Increased protein carbonylation and decreased antioxidant status in anemic H. pylori infected patients: effect of treatment. | 2012 Jul-Aug | Saudi J Gastroenterol | pmid:22824768 |
De Sanctis V et al. | Anti-Helicobacter pylori therapy in primary MALT lymphoma of rectum. | 2012 Jul-Aug | Tumori | pmid:23052174 |
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de Lalibera IB et al. | Meningoencephalitis associated with Mycoplasma pneumoniae. | 2012 Jan-Mar | Einstein (Sao Paulo) | pmid:23045836 |
Dhillon GS et al. | Clarithromycin for prevention of bronchiolitis obliterans syndrome in lung allograft recipients. | 2012 Jan-Feb | Clin Transplant | pmid:21352378 |
Onsun N et al. | Impact of Helicobacter pylori infection on severity of psoriasis and response to treatment. | 2012 Jan-Feb | Eur J Dermatol | pmid:22063790 |
Montero-Tinnirello J et al. | [Pulmonary hemorrhage due to leptospirosis]. | 2012 Jan-Feb | Med Intensiva | pmid:21592620 |
Dai WQ et al. | The eradicating Helicobacter pylori infection in duodenal ulcer patients by three short-term triple therapies in China: a multicenter clinical comparative study. | 2012 Jan-Feb | Hepatogastroenterology | pmid:22260837 |
Stout JE and Floto RA | Treatment of Mycobacterium abscessus: all macrolides are equal, but perhaps some are more equal than others. | 2012 | Am. J. Respir. Crit. Care Med. | pmid:23118083 |
Mouktaroudi M and Giamarellos-Bourboulis EJ | Macrolides for the therapy of nosocomial infections. | 2012 | Curr. Opin. Infect. Dis. | pmid:22248975 |
Yakoob J et al. | Prevalence of non Helicobacter pylori species in patients presenting with dyspepsia. | 2012 | BMC Gastroenterol | pmid:22226326 |
Perez AP et al. | Increased brain radioactivity by intranasal P-labeled siRNA dendriplexes within in situ-forming mucoadhesive gels. | 2012 | Int J Nanomedicine | pmid:22457595 |
Kumar R et al. | Synthesis and antibacterial activity of a novel series of acylides active against community acquired respiratory pathogens. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22153939 |
Choi HS et al. | Comparison of sequential and 7-, 10-, 14-d triple therapy for Helicobacter pylori infection. | 2012 | World J. Gastroenterol. | pmid:22654429 |
Majima Y et al. | Efficacy of combined treatment with S-carboxymethylcysteine (carbocisteine) and clarithromycin in chronic rhinosinusitis patients without nasal polyp or with small nasal polyp. | 2012 | Auris Nasus Larynx | pmid:21636230 |
Shakya N et al. | Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2'-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors. | 2012 | Bioorg. Med. Chem. | pmid:22664188 |
Milani M et al. | The status of antimicrobial resistance of Helicobacter pylori in Eastern Azerbaijan, Iran: comparative study according to demographics. | 2012 | J. Infect. Chemother. | pmid:22581031 |
Perić A et al. | Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the 'regulated on activation, normal T cell expressed and secreted' chemokine in the nasal secretions of patients with nasal polyposis. | 2012 | J Laryngol Otol | pmid:22559798 |
Stepanić V et al. | Physicochemical profile of macrolides and their comparison with small molecules. | 2012 | Eur J Med Chem | pmid:22152985 |
González-MartÃnez R et al. | Antibiotic prescription in the treatment of odontogenic infection by health professionals: a factor to consensus. | 2012 | Med Oral Patol Oral Cir Bucal | pmid:22143715 |
Greenstein RJ et al. | Vitamins A & D inhibit the growth of mycobacteria in radiometric culture. | 2012 | PLoS ONE | pmid:22235314 |
Chung JW et al. | Resistance of Helicobacter pylori strains to antibiotics in Korea with a focus on fluoroquinolone resistance. | 2012 | J. Gastroenterol. Hepatol. | pmid:21793912 |
von Müller L et al. | [Current data and trends on the development of antibiotic resistance of Clostridium difficile]. | 2012 | Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz | pmid:23114440 |
Davies BS et al. | Non-tuberculous slow-growing mycobacterial pulmonary infections in non-HIV-infected patients in south London. | 2012 | Scand. J. Infect. Dis. | pmid:23078529 |
Cajigas-Pezo D et al. | [Swelling of right knee in an immunologically compromised patient]. | 2012 | Enferm. Infecc. Microbiol. Clin. | pmid:22521279 |
Aguilar JA et al. | Decoupling two-dimensional NMR spectroscopy in both dimensions: pure shift NOESY and COSY. | 2012 | Angew. Chem. Int. Ed. Engl. | pmid:22588724 |
Yoon JH et al. | Trends in the eradication rates of Helicobacter pylori infection for eleven years. | 2012 | World J. Gastroenterol. | pmid:23236238 |
