clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Chlamydial Pneumonia D061387 2 associated lipids
Sacroiliitis D058566 1 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Renal Insufficiency D051437 8 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Chlamydophila Infections D023521 4 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
alpha 1-Antitrypsin Deficiency D019896 3 associated lipids
Tooth, Nonvital D019553 2 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Cardiovascular Abnormalities D018376 2 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Periodontal Attachment Loss D017622 7 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
Liver Failure, Acute D017114 11 associated lipids
IgA Deficiency D017098 2 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
Meningitis, Bacterial D016920 6 associated lipids
Angiomatosis, Bacillary D016917 2 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Ureaplasma Infections D016869 5 associated lipids
Empyema, Pleural D016724 2 associated lipids
Still's Disease, Adult-Onset D016706 2 associated lipids
Purpura, Thrombocytopenic, Idiopathic D016553 4 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Helicobacter Infections D016481 21 associated lipids
Bacteremia D016470 9 associated lipids
Prosthesis-Related Infections D016459 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

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Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Ploy MC et al. [Antibacterial activity of clarithromycin and its hydroxylated derivative and two other macrolides against thirty strains of Streptococcus pneumoniae]. 1994 Pathol. Biol. pmid:7824300
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Morikawa K et al. Immunomodulatory effects of three macrolides, midecamycin acetate, josamycin, and clarithromycin, on human T-lymphocyte function in vitro. 1994 Antimicrob. Agents Chemother. pmid:7532933
Lazard T et al. Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages. 1994 Tuber. Lung Dis. pmid:7949074
Inderlied CB et al. Activities of the benzoxazinorifamycin KRM 1648 and ethambutol against Mycobacterium avium complex in vitro and in macrophages. 1994 Antimicrob. Agents Chemother. pmid:7986017
Calì G et al. [Clarithromycin in the treatment of oral infections]. 1994 Minerva Stomatol pmid:7700226
Klemens SP and Cynamon MH Intermittent azithromycin for treatment of Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7986001
Cynamon MH et al. Comparative activities of azithromycin and clarithromycin against Mycobacterium avium infection in beige mice. 1994 Antimicrob. Agents Chemother. pmid:7979270
Rapp RP et al. New macrolide antibiotics: usefulness in infections caused by mycobacteria other than Mycobacterium tuberculosis. 1994 Ann Pharmacother pmid:7849341
Tessier MH et al. Clarithromycin for atypical mycobacterial lymphadenitis in non-immunocompromised children. 1994 Dec 24-31 Lancet pmid:7997032
Mor N et al. Accumulation of clarithromycin in macrophages infected with Mycobacterium avium. 1994 Jan-Feb Pharmacotherapy pmid:8159593
Winter J Intravenous clarithromycin. 1994 Mar 16-Apr 5 Br J Hosp Med pmid:8032567
Gersema LM et al. Suspected drug interaction between cyclosporine and clarithromycin. 1994 Mar-Apr J. Heart Lung Transplant. pmid:8031821
Heifets LB Quantitative cultures and drug susceptibility testing of Mycobacterium avium clinical isolates before and during the antimicrobial therapy. 1994 Mar-Apr Res. Microbiol. pmid:7809471
Dautzenberg B Clinical trials in Mycobacterium avium therapy: lessons to take home. 1994 Mar-Apr Res. Microbiol. pmid:7809472
Scaglione F et al. Effect of antibiotics on Bordetella pertussis adhering activity: hypothesis regarding mechanism of action. 1994 May-Jun Chemotherapy pmid:7515782
O'Connor NK and Fris J Clarithromycin-carbamazepine interaction in a clinical setting. 1994 Nov-Dec J Am Board Fam Pract pmid:7847111
Cama VA et al. Treatment of acute and chronic Cryptosporidium parvum infections in mice using clarithromycin and 14-OH clarithromycin. 1994 Sep-Oct J. Eukaryot. Microbiol. pmid:7804227
