clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Tracy TS and Johns M | Comment: delirium probably induced by clarithromycin in a patient receiving fluoxetine. | 1996 | Ann Pharmacother | pmid:8893135 |
Wintermeyer SM et al. | Dirithromycin: a new macrolide. | 1996 | Ann Pharmacother | pmid:8893122 |
Hunt Gerardo S et al. | Comparison of Etest to broth microdilution method for testing Streptococcus pneumoniae susceptibility to levofloxacin and three macrolides. | 1996 | Antimicrob. Agents Chemother. | pmid:8891154 |
Patel KB et al. | Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. | 1996 | Antimicrob. Agents Chemother. | pmid:8891147 |
Tateda K et al. | Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. | 1996 | Antimicrob. Agents Chemother. | pmid:8891128 |
Giacometti A et al. | In-vitro activity of macrolides alone and in combination with artemisin, atovaquone, dapsone, minocycline or pyrimethamine against Cryptosporidium parvum. | 1996 | J. Antimicrob. Chemother. | pmid:8889715 |
Tursi A et al. | One-week low-dose triple therapy vs. two-week medium-dose double therapy for H.pylori infection. | 1996 Jul-Aug | Hepatogastroenterology | pmid:8884304 |
Ji B et al. | Bactericidal activity of single dose of clarithromycin plus minocycline, with or without ofloxacin, against Mycobacterium leprae in patients. | 1996 | Antimicrob. Agents Chemother. | pmid:8878595 |
Pankuch GA et al. | MIC and time-kill study of antipneumococcal activities of RPR 106972 (a new oral streptogramin), RP 59500 (quinupristin-dalfopristin), pyostacine (RP 7293), penicillin G, cefotaxime, erythromycin, and clarithromycin against 10 penicillin-susceptible and -resistant pneumococci. | 1996 | Antimicrob. Agents Chemother. | pmid:8878583 |
Wenisch C et al. | Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. | 1996 | Antimicrob. Agents Chemother. | pmid:8878577 |
McLinn S and Williams D | Incidence of antibiotic-resistant Streptococcus pneumoniae and beta-lactamase-positive Haemophilus influenzae in clinical isolates from patients with otitis media. | 1996 | Pediatr. Infect. Dis. J. | pmid:8878239 |
Thor P et al. | Dysfunction in gastric myoelectric and motor activity in Helicobacter pylori positive gastritis patients with non-ulcer dyspesia. | 1996 | J. Physiol. Pharmacol. | pmid:8877902 |
Tursi A et al. | Helicobacter pylori eradication helps resolve pyloric and duodenal stenosis. | 1996 | J. Clin. Gastroenterol. | pmid:8877648 |
Dhaenens L et al. | In-vitro activities of clarithromycin and other antimicrobial agents against Helicobacter pylori isolated from children. | 1996 | J. Antimicrob. Chemother. | pmid:8877551 |
Fisher M et al. | The management of mycobacterial infections in HIV seropositive individuals. Jefferiss Wing Therapeutics and Protocols Group. | 1996 | Int J STD AIDS | pmid:8876354 |
Yousfi MM et al. | Metronidazole, ranitidine and clarithromycin combination for treatment of Helicobacter pylori infection (modified Bazzoli's triple therapy). | 1996 | Aliment. Pharmacol. Ther. | pmid:8871452 |
Ferguson PJ and Saulsbury FT | Successful treatment of chronic Mycobacterium abscessus otitis media with clarithromycin. | 1996 | Pediatr. Infect. Dis. J. | pmid:8866816 |
Xu G et al. | Effect of macrolide antibiotics on macrophage functions. | 1996 | Microbiol. Immunol. | pmid:8865152 |
Hackelsberger A and Malfertheiner P | A risk-benefit assessment of drugs used in the eradication of Helicobacter pylori infection. | 1996 | Drug Saf | pmid:8862962 |
Chiba N | Omeprazole and clarithromycin with and without metronidazole for the eradication of Helicobacter pylori. | 1996 | Am. J. Gastroenterol. | pmid:8855737 |
Schimkat M et al. | Rifabutin-associated anterior uveitis in patients infected with human immunodeficiency virus. | 1996 | Ger J Ophthalmol | pmid:8854102 |
Yousfi MM et al. | One-week triple therapy with omeprazole, amoxycillin and clarithromycin for treatment of Helicobacter pylori infection. | 1996 | Aliment. Pharmacol. Ther. | pmid:8853767 |
Cone LA et al. | Mania due to clarithromycin therapy in a patient who was not infected with human immunodeficiency virus. | 1996 | Clin. Infect. Dis. | pmid:8853002 |
Dammann HG | [Helicobacter pylori eradication: triple therapy versus dual therapy]. | 1996 | Fortschr. Med. | pmid:8852685 |
