clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Tuberculosis, Spinal D014399 1 associated lipids
Hypoproteinemia D007019 1 associated lipids
Myxoma D009232 1 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Granuloma, Plasma Cell D006104 1 associated lipids
Empyema, Tuberculous D004654 1 associated lipids
Tuberculosis, Ocular D014392 1 associated lipids
Encephalomyelitis, Acute Disseminated D004673 1 associated lipids
Serositis D012700 1 associated lipids
Euthyroid Sick Syndromes D005067 1 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Glossitis, Benign Migratory D005929 1 associated lipids
Parotid Diseases D010305 1 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Sacroiliitis D058566 1 associated lipids
Achlorhydria D000126 1 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Pseudomyxoma Peritonei D011553 1 associated lipids
Eye Infections D015817 1 associated lipids
Gastritis, Hypertrophic D005758 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Hyperemesis Gravidarum D006939 2 associated lipids
Cardiovascular Abnormalities D018376 2 associated lipids
Typhoid Fever D014435 2 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Diphtheria D004165 2 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Empyema, Pleural D016724 2 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Mastoiditis D008417 2 associated lipids
Periodontal Abscess D010508 2 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Duodenogastric Reflux D004383 2 associated lipids
Parotid Neoplasms D010307 2 associated lipids
Iritis D007500 2 associated lipids
IgA Deficiency D017098 2 associated lipids
Still's Disease, Adult-Onset D016706 2 associated lipids
Monoclonal Gammopathy of Undetermined Significance D008998 2 associated lipids
Eye Injuries, Penetrating D015807 2 associated lipids
Chlamydial Pneumonia D061387 2 associated lipids
Leprosy, Lepromatous D015440 2 associated lipids
Iris Diseases D007499 2 associated lipids
Angiomatosis, Bacillary D016917 2 associated lipids
Discitis D015299 2 associated lipids
Tuberculosis, Avian D014379 2 associated lipids
Immunoproliferative Small Intestinal Disease D007161 2 associated lipids
Tooth, Nonvital D019553 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Guay DR and Craft JC Overview of the pharmacology of clarithromycin suspension in children and a comparison with that in adults. 1993 Pediatr. Infect. Dis. J. pmid:8295810
Sader HS et al. In vitro activity of cefpodoxime compared with other oral cephalosporins tested against 5556 recent clinical isolates from five medical centers. 1993 Aug-Sep Diagn. Microbiol. Infect. Dis. pmid:8243035
Miller CA Infections, resistant microbes, and older adults. 1993 Jan-Feb Geriatr Nurs pmid:8383085
Ritchie DJ et al. In vitro activity of clarithromycin, cefprozil, and other common oral antimicrobial agents against gram-positive and gram-negative pathogens. 1993 Jan-Feb Clin Ther pmid:8458040
Albani F et al. Clarithromycin-carbamazepine interaction: a case report. 1993 Jan-Feb Epilepsia pmid:8422851
Adam D Clarithromycin 250 mg b.i.d. for 5 or 10 days in the treatment of adult patients with purulent bronchitis. 1993 Jul-Aug Infection pmid:8225636
Coles SJ et al. A comparative study of clarithromycin and amoxycillin suspensions in the treatment of pediatric patients with acute otitis media. 1993 Jul-Aug Infection pmid:8225637
Ohmori S et al. Effects of clarithromycin and its metabolites on the mixed function oxidase system in hepatic microsomes of rats. 1993 Mar-Apr Drug Metab. Dispos. pmid:8097709
Wallace RJ et al. Drug intolerance to high-dose clarithromycin among elderly patients. 1993 Mar-Apr Diagn. Microbiol. Infect. Dis. pmid:8477575
Scaglione F et al. A new model examining intracellular and extracellular activity of amoxicillin, azithromycin, and clarithromycin in infected cells. 1993 Nov-Dec Chemotherapy pmid:8222870
Wüst J and Hardegger U Penetration of clarithromycin into human saliva. 1993 Sep-Oct Chemotherapy pmid:8370320
Darling TN et al. Treatment of Mycobacterium haemophilum infection with an antibiotic regimen including clarithromycin. 1994 Br. J. Dermatol. pmid:7918014
Rolinson GN A clarithromycin sensitivity survey. 1994 J. Antimicrob. Chemother. pmid:7829420
Durodie J and Slocombe B A clarithromycin sensitivity survey. 1994 J. Antimicrob. Chemother. pmid:7829421
Sano M et al. [Inhibition of biofilm formation by clarithromycin (CAM) in an experimental model of complicated bladder infection--in vitro study using automated simulation of urinary antimicrobial concentration]. 1994 Kansenshogaku Zasshi pmid:7829898
Dorrell L et al. Toxicity of clarithromycin in the treatment of Mycobacterium avium complex infection in a patient with AIDS. 1994 J. Antimicrob. Chemother. pmid:7868416
Funke G et al. Development of resistance to macrolide antibiotics in an AIDS patient treated with clarithromycin for Campylobacter jejuni diarrhea. 1994 Eur. J. Clin. Microbiol. Infect. Dis. pmid:7805694
