clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Piccolomini R et al. | Bacteriostatic and bactericidal in vitro activities of clarithromycin and erythromycin against periodontopathic Actinobacillus actinomycetemcomitans. | 1998 | Antimicrob. Agents Chemother. | pmid:9797240 |
Horgen L et al. | Pulsed-exposure and postantibiotic leukocyte enhancement effects of amikacin, clarithromycin, clofazimine, and rifampin against intracellular Mycobacterium avium. | 1998 | Antimicrob. Agents Chemother. | pmid:9797242 |
Ouellet D et al. | Pharmacokinetic interaction between ritonavir and clarithromycin. | 1998 | Clin. Pharmacol. Ther. | pmid:9797791 |
Chodosh S et al. | Efficacy of oral ciprofloxacin vs. clarithromycin for treatment of acute bacterial exacerbations of chronic bronchitis. The Bronchitis Study Group. | 1998 | Clin. Infect. Dis. | pmid:9798025 |
Craft JC et al. | Clarithromycin resistance and susceptibility patterns of Mycobacterium avium strains isolated during prophylaxis for disseminated infection in patients with AIDS. | 1998 | Clin. Infect. Dis. | pmid:9798037 |
Shafran SD | Clarithromycin prophylaxis for disseminated Mycobacterium avium complex infection--efficacy and acquired resistance. | 1998 | Clin. Infect. Dis. | pmid:9798038 |
Cestari R | Ranitidine bismuth citrate (RBC) based triple therapy for 7 days is more effective than RBC plus clarithromycin for 14 days in dyspeptic patients with Helicobacter pylori infection. H. Pylori Lombardy Group. | 1998 | Aliment. Pharmacol. Ther. | pmid:9798804 |
Spadaccini A et al. | Triple regimens using lansoprazole or ranitidine bismuth citrate for Helicobacter pylori eradication. | 1998 | Aliment. Pharmacol. Ther. | pmid:9798805 |
Bortolotti M et al. | Effects of oral clarithromycin and amoxycillin on interdigestive gastrointestinal motility of patients with functional dyspepsia and Helicobacter pylori gastritis. | 1998 | Aliment. Pharmacol. Ther. | pmid:9798808 |
Hynes B | Contact granulomas. | 1998 | J Otolaryngol | pmid:9800633 |
Fabry W et al. | Comparison of the E test and a proportion dilution method for susceptibility testing of Mycobacterium tuberculosis. | 1995 | Zentralbl. Bakteriol. | pmid:9810662 |
Abouesh A and Hobbs WR | Clarithromycin-induced mania. | 1998 | Am J Psychiatry | pmid:9812131 |
Miehlke S et al. | Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection. | 1998 Nov-Dec | Digestion | pmid:9813387 |
Clark CL et al. | Antipneumococcal activities of levofloxacin and clarithromycin as determined by agar dilution, microdilution, E-test, and disk diffusion methodologies. | 1998 | J. Clin. Microbiol. | pmid:9817876 |
Björkholm B et al. | Rapid PCR detection of Helicobacter pylori-associated virulence and resistance genes directly from gastric biopsy material. | 1998 | J. Clin. Microbiol. | pmid:9817898 |
Arimori K et al. | Characteristic difference in gastrointestinal excretion of clarithromycin and roxithromycin. | 1998 | Biopharm Drug Dispos | pmid:9818709 |
Cirioni O et al. | In-vitro activity of lytic peptides alone and in combination with macrolides and inhibitors of dihydrofolate reductase against Pneumocystis carinii. | 1998 | J. Antimicrob. Chemother. | pmid:9818742 |
Vrioni G et al. | Treatment of disseminated Mycobacterium genavense infection in a murine model with ciprofloxacin, amikacin, ethambutol, clarithromycin and rifabutin. | 1998 | J. Antimicrob. Chemother. | pmid:9818747 |
Champney WS and Burdine R | Macrolide antibiotic inhibition of translation and 50S ribosomal subunit assembly in methicillin-resistant Staphylococcus aureus cells. | 1998 | Microb. Drug Resist. | pmid:9818968 |
Mermelstein HT | Clarithromycin-induced delirium in a general hospital. | 1998 Nov-Dec | Psychosomatics | pmid:9819955 |
Murata H et al. | Evaluation of the PyloriTek test for detection of Helicobacter pylori infection in cases with and without eradication therapy. | 1998 | Am. J. Gastroenterol. | pmid:9820380 |
Laine L et al. | Twice-daily, 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in duodenal ulcer disease: results of three multicenter, double-blind, United States trials. | 1998 | Am. J. Gastroenterol. | pmid:9820381 |
Kaeser YA et al. | Severe hypotension and bradycardia associated with verapamil and clarithromycin. | 1998 | Am J Health Syst Pharm | pmid:9825040 |
Ward TT et al. | Randomized, open-label trial of azithromycin plus ethambutol vs. clarithromycin plus ethambutol as therapy for Mycobacterium avium complex bacteremia in patients with human immunodeficiency virus infection. Veterans Affairs HIV Research Consortium. | 1998 | Clin. Infect. Dis. | pmid:9827282 |
