clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
pmid:11817788 | ||||
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Jain SK et al. | Lectin-Conjugated Clarithromycin and Acetohydroxamic Acid-Loaded PLGA Nanoparticles: a Novel Approach for Effective Treatment of H. pylori. | 2016 | AAPS PharmSciTech | pmid:26566630 |
Rowe BH et al. | Community-acquired pneumonia in North American emergency departments: drug resistance and treatment success with clarithromycin. | 2007 | Acad Emerg Med | pmid:17478882 |
Lew EA | Clarithromycin, lansoprazole, and metronidazole eradicated Helicobacter pylori infection in chronic renal insufficiency. | ACP J. Club | pmid:15122860 | |
Wang S et al. | A supra-monolayer nanopattern for organic nanoparticle array deposition. | 2013 | ACS Appl Mater Interfaces | pmid:23480527 |
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Klesiewicz K et al. | PCR-RFLP detection of point mutations A2143G and A2142G in 23S rRNA gene conferring resistance to clarithromycin in Helicobacter pylori strains. | 2014 | Acta Biochim. Pol. | pmid:24927236 |
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Brüning J et al. | Erythromycin A dimethyl sulfoxide disolvate 1.43-hydrate. | 2012 | Acta Crystallogr Sect E Struct Rep Online | pmid:22412590 |
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De Punzio C et al. | Isolation of Chlamydia trachomatis during IVF-ET. | 1991 Jul-Aug | Acta Eur. Fertil. | pmid:1844324 |
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Mark TM and Coleman M | It's Time to Take Clarithromycin Seriously in Multiple Myeloma. | 2016 | Acta Haematol. | pmid:26505907 |
Qiu XH et al. | Clarithromycin Synergistically Enhances Thalidomide Cytotoxicity in Myeloma Cells. | 2016 | Acta Haematol. | pmid:26505646 |
Holmberg LA et al. | Results from Two Consecutive Studies of Consolidation Therapy after Autologous Transplant for Multiple Myeloma: Thalidomide, Dexamethasone, and Clarithromycin or Lenalidomide, Dexamethasone, and Clarithromycin. | 2017 | Acta Haematol. | pmid:28355602 |
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Dabirmoghaddam P et al. | The efficacy of clarithromycin in patients with severe nasal polyposis. | 2013 | Acta Med Iran | pmid:23852839 |
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Lopes R et al. | [Antibiomania: a case of a manic episode induced by clarithromycin]. | 2011 Sep-Oct | Acta Med Port | pmid:22525636 |
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Koçkar C et al. | Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin. | 2001 | Acta Medica (Hradec Kralove) | pmid:11811084 |
Spengler G et al. | The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria. | 2004 | Acta Microbiol Immunol Hung | pmid:15571074 |
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