clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Fontana C et al. | Detection of clarithromycin-resistant Helicobacter pylori in stool samples. | 2003 | J. Clin. Microbiol. | pmid:12904368 |
Laine L | Is it time for quadruple therapy to be first line? | 2003 | Can. J. Gastroenterol. | pmid:12905979 |
Miyazaki M et al. | Macrolide antibiotics inhibit prostaglandin E2 synthesis and mRNA expression of prostaglandin synthetic enzymes in human leukocytes. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907132 |
Drummond MF et al. | An economic evaluation of sequential i.v./po moxifloxacin therapy compared to i.v./po co-amoxiclav with or without clarithromycin in the treatment of community-acquired pneumonia. | 2003 | Chest | pmid:12907538 |
Godoy AP et al. | Analysis of antimicrobial susceptibility and virulence factors in Helicobacter pylori clinical isolates. | 2003 | BMC Gastroenterol | pmid:12911839 |
Miyashita N et al. | In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae. | 2003 | J. Antimicrob. Chemother. | pmid:12917246 |
Walsh F et al. | High-level telithromycin resistance in laboratory-generated mutants of Streptococcus pneumoniae. | 2003 | J. Antimicrob. Chemother. | pmid:12917252 |
Clarkson JE et al. | Interventions for preventing oral mucositis for patients with cancer receiving treatment. | 2003 | Cochrane Database Syst Rev | pmid:12917895 |
Mauriello JA | Atypical mycobacterial infection of the periocular region after periocular and facial surgery. | 2003 | Ophthalmic Plast Reconstr Surg | pmid:12918551 |
Baron BW et al. | Thrombotic thrombocytopenic purpura after cephalosporin administration: a possible relationship. | 2003 | Transfusion | pmid:12919436 |
Holzer MP et al. | [Diagnosis and treatment of mycobacterial keratitis following LASIK. Case report and review of the literature]. | 2003 | Ophthalmologe | pmid:12920556 |
Isomoto H et al. | A case of mucosa-associated lymphoid tissue lymphoma of the ampulla of Vater: successful treatment with radiation therapy. | 2003 | Eur J Gastroenterol Hepatol | pmid:12923379 |
Shimokata K | Treatment of pulmonary disease caused by Mycobacterium avium complex. | 2003 | Intern. Med. | pmid:12924480 |
Kobashi Y and Matsushima T | The effect of combined therapy according to the guidelines for the treatment of Mycobacterium avium complex pulmonary disease. | 2003 | Intern. Med. | pmid:12924489 |
Jones ME et al. | In vitro susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis: a European multicenter study during 2000-2001. | 2003 | Clin. Microbiol. Infect. | pmid:12925097 |
Loffeld RJ and Fijen CA | Antibiotic resistance of Helicobacter pylori: a cross-sectional study in consecutive patients, and relation to ethnicity. | 2003 | Clin. Microbiol. Infect. | pmid:12925098 |
Bozdogan B et al. | Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers. | 2003 | Clin. Microbiol. Infect. | pmid:12925106 |
Ioannidou S et al. | In vitro activity of telithromycin (HMR 3647) against Greek Streptococcus pyogenes and Streptococcus pneumoniae clinical isolates with different macrolide susceptibilities. | 2003 | Clin. Microbiol. Infect. | pmid:12925112 |
Bozdogan B et al. | Activity of telithromycin compared with seven other agents against 1039 Streptococcus pyogenes pediatric isolates from ten centers in central and eastern Europe. | 2003 | Clin. Microbiol. Infect. | pmid:12925122 |
Ohsaki Y et al. | Alterations in penicillin binding protein gene of Streptococcus pneumoniae and their correlation with susceptibility patterns. | 2003 | Int. J. Antimicrob. Agents | pmid:12927954 |