Adamek RJ et al. Modified short-term triple therapy--ranitidine, clarithromycin, and metronidazole--for cure of Helicobacter pylori infection. 1995 Am. J. Gastroenterol. pmid:7801936
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Musher DM Clarithromycin therapy for Mycobacterium avium complex bacteremia. 1995 Ann. Intern. Med. pmid:7778830
van der Meer JT and Danner SA Clarithromycin therapy for Mycobacterium avium complex bacteremia. 1995 Ann. Intern. Med. pmid:7778831
Burette A and Glupczynski Y Helicobacter pylori: the place of the new macrolides in the eradication of the bacteria in peptic ulcer disease. 1995 Infection pmid:7782116
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Comley JC and Sterling AM Effect of atovaquone and atovaquone drug combinations on prophylaxis of Pneumocystis carinii pneumonia in SCID mice. 1995 Antimicrob. Agents Chemother. pmid:7785975
Struillou L et al. Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. 1995 Antimicrob. Agents Chemother. pmid:7785988
Fong IW et al. Clarithromycin versus cefaclor in lower respiratory tract infections. The Canadian Bronchitis Study Group. 1995 Clin Invest Med pmid:7788958
Goddard A and Logan R One-week low-dose triple therapy: new standards for Helicobacter pylori treatment. 1995 Eur J Gastroenterol Hepatol pmid:7866804
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Weits J and Sprenger HG [Surgical treatment of lymphadenitis caused by non-tuberculous mycobacteria in children]. 1995 Ned Tijdschr Geneeskd pmid:8524431
Block S et al. Mycoplasma pneumoniae and Chlamydia pneumoniae in pediatric community-acquired pneumonia: comparative efficacy and safety of clarithromycin vs. erythromycin ethylsuccinate. 1995 Pediatr. Infect. Dis. J. pmid:7667050
Nash KA and Inderlied CB Genetic basis of macrolide resistance in Mycobacterium avium isolated from patients with disseminated disease. 1995 Antimicrob. Agents Chemother. pmid:8592991
Ramírez Ramos A [Treatment of Helicobacter pylori infection: current status]. 1995 Rev Gastroenterol Peru pmid:8520021
Savarino V et al. What is the meaning of ranitidine in successful triple-therapy against Helicobacter pylori infection? 1995 Am. J. Gastroenterol. pmid:8540537
Gustavson LE et al. Effect of omeprazole on concentrations of clarithromycin in plasma and gastric tissue at steady state. 1995 Antimicrob. Agents Chemother. pmid:8540719
Ostroff SM et al. Preventing disseminated Mycobacterium avium complex disease in patients infected with human immunodeficiency virus. 1995 Clin. Infect. Dis. pmid:8547516
Odagiri S Levofloxacin in patients with severe respiratory tract infection. 1995 Drugs pmid:8549387
Lee D et al. Localized Mycobacterium avium-intracellulare mastitis in an immunocompetent woman with silicone breast implants. 1995 Plast. Reconstr. Surg. pmid:7809228
Gill CJ et al. In vivo evaluation of three acid-stable azalide compounds, L-701,677, L-708,299 and L-708,365 compared to erythromycin, azithromycin and clarithromycin. 1995 J. Antibiot. pmid:7490222
Gelber RH Successful treatment of a lepromatous patient with clarithromycin. 1995 Int. J. Lepr. Other Mycobact. Dis. pmid:7730711
Midoneck SR and Etingin OR Clarithromycin-related toxic effects of digoxin. 1995 N. Engl. J. Med. pmid:7477159
Forslund T et al. Disseminated cutaneous infection due to Mycobacterium chelonae in a patient with rheumatoid arthritis, amyloidosis, and renal failure. 1995 Nephrol. Dial. Transplant. pmid:7478131
Cavalieri SJ et al. Synergistic activities of clarithromycin and antituberculous drugs against multidrug-resistant Mycobacterium tuberculosis. 1995 Antimicrob. Agents Chemother. pmid:7492101
Englishby VL Case reports of death associated with pseudomembranous colitis and clarithromycin. 1995 Eur J Gastroenterol Hepatol pmid:7496875
Schepp W [Omeprazole + clarithromycin + metronidazole--a new standard for eradication of Helicobacter pylori]. 1995 Z Gastroenterol pmid:7502558
