clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Takagi M et al. | Underlying mechanism of drug-drug interaction between pioglitazone and gemfibrozil: Gemfibrozil acyl-glucuronide is a mechanism-based inhibitor of CYP2C8. | 2015 | Drug Metab. Pharmacokinet. | pmid:26195223 |
Li Y et al. | Liposomal co-delivery of daptomycin and clarithromycin at an optimized ratio for treatment of methicillin-resistant Staphylococcus aureus infection. | 2015 | Drug Deliv | pmid:24471983 |
Sharara AI et al. | Letter: clarithromycin dose for H. pylori therapy remains unresolved--authors' reply. | 2015 | Aliment. Pharmacol. Ther. | pmid:26238584 |
Graham DY and Gisbert JP | Letter: clarithromycin dose for H. pylori therapy remains unresolved. | 2015 | Aliment. Pharmacol. Ther. | pmid:26238583 |
Navarro-Jarabo JM et al. | Prevalence of Primary Resistance of Helicobacter pylori to Clarithromycin and Levofloxacin in Southern Spain. | 2015 | Digestion | pmid:26227669 |
Ufuk A et al. | In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383. | 2015 | Pharm. Res. | pmid:26224396 |
Cohen O et al. | Colchicine-clarithromycin-induced rhabdomyolysis in Familial Mediterranean Fever patients under treatment for Helicobacter pylori. | 2015 | Rheumatol. Int. | pmid:26210999 |
Antony SJ | Catheter related line sepsis resulting from Mycobacterium chelonae infection in an immunocompromised host. | 2015 | Infect Disord Drug Targets | pmid:26205798 |
Chowdhary M et al. | Intracranial abscess due to Mycobacterium avium complex in an immunocompetent host: a case report. | 2015 | BMC Infect. Dis. | pmid:26201464 |
Zheng H et al. | Association of the in vitro susceptibility of clinical isolates of chlamydia trachomatis with serovar and duration of antibiotic exposure. | 2015 | Sex Transm Dis | pmid:25668641 |
Jung IY et al. | A case of bronchiolitis obliterans organizing pneumonia in an HIV-infected Korean patient successfully treated with clarithromycin. | 2015 | BMC Infect. Dis. | pmid:26201392 |
Sobajima T et al. | A Case of Pulmonary Actinomycosis Associated With Aspiration of Cedar Leaves. | 2015 | J Bronchology Interv Pulmonol | pmid:26165898 |
Gunjan S et al. | Clarithromycin enhances the antimalarial efficacy of mefloquine via its increased bioavailability and disrupting P. falciparum apicoplast. | 2015 | Life Sci. | pmid:26164186 |
Chou HW et al. | Risks of cardiac arrhythmia and mortality among patients using new-generation macrolides, fluoroquinolones, and β-lactam/β-lactamase inhibitors: a Taiwanese nationwide study. | 2015 | Clin. Infect. Dis. | pmid:25409476 |
Jeong BH et al. | Intermittent antibiotic therapy for nodular bronchiectatic Mycobacterium avium complex lung disease. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:25393520 |
Hill FJ et al. | From a fish tank injury to hospital haemodialysis: the serious consequences of drug interactions. | 2015 | BMJ Case Rep | pmid:26106178 |
Yu T et al. | Study on clarithromycin lactobionate based dual selector systems for the enantioseparation of basic drugs in capillary electrophoresis. | 2015 | J Sep Sci | pmid:26097042 |
Trotti LM et al. | Clarithromycin in γ-aminobutyric acid-Related hypersomnolence: A randomized, crossover trial. | 2015 | Ann. Neurol. | pmid:26094838 |
Tai WC et al. | Seven-Day Nonbismuth Containing Quadruple Therapy Could Achieve a Grade "A" Success Rate for First-Line Helicobacter pylori Eradication. | 2015 | Biomed Res Int | pmid:26090428 |