Fujii R et al. [Clinical studies on clarithromycin dry syrup in the pediatric field. Pediatric Study Group of TE-031 Dry Syrup]. 1994 Jpn J Antibiot pmid:7807690
Ishida K et al. In vitro and in vivo activities of macrolides against Mycoplasma pneumoniae. 1994 Antimicrob. Agents Chemother. pmid:8031048
Guelar A et al. [Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. 1994 Enferm. Infecc. Microbiol. Clin. pmid:8011719
Aspin MM et al. Comparative study of the safety and efficacy of clarithromycin and amoxicillin-clavulanate in the treatment of acute otitis media in children. 1994 J. Pediatr. pmid:8021763
Chaisson RE et al. Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. AIDS Clinical Trials Group Protocol 157 Study Team. 1994 Ann. Intern. Med. pmid:7978715
Goldberger M and Masur H Clarithromycin therapy for Mycobacterium avium complex disease in patients with AIDS: potential and problems. 1994 Ann. Intern. Med. pmid:7978725
Ohgaki N Bacterial biofilm in chronic airway infection. 1994 Kansenshogaku Zasshi pmid:8138670
Yasuda H et al. Interaction between clarithromycin and biofilms formed by Staphylococcus epidermidis. 1994 Antimicrob. Agents Chemother. pmid:8141568
Uveitis associated with rifabutin therapy. 1994 MMWR Morb. Mortal. Wkly. Rep. pmid:8072478
Labenz J and Stolte M [Current therapy of Helicobacter pylori infection]. 1994 Leber Magen Darm pmid:8145628
Logan RP et al. Eradication of Helicobacter pylori with clarithromycin and omeprazole. 1994 Gut pmid:8150340
Fujii K et al. In vitro and in vivo antibacterial activities of KRM-1648 and KRM-1657, new rifamycin derivatives. 1994 Antimicrob. Agents Chemother. pmid:8067748
Goldman RC et al. Tight binding of clarithromycin, its 14-(R)-hydroxy metabolite, and erythromycin to Helicobacter pylori ribosomes. 1994 Antimicrob. Agents Chemother. pmid:7979278
Roblin PM et al. Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia. 1994 Antimicrob. Agents Chemother. pmid:7979292
Bermudez LE et al. Activity of KRM 1648 alone or in combination with ethambutol or clarithromycin against Mycobacterium avium in beige mouse model of disseminated infection. 1994 Antimicrob. Agents Chemother. pmid:7986018
al-Assi MT et al. Clarithromycin-amoxycillin therapy for Helicobacter pylori infection. 1994 Aliment. Pharmacol. Ther. pmid:7986970
Neri M et al. Omeprazole, bismuth and clarithromycin in the sequential treatment of Helicobacter pylori infection. 1994 Aliment. Pharmacol. Ther. pmid:7986974
[Recent advances in macrolide antibiotics: focused on clarithromycin. Discussion]. 1994 Jpn J Antibiot pmid:7990251
Wallace RJ et al. Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease. 1994 Am. J. Respir. Crit. Care Med. pmid:8173775
Husson RN et al. Orally administered clarithromycin for the treatment of systemic Mycobacterium avium complex infection in children with acquired immunodeficiency syndrome. 1994 J. Pediatr. pmid:8176574
Alder J et al. Treatment of experimental Pneumocystis carinii infection by combination of clarithromycin and sulphamethoxazole. 1994 J. Antimicrob. Chemother. pmid:8182006
Bermudez LE et al. Clarithromycin, dapsone, and a combination of both used to treat or prevent disseminated Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7695252
Mor N et al. Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium. 1994 Antimicrob. Agents Chemother. pmid:7695255
Calì G et al. [Clarithromycin in the treatment of oral infections]. 1994 Minerva Stomatol pmid:7700226
Reed PI The ECP-IM intervention study. 1994 Eur. J. Cancer Prev. pmid:7735056
Kodama R et al. Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori. 1994 Eur J Gastroenterol Hepatol pmid:7735929
Spangler SK et al. Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. 1994 Antimicrob. Agents Chemother. pmid:8192445
Jones RN et al. Validation of NCCLS macrolide (azithromycin, clarithromycin, and erythromycin) interpretive criteria for Haemophilus influenzae tested with the Haemophilus test medium. National Committee for Clinical Laboratory Standards. 1994 Diagn. Microbiol. Infect. Dis. pmid:7924221
Wolinsky E Mycobacterium avium strains resistant to clarithromycin and azithromycin. 1994 Antimicrob. Agents Chemother. pmid:8031406
Klemens SP and Cynamon MH Activities of azithromycin and clarithromycin against nontuberculous mycobacteria in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7979271
Kanatani MS and Guglielmo BJ The new macrolides. Azithromycin and clarithromycin. 1994 West. J. Med. pmid:8128699
Yoshida K et al. Chlamydia trachomatis infection in the semen of asymptomatic infertile men: detection of the antigen by in situ hybridization. 1994 Urol. Int. pmid:7855940
Yamada S et al. [A child with iritis due to Chlamydia pneumoniae infection]. 1994 Kansenshogaku Zasshi pmid:7876679