clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Heifets L et al. | Capreomycin is active against non-replicating M. tuberculosis. | 2005 | Ann. Clin. Microbiol. Antimicrob. | pmid:15804353 |
Gould SW et al. | The need for continued monitoring of antibiotic resistance patterns in clinical isolates of Staphylococcus aureus from London and Malta. | 2010 | Ann. Clin. Microbiol. Antimicrob. | pmid:20663145 |
Sethi S et al. | Antibiotic activity of telithromycin and comparators against bacterial pathogens isolated from 3,043 patients with acute exacerbation of chronic bronchitis. | 2005 | Ann. Clin. Microbiol. Antimicrob. | pmid:15755326 |
Sankar MM et al. | In-vitro antimycobacterial drug susceptibility testing of non-tubercular mycobacteria by tetrazolium microplate assay. | 2008 | Ann. Clin. Microbiol. Antimicrob. | pmid:18620572 |
Destura RV et al. | Laboratory diagnosis and susceptibility profile of Helicobacter pylori infection in the Philippines. | 2004 | Ann. Clin. Microbiol. Antimicrob. | pmid:15546485 |
Tanabe H et al. | Vonoprazan-based triple therapy is non-inferior to susceptibility-guided proton pump inhibitor-based triple therapy for Helicobacter pylori eradication. | 2018 | Ann. Clin. Microbiol. Antimicrob. | pmid:29950163 |
Akram FE et al. | A combination of silver nanoparticles and visible blue light enhances the antibacterial efficacy of ineffective antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). | 2016 | Ann. Clin. Microbiol. Antimicrob. | pmid:27530257 |
Bago J et al. | Antimicrobial resistance of H. pylori to the outcome of 10-days vs. 7-days Moxifloxacin based therapy for the eradication: a randomized controlled trial. | 2010 | Ann. Clin. Microbiol. Antimicrob. | pmid:20398300 |
Zanetti S et al. | "In vitro" activities of antimycobacterial agents against Mycobacterium avium subsp. paratuberculosis linked to Crohn's disease and paratuberculosis. | 2006 | Ann. Clin. Microbiol. Antimicrob. | pmid:17107610 |
Chen J et al. | Application of next-generation sequencing to characterize novel mutations in clarithromycin-susceptible Helicobacter pylori strains with A2143G of 23S rRNA gene. | 2018 | Ann. Clin. Microbiol. Antimicrob. | pmid:29562911 |
Seck A et al. | Primary antibiotic resistance and associated mechanisms in Helicobacter pylori isolates from Senegalese patients. | 2013 | Ann. Clin. Microbiol. Antimicrob. | pmid:23298145 |
Dohar J et al. | Activity of telithromycin and comparators against bacterial pathogens isolated from 1,336 patients with clinically diagnosed acute sinusitis. | 2004 | Ann. Clin. Microbiol. Antimicrob. | pmid:15287988 |
Jones ME et al. | Emerging resistance among bacterial pathogens in the intensive care unit--a European and North American Surveillance study (2000-2002). | 2004 | Ann. Clin. Microbiol. Antimicrob. | pmid:15283864 |
Mohan S et al. | Physician behaviour for antimicrobial prescribing for paediatric upper respiratory tract infections: a survey in general practice in Trinidad, West Indies. | 2004 | Ann. Clin. Microbiol. Antimicrob. | pmid:15196306 |
Bolland MJ et al. | Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report. | 2008 | Ann. Clin. Microbiol. Antimicrob. | pmid:18226256 |
Korkmaz S et al. | Unusual manifestations of acute Q fever: autoimmune hemolytic anemia and tubulointerstitial nephritis. | 2012 | Ann. Clin. Microbiol. Antimicrob. | pmid:22607576 |
Myers AL et al. | Genetic commonality of macrolide-resistant group A beta hemolytic streptococcus pharyngeal strains. | 2009 | Ann. Clin. Microbiol. Antimicrob. | pmid:19951439 |
