clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Zhao C et al. | [Resistance surveillance of major pathogens for adult community-acquired respiratory tract infections in China: a multicenter study 2012]. | 2015 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:25791651 |
Chen PR and Tan SY | [The treatment outcomes of 21 cases of rapidly growing mycobacteria related pulmonary disease]. | 2013 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:23856140 |
Sun H et al. | [Antimicrobial susceptibility of community-acquired respiratory tract pathogens isolated from class B hospitals in China during 2013 and 2014]. | 2016 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:26792053 |
Yan WH et al. | [Preliminary study on in-vitro induction of antibiotic resistance in Helicobacter pylori strains isolated from children]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:18021568 |
Hua CZ et al. | [Serotypes and antibiotics-resistance patterns of 247 strains of Haemophilus Influenzae isolated from children in Hangzhou]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15631716 |
Chen J et al. | [Prevalence of Helicobacter pylori resistant to clarithromycin, amoxicillin and metronidazole in children]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:16221349 |
Huang J et al. | [A 10-day sequential therapy for eradication of Helicobacter pylori infection in children]. | 2012 | Zhonghua Er Ke Za Zhi | pmid:23158730 |
Chen J et al. | [Prevalence and mechanism of Helicobacter pylori resistance to clarithromycin in children]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15631715 |
Yang H et al. | [Macrolide-resistant Streptococcus pneumoniae in the pediatric population in Beijing]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15733368 |
Wang Y et al. | [Analysis of the infection status and the drug resistance of mycoplasma and chlamydiae in genitourinary tracts of children with suspected nongonococcal urethritis]. | 2009 | Zhonghua Er Ke Za Zhi | pmid:19573386 |