clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Chlamydial Pneumonia D061387 2 associated lipids
Sacroiliitis D058566 1 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Renal Insufficiency D051437 8 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Chlamydophila Infections D023521 4 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
alpha 1-Antitrypsin Deficiency D019896 3 associated lipids
Tooth, Nonvital D019553 2 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Cardiovascular Abnormalities D018376 2 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Periodontal Attachment Loss D017622 7 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
Liver Failure, Acute D017114 11 associated lipids
IgA Deficiency D017098 2 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
Meningitis, Bacterial D016920 6 associated lipids
Angiomatosis, Bacillary D016917 2 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Ureaplasma Infections D016869 5 associated lipids
Empyema, Pleural D016724 2 associated lipids
Still's Disease, Adult-Onset D016706 2 associated lipids
Purpura, Thrombocytopenic, Idiopathic D016553 4 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Helicobacter Infections D016481 21 associated lipids
Bacteremia D016470 9 associated lipids
Prosthesis-Related Infections D016459 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

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Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Morikawa K et al. Modulatory effect of antibiotics on cytokine production by human monocytes in vitro. 1996 Antimicrob. Agents Chemother. pmid:8726002
Arain TM et al. Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery. 1996 Antimicrob. Agents Chemother. pmid:8726034
Shafran SD et al. A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin versus rifampin, ethambutol, clofazimine, and ciprofloxacin. Canadian HIV Trials Network Protocol 010 Study Group. 1996 N. Engl. J. Med. pmid:8676931
Shimoyama T et al. Validity of various diagnostic tests to evaluate cure of Helicobacter pylori infection. 1996 J. Gastroenterol. pmid:8680535
Berg-Candolfi M and Candolfi E Depression of the N-demethylation of erythromycin, azithromycin, clarithromycin and clindamycin in murine Toxoplasma infection. 1996 Int. J. Parasitol. pmid:9024879
MacConnachie AM Clarithromycin (klaricid, Abbott). 1996 Intensive Crit Care Nurs pmid:8696027
Meier A et al. Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population. 1996 J. Infect. Dis. pmid:8699066
Griffith DE et al. Varying dosages of rifabutin affect white blood cell and platelet counts in human immunodeficiency virus--negative patients who are receiving multidrug regimens for pulmonary Mycobacterium avium complex disease. 1996 Clin. Infect. Dis. pmid:8953085
Sellal A et al. [Maintenance treatment of cerebral toxoplasmosis in AIDS: role of clarithromycin-minocycline combination]. 1996 Presse Med pmid:8685115
Schouenborg P [Clarithromycin]. 1996 Ugeskr. Laeg. pmid:8686028
Goddard AF et al. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice. 1996 Gastroenterology pmid:8690200
Bowersox J CPCRA researchers present OI studies at Vancouver. 1996 NIAID AIDS Agenda pmid:11363924
MAC management. 1996 PI Perspect pmid:11363967
Pellegrin I et al. Activity of rifabutin, clarithromycin, ethambutol, sparfloxacin and amikacin, alone and in combination, against Mycobacterium avium complex in human macrophages. 1996 J. Antimicrob. Chemother. pmid:9182107
Apseloff G et al. Severe neutropenia caused by recommended prophylactic doses of rifabutin. 1996 Lancet pmid:8782773
Gisbert JP et al. Response to article by Forné et al. 1996 Am. J. Gastroenterol. pmid:8561132
Steinman MA and Steinman TI Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulatory peritoneal dialysis. 1996 Am. J. Kidney Dis. pmid:8546130
Pankuch GA et al. MIC and time-kill study of antipneumococcal activities of RPR 106972 (a new oral streptogramin), RP 59500 (quinupristin-dalfopristin), pyostacine (RP 7293), penicillin G, cefotaxime, erythromycin, and clarithromycin against 10 penicillin-susceptible and -resistant pneumococci. 1996 Antimicrob. Agents Chemother. pmid:8878583
