clarithromycin

clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.

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Introduction

To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with clarithromycin?

clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with clarithromycin

MeSH term MeSH ID Detail
Chlamydial Pneumonia D061387 2 associated lipids
Sacroiliitis D058566 1 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Upper Extremity Deep Vein Thrombosis D056824 1 associated lipids
Leprosy, Paucibacillary D056005 2 associated lipids
Extensively Drug-Resistant Tuberculosis D054908 1 associated lipids
Buruli Ulcer D054312 1 associated lipids
Immune Reconstitution Inflammatory Syndrome D054019 1 associated lipids
Renal Insufficiency D051437 8 associated lipids
Desulfovibrionaceae Infections D045824 5 associated lipids
Chlamydophila Infections D023521 4 associated lipids
Epilepsy, Partial, Motor D020938 1 associated lipids
Central Nervous System Protozoal Infections D020808 3 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
alpha 1-Antitrypsin Deficiency D019896 3 associated lipids
Tooth, Nonvital D019553 2 associated lipids
Gingival Overgrowth D019214 7 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Cryptogenic Organizing Pneumonia D018549 3 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Soft Tissue Infections D018461 2 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Cardiovascular Abnormalities D018376 2 associated lipids
Tuberculosis, Multidrug-Resistant D018088 6 associated lipids
Cytomegalovirus Retinitis D017726 2 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Periodontal Attachment Loss D017622 7 associated lipids
Kleine-Levin Syndrome D017593 1 associated lipids
Cutaneous Fistula D017577 1 associated lipids
Pityriasis Rosea D017515 3 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Skin Diseases, Bacterial D017192 8 associated lipids
Liver Failure, Acute D017114 11 associated lipids
IgA Deficiency D017098 2 associated lipids
AIDS-Related Opportunistic Infections D017088 9 associated lipids
Common Variable Immunodeficiency D017074 4 associated lipids
Meningitis, Bacterial D016920 6 associated lipids
Angiomatosis, Bacillary D016917 2 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Ureaplasma Infections D016869 5 associated lipids
Empyema, Pleural D016724 2 associated lipids
Still's Disease, Adult-Onset D016706 2 associated lipids
Purpura, Thrombocytopenic, Idiopathic D016553 4 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Helicobacter Infections D016481 21 associated lipids
Bacteremia D016470 9 associated lipids
Prosthesis-Related Infections D016459 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with clarithromycin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with clarithromycin?

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Location Cross reference Weighted score Related literatures
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What functions are associated with clarithromycin?


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Function Cross reference Weighted score Related literatures

What lipids are associated with clarithromycin?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with clarithromycin?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with clarithromycin?

Mouse Model

Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).

Knock-out

Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).