Roberts JC et al. | Fatal necrotizing pneumonia due to a Panton-Valentine leukocidin positive community-associated methicillin-sensitive Staphylococcus aureus and Influenza co-infection: a case report. | 2008 | Ann. Clin. Microbiol. Antimicrob. | pmid:18284686 |
Ribeiro ML et al. | Mutations in the 23S rRNA gene are associated with clarithromycin resistance in Helicobacter pylori isolates in Brazil. | 2003 | Ann. Clin. Microbiol. Antimicrob. | pmid:14633281 |
Ali SM et al. | Antimicrobial activities of Eugenol and Cinnamaldehyde against the human gastric pathogen Helicobacter pylori. | 2005 | Ann. Clin. Microbiol. Antimicrob. | pmid:16371157 |
Ben Mansour K et al. | Primary resistance to clarithromycin, metronidazole and amoxicillin of Helicobacter pylori isolated from Tunisian patients with peptic ulcers and gastritis: a prospective multicentre study. | 2010 | Ann. Clin. Microbiol. Antimicrob. | pmid:20707901 |
Tsumoto C et al. | Long-term efficacy of Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura: 7-year follow-up prospective study. | 2009 | Ann. Hematol. | pmid:19096845 |
Soler JA et al. | H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): a prospective cohort study. | 2009 | Ann. Hematol. | pmid:19159929 |
Kornacker M et al. | Occurrence of sarcoidosis subsequent to chemotherapy for non-Hodgkin's lymphoma: report of two cases. | 2002 | Ann. Hematol. | pmid:11907791 |
Kato H et al. | Addition of clarithromycin to lenalidomide/low-dose dexamethasone was effective in a case of relapsed myeloma after long-term use of lenalidomide. | 2013 | Ann. Hematol. | pmid:23625297 |
Bilgilier C et al. | Prevalence of clarithromycin-resistant Helicobacter pylori strains in gastric mucosa-associated lymphoid tissue lymphoma patients. | 2016 | Ann. Hematol. | pmid:27091350 |
Huang HC et al. | Primary central nervous system diffuse large B cell lymphoma transformed from orbital mucosa-associated lymphoid tissue lymphoma: complete response to combined intrathecal and systemic rituximab. | 2013 | Ann. Hematol. | pmid:23242476 |
Kim H et al. | Efficacy of Helicobacter pylori eradication for the 1st line treatment of immune thrombocytopenia patients with moderate thrombocytopenia. | 2015 | Ann. Hematol. | pmid:25501820 |
Kobayashi T et al. | The potential role of clarithromycin addition to lenalidomide and dexamethasone therapy (BiRd) in multiple myeloma. | 2018 | Ann. Hematol. | pmid:29427183 |
Todo K et al. | Severe Helicobacter pylori gastritis-related thrombocytopenia and iron deficiency anemia in an adolescent female. | 2016 | Ann. Hematol. | pmid:26957356 |
Alpen B et al. | Helicobacter pylori eradication therapy in gastric high grade non Hodgkin's lymphoma (NHL). | 2001 | Ann. Hematol. | pmid:11757689 |
Tsutsumi Y et al. | Randomized study of Helicobacter pylori eradication therapy and proton pump inhibitor monotherapy for idiopathic thrombocytopenic purpura. | 2005 | Ann. Hematol. | pmid:16078036 |
Souto Filho JTD et al. | Long-term complete remission of primary gastric plasmacytoma following endoscopic resection. | 2017 | Ann. Hematol. | pmid:28315923 |
Musher DM | Clarithromycin therapy for Mycobacterium avium complex bacteremia. | 1995 | Ann. Intern. Med. | pmid:7778830 |
van der Meer JT and Danner SA | Clarithromycin therapy for Mycobacterium avium complex bacteremia. | 1995 | Ann. Intern. Med. | pmid:7778831 |
Patel AM et al. | Statin toxicity from macrolide antibiotic coprescription: a population-based cohort study. | 2013 | Ann. Intern. Med. | pmid:23778904 |