Widgerow AD et al. Atypical Mycobacterium and breast surgery. 1995 Ann Plast Surg pmid:7486746
Tamaoki J et al. Effect of clarithromycin on sputum production and its rheological properties in chronic respiratory tract infections. 1995 Antimicrob. Agents Chemother. pmid:7486901
Mushatt DM and Witzig RS Successful treatment of Mycobacterium abscessus infections with multidrug regimens containing clarithromycin. 1995 Clin. Infect. Dis. pmid:7620048
Vance E et al. Pharmacokinetics of clarithromycin and zidovudine in patients with AIDS. 1995 Antimicrob. Agents Chemother. pmid:7574530
Singh N and Yu VL Clarithromycin therapy for Mycobacterium avium complex bacteremia. 1995 Ann. Intern. Med. pmid:7632282
Michałowska-Mitczuk D [Patients with chronic sputum positive tuberculosis-a therapeutic problem]. 1995 Pneumonol Alergol Pol pmid:7633360
Colizza DF Pertussis update. 1995 J Sch Health pmid:7637337
Fabry W et al. Comparison of the E test and a proportion dilution method for susceptibility testing of Mycobacterium tuberculosis. 1995 Zentralbl. Bakteriol. pmid:9810662
Katelaris PH et al. A randomized prospective comparison of clarithromycin versus amoxycillin in combination with omeprazole for eradication of Helicobacter pylori. 1995 Aliment. Pharmacol. Ther. pmid:7605864
Yousfi MM et al. Metronidazole, omeprazole and clarithromycin: an effective combination therapy for Helicobacter pylori infection. 1995 Aliment. Pharmacol. Ther. pmid:7605865
Chevalley GF et al. [Uveitis associated with rifabutin treatment. Apropos of 3 patients]. 1995 Klin Monbl Augenheilkd pmid:7609395
Blum AL et al. [Functional dyspepsia: approaches to Helicobacter pylori eradication therapy]. 1995 Leber Magen Darm pmid:7609589
Labenz J et al. [Short-term triple therapy with pantoprazole, clarithromycin and metronidazole in eradication of Helicobacter pylori]. 1995 Leber Magen Darm pmid:7609590
Reppun JI From prontolyn to biaxin: the half-century of antibiotics. 1995 Hawaii Med J pmid:7628918
Chin DP and Hopewell PC How to treat bacteraemic Mycobacterium avium complex disease. 1995 Lancet pmid:7564723
Kuhn SM et al. Treatment of Mycobacterium marinum facial abscess using clarithromycin. 1995 Pediatr. Infect. Dis. J. pmid:7567299
Forné M et al. Impact of colloidal bismuth subnitrate in the eradication rates of Helicobacter pylori infection-associated duodenal ulcer using a short treatment regimen with omeprazole and clarithromycin: a randomized study. 1995 Am. J. Gastroenterol. pmid:7733075
Tebas P et al. Rapid development of resistance to clarithromycin following monotherapy for disseminated Mycobacterium chelonae infection in a heart transplant patient. 1995 Clin. Infect. Dis. pmid:7742453
Teare JP et al. Pseudomembranous colitis following clarithromycin therapy. 1995 Eur J Gastroenterol Hepatol pmid:7743311
Pollak PT et al. Delirium probably induced by clarithromycin in a patient receiving fluoxetine. 1995 Ann Pharmacother pmid:7655131
Ozmen MM and Johnson CD Is short-term triple therapy with lansoprazole, clarithromycin, and metronidazole a definitive answer for Helicobacter pylori eradication? 1995 Am. J. Gastroenterol. pmid:7661197
Savarino V et al. New insight in the mechanism of omeprazole antimicrobial combinations to eradicate Helicobacter pylori. 1995 Am. J. Gastroenterol. pmid:7717343
Saito H et al. Therapeutic effect of KRM-1648 with various antimicrobials against Mycobacterium avium complex infection in mice. 1995 Tuber. Lung Dis. pmid:7718848
Hedenmo M and Eriksson BM Liquid chromatographic determination of the macrolide antibiotics roxithromycin and clarithromycin in plasma by automated solid-phase extraction and electrochemical detection. 1995 J Chromatogr A pmid:7719451
Metz DC and Getz HD Helicobacter pylori gastritis therapy with omeprazole and clarithromycin increases serum carbamazepine levels. 1995 Dig. Dis. Sci. pmid:7720489
Cahill RJ et al. Effect of eradication of Helicobacter pylori infection on gastric epithelial cell proliferation. 1995 Dig. Dis. Sci. pmid:7648960