Experimental Pneumococcal Meningitis

Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with clarithromycin

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Authors Title Published Journal PubMed Link
Shimoyama T et al. Validity of various diagnostic tests to evaluate cure of Helicobacter pylori infection. 1996 J. Gastroenterol. pmid:8680535
MacConnachie AM Clarithromycin (klaricid, Abbott). 1996 Intensive Crit Care Nurs pmid:8696027
Meier A et al. Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population. 1996 J. Infect. Dis. pmid:8699066
Sellal A et al. [Maintenance treatment of cerebral toxoplasmosis in AIDS: role of clarithromycin-minocycline combination]. 1996 Presse Med pmid:8685115
Schouenborg P [Clarithromycin]. 1996 Ugeskr. Laeg. pmid:8686028
Goddard AF et al. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice. 1996 Gastroenterology pmid:8690200
Lambert JR Pharmacology of the gastric mucosa: a rational approach to Helicobacter polytherapy. 1996 Gastroenterology pmid:8690219
Bates JH Mycobacterium avium disease: progress at last. 1996 Am. J. Respir. Crit. Care Med. pmid:8665029
Wallace RJ et al. Clarithromycin regimens for pulmonary Mycobacterium avium complex. The first 50 patients. 1996 Am. J. Respir. Crit. Care Med. pmid:8665032
Frothingham R Clarithromycin treatment for Mycobacterium avium-intracellulare complex lung disease. 1996 Am. J. Respir. Crit. Care Med. pmid:8665069
Segreti J et al. In vitro activity of macrolides against intracellular Legionella pneumophila. 1996 Diagn. Microbiol. Infect. Dis. pmid:8902407
Apseloff G et al. Severe neutropenia caused by recommended prophylactic doses of rifabutin. 1996 Lancet pmid:8782773
Gisbert JP et al. Response to article by Forné et al. 1996 Am. J. Gastroenterol. pmid:8561132
Steinman MA and Steinman TI Clarithromycin-associated visual hallucinations in a patient with chronic renal failure on continuous ambulatory peritoneal dialysis. 1996 Am. J. Kidney Dis. pmid:8546130
Pankuch GA et al. MIC and time-kill study of antipneumococcal activities of RPR 106972 (a new oral streptogramin), RP 59500 (quinupristin-dalfopristin), pyostacine (RP 7293), penicillin G, cefotaxime, erythromycin, and clarithromycin against 10 penicillin-susceptible and -resistant pneumococci. 1996 Antimicrob. Agents Chemother. pmid:8878583
Ednie LM et al. Comparative activities of clarithromycin, erythromycin, and azithromycin against penicillin-susceptible and penicillin-resistant pneumococci. 1996 Antimicrob. Agents Chemother. pmid:8843313
Nash KA and Inderlied CB Rapid detection of mutations associated with macrolide resistance in Mycobacterium avium complex. 1996 Antimicrob. Agents Chemother. pmid:8807078
Tateda K et al. Direct evidence for antipseudomonal activity of macrolides: exposure-dependent bactericidal activity and inhibition of protein synthesis by erythromycin, clarithromycin, and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891128
van der Hulst RW et al. Therapeutic options after failed Helicobacter pylori eradication therapy. 1996 Am. J. Gastroenterol. pmid:8931413
Alder JD et al. Relevance of the ferret model of Helicobacter-induced gastritis to evaluation of antibacterial therapies. 1996 Am. J. Gastroenterol. pmid:8931416
Vilmànyi E et al. Clarithromycin pharmacokinetics after oral administration with or without fasting in crossbred beagles. 1996 J Small Anim Pract pmid:8934426
Yago K et al. [Protein binding of clarithromycin in patients with chronic renal failure]. 1996 Jpn J Antibiot pmid:8935121
Koguchi M et al. [Antimicrobial activities of clarithromycin against clinical isolates]. 1996 Jpn J Antibiot pmid:8935125
Tomioka H et al. [Preclinical study of therapeutic agents used against Mycobacterium avium complex infections--with special reference to new macrolides and new quinolones]. 1996 Kekkaku pmid:8999135
Tsuyuguchi K [In vitro anti-MAC activities of new quinolones in focus (1)]. 1996 Kekkaku pmid:8999136