Steinman MA et al. | Changing use of antibiotics in community-based outpatient practice, 1991-1999. | 2003 | Ann. Intern. Med. | pmid:12667022 |
Chaisson RE et al. | Clarithromycin therapy for bacteremic Mycobacterium avium complex disease. A randomized, double-blind, dose-ranging study in patients with AIDS. AIDS Clinical Trials Group Protocol 157 Study Team. | 1994 | Ann. Intern. Med. | pmid:7978715 |
Goldberger M and Masur H | Clarithromycin therapy for Mycobacterium avium complex disease in patients with AIDS: potential and problems. | 1994 | Ann. Intern. Med. | pmid:7978725 |
Shafran SD et al. | Successful discontinuation of therapy for disseminated Mycobacterium avium complex infection after effective antiretroviral therapy. | 2002 | Ann. Intern. Med. | pmid:12416943 |
Vaira D et al. | Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a randomized trial. | 2007 | Ann. Intern. Med. | pmid:17438314 |
Singh N and Yu VL | Clarithromycin therapy for Mycobacterium avium complex bacteremia. | 1995 | Ann. Intern. Med. | pmid:7632282 |
Wallace RJ et al. | Clinical trial of clarithromycin for cutaneous (disseminated) infection due to Mycobacterium chelonae. | 1993 | Ann. Intern. Med. | pmid:8357113 |
Neu HC | New macrolide antibiotics: azithromycin and clarithromycin. | 1992 | Ann. Intern. Med. | pmid:1310839 |
McMahon BJ et al. | The relationship among previous antimicrobial use, antimicrobial resistance, and treatment outcomes for Helicobacter pylori infections. | 2003 | Ann. Intern. Med. | pmid:13679322 |
Sjölund M et al. | Long-term persistence of resistant Enterococcus species after antibiotics to eradicate Helicobacter pylori. | 2003 | Ann. Intern. Med. | pmid:13679325 |
Summaries for patients. Past antibiotic use affects resistance and outcomes of Helicobacter pylori infection. | 2003 | Ann. Intern. Med. | pmid:13679344 | |
Summaries for patients. Effects of antibiotic treatment for Helicobacter pylori on normal bowel bacteria. | 2003 | Ann. Intern. Med. | pmid:13679347 | |
Liviu L et al. | Pancreatitis induced by clarithromycin. | 1996 | Ann. Intern. Med. | pmid:8849171 |
Seow J and Chew FT | Risk factors for Helicobacter pylori resistance. | 2004 | Ann. Intern. Med. | pmid:15172911 |
Jafri NS et al. | Meta-analysis: sequential therapy appears superior to standard therapy for Helicobacter pylori infection in patients naive to treatment. | 2008 | Ann. Intern. Med. | pmid:18490667 |
Berk SL | New macrolide antibiotics. | 1992 | Ann. Intern. Med. | pmid:1386966 |
Ohkusa T et al. | Disappearance of hyperplastic polyps in the stomach after eradication of Helicobacter pylori. A randomized, clinical trial. | 1998 | Ann. Intern. Med. | pmid:9841603 |
Summaries for patients. Factors associated with Helicobacter pylori infections in the United States that are resistant to usual antibiotics. | 2002 | Ann. Intern. Med. | pmid:11797613 | |
De Francesco V et al. | Clarithromycin-resistant genotypes and eradication of Helicobacter pylori. | 2006 | Ann. Intern. Med. | pmid:16418408 |
Meyer JM et al. | Risk factors for Helicobacter pylori resistance in the United States: the surveillance of H. pylori antimicrobial resistance partnership (SHARP) study, 1993-1999. | 2002 | Ann. Intern. Med. | pmid:11777360 |
Trivedi S et al. | Clarithromycin and digoxin toxicity. | 1998 | Ann. Intern. Med. | pmid:9518419 |
