clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Bazzoli F et al. | What can be learnt from the new data about antibiotic resistance? Are there any practical clinical consequences of Helicobacter pylori antibiotic resistance? | 1999 | Eur J Gastroenterol Hepatol | pmid:10503822 |
Mégraud F | Resistance of Helicobacter pylori to antibiotics: the main limitation of current proton-pump inhibitor triple therapy. | 1999 | Eur J Gastroenterol Hepatol | pmid:10503821 |
Spiller RC | Is there any difference in Helicobacter pylori eradication rates in patients with active peptic ulcer, inactive peptic ulcer and functional dyspepsia? | 1999 | Eur J Gastroenterol Hepatol | pmid:10503819 |
Unge P | The OAC and OMC options. | 1999 | Eur J Gastroenterol Hepatol | pmid:10503817 |
Gómez G et al. | Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin. | 1999 | Transplant. Proc. | pmid:10500563 |
Landesman KA et al. | Rhabdomyolysis associated with the combined use of hydroxymethylglutaryl-coenzyme A reductase inhibitors with gemfibrozil and macrolide antibiotics. | 1999 | Conn Med | pmid:10500341 |
Zgoulli S et al. | Microencapsulation of erythromycin and clarithromycin using a spray-drying technique. | 1999 Sep-Oct | J Microencapsul | pmid:10499837 |
Ellenrieder V et al. | Prevalence of resistance to clarithromycin and its clinical impact on the efficacy of Helicobacter pylori eradication. | 1999 | Scand. J. Gastroenterol. | pmid:10499474 |
Hirsh DC and Jang SS | Antimicrobial susceptibility of Nocardia nova isolated from five cats with nocardiosis. | 1999 | J. Am. Vet. Med. Assoc. | pmid:10496134 |
Osato MS et al. | Metronidazole and clarithromycin resistance amongst Helicobacter pylori isolates from a large metropolitan hospital in the United States. | 1999 | Int. J. Antimicrob. Agents | pmid:10493611 |
Moore PA | Dental therapeutic indications for the newer long-acting macrolide antibiotics. | 1999 | J Am Dent Assoc | pmid:10492541 |
Gutiérrez-Cabano CA and Raynald AC | Gastroprotective effect of intragastric clarithromycin against damage induced by ethanol in rats. | 1999 | Dig. Dis. Sci. | pmid:10492159 |
RodrÃguez Téllez M et al. | Morphometric estimation of acid output in duodenal ulcer associated with Helicobacter pylori infection. | 1999 | Rev Esp Enferm Dig | pmid:10491487 |
Tyagi AK et al. | An unreported side effect of topical clarithromycin when used successfully to treat Mycobacterium avium-intracellulare keratitis. | 1999 | Cornea | pmid:10487437 |
Matsuoka M et al. | Simultaneous colonisation of Helicobacter pylori with and without mutations in the 23S rRNA gene in patients with no history of clarithromycin exposure. | 1999 | Gut | pmid:10486356 |
Klapper SR and Patrinely JR | Periocular atypical mycobacterial infections. | 1999 | Ophthalmology | pmid:10485521 |
Gidoh M | [The control leprous peripheral neuropathy and chemotherapy]. | 1999 | Nihon Hansenbyo Gakkai Zasshi | pmid:10481449 |
Sato K et al. | [MICs and MBCs of levofloxacin, clarithromycin, and KRM-1648 for Mycobacterium tuberculosis and M. avium complex residing in MONO-MAC-6 human macrophage-like cell and A-549 human type II alveolar epithelial cell lines]. | 1999 | Kekkaku | pmid:10481412 |
Gómez Cubillos C et al. | [Can macrolide treatment delay the diagnosis of tuberculosis?]. | 1999 | An Med Interna | pmid:10481348 |
Geiderman JM | Central nervous system disturbances following clarithromycin ingestion. | 1999 | Clin. Infect. Dis. | pmid:10476775 |
Mikamo H et al. | Adequate macrolide treatment schedules for uterine cervicitis caused by Chlamydia trachomatis. | 1999 Sep-Oct | Chemotherapy | pmid:10473928 |
Tanaka E et al. | Effect of clarithromycin regimen for Mycobacterium avium complex pulmonary disease. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10471610 |
Bui KQ et al. | Mononuclear and polymorphonuclear leukocyte dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex prophylaxis. | 1999 | Antimicrob. Agents Chemother. | pmid:10471584 |
Kamada T et al. | Effect of smoking and histological gastritis severity on the rate of H. pylori eradication with omeprazole, amoxicillin, and clarithromycin. | 1999 | Helicobacter | pmid:10469195 |
Catalano F et al. | Comparative treatment of Helicobacter pylori-positive duodenal ulcer using pantoprazole at low and high doses versus omeprazole in triple therapy. | 1999 | Helicobacter | pmid:10469192 |
Sung JJ et al. | One-week ranitidine bismuth citrate in combinations with metronidazole, amoxycillin and clarithromycin in the treatment of Helicobacter pylori infection: the RBC-MACH study. | 1999 | Aliment. Pharmacol. Ther. | pmid:10468684 |