Nguyen AT et al. | Use of Topical Besifloxacin in the Treatment of Mycobacterium chelonae Ocular Surface Infections. | 2015 | Cornea | pmid:26075451 |
Fujiki S et al. | Suppressed Release of Clarithromycin from Tablets by Crystalline Phase Transition of Metastable Polymorph Form I. | 2015 | J Pharm Sci | pmid:26053058 |
Zeng M et al. | Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study. | 2015 | BMC Immunol. | pmid:26047816 |
Converse PJ et al. | Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease. | 2015 | PLoS Negl Trop Dis | pmid:26042792 |
Klain V and Timmerman L | Comment on The dangers of gastritis: a case of clarithromycin-associated brief psychotic episode. | 2015 | J. Nerv. Ment. Dis. | pmid:26034875 |
AktaÅŸ B et al. | The impact of amalgam dental fillings on the frequency of Helicobacter pylori infection and H. pylori eradication rates in patients treated with concomitant, quadruple, and levofloxacin-based therapies. | 2015 | Eur J Gastroenterol Hepatol | pmid:25919773 |
Lam A et al. | Itraconazole and clarithromycin inhibit P-glycoprotein activity in primary human sinonasal epithelial cells. | 2015 | Int Forum Allergy Rhinol | pmid:25907295 |
Luo RF et al. | Rapid Detection of Acquired and Inducible Clarithromycin Resistance in Mycobacterium abscessus Group by a Simple Real-Time PCR Assay. | 2015 | J. Clin. Microbiol. | pmid:25903572 |
Kumarihamy KW et al. | A rare complication of pulmonary tuberculosis: a case report. | 2015 | BMC Res Notes | pmid:25888831 |
Almeida N et al. | Beyond Maastricht IV: are standard empiric triple therapies for Helicobacter pylori still useful in a South-European country? | 2015 | BMC Gastroenterol | pmid:25886722 |
Kim JS et al. | Sequential or concomitant therapy for eradication of Helicobacter pylori infection: A systematic review and meta-analysis. | 2015 | J. Gastroenterol. Hepatol. | pmid:25867718 |
Heo J et al. | Concomitant and hybrid therapy for Helicobacter pylori infection: A randomized clinical trial. | 2015 | J. Gastroenterol. Hepatol. | pmid:25867608 |
Sugita S et al. | EGFR-independent autophagy induction with gefitinib and enhancement of its cytotoxic effect by targeting autophagy with clarithromycin in non-small cell lung cancer cells. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25858318 |
Mitsui Y et al. | Gastric inflammatory fibroid polyp morphologically changed by Helicobacter pylori eradication. | 2015 | Clin J Gastroenterol | pmid:25733031 |
Ben Chaabane N and Al-Adhba HS | Ciprofloxacin-containing versus clarithromycin-containing sequential therapy for Helicobacter pylori eradication: A randomized trial. | 2015 | Indian J Gastroenterol | pmid:25721770 |
Townsell MY et al. | Pathology in practice. Canine distemper virus disease in a dog. | 2015 | J. Am. Vet. Med. Assoc. | pmid:25719842 |
Scherübl H et al. | [What is new in treating Helicobacter pylori infection?]. | 2015 | Dtsch. Med. Wochenschr. | pmid:25704525 |
Aoki H et al. | Clarithromycin highly-loaded gastro-floating fine granules prepared by high-shear melt granulation can enhance the efficacy of Helicobacter pylori eradication. | 2015 | Eur J Pharm Biopharm | pmid:25703356 |
Baysal B et al. | Effect of pantoprazole and Helicobacter pylori therapy on uninvestigated dyspeptic patients. | 2015 | Turk J Gastroenterol | pmid:25698264 |
Burton AJ et al. | Efficacy of liposomal gentamicin against Rhodococcus equi in a mouse infection model and colocalization with R. equi in equine alveolar macrophages. | 2015 | Vet. Microbiol. | pmid:25666452 |