Al-Abri SS et al. | An audit of inpatient management of community-acquired pneumonia in Oman: a comparison with regional clinical guidelines. | 2012 | J Infect Public Health | pmid:22632599 |
Shih HY et al. | Comparison between Single-Dose Esomeprazole- and Pantoprazole-Based Triple Therapy on the Effectiveness for Helicobacter pylori Eradication in Taiwanese Population. | 2012 | Gastroenterol Res Pract | pmid:22829808 |
Sanaei Dashti A et al. | Nasopharyngeal carrier rate of Streptococcus pneumoniae in children: serotype distribution and antimicrobial resistance. | 2012 | Arch Iran Med | pmid:22827788 |
Cao S et al. | Pharmacokinetic interactions between ilaprazole and clarithromycin following ilaprazole, clarithromycin and amoxicillin triple therapy. | 2012 | Acta Pharmacol. Sin. | pmid:22820908 |
Saito R et al. | Molecular mechanism of macrolide-lincosamide resistance in Moraxella catarrhalis. | 2012 | J. Med. Microbiol. | pmid:22820696 |
Kido T et al. | Two cases of primary ciliary dyskinesia with different responses to macrolide treatment. | 2012 | Intern. Med. | pmid:22576394 |
Flamm RK et al. | Macrolide and tetracycline resistance among Moraxella catarrhalis isolates from 2009 to 2011. | 2012 | Diagn. Microbiol. Infect. Dis. | pmid:22819241 |
Girgis DO et al. | Ocular infections caused by non-tuberculous mycobacteria: update on epidemiology and management. | 2012 | Clin. Experiment. Ophthalmol. | pmid:21902780 |
Kuo CH et al. | The Optimal First-Line Therapy of Helicobacter pylori Infection in Year 2012. | 2012 | Gastroenterol Res Pract | pmid:22792095 |
Marzouk H et al. | The utility of nasopharyngeal culture in the management of chronic adenoiditis. | 2012 | Int. J. Pediatr. Otorhinolaryngol. | pmid:22784508 |
Dore MP et al. | Efficacy of a "Rescue" Ciprofloxacin-Based Regimen for Eradication of Helicobacter pylori Infection after Treatment Failures. | 2012 | Gastroenterol Res Pract | pmid:22666234 |
Lange JN et al. | Sensitivity of human strains of Oxalobacter formigenes to commonly prescribed antibiotics. | 2012 | Urology | pmid:22656407 |
Blumenthal A et al. | M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. | 2012 | PLoS ONE | pmid:22649518 |
Sugimoto M and Furuta T | Efficacy of esomeprazole in treating acid-related diseases in Japanese populations. | 2012 | Clin Exp Gastroenterol | pmid:22649281 |
Henneman A and Thornby KA | Risk of hypotension with concomitant use of calcium-channel blockers and macrolide antibiotics. | 2012 | Am J Health Syst Pharm | pmid:22644980 |
Gatta L et al. | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305217 |
Dicicco M et al. | Efficacy of clarithromycin on biofilm formation of methicillin-resistant Staphylococcus pseudintermedius. | 2012 | BMC Vet. Res. | pmid:23171620 |
Graham DY and Trespalacios AA | Treatment of Helicobacter pylori in Latin America. | 2012 | Lancet | pmid:22305218 |
Noguchi S et al. | Clarithromycin form I determined by synchrotron X-ray powder diffraction. | 2012 | Acta Crystallogr C | pmid:22307251 |
Soares DN et al. | Cross-sectional microhardness of bovine enamel subjected to three paediatric liquid oral medicines: an in vitro study. | 2012 | Eur Arch Paediatr Dent | pmid:23043884 |
Loghmari H et al. | Clarithromycin versus metronidazole in first-line Helicobacter pylori eradication. Prospective randomized study of 85 Tunisian adults. | 2012 | Tunis Med | pmid:22311445 |
Shiota S et al. | Association of helicobacter pylori dupA with the failure of primary eradication. | 2012 | J. Clin. Gastroenterol. | pmid:22298090 |
Bayles T et al. | Clarithromycin for community-acquired pneumonia: beware drug interactions. | 2012 | Intern Med J | pmid:23046194 |
Liang JH et al. | Structure-activity relationships of novel alkylides: 3-O-arylalkyl clarithromycin derivatives with improved antibacterial activities. | 2012 | Eur J Med Chem | pmid:22301216 |
Lembo G et al. | Successful treatment of Mycobacterium terrae complex infection of the knee. | 2012 | J Clin Rheumatol | pmid:23047536 |
Rudramurthy M et al. | Nasal vestibulitis due to Nocardiopsis dassonvillei in a diabetic patient. | 2012 | J. Med. Microbiol. | pmid:22556323 |
Zhou YQ et al. | Modified Sequential Therapy Regimen versus Conventional Triple Therapy for Helicobacter Pylori Eradication in Duodenal Ulcer Patients in China: A Multicenter Clinical Comparative Study. | 2012 | Gastroenterol Res Pract | pmid:22550478 |
Kamijo F et al. | A Case of Mycobacterial Skin Disease Caused by Mycobacterium peregrinum, and a Review of Cutaneous Infection. | 2012 | Case Rep Dermatol | pmid:22548041 |
Talebi Bezmin Abadi A et al. | Primary resistance of Helicobacter pylori to levofloxacin and moxifloxacine in Iran. | 2012 | Intern Emerg Med | pmid:21437583 |