Paré P et al. | Comparison of ranitidine bismuth citrate plus clarithromycin with omeprazole plus clarithromycin for the eradication of Helicobacter pylori. | 1999 | Aliment. Pharmacol. Ther. | pmid:10468683 |
Gschwantler M et al. | Famotidine versus omeprazole in combination with clarithromycin and metronidazole for eradication of Helicobacter pylori--a randomized, controlled trial. | 1999 | Aliment. Pharmacol. Ther. | pmid:10468682 |
Gooderham MJ et al. | Concomitant digoxin toxicity and warfarin interaction in a patient receiving clarithromycin. | 1999 Jul-Aug | Ann Pharmacother | pmid:10466907 |
Sendi PP et al. | Systematic validation of disease models for pharmacoeconomic evaluations. Swiss HIV Cohort Study. | 1999 | J Eval Clin Pract | pmid:10461580 |
Boyanova L et al. | Characteristics and trends in macrolide resistance among Helicobacter pylori strains isolated in Bulgaria over four years. | 1999 | Diagn. Microbiol. Infect. Dis. | pmid:10459482 |
Labenz J and Stolte M | [Is lack of stomach carcinoma prevention by Helicobacter pylori eradication unethical?]. | 1999 | Z Gastroenterol | pmid:10458014 |
Härtig G et al. | [Symptomatic psychosis in bland sinus thrombosis and antibiotic therapy]. | 1999 | Psychiatr Prax | pmid:10457975 |
Pandita D and Carson PJ | Thyroid abscess caused by Mycobacterium chelonae. | 1999 | Clin. Infect. Dis. | pmid:10452671 |
Gordin FM et al. | A randomized, placebo-controlled study of rifabutin added to a regimen of clarithromycin and ethambutol for treatment of disseminated infection with Mycobacterium avium complex. | 1999 | Clin. Infect. Dis. | pmid:10452638 |
Anzueto A et al. | The infection-free interval: its use in evaluating antimicrobial treatment of acute exacerbation of chronic bronchitis. | 1999 | Clin. Infect. Dis. | pmid:10451195 |
Enroth H et al. | Occurence of resistance mutation and clonal expansion in Helicobacter pylori multiple-strain infection: a potential risk in clarithromycin-based therapy. | 1999 | Clin. Infect. Dis. | pmid:10451171 |
Hewitt RG et al. | Prevention of disseminated Mycobacterium avium complex infection with reduced dose clarithromycin in patients with advanced HIV disease. | 1999 | AIDS | pmid:10449290 |
Ali' A et al. | A second-line anti-Helicobacter pylori therapy in patients with previously failed treatment. | 1999 | Am. J. Gastroenterol. | pmid:10445583 |
Bazzoli F | My approach to Helicobacter pylori eradication. | 1999 | Eur J Gastroenterol Hepatol | pmid:10443911 |
Shimada N et al. | [A case of acute renal failure with rhabdomyolysis caused by the interaction of theophylline and clarithromycin]. | 1999 | Nihon Jinzo Gakkai Shi | pmid:10441997 |
Lipsky BA et al. | Treating acute bacterial exacerbations of chronic bronchitis in patients unresponsive to previous therapy: sparfloxacin versus clarithromycin. | 1999 | Clin Ther | pmid:10440620 |
Cohn DL et al. | A prospective randomized trial of four three-drug regimens in the treatment of disseminated Mycobacterium avium complex disease in AIDS patients: excess mortality associated with high-dose clarithromycin. Terry Beirn Community Programs for Clinical Research on AIDS. | 1999 | Clin. Infect. Dis. | pmid:10433575 |
Schmitt H et al. | Successful treatment of pulmonary Mycobacterium xenopi infection in a natural killer cell-deficient patient with clarithromycin, rifabutin, and sparfloxacin. | 1999 | Clin. Infect. Dis. | pmid:10433574 |
Baena DÃez JM et al. | [Are 5 days of omeprazole plus 2 antibiotics enough for eradication of H. pylori? Comments on sample size]. | 1999 | Rev Clin Esp | pmid:10432821 |
Owen RJ et al. | Effect of clarithromycin and omeprazole therapy on the diversity and stability of genotypes of Helicobacter pylori from duodenal ulcer patients. | 1999 | Microb. Drug Resist. | pmid:10432275 |
Kyzekova J and Mour J | The effect of eradication therapy on histological changes in the gastric mucosa in patients with non-ulcer dyspepsia and Helicobacter pylori infection. Prospective randomized intervention study. | 1999 May-Jun | Hepatogastroenterology | pmid:10430396 |
Credito KL et al. | Activity of telithromycin (HMR 3647) against anaerobic bacteria compared to those of eight other agents by time-kill methodology. | 1999 | Antimicrob. Agents Chemother. | pmid:10428930 |
Johnson MM et al. | Effect of carbon dioxide on testing of susceptibilities of respiratory tract pathogens to macrolide and azalide antimicrobial agents. | 1999 | Antimicrob. Agents Chemother. | pmid:10428903 |
Grimm KJ | Treatment of Helicobacter pylori infection in functional dyspepsia. | 1999 | J Fam Pract | pmid:10428242 |