Sifrim D et al. | Comparison of the effects of midecamycin acetate and clarithromycin on gastrointestinal motility in man. | 1992 | Drugs Exp Clin Res | pmid:1292916 |
Toy BR and Frank PJ | Outbreak of Mycobacterium abscessus infection after soft tissue augmentation. | 2003 | Dermatol Surg | pmid:12930343 |
Parr DG et al. | Panniculitis secondary to extravasation of clarithromycin in a patient with alpha 1-antitrypsin deficiency (phenotype PiZ). | 2003 | Br. J. Dermatol. | pmid:12932253 |
Kindergarten-based outbreak of perianal group A streptococcal infection. | 2003 | Arch. Dis. Child. | pmid:12937107 | |
Ebrahimi-Dariani N et al. | The efficacy of furazolidone-based quadruple therapy for eradication of Helicobacter pylori infection in Iranian patients resistant to metronidazole-based quadruple therapy. | 2003 | Med. Sci. Monit. | pmid:12942042 |
Gordon KA et al. | Comparison of Streptococcus pneumoniae and Haemophilus influenzae susceptibilities from community-acquired respiratory tract infections and hospitalized patients with pneumonia: five-year results for the SENTRY Antimicrobial Surveillance Program. | 2003 | Diagn. Microbiol. Infect. Dis. | pmid:12944021 |
Forslöw U et al. | Early chemotherapy for non-tuberculous mycobacterial infections in patients with cystic fibrosis. | 2003 | Acta Paediatr. | pmid:12948065 |
Uthaisaengsook W | Low dose, one-week triple therapy (lanzoprazole, amoxycillin, clarithromycin) for eradication of Helicobacter pylori infection. | 2003 | J Med Assoc Thai | pmid:12948252 |
Sagir A et al. | Inhibition of cytochrome P450 3A: relevant drug interactions in gastroenterology. | 2003 | Digestion | pmid:12949438 |
Nakamura M et al. | Gastric juice, gastric tissue and blood antibiotic concentrations following omeprazole, amoxicillin and clarithromycin triple therapy. | 2003 | Helicobacter | pmid:12950601 |
Miehlke S et al. | A prospective, randomized study of quadruple therapy and high-dose dual therapy for treatment of Helicobacter pylori resistant to both metronidazole and clarithromycin. | 2003 | Helicobacter | pmid:12950604 |
Baier RJ et al. | Failure of erythromycin to eliminate airway colonization with ureaplasma urealyticum in very low birth weight infants. | 2003 | BMC Pediatr | pmid:12956892 |
Zhang L et al. | P-glycoprotein restricted transport of nimodipine across blood-brain barrier. | 2003 | Acta Pharmacol. Sin. | pmid:12956939 |
Abeyama K et al. | Antibiotic cyclic AMP signaling by "primed" leukocytes confers anti-inflammatory cytoprotection. | 2003 | J. Leukoc. Biol. | pmid:12960287 |
Andrzejewska E et al. | Characterization of Helicobacter pylori strainsisolated before and after therapy. | 2003 | Med. Sci. Monit. | pmid:12960930 |
Dautzenberg B | [Treatment of atypical mycobacterium infections: current state and therapeutic perspectives]. | 1992 | Rev Pneumol Clin | pmid:1296257 |
Gamova NA | [Drug sensitivity of Ureaplasma urealyticum, persisting in patients with chronic inflammatory diseases of the urogenital tract]. | 2003 Jul-Aug | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:12966887 |
Johnson DM et al. | Susceptibility trends of haemophilus influenzae and Moraxella catarrhalis against orally administered antimicrobial agents: five-year report from the SENTRY Antimicrobial Surveillance Program. | 2003 | Diagn. Microbiol. Infect. Dis. | pmid:12967753 |
Malfertheiner P et al. | Helicobacter pylori eradication is beneficial in the treatment of functional dyspepsia. | 2003 | Aliment. Pharmacol. Ther. | pmid:12969088 |
Nista EC et al. | Levofloxacin-based triple therapy vs. quadruple therapy in second-line Helicobacter pylori treatment: a randomized trial. | 2003 | Aliment. Pharmacol. Ther. | pmid:12969089 |