Sakatani M [Pilot studies on the treatment of Mycobacterium avium complex lung disease--new macrolides and new quinolones. (1) Continuous positive cases (failure of the initial chemotherapy)]. 1996 Kekkaku pmid:8999139
Tanaka E [Pilot studies on the treatment of Mycobacterium avium complex lung disease--new macrolides and new quinolones. (2) Multi-drug chemotherapy for initial cases on trial]. 1996 Kekkaku pmid:8999140
Koeck JL et al. Disseminated Mycobacterium simiae infection in a patient with AIDS: clinical features and treatment. 1996 Clin. Infect. Dis. pmid:8909856
Liviu L et al. Pancreatitis induced by clarithromycin. 1996 Ann. Intern. Med. pmid:8849171
Dammann HG [Helicobacter pylori eradication: triple therapy versus dual therapy]. 1996 Fortschr. Med. pmid:8852685
Cone LA et al. Mania due to clarithromycin therapy in a patient who was not infected with human immunodeficiency virus. 1996 Clin. Infect. Dis. pmid:8853002
Yousfi MM et al. One-week triple therapy with omeprazole, amoxycillin and clarithromycin for treatment of Helicobacter pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8853767
Schimkat M et al. Rifabutin-associated anterior uveitis in patients infected with human immunodeficiency virus. 1996 Ger J Ophthalmol pmid:8854102
Chiba N Omeprazole and clarithromycin with and without metronidazole for the eradication of Helicobacter pylori. 1996 Am. J. Gastroenterol. pmid:8855737
Engelhardt E et al. [Postoperative infection with Mycobacterium chelonae]. 1996 Hautarzt pmid:9036143
Kelleher P et al. Uveitis associated with rifabutin and macrolide therapy for Mycobacterium avium intracellulare infection in AIDS patients. 1996 Genitourin Med pmid:9038637
Stone GG et al. Identification of a 23S rRNA gene mutation in clarithromycin-resistant Helicobacter pylori. 1996 Helicobacter pmid:9432314
Pozniak A and Nelson MR Against the proposition: all patients with advanced HIV disease should be offered rifabutin prophylaxis. 1996 Genitourin Med pmid:8976832
Torriani FJ et al. Disseminated Mycobacterium avium complex: correlation between blood and tissue burden. 1996 J. Infect. Dis. pmid:8603975
Vakil N and Fennerty MB Cost-effectiveness of treatment regimens for the eradication of Helicobacter pylori in duodenal ulcer. 1996 Am. J. Gastroenterol. pmid:8607487
Treiber G The influence of drug dosage on Helicobacter pylori eradication: a cost-effectiveness analysis. 1996 Am. J. Gastroenterol. pmid:8607488
Shaheen N and Grimm IS Fulminant hepatic failure associated with clarithromycin. 1996 Am. J. Gastroenterol. pmid:8607519
Horowitz RS et al. Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction. 1996 Arch. Intern. Med. pmid:8607732
Labenz J et al. [Ulcer healing through the elimination of Helicobacter pylori: is a week of therapy enough?]. 1996 Dtsch. Med. Wochenschr. pmid:8565802
Tursi A et al. Helicobacter pylori eradication helps resolve pyloric and duodenal stenosis. 1996 J. Clin. Gastroenterol. pmid:8877648
Goh KL et al. Helicobacter pylori eradication with short-term therapy leads to duodenal ulcer healing without the need for continued acid suppression therapy. 1996 Eur J Gastroenterol Hepatol pmid:8804868
Thor P et al. Dysfunction in gastric myoelectric and motor activity in Helicobacter pylori positive gastritis patients with non-ulcer dyspesia. 1996 J. Physiol. Pharmacol. pmid:8877902
Berger C et al. Treatment of nontuberculous mycobacterial lymphadenitis with clarithromycin plus rifabutin. 1996 J. Pediatr. pmid:8774511
Ji B et al. Bactericidal activity of single dose of clarithromycin plus minocycline, with or without ofloxacin, against Mycobacterium leprae in patients. 1996 Antimicrob. Agents Chemother. pmid:8878595
Heifets L Susceptibility testing of Mycobacterium avium complex isolates. 1996 Antimicrob. Agents Chemother. pmid:8843278
Alper CM et al. Efficacy of clarithromycin treatment of acute otitis media caused by infection with penicillin-susceptible, -intermediate, and -resistant Streptococcus pneumoniae in the chinchilla. 1996 Antimicrob. Agents Chemother. pmid:8843299