Dautzenberg B et al. Clarithromycin in the treatment of Mycobacterium avium lung infections in patients without AIDS. Clarithromycin Study Group of France. 1995 Chest pmid:7705112
Gross RH et al. Corneal pharmacokinetics of topical clarithromycin. 1995 Invest. Ophthalmol. Vis. Sci. pmid:7706046
Frotz H et al. [Ranitidine and clarithromycin for eradication of Helicobacter pylori in patients with duodenal ulcer]. 1995 Arzneimittelforschung pmid:7710445
Deltenre M et al. Omeprazole-based antimicrobial therapies: results in 198 Helicobacter pylori-positive patients. 1995 Eur J Gastroenterol Hepatol pmid:8574734
Fukuda Y et al. Combination therapy with mucosal protective agent for the eradication of Helicobacter pylori. 1995 Eur J Gastroenterol Hepatol pmid:8574735
Graham DY Clarithromycin for treatment of Helicobacter pylori infections. 1995 Eur J Gastroenterol Hepatol pmid:8574737
Takimoto T et al. Dual therapy with lansoprazole and clarithromycin for eradication of Helicobacter pylori. 1995 Eur J Gastroenterol Hepatol pmid:8574739
Uemura N et al. Effect of Helicobacter pylori eradication on the healing and recurrence of peptic ulcer: combination therapy with low-dose omeprazole and clarithromycin. 1995 Eur J Gastroenterol Hepatol pmid:8574740
Ishii K et al. In vitro dissolution tests corresponding to the in vivo dissolution of clarithromycin tablets in the stomach and intestine. 1995 Chem. Pharm. Bull. pmid:8575034
Diehl HG [One week triple therapy for eradication of Helicobacter pylori infection: simple and effective]. 1995 Leber Magen Darm pmid:8577220
Götz JM et al. Triple therapy with ranitidine, clarithromycin, and metronidazole in the treatment of Helicobacter pylori. 1995 Scand. J. Gastroenterol. Suppl. pmid:8578230
Pavlopoulou J et al. Randomized controlled study of clarithromycin versus cefaclor suspensions in the treatment of acute otitis media in children. 1995 J Chemother pmid:8904139
Atkinson BA et al. Treatment of Mycobacterium haemophilum infection in a murine model with clarithromycin, rifabutin, and ciprofloxacin. 1995 Antimicrob. Agents Chemother. pmid:8619588
Ford A et al. Clarithromycin-induced digoxin toxicity in a patient with AIDS. 1995 Clin. Infect. Dis. pmid:8645810
Gidoh M and Saito H [Present status of studies on antileprosy drugs]. 1995 Nihon Rai Gakkai Zasshi pmid:8582877
Gioulekas J and Hall A Uveitis associated with rifabutin therapy. 1995 Aust N Z J Ophthalmol pmid:11980079
Nishi K et al. [Effect of clarithromycin on symptoms and mucociliary transport in patients with sino-bronchial syndrome]. 1995 Nihon Kyobu Shikkan Gakkai Zasshi pmid:8821993
Piersimoni C et al. Activity of seven antimicrobial agents, alone and in combination, against AIDS-associated isolates of Mycobacterium avium complex. 1995 J. Antimicrob. Chemother. pmid:8830013
Labenz J et al. High-dose omeprazole plus amoxicillin or clarithromycin cures Helicobacter pylori infection in duodenal ulcer disease. 1995 Digestion pmid:7895926
Reid R et al. Pneumococcal meningitis during therapy of otitis media with clarithromycin. 1995 Pediatr. Infect. Dis. J. pmid:8786899
Van Asselt GJ et al. Susceptibility of Streptococcus pyogenes to azithromycin, clarithromycin, erythromycin and roxithromycin in vitro. 1995 J. Med. Microbiol. pmid:7563004
Parasakthi N and Goh KL Primary and acquired resistance to clarithromycin among Helicobacter pylori strains in Malaysia. 1995 Am. J. Gastroenterol. pmid:7872306
Kadayifçi A et al. Low dose clarithromycin plus omeprazole eradicates Helicobacter pylori in duodenal ulcer disease. 1995 Am. J. Gastroenterol. pmid:7872307
Clarithromycin for MAC. 1995 AIDS Patient Care pmid:11361361
Brown BA et al. Clarithromycin-induced hepatotoxicity. 1995 Clin. Infect. Dis. pmid:7795060
Raffi F et al. Breakthrough cerebral toxoplasmosis in patients with AIDS who are being treated with clarithromycin. 1995 Clin. Infect. Dis. pmid:7795062
Sharma PK and Tami TA AIDS: lessons from the last decade and prospects for the future. 1995 Ear Nose Throat J pmid:7796740