Hassan C et al. | Sequential treatment for Helicobacter pylori eradication in duodenal ulcer patients: improving the cost of pharmacotherapy. | 2003 | Aliment. Pharmacol. Ther. | pmid:12969091 |
Lohitnavy O et al. | Average bioequivalence of generic clarithromycin tablets in healthy Thai male volunteers. | 2003 | Biopharm Drug Dispos | pmid:12973819 |
Hiyama T et al. | Prevalence of Helicobacter pylori resistance to clarithromycin and metronidazole determined by 23S ribosomal RNA and rdxA gene analyses in Hiroshima, Japan. | 2003 | J. Gastroenterol. Hepatol. | pmid:12974909 |
McCarthy DM et al. | Impact of cotherapy with some proton pump inhibitors on medical claims among HMO patients already using other common drugs also cleared by cytochrome P450. | 2003 Sep-Oct | Am J Ther | pmid:12975717 |
Calzolari E et al. | The efficacy of clarythromycin (A-56268, TE-031) in the treatment of genital chlamydial infection. | 1992 | Drugs Exp Clin Res | pmid:1306155 |
Bale MJ et al. | MIC quality control guidelines for Haemophilus susceptibility tests using cefdinir (FK482), cefepime, cefetamet, cefpirome, ceftibuten, fleroxacin, temafloxacin, clarithromycin, RP59500, and trospectomycin. | 1992 | J. Clin. Microbiol. | pmid:1310329 |
Neu HC | New macrolide antibiotics: azithromycin and clarithromycin. | 1992 | Ann. Intern. Med. | pmid:1310839 |
Wong WM et al. | Effects of primary metronidazole and clarithromycin resistance to Helicobacter pylori on omeprazole, metronidazole, and clarithromycin triple-therapy regimen in a region with high rates of metronidazole resistance. | 2003 | Clin. Infect. Dis. | pmid:13130398 |
Brown BA et al. | Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms. | 1992 | Antimicrob. Agents Chemother. | pmid:1317144 |
Bahal N and Nahata MC | The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin. | 1992 | Ann Pharmacother | pmid:1318761 |
Hammerschlag MR et al. | In vitro activities of azithromycin, clarithromycin, L-ofloxacin, and other antibiotics against Chlamydia pneumoniae. | 1992 | Antimicrob. Agents Chemother. | pmid:1324650 |
Paulsen P et al. | Influence of azithromycin and other macrolides on the intracellular killing of Staphylococcus aureus by human polymorphonuclear leucocytes of healthy donors and a patient with Chédiak-Higashi syndrome. | 1992 | Chemotherapy | pmid:1324831 |
Cynamon MH and Klemens SP | Activity of azithromycin against Mycobacterium avium infection in beige mice. | 1992 | Antimicrob. Agents Chemother. | pmid:1329622 |
Cohen Y et al. | Activities of WIN-57273, minocycline, clarithromycin, and 14-hydroxy-clarithromycin against Mycobacterium avium complex in human macrophages. | 1992 | Antimicrob. Agents Chemother. | pmid:1332586 |
Klemens SP et al. | Activity of clarithromycin against Mycobacterium avium complex infection in beige mice. | 1992 | Antimicrob. Agents Chemother. | pmid:1336945 |
Ji B et al. | Bactericidal activities of single or multiple doses of various combinations of new antileprosy drugs and/or rifampin against M. leprae in mice. | 1992 | Int. J. Lepr. Other Mycobact. Dis. | pmid:1338596 |
Logan RP et al. | Clarithromycin and omeprazole for Helicobacter pylori. | 1992 | Lancet | pmid:1353155 |
Chapelsky MC et al. | Renal tubular enzyme effects of clarithromycin in comparison with gentamicin and placebo in volunteers. | 1992 Jul-Aug | Drug Saf | pmid:1355971 |
Takeda H et al. | [A study to clarify the mechanism of the usefulness of the macrolides--the influence of clarithromycin to biofilm with P. aeruginosa]. | 1992 | Kansenshogaku Zasshi | pmid:1363435 |