Rana KZ et al. Clarithromycin does not affect phosphorylation of zidovudine in vitro. 1996 Antimicrob. Agents Chemother. pmid:8843311
Flamm RK et al. Kill kinetics of antimicrobial agents against Helicobacter pylori. 1996 J. Antimicrob. Chemother. pmid:8937967
Bermudez LE et al. Effect of ethambutol on emergence of clarithromycin-resistant Mycobacterium avium complex in the beige mouse model. 1996 J. Infect. Dis. pmid:8940212
Nagashima R et al. Regression of duodenal mucosa-associated lymphoid tissue lymphoma after eradication of Helicobacter pylori. 1996 Gastroenterology pmid:8942749
Ferguson PJ and Saulsbury FT Successful treatment of chronic Mycobacterium abscessus otitis media with clarithromycin. 1996 Pediatr. Infect. Dis. J. pmid:8866816
Yamamoto T et al. Activity of KRM-1648 alone or in combination with both ethambutol and kanamycin or clarithromycin against Mycobacterium intracellulare infections in beige mice. 1996 Antimicrob. Agents Chemother. pmid:8834892
Ji B et al. How effective is KRM-1648 in treatment of disseminated Mycobacterium avium complex infections in beige mice? 1996 Antimicrob. Agents Chemother. pmid:8834894
Dattwyler RJ et al. Clarithromycin in treatment of early Lyme disease: a pilot study. 1996 Antimicrob. Agents Chemother. pmid:8834900
Versalovic J et al. Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori. 1996 Antimicrob. Agents Chemother. pmid:8834903
Wallace RJ et al. Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus. 1996 Antimicrob. Agents Chemother. pmid:8807061
Gillum JG et al. Effect of combination therapy with ciprofloxacin and clarithromycin on theophylline pharmacokinetics in healthy volunteers. 1996 Antimicrob. Agents Chemother. pmid:8807068
McLinn S and Williams D Incidence of antibiotic-resistant Streptococcus pneumoniae and beta-lactamase-positive Haemophilus influenzae in clinical isolates from patients with otitis media. 1996 Pediatr. Infect. Dis. J. pmid:8878239
Gross U and Pohl F Influence of antimicrobial agents on replication and stage conversion of Toxoplasma gondii. 1996 Curr. Top. Microbiol. Immunol. pmid:8791704
Peterson WL et al. Ranitidine bismuth citrate plus clarithromycin is effective for healing duodenal ulcers, eradicating H. pylori and reducing ulcer recurrence. RBC H. pylori Study Group. 1996 Aliment. Pharmacol. Ther. pmid:8791947
Delchier JC et al. Omeprazole-amoxycillin versus omeprazole-amoxycillin-clarithromycin in the eradication of Helicobacter pylori. 1996 Aliment. Pharmacol. Ther. pmid:8791948
Jaup BH and Norrby A Comparison of two low-dose one-week triple therapy regimens with and without metronidazole for cure of H. pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8791950
Wenisch C et al. Effect of single oral dose of azithromycin, clarithromycin, and roxithromycin on polymorphonuclear leukocyte function assessed ex vivo by flow cytometry. 1996 Antimicrob. Agents Chemother. pmid:8878577
Moayyedi P et al. Comparison of one or two weeks of lansoprazole, amoxicillin, and clarithromycin in the treatment of Helicobacter pylori. 1996 Helicobacter pmid:9398880
Mégraud F and Malfertheiner P Treatment of Helicobacter pylori infection: summary of a meeting at the Fourth United European Gastroenterology Week, September 20, 1995. 1996 Helicobacter pmid:9398889
O'Morain C et al. Double-blind, multicenter, placebo-controlled evaluation of clarithromycin and omeprazole for Helicobacter pylori-associated duodenal ulcer. 1996 Helicobacter pmid:9398893
Lind T et al. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study. 1996 Helicobacter pmid:9398894
van der Hulst RW et al. Treatment of Helicobacter pylori infection: a review of the world literature. 1996 Helicobacter pmid:9398908
NIAID study rules out high-dose clarithromycin for AIDS-related MAC. 1996 AIDS Patient Care STDS pmid:11361534