Goodman JJ and Martin SI | Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections. | 2012 | Ther Clin Risk Manag | pmid:22547933 |
Werth S et al. | Efficacy and safety of venous thromboembolism prophylaxis with apixaban in major orthopedic surgery. | 2012 | Ther Clin Risk Manag | pmid:22547932 |
Arora S and Budhiraja RD | Chitosan-alginate microcapsules of amoxicillin for gastric stability and mucoadhesion. | 2012 | J Adv Pharm Technol Res | pmid:22470897 |
Rozza AL et al. | Morphologic and pharmacological investigations in the epicatechin gastroprotective effect. | 2012 | Evid Based Complement Alternat Med | pmid:22666296 |
Czekalski N et al. | Increased levels of multiresistant bacteria and resistance genes after wastewater treatment and their dissemination into lake geneva, Switzerland. | 2012 | Front Microbiol | pmid:22461783 |
Khan GA et al. | The development and application of a system for simultaneously determining anti-infectives and nasal decongestants using on-line solid-phase extraction and liquid chromatography-tandem mass spectrometry. | 2012 | J Pharm Biomed Anal | pmid:22459504 |
Gisbert JP and Calvet X | Update on non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori. | 2012 | Clin Exp Gastroenterol | pmid:22457599 |
Hahn DL et al. | Chlamydia pneumoniae-specific IgE is prevalent in asthma and is associated with disease severity. | 2012 | PLoS ONE | pmid:22545149 |
Wang H et al. | [Antimicrobial susceptibility of community-acquired respiratory tract pathogens isolated from adults in China during 2009 and 2010]. | 2012 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:22455967 |
Noto MJ and Wheeler AP | Macrolides for acute lung injury. | 2012 | Chest | pmid:22553255 |
Onoe H et al. | Buruli ulcer accompanied by pain in a Japanese patient. | 2012 | J. Dermatol. | pmid:22168180 |
Zautner AE | Adenotonsillar disease. | 2012 | Recent Pat Inflamm Allergy Drug Discov | pmid:22452646 |
Peters J et al. | Clarithromycin is absorbed by an intestinal uptake mechanism that is sensitive to major inhibition by rifampicin: results of a short-term drug interaction study in foals. | 2012 | Drug Metab. Dispos. | pmid:22170330 |
Li Y et al. | Detection of clarithromycin resistance in Helicobacter pylori following noncryogenic storage of rapid urease tests for 30 days. | 2012 | J Dig Dis | pmid:22188917 |
Chang CS et al. | Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells. | 2012 | Eur J Med Chem | pmid:22217866 |
Kargar M et al. | Real-time PCR for Helicobacter pylori quantification and detection of clarithromycin resistance in gastric tissue from patients with gastrointestinal disorders. | 2012 | Res. Microbiol. | pmid:22177975 |
Srivastav NC et al. | Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22178557 |
Youn YS and Lee KY | Mycoplasma pneumoniae pneumonia in children. | 2012 | Korean J Pediatr | pmid:22375148 |
Gisbert JP et al. | Fourth-line rescue therapy with rifabutin in patients with three Helicobacter pylori eradication failures. | 2012 | Aliment. Pharmacol. Ther. | pmid:22372560 |
Maselli DJ et al. | Clinical evaluation of the role of ceftaroline in the management of community acquired bacterial pneumonia. | 2012 | Infect Drug Resist | pmid:22355258 |
Iino R et al. | A microfluidic device for simple and rapid evaluation of multidrug efflux pump inhibitors. | 2012 | Front Microbiol | pmid:22347225 |
Dholakia Y et al. | Drug-resistant tuberculosis: Study of clinical practices of chest physicians, Maharashtra, India. | 2012 | Lung India | pmid:22345911 |
Carlos CA et al. | Mycobacterial infection identified with broad-range PCR amplification and suspension array identification. | 2012 | J. Cutan. Pathol. | pmid:22764735 |
Tonkic A et al. | Time trends of primary antibiotic resistance of Helicobacter pylori isolates in Southern Croatia. | 2012 | J Chemother | pmid:22759765 |
Wang YJ et al. | Rapid quantitative analysis of clarithromycin in rat plasma by UPLC-MS/MS after intravenous injection of the clarithromycin-loaded ultrafine PLGA nanoparticles. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:22483396 |
Erdur B et al. | Comparison of sequential and standard therapy for Helicobacter pylori eradication in children and investigation of clarithromycin resistance. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22465935 |
McNulty CA et al. | Is Helicobacter pylori antibiotic resistance surveillance needed and how can it be delivered? | 2012 | Aliment. Pharmacol. Ther. | pmid:22469191 |
Jakopović IP et al. | Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22503348 |