Yang YJ et al. | Ten days of levofloxacin-containing concomitant therapy can achieve effective Helicobacter pylori eradication in patients with type 2 diabetes. | 2017 | Ann. Med. | pmid:28266875 |
Trotti LM et al. | Clarithromycin in γ-aminobutyric acid-Related hypersomnolence: A randomized, crossover trial. | 2015 | Ann. Neurol. | pmid:26094838 |
Ferreri AJ et al. | High-dose clarithromycin is an active monotherapy for patients with relapsed/refractory extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT): the HD-K phase II trial. | 2015 | Ann. Oncol. | pmid:25935794 |
Di Raimondo F et al. | Is endoscopic ultrasound clinically useful for follow-up of gastric lymphoma? | 2007 | Ann. Oncol. | pmid:17065587 |
Rhee CS et al. | Effects of clarithromycin on rheological properties of nasal mucus in patients with chronic sinusitis. | 2000 | Ann. Otol. Rhinol. Laryngol. | pmid:10823478 |
Heffernan CB et al. | Does Clarithromycin Cause Hearing Loss? A 12-Year Review of Clarithromycin Therapy for Nontuberculous Mycobacterial Lymphadenitis in Children. | 2018 | Ann. Otol. Rhinol. Laryngol. | pmid:30032669 |
Clifford K et al. | Double-blind comparative trial of ciprofloxacin versus clarithromycin in the treatment of acute bacterial sinusitis. Sinusitis Infection Study Group. | 1999 | Ann. Otol. Rhinol. Laryngol. | pmid:10214783 |
Mullin D et al. | Mycobacterium chelonae infections involving the head and neck. | 2009 | Ann. Otol. Rhinol. Laryngol. | pmid:19894399 |
Callaghan R and Allen M | Mycobacterium malmoense infection of the knee. | 2003 | Ann. Rheum. Dis. | pmid:14583565 |
Hiramatsu M et al. | Risk factors that affect the surgical outcome in the management of focal bronchiectasis in a developed country. | 2012 | Ann. Thorac. Surg. | pmid:22119119 |
Fan X et al. | Lung perfusion with clarithromycin ameliorates lung function after cardiopulmonary bypass. | 2006 | Ann. Thorac. Surg. | pmid:16488691 |
Nelson KG et al. | Results of operation in Mycobacterium avium-intracellulare lung disease. | 1998 | Ann. Thorac. Surg. | pmid:9725364 |
Kadir IS et al. | Recurrent acute rheumatic fever: a forgotten diagnosis? | 2004 | Ann. Thorac. Surg. | pmid:15276555 |
Bossert T et al. | Successful management of two heart transplant recipients with mycobacterial pulmonary infections. | 2005 | Ann. Thorac. Surg. | pmid:16039241 |
Watanabe M et al. | Early pulmonary resection for Mycobacterium avium complex lung disease treated with macrolides and quinolones. | 2006 | Ann. Thorac. Surg. | pmid:16731124 |
Gintovt EA | [Use of clarithromycin in the treatment of atopic dermatitis complicated by staphylococcal infection]. | 2004 | Antibiot. Khimioter. | pmid:15164520 |
Vasil'ev IuV and Zvenigorodskaia LA | [Fromilide (clarithromycin) in eradication of Helicobacter pylori in patients with duodenal ulcer]. | 2002 | Antibiot. Khimioter. | pmid:12365323 |
Iakovlev EA et al. | [Present stage of chemotherapy and chemoprophylaxis of rickettsiosis and Q fever]. | 2011 | Antibiot. Khimioter. | pmid:22856156 |
Iakovlev VP | [New semisynthetic macrolides. Clarithromycin--its importance in the current therapy of bacterial infections]. | 1999 | Antibiot. Khimioter. | pmid:10635418 |
Evdokimova AG et al. | [New approaches to therapy of Helicobacterpylori infection (by the materials of the Maastricht Consensus-IV, Florence, 2010)]. | 2013 | Antibiot. Khimioter. | pmid:24640139 |
Iakovlev VP et al. | [Macrolide antibiotic clarithromycin (Klabax) in treatment of community-acquired respiratory tract infections]. | 2000 | Antibiot. Khimioter. | pmid:11210297 |