Matsuoka N et al. Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells. 1996 Clin. Exp. Immunol. pmid:9099936
Tateda K et al. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891128
Hunt Gerardo S et al. Comparison of Etest to broth microdilution method for testing Streptococcus pneumoniae susceptibility to levofloxacin and three macrolides. 1996 Antimicrob. Agents Chemother. pmid:8891154
Wintermeyer SM et al. Dirithromycin: a new macrolide. 1996 Ann Pharmacother pmid:8893122
van der Hulst RW et al. Therapeutic options after failed Helicobacter pylori eradication therapy. 1996 Am. J. Gastroenterol. pmid:8931413
Alder JD et al. Relevance of the ferret model of Helicobacter-induced gastritis to evaluation of antibacterial therapies. 1996 Am. J. Gastroenterol. pmid:8931416
Vilmànyi E et al. Clarithromycin pharmacokinetics after oral administration with or without fasting in crossbred beagles. 1996 J Small Anim Pract pmid:8934426
Yago K et al. [Protein binding of clarithromycin in patients with chronic renal failure]. 1996 Jpn J Antibiot pmid:8935121
Koguchi M et al. [Antimicrobial activities of clarithromycin against clinical isolates]. 1996 Jpn J Antibiot pmid:8935125
Kuo CC et al. In vitro activities of azithromycin, clarithromycin, and other antibiotics against Chlamydia pneumoniae. 1996 Antimicrob. Agents Chemother. pmid:8913488
Aoyama T et al. Efficacy of short-term treatment of pertussis with clarithromycin and azithromycin. 1996 J. Pediatr. pmid:8917247
Alarcón T et al. In vitro activity of omeprazole in combination with several antimicrobial agents against clinical isolates of Helicobacter pylori. 1996 Eur. J. Clin. Microbiol. Infect. Dis. pmid:9031877
Burucoa C et al. Western blot monitoring of disseminated Nocardia nova infection treated with clarithromycin, imipenem, and surgical drainage. 1996 Eur. J. Clin. Microbiol. Infect. Dis. pmid:9031879
Koeck JL et al. Disseminated Mycobacterium simiae infection in a patient with AIDS: clinical features and treatment. 1996 Clin. Infect. Dis. pmid:8909856
Liviu L et al. Pancreatitis induced by clarithromycin. 1996 Ann. Intern. Med. pmid:8849171
Hackelsberger A and Malfertheiner P A risk-benefit assessment of drugs used in the eradication of Helicobacter pylori infection. 1996 Drug Saf pmid:8862962
Dammann HG [Helicobacter pylori eradication: triple therapy versus dual therapy]. 1996 Fortschr. Med. pmid:8852685
Cone LA et al. Mania due to clarithromycin therapy in a patient who was not infected with human immunodeficiency virus. 1996 Clin. Infect. Dis. pmid:8853002
Yousfi MM et al. One-week triple therapy with omeprazole, amoxycillin and clarithromycin for treatment of Helicobacter pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8853767
Ramirez Mayans JA et al. [Elimination of Helicobacter pylori in patients with recurrent abdominal pain with simultaneous administration of ranitidine, bismuth subsalicylate and clarithromycin]. 1996 Acta Gastroenterol. Latinoam. pmid:9363265
Stone GG et al. Identification of a 23S rRNA gene mutation in clarithromycin-resistant Helicobacter pylori. 1996 Helicobacter pmid:9432314
Cammarota G et al. Helicobacter pylori eradication using one-week low-dose lansoprazole plus amoxycillin and either clarithromycin or azithromycin. 1996 Aliment. Pharmacol. Ther. pmid:8971300
Pilotto A et al. Cure of Helicobacter pylori infection in the elderly: effects of eradication on gastritis and serological markers. 1996 Aliment. Pharmacol. Ther. pmid:8971305
Adachi T et al. Eosinophil apoptosis caused by theophylline, glucocorticoids, and macrolides after stimulation with IL-5. 1996 J. Allergy Clin. Immunol. pmid:8977529
Dammann HG Therapy with omeprazole and clarithromycin increases serum carbamazepine levels in patients with H. pylori gastritis. 1996 Dig. Dis. Sci. pmid:8617126