Cogo R et al. | [Dynamics of sIgA concentration in bronchial secretions in patients with COBP treated with clarithromycin]. | 1991 Jan-Dec | G Ital Chemioter | pmid:1365564 |
Nalepa P et al. | Short-course therapy of acute bacterial exacerbation of chronic bronchitis: a double-blind, randomized, multicenter comparison of extended-release versus immediate-release clarithromycin. | 2003 | Curr Med Res Opin | pmid:13678478 |
Takker U et al. | Comparison of 5 days of extended-release clarithromycin versus 10 days of penicillin V for the treatment of streptococcal pharyngitis/tonsillitis: results of a multicenter, double-blind, randomized study in adolescent and adult patients. | 2003 | Curr Med Res Opin | pmid:13678479 |
McMahon BJ et al. | The relationship among previous antimicrobial use, antimicrobial resistance, and treatment outcomes for Helicobacter pylori infections. | 2003 | Ann. Intern. Med. | pmid:13679322 |
Sjölund M et al. | Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori. | 2003 | Ann. Intern. Med. | pmid:13679325 |
Summaries for patients. Past antibiotic use affects resistance and outcomes of Helicobacter pylori infection. | 2003 | Ann. Intern. Med. | pmid:13679344 | |
Summaries for patients. Effects of antibiotic treatment for Helicobacter pylori on normal bowel bacteria. | 2003 | Ann. Intern. Med. | pmid:13679347 | |
Peters DH and Clissold SP | Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential. | 1992 | Drugs | pmid:1379907 |
Berk SL | New macrolide antibiotics. | 1992 | Ann. Intern. Med. | pmid:1386966 |
Chu SY et al. | Absolute bioavailability of clarithromycin after oral administration in humans. | 1992 | Antimicrob. Agents Chemother. | pmid:1387301 |
Yajko DM et al. | Comparison of the intracellular activities of clarithromycin and erythromycin against Mycobacterium avium complex strains in J774 cells and in alveolar macrophages from human immunodeficiency virus type 1-infected individuals. | 1992 | Antimicrob. Agents Chemother. | pmid:1387302 |
de Lalla F et al. | Clarithromycin-ciprofloxacin-amikacin for therapy of Mycobacterium avium-Mycobacterium intracellulare bacteremia in patients with AIDS. | 1992 | Antimicrob. Agents Chemother. | pmid:1387303 |
Friend DR | Polyacrylate resin microcapsules for taste masking of antibiotics. | 1992 Oct-Dec | J Microencapsul | pmid:1403495 |
Heifets LB et al. | Bacteriostatic and bactericidal activities of gentamicin alone and in combination with clarithromycin against Mycobacterium avium. | 1992 | Antimicrob. Agents Chemother. | pmid:1416852 |
Brown BA et al. | Activities of clarithromycin against eight slowly growing species of nontuberculous mycobacteria, determined by using a broth microdilution MIC system. | 1992 | Antimicrob. Agents Chemother. | pmid:1416891 |
Biehle J and Cavalieri SJ | In vitro susceptibility of Mycobacterium kansasii to clarithromycin. | 1992 | Antimicrob. Agents Chemother. | pmid:1416897 |
Sturgill MG and Rapp RP | Clarithromycin: review of a new macrolide antibiotic with improved microbiologic spectrum and favorable pharmacokinetic and adverse effect profiles. | 1992 | Ann Pharmacother | pmid:1421677 |
Ruf B et al. | Effectiveness of the macrolide clarithromycin in the treatment of Mycobacterium avium complex infection in HIV-infected patients. | 1992 Sep-Oct | Infection | pmid:1428183 |
Veldhuyzen van Zanten S et al. | Absence of symptomatic benefit of lansoprazole, clarithromycin, and amoxicillin triple therapy in eradication of Helicobacter pylori positive, functional (nonulcer) dyspepsia. | 2003 | Am. J. Gastroenterol. | pmid:14499772 |