Vermot D et al. | Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis. | 1996 | Antimicrob. Agents Chemother. | pmid:8851620 |
Amsden GW | Erythromycin, clarithromycin, and azithromycin: are the differences real? | 1996 Jan-Feb | Clin Ther | pmid:8851453 |
O'Hara K and Yamamoto K | Reaction of roxithromycin and clarithromycin with macrolide-inactivating enzymes from highly erythromycin-resistant Escherichia coli. | 1996 | Antimicrob. Agents Chemother. | pmid:8849224 |
Liviu L et al. | Pancreatitis induced by clarithromycin. | 1996 | Ann. Intern. Med. | pmid:8849171 |
Ednie LM et al. | Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci. | 1996 | Antimicrob. Agents Chemother. | pmid:8843313 |
Rana KZ et al. | Clarithromycin does not affect phosphorylation of zidovudine in vitro. | 1996 | Antimicrob. Agents Chemother. | pmid:8843311 |
Alper CM et al. | Efficacy of clarithromycin treatment of acute otitis media caused by infection with penicillin-susceptible, -intermediate, and -resistant Streptococcus pneumoniae in the chinchilla. | 1996 | Antimicrob. Agents Chemother. | pmid:8843299 |
Heifets L | Susceptibility testing of Mycobacterium avium complex isolates. | 1996 | Antimicrob. Agents Chemother. | pmid:8843278 |
Yousfi MM et al. | Resolution of a metaplastic duodenal polyp after cure of Helicobacter pylori infection. | 1996 | J. Clin. Gastroenterol. | pmid:8835902 |
Versalovic J et al. | Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. | 1996 | Antimicrob. Agents Chemother. | pmid:8834903 |
Dattwyler RJ et al. | Clarithromycin in treatment of early Lyme disease: a pilot study. | 1996 | Antimicrob. Agents Chemother. | pmid:8834900 |
Ji B et al. | How effective is KRM-1648 in treatment of disseminated Mycobacterium avium complex infections in beige mice? | 1996 | Antimicrob. Agents Chemother. | pmid:8834894 |
Yamamoto T et al. | Activity of KRM-1648 alone or in combination with both ethambutol and kanamycin or clarithromycin against Mycobacterium intracellulare infections in beige mice. | 1996 | Antimicrob. Agents Chemother. | pmid:8834892 |
Ji B et al. | Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice. | 1996 | Antimicrob. Agents Chemother. | pmid:8834886 |
Vangala R and Cernek PK | Hypersensitivity reaction to clarithromycin. | 1996 | Ann Pharmacother | pmid:8833572 |
Erah PO et al. | Ion-pair high-performance liquid chromatographic assay method for the assessment of clarithromycin stability in aqueous solution and in gastric juice. | 1996 | J. Chromatogr. B, Biomed. Appl. | pmid:8832427 |
Piersimoni C et al. | Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of Mycobacterium avium complex. | 1995 | J. Antimicrob. Chemother. | pmid:8830013 |
Webb DD | Practice guidelines for treatment of peptic ulcer disease. | 1996 | JAMA | pmid:8827959 |
Pijpers E et al. | A clarithromycin-induced myasthenic syndrome. | 1996 | Clin. Infect. Dis. | pmid:8824993 |
Xu G et al. | [Effect of clarithromycin on cytocidal activity against Pseudomonas aeruginosa in mice peritoneal cavity]. | 1996 | Kansenshogaku Zasshi | pmid:8822058 |
Nishi K et al. | [Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome]. | 1995 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8821993 |
Sketris IS et al. | Possible role of the intestinal P-450 enzyme system in a cyclosporine-clarithromycin interaction. | 1996 Mar-Apr | Pharmacotherapy | pmid:8820476 |
Nash KA and Inderlied CB | Rapid detection of mutations associated with macrolide resistance in Mycobacterium avium complex. | 1996 | Antimicrob. Agents Chemother. | pmid:8807078 |
Gillum JG et al. | Effect of combination therapy with ciprofloxacin and clarithromycin on theophylline pharmacokinetics in healthy volunteers. | 1996 | Antimicrob. Agents Chemother. | pmid:8807068 |
Wallace RJ et al. | Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. | 1996 | Antimicrob. Agents Chemother. | pmid:8807061 |
Conte JE et al. | Single-dose intrapulmonary pharmacokinetics of azithromycin, clarithromycin, ciprofloxacin, and cefuroxime in volunteer subjects. | 1996 | Antimicrob. Agents Chemother. | pmid:8807050 |