Cowan R et al. | Mycobacterium ulcerans treatment--can antibiotic duration be reduced in selected patients? | 2015 | PLoS Negl Trop Dis | pmid:25658304 |
Blix HS et al. | Antibiotic prescriptions and cycles of Mycoplasma pneumoniae infections in Norway: can a nationwide prescription register be used for surveillance? | 2015 | Epidemiol. Infect. | pmid:25388750 |
Brown-Elliott BA et al. | Utility of sequencing the erm(41) gene in isolates of Mycobacterium abscessus subsp. abscessus with low and intermediate clarithromycin MICs. | 2015 | J. Clin. Microbiol. | pmid:25653399 |
Iino Y et al. | Clinical effects of clarithromycin on persistent inflammation following Haemophilus influenzae-positive acute otitis media. | 2015 | Acta Otolaryngol. | pmid:25649881 |
Brown-Elliott BA et al. | Absence of a functional erm gene in isolates of Mycobacterium immunogenum and the Mycobacterium mucogenicum group, based on in vitro clarithromycin susceptibility. | 2015 | J. Clin. Microbiol. | pmid:25568437 |
Amiri M | Impact of Helicobacter pylori Eradication Therapy on Platelet Counts in Patients With Chronic Idiopathic Thrombocytopenic Purpura. | 2015 | Glob J Health Sci | pmid:26925898 |
Haghi M et al. | Immunomodulatory effects of a low-dose clarithromycin-based macrolide solution pressurised metered dose inhaler. | 2015 | Pharm. Res. | pmid:25537341 |
Kam Y et al. | Sweat but no gain: inhibiting proliferation of multidrug resistant cancer cells with "ersatzdroges". | 2015 | Int. J. Cancer | pmid:25156304 |
Li DQ et al. | Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4. | 2015 | CMAJ | pmid:25534598 |
Yildizoglu U et al. | Effect of antibiotic use on bacterial flora of tonsil core in patients with recurrent tonsillitis. | 2015 | Eur Arch Otorhinolaryngol | pmid:25510984 |
Jiang F et al. | The influences of CYP2D6 genotypes and drug interactions on the pharmacokinetics of venlafaxine: exploring predictive biomarkers for treatment outcomes. | 2015 | Psychopharmacology (Berl.) | pmid:25510856 |
Zhang L et al. | [Minocycline quadruple versus tailored therapy in retreatment of Helicobacter pylori infection]. | 2015 | Zhonghua Nei Ke Za Zhi | pmid:26887366 |
Montes M et al. | Helicobacter pylori Infection in Children. Antimicrobial Resistance and Treatment Response. | 2015 | Helicobacter | pmid:25382231 |
Wang B et al. | Review: efficacy and safety of hybrid therapy for Helicobacter pylori infection: a systematic review and meta-analysis. | 2015 | Helicobacter | pmid:25381839 |
Yoon K et al. | Ultimate eradication rate of Helicobacter pylori after first, second, or third-line therapy in Korea. | 2015 | J. Gastroenterol. Hepatol. | pmid:25363555 |
Frew JW and Nguyen RT | Tattoo-associated mycobacterial infections: an emerging public health issue. | 2015 | Med. J. Aust. | pmid:26852055 |
Park JB et al. | Modulation of microenvironmental pH and utilization of alkalizers in crystalline solid dispersion for enhanced solubility and stability of clarithromicin. | 2015 | Arch. Pharm. Res. | pmid:25213008 |
Anton E et al. | Randomized Trial of Clarithromycin for Mediterranean Spotted Fever. | 2015 | Antimicrob. Agents Chemother. | pmid:26711765 |
Bang CS et al. | Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection. | 2015 | Gut Liver | pmid:25167799 |
Hasegawa T et al. | Image of the month: Disseminated Nontuberculous Mycobacteriosis. | 2015 | Am. J. Gastroenterol. | pmid:26673493 |