New data suggest antibiotic clarithromycin is effective in prolonging life of AIDS patients. 1996 AIDS Patient Care STDS pmid:11361575
Clarithromycin and MAC. 1996 AIDS Patient Care STDS pmid:11361673
Harris AW et al. Lansoprazole, clarithromycin and metronidazole for seven days in Helicobacter pylori infection. 1996 Aliment. Pharmacol. Ther. pmid:8971302
Moshkowitz M et al. One week triple therapy with omeprazole, clarithromycin and tinidazole for Helicobacter pylori: differing efficacy in previously treated and untreated patients. 1996 Aliment. Pharmacol. Ther. pmid:8971304
Laine L et al. Randomized comparison of differing periods of twice-a-day triple therapy for the eradication of Helicobacter pylori. 1996 Aliment. Pharmacol. Ther. pmid:8971306
Naoki K et al. [Two cases of pulmonary disease caused by Mycobacterium chelonae subsp. abscessus]. 1996 Nihon Kyobu Shikkan Gakkai Zasshi pmid:8976085
Patel KB et al. Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. 1996 Antimicrob. Agents Chemother. pmid:8891147
Pinzani V et al. [Occurrence of anterior uveitis in a HIV patient treated with rifabutin, ethambutol, clarithromycin]. 1995 Sep-Oct Therapie pmid:8571297
Dalston MO et al. [Clarithromycin combined with pyrimethamine in cerebral toxoplasmosis--a report of 2 cases]. 1995 Oct-Dec Rev. Soc. Bras. Med. Trop. pmid:8668843
Sternon J et al. Azithromycin compared with clarithromycin in the treatment of adult patients with acute purulent tracheobronchitis: a cost of illness study. 1995 Nov-Dec J. Int. Med. Res. pmid:8746608
Stein GE et al. A preliminary study of clarithromycin versus doxycycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis. 1995 Nov-Dec Pharmacotherapy pmid:8602379
Hashisaki GT Update on macrolide antibiotics. 1995 May-Jun Am J Otolaryngol pmid:7661309
Kees F et al. Serum and cellular pharmacokinetics of clarithromycin 500 mg q.d. and 250 mg b.i.d. in volunteers. 1995 May-Jun Infection pmid:7499006
Claussen DW The most commonly prescribed medications in the United States: Part 3. 1995 Jul-Aug Gastroenterol Nurs pmid:7654815
Lee D et al. Localized Mycobacterium avium-intracellulare mastitis in an immunocompetent woman with silicone breast implants. 1995 Plast. Reconstr. Surg. pmid:7809228
Xu G et al. [Effect of clarithromycin on macrophage functions]. 1995 Kansenshogaku Zasshi pmid:7594777
Gelber RH et al. Activity of combinations of dapsone, rifampin, minocycline, clarithromycin, and sparfloxacin against M. leprae-infected mice. 1995 Int. J. Lepr. Other Mycobact. Dis. pmid:7602221
Milde P et al. Cutaneous bacillary angiomatosis in a patient with chronic lymphocytic leukemia. 1995 Arch Dermatol pmid:7543264
Lacassin F et al. Clarithromycin-minocycline combination as salvage therapy for toxoplasmosis in patients infected with human immunodeficiency virus. 1995 Antimicrob. Agents Chemother. pmid:7695324
Schütze K and Hentschel E Duodenal ulcer healing after 7-day treatment: a pilot study with lansoprazole, amoxicillin and clarithromycin. 1995 Z Gastroenterol pmid:8600661
Lounis N et al. Selection of clarithromycin-resistant Mycobacterium avium complex during combined therapy using the beige mouse model. 1995 Antimicrob. Agents Chemother. pmid:7793860
Fattorini L et al. In vitro and ex vivo activities of antimicrobial agents used in combination with clarithromycin, with or without amikacin, against Mycobacterium avium. 1995 Antimicrob. Agents Chemother. pmid:7793873
Abbott files SNDA for MAC prophylaxis. 1995 J Int Assoc Physicians AIDS Care pmid:11362606
Cohen Y et al. Use of normal C57BL/6 mice with established Mycobacterium avium infections as an alternative model for evaluation of antibiotic activity. 1995 Antimicrob. Agents Chemother. pmid:7793882
Pierce M Another perspective on MAC prophylaxis. Interview by Gordon Nary. 1995 J Int Assoc Physicians AIDS Care pmid:11362746
Archange YR et al. Clarithromycin prophylaxis against disseminated Mycobacterium avium complex in patients with AIDS. 1995 J Int Assoc Physicians AIDS Care pmid:11362747