Goh KL et al. | Helicobacter pylori eradication with short-term therapy leads to duodenal ulcer healing without the need for continued acid suppression therapy. | 1996 | Eur J Gastroenterol Hepatol | pmid:8804868 |
Papp J et al. | Efficacy of nizatidine, clarithromycin and bismuth subcitrate therapy for Helicobacter pylori eradication in duodenal ulcer patients--a preliminary report. | 1996 Jul-Aug | Br J Clin Pract | pmid:8794601 |
Tursi A et al. | Low-dose omeprazole plus clarithromycin and either tinidazole or amoxycillin for Helicobacter pylori infection. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791952 |
Weldon MJ et al. | A seven-day Helicobacter pylori treatment regimen using clarithromycin, omeprazole and tripotassium dicitrato bismuthate. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791951 |
Jaup BH and Norrby A | Comparison of two low-dose one-week triple therapy regimens with and without metronidazole for cure of H. pylori infection. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791950 |
Delchier JC et al. | Omeprazole-amoxycillin versus omeprazole-amoxycillin-clarithromycin in the eradication of Helicobacter pylori. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791948 |
Peterson WL et al. | Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence. RBC H. pylori Study Group. | 1996 | Aliment. Pharmacol. Ther. | pmid:8791947 |
Gross U and Pohl F | Influence of antimicrobial agents on replication and stage conversion of Toxoplasma gondii. | 1996 | Curr. Top. Microbiol. Immunol. | pmid:8791704 |
Mehaffey PC et al. | Evaluation of in vitro spectra of activity of azithromycin, clarithromycin, and erythromycin tested against strains of Neisseria gonorrhoeae by reference agar dilution, disk diffusion, and Etest methods. | 1996 | J. Clin. Microbiol. | pmid:8789046 |
Welsh L et al. | In vitro activities of azithromycin, clarithromycin, erythromycin, and tetracycline against 13 strains of Chlamydia pneumoniae. | 1996 | Antimicrob. Agents Chemother. | pmid:8787907 |
Reid R et al. | Pneumococcal meningitis during therapy of otitis media with clarithromycin. | 1995 | Pediatr. Infect. Dis. J. | pmid:8786899 |
Bagarazzi ML et al. | Pulmonary Mycobacterium gordonae infection in a two-year-old child: case report. | 1996 | Clin. Infect. Dis. | pmid:8783736 |
Plemmons RM et al. | Otitis media and mastoiditis due to Mycobacterium fortuitum: case report, review of four cases, and a cautionary note. | 1996 | Clin. Infect. Dis. | pmid:8783722 |
Apseloff G et al. | Severe neutropenia caused by recommended prophylactic doses of rifabutin. | 1996 | Lancet | pmid:8782773 |
Roesch W | Cost-effectiveness of H. pylori eradication. | 1996 | J. Physiol. Pharmacol. | pmid:8777309 |
Deltenre M et al. | Strategies for Helicobacter pylori eradication in 1995: a review of international and Belgian experience. | 1996 | J. Physiol. Pharmacol. | pmid:8777308 |
Gabryelewicz A | Critical evaluation of the treatment of peptic ulcer diseases associated with Helicobacter pylori infection. | 1996 | J. Physiol. Pharmacol. | pmid:8777307 |
Sito E et al. | One week treatment with omeprazole, clarithromycin and tinidazole or lansoprazole, amoxicillin and metronidazole for cure of Helicobacter pylori infection in duodenal ulcer patients. | 1996 | J. Physiol. Pharmacol. | pmid:8777303 |
Berger C et al. | Treatment of nontuberculous mycobacterial lymphadenitis with clarithromycin plus rifabutin. | 1996 | J. Pediatr. | pmid:8774511 |
Jordan WC | Clarithromycin prophylaxis against Cryptosporidium enteritis in patients with AIDS. | 1996 | J Natl Med Assoc | pmid:8764523 |
Géhanno P et al. | [Clarithromycin versus amoxicillin-clavulanic acid in the treatment of acute maxillary sinusitis in adults]. | 1996 | Pathol. Biol. | pmid:8763594 |
Sander P et al. | Ribosomal drug resistance in mycobacteria. | 1996 Jan-Feb | Res. Microbiol. | pmid:8761724 |
Debets-Ossenkopp YJ et al. | Mechanism of clarithromycin resistance in clinical isolates of Helicobacter pylori. | 1996 | FEMS Microbiol. Lett. | pmid:8759787 |
Tursi A et al. | Short-term low-dose triple therapy with lansoprazole plus amoxycillin and clarithromycin for Helicobacter pylori eradication. | 1996 | Am. J. Gastroenterol. | pmid:8759696 |