Meyboom RH et al. [Possible potentiation of phenprocoumon by clarithromycin and roxithromycin]. 1996 Ned Tijdschr Geneeskd pmid:8628425
Satoh K et al. Efficacy of clarithromycin in eradicating Helicobacter pylori. 1996 J. Gastroenterol. pmid:8959520
Hunt RH Eradication of Helicobacter pylori infection. 1996 Am. J. Med. pmid:8644782
Shimoyama T et al. Ecabet sodium eradicates Helicobacter pylori infection in gastric ulcer patients. 1996 J. Gastroenterol. pmid:8959522
Tonokatsu Y et al. Eradication of Helicobacter pylori followed by reinfection. 1996 J. Gastroenterol. pmid:8959526
Murakami K et al. Atopic dermatitis successfully treated by eradication of Helicobacter pylori. 1996 J. Gastroenterol. pmid:8959527
Torriani FJ et al. Disseminated Mycobacterium avium complex: correlation between blood and tissue burden. 1996 J. Infect. Dis. pmid:8603975
Diemer PR et al. [Rifabutin-induced hypopyon iritis in HIV infection]. 1996 Klin Monbl Augenheilkd pmid:8965476
Vakil N and Fennerty MB Cost-effectiveness of treatment regimens for the eradication of Helicobacter pylori in duodenal ulcer. 1996 Am. J. Gastroenterol. pmid:8607487
Labenz J [Current developments in Helicobacter pylori therapy]. 1996 Leber Magen Darm pmid:8965606
Treiber G The influence of drug dosage on Helicobacter pylori eradication: a cost-effectiveness analysis. 1996 Am. J. Gastroenterol. pmid:8607488
Grau E et al. Interaction between clarithromycin and oral anticoagulants. 1996 Ann Pharmacother pmid:8968465
Shaheen N and Grimm IS Fulminant hepatic failure associated with clarithromycin. 1996 Am. J. Gastroenterol. pmid:8607519
Muñoz N et al. Chemoprevention trial on precancerous lesions of the stomach in Venezuela: summary of study design and baseline data. 1996 IARC Sci. Publ. pmid:8923024
Dhaenens L et al. In-vitro activities of clarithromycin and other antimicrobial agents against Helicobacter pylori isolated from children. 1996 J. Antimicrob. Chemother. pmid:8877551
Tursi A et al. Helicobacter pylori eradication helps resolve pyloric and duodenal stenosis. 1996 J. Clin. Gastroenterol. pmid:8877648
Thor P et al. Dysfunction in gastric myoelectric and motor activity in Helicobacter pylori positive gastritis patients with non-ulcer dyspesia. 1996 J. Physiol. Pharmacol. pmid:8877902
Ji B et al. Bactericidal activity of single dose of clarithromycin plus minocycline, with or without ofloxacin, against Mycobacterium leprae in patients. 1996 Antimicrob. Agents Chemother. pmid:8878595
Heifets L Susceptibility testing of Mycobacterium avium complex isolates. 1996 Antimicrob. Agents Chemother. pmid:8843278
Alper CM et al. Efficacy of clarithromycin treatment of acute otitis media caused by infection with penicillin-susceptible, -intermediate, and -resistant Streptococcus pneumoniae in the chinchilla. 1996 Antimicrob. Agents Chemother. pmid:8843299
Chen S et al. [Omeprazole, clarithromycin and amoxicillin therapy for Helicobacter pylori infection]. 1996 Zhonghua Nei Ke Za Zhi pmid:9592303
Liu W et al. [Clarithromycin combined short-term triple therapies for eradication of Helicobacter pylori infection]. 1996 Zhonghua Nei Ke Za Zhi pmid:9592304
Xu G et al. [Effect of clarithromycin on cytocidal activity against Pseudomonas aeruginosa in mice peritoneal cavity]. 1996 Kansenshogaku Zasshi pmid:8822058
Pijpers E et al. A clarithromycin-induced myasthenic syndrome. 1996 Clin. Infect. Dis. pmid:8824993
Webb DD Practice guidelines for treatment of peptic ulcer disease. 1996 JAMA pmid:8827959
Erah PO et al. Ion-pair high-performance liquid chromatographic assay method for the assessment of clarithromycin stability in aqueous solution and in gastric juice. 1996 J. Chromatogr. B, Biomed. Appl. pmid:8832427
Three new studies expand understanding of MAC therapy. 1996 Am J Health Syst Pharm pmid:8899122
Vangala R and Cernek PK Hypersensitivity reaction to clarithromycin. 1996 Ann Pharmacother pmid:8833572
Ji B et al. Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice. 1996 Antimicrob. Agents Chemother. pmid:8834886