Keshavarz Azizi Raftar S et al. | The Helicobacter pylori resistance rate to clarithromycin in Iran. | 2015 | Microb. Drug Resist. | pmid:25144338 |
Stepney R et al. | Case report: Improved gum health. | 2015 | Br Dent J | pmid:26657423 |
Winters N et al. | Efficacy and safety of World Health Organization group 5 drugs for multidrug-resistant tuberculosis treatment. | 2015 | Eur. Respir. J. | pmid:26381514 |
Dogan Z et al. | The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study. | 2015 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | pmid:24993741 |
John A et al. | Does emerging Clarithromycin resistance signal an obituary to empirical standard triple therapy for Helicobacter pylori infection? | 2015 | Indian J Gastroenterol | pmid:26541342 |
Mel-Hennawi D and Ahmed MR | Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion. | 2015 | J Laryngol Otol | pmid:26521817 |
Parra D et al. | In vitro efficacy of daptomycin and teicoplanin combined with ethanol, clarithromycin or gentamicin as catheter lock solutions. | 2015 | BMC Microbiol. | pmid:26518881 |
Xing J et al. | The application of high-resolution mass spectrometry-based data-mining tools in tandem to metabolite profiling of a triple drug combination in humans. | 2015 | Anal. Chim. Acta | pmid:26515003 |
Demirci H et al. | Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. | 2015 | Turk J Gastroenterol | pmid:26510082 |
Mesgarpour B et al. | A population-based analysis of the risk of drug interaction between clarithromycin and statins for hospitalisation or death. | 2015 | Lipids Health Dis | pmid:26497728 |
Namkoong H et al. | Successful resumption of tocilizumab for rheumatoid arthritis after resection of a pulmonary Mycobacterium avium complex lesion: a case report. | 2015 | BMC Pulm Med | pmid:26496968 |
Wang CH et al. | Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication: A prospective single-center study from China. | 2015 | World J. Gastroenterol. | pmid:26494972 |
Bérard A et al. | Use of macrolides during pregnancy and the risk of birth defects: a population-based study. | 2015 | Pharmacoepidemiol Drug Saf | pmid:26513406 |
Weiss S et al. | Efficacy of Single and Combined Antibiotic Treatments of Anthrax in Rabbits. | 2015 | Antimicrob. Agents Chemother. | pmid:26392505 |
Kiesewetter B et al. | Clarithromycin Leading to Complete Remission in the First-Line Treatment of Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma. | 2015 | J. Clin. Oncol. | pmid:24778391 |
Agrawal V et al. | A Case of Hypotension and Bradycardia Precipitated by Drug Interaction of Clarithromycin and Calcium-Channel Blocker. | 2015 | J Am Geriatr Soc | pmid:26389998 |
Hauser G et al. | Probiotics for standard triple Helicobacter pylori eradication: a randomized, double-blind, placebo-controlled trial. | 2015 | Medicine (Baltimore) | pmid:25929897 |
Yin SM et al. | Disseminated Mycobacterium kansasii disease in complete DiGeorge syndrome. | 2015 | J. Clin. Immunol. | pmid:26048260 |
Glocker EO | The Need for Resistance Surveillance and Antimicrobial Susceptibility Testing of Helicobacter pylori. | 2015 | Digestion | pmid:26372776 |
Bruhn DF et al. | In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics. | 2015 | Sci Rep | pmid:26365087 |
Ledwoń A et al. | Multidrug therapy of Mycobacterium avium subsp. avium infection in experimentally inoculated budgerigars (Melopsittacus undulatus). | 2015 | Avian Pathol. | pmid:26364975 |
Nakamura M et al. | Clarithromycin ameliorates pulmonary inflammation induced by short term cigarette smoke exposure in mice. | 2015 | Pulm Pharmacol Ther | pmid:26363279 |