Santander C et al. | Antimicrobial therapy for Helicobacter pylori infection versus long-term maintenance antisecretion treatment in the prevention of recurrent hemorrhage from peptic ulcer: prospective nonrandomized trial on 125 patients. | 1996 | Am. J. Gastroenterol. | pmid:8759659 |
Sternon J et al. | Azithromycin compared with clarithromycin in the treatment of adult patients with acute purulent tracheobronchitis: a cost of illness study. | 1995 Nov-Dec | J. Int. Med. Res. | pmid:8746608 |
Markham A and McTavish D | Clarithromycin and omeprazole as helicobacter pylori eradication therapy in patients with H. pylori-associated gastric disorders. | 1996 | Drugs | pmid:8741237 |
Akamatsu H et al. | Enhanced effect of clarithromycin on neutrophil function in vitro. | 1996 Mar-Apr | J. Int. Med. Res. | pmid:8737228 |
Lebrun L et al. | Evaluation of the Etest for rapid susceptibility testing of Mycobacterium avium to clarithromycin. | 1996 | J. Antimicrob. Chemother. | pmid:8737150 |
Koga T et al. | In-vitro and in-vivo antibacterial activity of plaunotol, a cytoprotective antiulcer agent, against Helicobacter pylori. | 1996 | J. Antimicrob. Chemother. | pmid:8737142 |
Cayla R | [How to eradicate Helicobacter pylori?]. | 1996 | Gastroenterol. Clin. Biol. | pmid:8734380 |
Deltenre M et al. | [How to eradicate Helicobacter pylori in 1995? Critical review of available treatments]. | 1996 | Gastroenterol. Clin. Biol. | pmid:8734370 |
Heifets LB | Clarithromycin against Mycobacterium avium complex infections. | 1996 | Tuber. Lung Dis. | pmid:8733409 |
Bachelez H et al. | Disseminated varioliform pustular eruption due to Mycobacterium avium intracellulare in an HIV-infected patient. | 1996 | Br. J. Dermatol. | pmid:8733397 |
Labenz J et al. | One-week triple therapy with omeprazole, amoxycillin and either clarithromycin or metronidazole for cure of Helicobacter pylori infection. | 1996 | Aliment. Pharmacol. Ther. | pmid:8730252 |
Dalla Libera M et al. | High effectiveness and safety of one-week antibiotic regimen in Helicobacter pylori eradication. | 1996 | Aliment. Pharmacol. Ther. | pmid:8730251 |
Gillum JG et al. | Effect of clarithromycin on the pharmacokinetics of 2',3'-dideoxyinosine in patients who are seropositive for human immunodeficiency virus. | 1996 | Clin. Infect. Dis. | pmid:8729217 |
Darouiche RO et al. | Recurrent disseminated infection with Mycobacterium avium complex identified in tissues by molecular analysis. | 1996 | Clin. Infect. Dis. | pmid:8729215 |
Vasquez A et al. | Metronidazole and clarithromycin resistance in Helicobacter pylori determined by measuring MICs of antimicrobial agents in color indicator egg yolk agar in a miniwell format. The Gastrointestinal Physiology Working Group of Universidad Peruana Cayetano Heredia and the Johns Hopkins University. | 1996 | J. Clin. Microbiol. | pmid:8727909 |
Mertl SL | The role of clarithromycin in the prophylaxis of disseminated Mycobacterium avium-intracellulare infection in patients with AIDS. | 1996 May-Jun | Pharmacotherapy | pmid:8726597 |
Arain TM et al. | Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery. | 1996 | Antimicrob. Agents Chemother. | pmid:8726034 |
Morikawa K et al. | Modulatory effect of antibiotics on cytokine production by human monocytes in vitro. | 1996 | Antimicrob. Agents Chemother. | pmid:8726002 |
H. pylori treatment recognized by FDA. | 1996 | Am J Health Syst Pharm | pmid:8725200 | |
Barry AL et al. | Reassessment of methods for testing the susceptibility of Haemophilus influenzae to clarithromycin. | 1996 | J. Antimicrob. Chemother. | pmid:8722555 |
Goddard AF and Logan RP | Antimicrobial resistance and Helicobacter pylori. | 1996 | J. Antimicrob. Chemother. | pmid:8722530 |
Bazzoli F | Italian omeprazole triple therapy--a 1-week regimen. | 1996 | Scand. J. Gastroenterol. Suppl. | pmid:8722395 |
Unge P | Review of Helicobacter pylori eradication regimens. | 1996 | Scand. J. Gastroenterol. Suppl. | pmid:8722388 |
Lowe SH et al. | Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol. | 1996 | Neth J Med | pmid:8710040 |
Araki J et al. | [A case of Mounier-Kuhn syndrome]. | 1996 | Nippon Naika Gakkai Zasshi | pmid:8708483 |
Meier A et al. | Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population. | 1996 | J. Infect. Dis. | pmid:8699066 |