Tagawa A et al. | [A case of lung infection due to Mycobacterium abscessus]. | 2003 | Nihon Kokyuki Gakkai Zasshi | pmid:14503341 |
Mak SK et al. | A retrospective study on efficacy of proton-pump inhibitor-based triple therapy for eradication of Helicobacter pylori in patients with chronic renal failure. | 2003 | Singapore Med J | pmid:14503780 |
Liu CC et al. | Maintenance treatment is not necessary after Helicobacter pylori eradication and healing of bleeding peptic ulcer: a 5-year prospective, randomized, controlled study. | 2003 | Arch. Intern. Med. | pmid:14504114 |
Hashimoto Y et al. | Clarithromycin inhibits the development of dermatitis in NC/Nga mice. | 2003 | Chemotherapy | pmid:14504432 |
Nash KA | Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38). | 2003 | Antimicrob. Agents Chemother. | pmid:14506008 |
Best LM et al. | Multilaboratory comparison of proficiencies in susceptibility testing of Helicobacter pylori and correlation between agar dilution and E test methods. | 2003 | Antimicrob. Agents Chemother. | pmid:14506021 |
Andereya S et al. | Reactive knee and ankle joint arthritis: abnormal manifestation of Legionella pneumophila. | 2004 | Rheumatol. Int. | pmid:14513269 |
Mikamo H et al. | Clinical efficacy of clarithromycin against uterine cervical and pharyngeal Chlamydia trachomatis and the sensitivity of polymerase chain reaction to detect C. trachomatis at various time points after treatment. | 2003 | J. Infect. Chemother. | pmid:14513403 |
Terao H et al. | Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice. | 2003 | Mediators Inflamm. | pmid:14514469 |
Tsui PT et al. | Severe acute respiratory syndrome: clinical outcome and prognostic correlates. | 2003 | Emerging Infect. Dis. | pmid:14519241 |
Talbot TR et al. | Ehrlichia chaffeensis infections among HIV-infected patients in a human monocytic ehrlichiosis-endemic area. | 2003 | Emerging Infect. Dis. | pmid:14519250 |
Pérez-Trallero E et al. | Fluoroquinolone and macrolide treatment failure in pneumococcal pneumonia and selection of multidrug-resistant isolates. | 2003 | Emerging Infect. Dis. | pmid:14519256 |
Noviello S et al. | Comparative activity of garenoxacin and other agents by susceptibility and time-kill testing against Staphylococcus aureus, Streptococcus pyogenes and respiratory pathogens. | 2003 | J. Antimicrob. Chemother. | pmid:14519672 |
Iino Y et al. | Nasopharyngeal flora and drug susceptibility in children with macrolide therapy. | 2003 | Laryngoscope | pmid:14520106 |
Bitnun A et al. | Children hospitalized with severe acute respiratory syndrome-related illness in Toronto. | 2003 | Pediatrics | pmid:14523209 |
Aboulafia DM | Thalidomide-based treatment for HIV-associated multiple myeloma: a case report. | 2003 | AIDS Read | pmid:14524324 |
Benito JR et al. | [Community-acquired pneumonia due to Legionella pneumophila serogroup 1. Study of 97 cases]. | 2003 | Enferm. Infecc. Microbiol. Clin. | pmid:14525703 |
Polat A and Inan M | Cold agglutinin disease after hepatitis A infection in a child. | 2003 | J. Pediatr. Hematol. Oncol. | pmid:14528114 |
Suzuki H et al. | Current consensus on the diagnosis and treatment of H. pylori-associated gastroduodenal disease. | 2003 | Keio J Med | pmid:14529149 |
Malaty W et al. | Clinical inquiries. What regimens eradicate Helicobacter pylori? | 2003 | J Fam Pract | pmid:14529606 |
Tsang OT et al. | Severe acute respiratory syndrome: Relapse? Hospital infection? | 2003 | Emerging Infect. Dis. | pmid:14531379 |
Denny FW | Current management of streptococcal pharyngitis. | 1992 | J Fam Pract | pmid:1453145 |