Brusselle GG | Are the antimicrobial properties of macrolides required for their therapeutic efficacy in chronic neutrophilic airway diseases? | 2015 | Thorax | pmid:25870311 |
Picoli SU et al. | Resistance to amoxicillin, clarithromycin and ciprofloxacin of Helicobacter pylori isolated from Southern Brazil patients. | 2014 May-Jun | Rev. Inst. Med. Trop. Sao Paulo | pmid:24878996 |
UÄŸurlu T et al. | Optimization and evaluation of clarithromycin floating tablets using experimental mixture design. | 2014 Mar-Apr | Acta Pol Pharm | pmid:25272652 |
Skvarc M et al. | Multi locus sequence typing (MLST) used as a tool to confirm the ability of susceptible Helicobacter pylori strains to gain resistance to clarithromycin during eradication therapy. | 2014 Jan-Feb | Hepatogastroenterology | pmid:24895826 |
Vanderpas J et al. | Follow-up of Helicobacter pylori infection in children over two decades (1988-2007): persistence, relapse and acquisition rates. | 2014 | Epidemiol. Infect. | pmid:23809783 |
Vu DH et al. | Simultaneous determination of rifampicin, clarithromycin and their metabolites in dried blood spots using LC-MS/MS. | 2014 | Talanta | pmid:24607103 |
Zaiem A et al. | Clarithromycin induced psoriasis in a 37-year old man. | 2014 | Curr Drug Saf | pmid:24410388 |
Malfertheiner P and Selgrad M | Helicobacter pylori. | 2014 | Curr. Opin. Gastroenterol. | pmid:25268839 |
Ito Y et al. | The influence of environmental exposure on the response to antimicrobial treatment in pulmonary Mycobacterial avium complex disease. | 2014 | BMC Infect. Dis. | pmid:25266993 |
de Miguel-Martinez I et al. | [Bacteriemia due to Mycobacterium canariasense in an oncohematological patient with a long-term central device]. | 2014 | Enferm. Infecc. Microbiol. Clin. | pmid:25262854 |
Boleda MR et al. | Survey of the occurrence of pharmaceuticals in Spanish finished drinking waters. | 2014 | Environ Sci Pollut Res Int | pmid:24756682 |
Nilsson MF and Webster WS | Effects of macrolide antibiotics on rat embryonic heart function in vitro. | 2014 | Birth Defects Res. B Dev. Reprod. Toxicol. | pmid:24753334 |
Wallace RJ et al. | Macrolide/Azalide therapy for nodular/bronchiectatic mycobacterium avium complex lung disease. | 2014 | Chest | pmid:24457542 |
Molina-Infante J and Gisbert JP | Optimizing clarithromycin-containing therapy for Helicobacter pylori in the era of antibiotic resistance. | 2014 | World J. Gastroenterol. | pmid:25132750 |
Heo J et al. | A randomised clinical trial of 10-day concomitant therapy and standard triple therapy for Helicobacter pylori eradication. | 2014 | Dig Liver Dis | pmid:25132282 |
Oh DH et al. | Efficacy of hybrid therapy as first-line regimen for Helicobacter pylori infection compared with sequential therapy. | 2014 | J. Gastroenterol. Hepatol. | pmid:24955448 |
Patel K et al. | Oral delivery of paclitaxel nanocrystal (PNC) with a dual Pgp-CYP3A4 inhibitor: preparation, characterization and antitumor activity. | 2014 | Int J Pharm | pmid:24954663 |
Vafaeimanesh J et al. | Expression comparison of azithromycin and clarithromycin in triple-therapy regimens for eradication of Helicobacter pylori in hemodialysis patients. | 2014 | Saudi J Kidney Dis Transpl | pmid:24434382 |
Zhou L et al. | Relationship of Helicobacter pylori eradication with gastric cancer and gastric mucosal histological changes: a 10-year follow-up study. | 2014 | Chin. Med. J. | pmid:24762588 |