Yamamoto T et al. Activity of KRM-1648 alone or in combination with both ethambutol and kanamycin or clarithromycin against Mycobacterium intracellulare infections in beige mice. 1996 Antimicrob. Agents Chemother. pmid:8834892
Ji B et al. How effective is KRM-1648 in treatment of disseminated Mycobacterium avium complex infections in beige mice? 1996 Antimicrob. Agents Chemother. pmid:8834894
Dattwyler RJ et al. Clarithromycin in treatment of early Lyme disease: a pilot study. 1996 Antimicrob. Agents Chemother. pmid:8834900
Yousfi MM et al. Resolution of a metaplastic duodenal polyp after cure of Helicobacter pylori infection. 1996 J. Clin. Gastroenterol. pmid:8835902
Versalovic J et al. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. 1996 Antimicrob. Agents Chemother. pmid:8834903
Wallace RJ et al. Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. 1996 Antimicrob. Agents Chemother. pmid:8807061
Gillum JG et al. Effect of combination therapy with ciprofloxacin and clarithromycin on theophylline pharmacokinetics in healthy volunteers. 1996 Antimicrob. Agents Chemother. pmid:8807068
McLinn S and Williams D Incidence of antibiotic-resistant Streptococcus pneumoniae and beta-lactamase-positive Haemophilus influenzae in clinical isolates from patients with otitis media. 1996 Pediatr. Infect. Dis. J. pmid:8878239
Riff DS et al. Triple therapy with lansoprazole, clarithromycin, and amoxicillin for the cure of Helicobacter pylori infection: a short report. 1996 Helicobacter pmid:9398874
Harford W et al. Double-blind, multicenter evaluation of lansoprazole and amoxicillin dual therapy for the cure of Helicobacter pylori infection. 1996 Helicobacter pmid:9398875
Schwartz H et al. Seven-day triple therapy with lansoprazole, clarithromycin, and metronidazole for the cure of Helicobacter pylori infection: a short report. 1996 Helicobacter pmid:9398876
Wenisch C et al. Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. 1996 Antimicrob. Agents Chemother. pmid:8878577
Jaup BK Duodenal ulcer healing after 7-day treatment: a pilot study with lansoprazole, amoxicillin, and clarithromycin. 1996 Helicobacter pmid:9398878
Moayyedi P et al. Comparison of one or two weeks of lansoprazole, amoxicillin, and clarithromycin in the treatment of Helicobacter pylori. 1996 Helicobacter pmid:9398880
Mégraud F and Malfertheiner P Treatment of Helicobacter pylori infection: summary of a meeting at the Fourth United European Gastroenterology Week, September 20, 1995. 1996 Helicobacter pmid:9398889
O'Morain C et al. Double-blind, multicenter, placebo-controlled evaluation of clarithromycin and omeprazole for Helicobacter pylori-associated duodenal ulcer. 1996 Helicobacter pmid:9398893
Lind T et al. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study. 1996 Helicobacter pmid:9398894
van der Hulst RW et al. Treatment of Helicobacter pylori infection: a review of the world literature. 1996 Helicobacter pmid:9398908
NIAID study rules out high-dose clarithromycin for AIDS-related MAC. 1996 AIDS Patient Care STDS pmid:11361534
New data suggest antibiotic clarithromycin is effective in prolonging life of AIDS patients. 1996 AIDS Patient Care STDS pmid:11361575
Clarithromycin and MAC. 1996 AIDS Patient Care STDS pmid:11361673
Markham A and McTavish D Clarithromycin and omeprazole as helicobacter pylori eradication therapy in patients with H. pylori-associated gastric disorders. 1996 Drugs pmid:8741237
Unge P Review of Helicobacter pylori eradication regimens. 1996 Scand. J. Gastroenterol. Suppl. pmid:8722388
Bazzoli F Italian omeprazole triple therapy--a 1-week regimen. 1996 Scand. J. Gastroenterol. Suppl. pmid:8722395
Goddard AF and Logan RP Antimicrobial resistance and Helicobacter pylori. 1996 J. Antimicrob. Chemother. pmid:8722530
Patel KB et al. Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891147
Barry AL et al. Reassessment of methods for testing the susceptibility of Haemophilus influenzae to clarithromycin. 1996 J. Antimicrob. Chemother. pmid:8722555
H. pylori treatment recognized by FDA. 1996 Am J Health Syst Pharm pmid:8725200