Shcherbakov PL | [Clarithromycin in eradication therapy of helicobacter infections in children]. | 2001 | Antibiot. Khimioter. | pmid:11871315 |
Sazykin IuO et al. | [Clarithromycin and tumor chemotherapy]. | 2000 | Antibiot. Khimioter. | pmid:11210301 |
Iutanova NS | [Clinical efficacy of clarithromycin delayed release dosage form in the treatment of community-acquired pneumonia]. | 2004 | Antibiot. Khimioter. | pmid:15344392 |
Budanov SV and Vasil'ev AN | [Clarithromycin: specific features of antimicrobial spectrum and clinical use]. | 2004 | Antibiot. Khimioter. | pmid:15285409 |
Guchev IA et al. | [Evaluation of clarithromycin efficacy in the treatment of community-acquired pneumonia on the basis of the Binax NOW test results (a prospective open trial)]. | 2002 | Antibiot. Khimioter. | pmid:12619516 |
Aoki D et al. | Roxithromycin inhibits angiogenesis of human hepatoma cells in vivo by suppressing VEGF production. | Anticancer Res. | pmid:15816530 | |
Ohara T et al. | Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice. | 2004 Nov-Dec | Anticancer Res. | pmid:15736403 |
Svensson M et al. | Pharmacodynamic effects of nitroimidazoles alone and in combination with clarithromycin on Helicobacter pylori. | 2002 | Antimicrob. Agents Chemother. | pmid:12069981 |
Comley JC and Sterling AM | Effect of atovaquone and atovaquone drug combinations on prophylaxis of Pneumocystis carinii pneumonia in SCID mice. | 1995 | Antimicrob. Agents Chemother. | pmid:7785975 |
Alder J et al. | Efficacy of clarithromycin for treatment of experimental Lyme disease in vivo. | 1993 | Antimicrob. Agents Chemother. | pmid:8328782 |
Collins L and Franzblau SG | Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. | 1997 | Antimicrob. Agents Chemother. | pmid:9145860 |
Bosnar M et al. | Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin. | 2005 | Antimicrob. Agents Chemother. | pmid:15917536 |
Burton AJ et al. | Activity of clarithromycin or rifampin alone or in combination against experimental Rhodococcus equi infection in mice. | 2015 | Antimicrob. Agents Chemother. | pmid:25824218 |
Kohyama T et al. | Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. | 1999 | Antimicrob. Agents Chemother. | pmid:10103198 |
Abduljalil K et al. | Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration. | 2009 | Antimicrob. Agents Chemother. | pmid:19414584 |
Stone GG et al. | A PCR-oligonucleotide ligation assay to determine the prevalence of 23S rRNA gene mutations in clarithromycin-resistant Helicobacter pylori. | 1997 | Antimicrob. Agents Chemother. | pmid:9056021 |
Heifets L et al. | Mycobacterium avium strains resistant to clarithromycin and azithromycin. | 1993 | Antimicrob. Agents Chemother. | pmid:8031351 |
Jesus FP et al. | In Vitro and In Vivo Antimicrobial Activities of Minocycline in Combination with Azithromycin, Clarithromycin, or Tigecycline against Pythium insidiosum. | 2015 | Antimicrob. Agents Chemother. | pmid:26459895 |
Fernandes PB et al. | In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide. | 1986 | Antimicrob. Agents Chemother. | pmid:2949695 |
Gelber RH et al. | Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice. | 1991 | Antimicrob. Agents Chemother. | pmid:1648889 |
Welsh L et al. | In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8787907 |
Best LM et al. | Multilaboratory comparison of proficiencies in susceptibility testing of Helicobacter pylori and correlation between agar dilution and E test methods. | 2003 | Antimicrob. Agents Chemother. | pmid:14506021 |