Howden CW and Hunt RH | Treating Helicobacter pylori. | 1998 | Arch. Intern. Med. | pmid:9827792 |
Anzueto A et al. | Etiology, susceptibility, and treatment of acute bacterial exacerbations of complicated chronic bronchitis in the primary care setting: ciprofloxacin 750 mg b.i.d. versus clarithromycin 500 mg b.i.d. Bronchitis Study Group. | 1998 Sep-Oct | Clin Ther | pmid:9829441 |
Dhawan VK et al. | Vancomycin-resistant enterococcal colonization in nonhospitalized HIV-infected patients. | 1998 | West. J. Med. | pmid:9830355 |
Shafran SD | Prevention and treatment of disseminated Mycobacterium avium complex infection in human immunodeficiency virus-infected individuals. | 1998 Jul-Sep | Int. J. Infect. Dis. | pmid:9831675 |
Valsecchi R and Pigatto P | Chronic urticaria and Helicobacter pylori. | 1998 | Acta Derm. Venereol. | pmid:9833044 |
Sackoff J et al. | Prophylaxis for opportunistic infections among HIV-infected patients receiving medical care. | 1998 | J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. | pmid:9833748 |
van Haarst AD et al. | The influence of cisapride and clarithromycin on QT intervals in healthy volunteers. | 1998 | Clin. Pharmacol. Ther. | pmid:9834046 |
Xia HH et al. | Metronidazole- and clarithromycin-resistant Helicobacter pylori in dyspeptic patients in western Sydney as determined by testing multiple isolates from different gastric sites. | 1998 | J. Gastroenterol. Hepatol. | pmid:9835322 |
Berry V et al. | Bacteriological efficacies of three macrolides compared with those of amoxicillin-clavulanate against Streptococcus pneumoniae and Haemophilus influenzae. | 1998 | Antimicrob. Agents Chemother. | pmid:9835514 |
Hogan PA and Sheehan DJ | Macrolide susceptibility and beta-lactamase production among haemophilus influenzae isolates in the United States, 1996-1997. | 1998 | Antimicrob. Agents Chemother. | pmid:9835536 |
Borody TJ et al. | Eradication therapies for Helicobacter pylori. | 1998 | J. Gastroenterol. | pmid:9840019 |
Moayyedi P et al. | Relevance of antibiotic sensitivities in predicting failure of omeprazole, clarithromycin, and tinidazole to eradicate Helicobacter pylori. | 1998 | J. Gastroenterol. | pmid:9840021 |
Ohkusa T et al. | Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori. A randomized, clinical trial. | 1998 | Ann. Intern. Med. | pmid:9841603 |
Kato S et al. | Safety and efficacy of one-week triple therapy for eradicating Helicobacter pylori in children. | 1998 | Helicobacter | pmid:9844069 |
Gisbert JP et al. | [Omeprazole plus 2 antibiotics for the eradication of H. pylori, are 5 days of treatment sufficient?]. | 1998 | Rev Clin Esp | pmid:9844453 |
Gisbert JP et al. | [Role of pantoprazole in the eradicating treatment of Helicobacter pylori]. | 1998 | Rev Clin Esp | pmid:9844458 |
Gudjonsson H et al. | High Helicobacter pylori eradication rate with a 1-week regimen containing ranitidine bismuth citrate. | 1998 | Aliment. Pharmacol. Ther. | pmid:9845401 |
Coudron PE and Stratton CW | In-vitro evaluation of nitrofurantoin as an alternative agent for metronidazole in combination antimicrobial therapy against Helicobacter pylori. | 1998 | J. Antimicrob. Chemother. | pmid:9848452 |
Cadwgan AM et al. | Neisseria meningitidis W135 pneumonia with sepicaemia in a nonogenarian. | 1998 | Scott Med J | pmid:9854302 |
Shimoyama T et al. | Healing of cimetidine-resistant Ménétrier's disease by eradication of Helicobacter pylori infection. | 1998 | J. Clin. Gastroenterol. | pmid:9855268 |
Adelglass J et al. | A multicenter, investigator-blinded, randomized comparison of oral levofloxacin and oral clarithromycin in the treatment of acute bacterial sinusitis. | 1998 Nov-Dec | Pharmacotherapy | pmid:9855324 |
Blum AL et al. | Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group. | 1998 | N. Engl. J. Med. | pmid:9862942 |
Maeda S et al. | Helicobacter pylori specific nested PCR assay for the detection of 23S rRNA mutation associated with clarithromycin resistance. | 1998 | Gut | pmid:9863474 |
Al-Sibai MB et al. | Ocular penetration of oral clarithromycin in humans. | 1998 | J Ocul Pharmacol Ther | pmid:9867340 |
Wallace RJ and Brown BA | Catheter sepsis due to Mycobacterium chelonae. | 1998 | J. Clin. Microbiol. | pmid:9867491 |
Shafran SD et al. | Does in vitro susceptibility to rifabutin and ethambutol predict the response to treatment of Mycobacterium avium complex bacteremia with rifabutin, ethambutol, and clarithromycin? Canadian HIV Trials Network Protocol 010 Study Group. | 1998 | Clin. Infect. Dis. | pmid:9868650 |