clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Collina G et al. | Atypical cutaneous mycobacteriosis diagnosed by polymerase chain reaction. | 2002 | Br. J. Dermatol. | pmid:12366430 |
Wallwork B et al. | Clarithromycin and prednisolone inhibit cytokine production in chronic rhinosinusitis. | 2002 | Laryngoscope | pmid:12368623 |
Suryanarayan K et al. | Nontuberculous mycobacterial infections in pediatric acute leukemia. | 2002 | J. Pediatr. Hematol. Oncol. | pmid:12368695 |
Iseman MD | Medical management of pulmonary disease caused by Mycobacterium avium complex. | 2002 | Clin. Chest Med. | pmid:12370999 |
Tanaka E et al. | Successful treatment with faropenem and clarithromycin of pulmonary Mycobacterium abscessus infection. | 2002 | J. Infect. Chemother. | pmid:12373490 |
Nicholson SC et al. | Haemophilus influenzae in respiratory tract infections in community-based clinical practice: therapy with gatifloxacin. | 2002 | Diagn. Microbiol. Infect. Dis. | pmid:12376039 |
Kim KS et al. | Mutations in the 23S rRNA gene of Helicobacter pylori associated with clarithromycin resistance. | 2002 | J. Korean Med. Sci. | pmid:12378008 |
Weiss LR | Open-label, randomized comparison of the efficacy and tolerability of clarithromycin, levofloxacin, and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitis. | 2002 | Clin Ther | pmid:12380633 |
Mohar A et al. | Eradication rate of Helicobacter pylori in a Mexican population at high risk for gastric cancer and use of serology to assess cure. | 2002 | Am. J. Gastroenterol. | pmid:12385434 |
Sullivan B et al. | Comparison of azithromycin and clarithromycin in triple therapy regimens for the eradication of Helicobacter pylori. | 2002 | Am. J. Gastroenterol. | pmid:12385435 |
De Francesco V et al. | Sequential eradicating therapy: a treatment that does not discriminate Helicobacter pylori strains in patients with nonulcer dyspepsia? | 2002 | Am. J. Gastroenterol. | pmid:12385470 |
File TM et al. | Outcome of treatment of respiratory tract infections due to Streptococcus pneumoniae, including drug-resistant strains, with pharmacokinetically enhanced amoxycillin/clavulanate. | 2002 | Int. J. Antimicrob. Agents | pmid:12385678 |
Thadepalli H et al. | Comparison of telithromycin, a new ketolide, with erythromycin and clarithromycin for the treatment of Haemophilus influenzae pneumonia in suckling, middle aged and senescent mice. | 2002 | Int. J. Antimicrob. Agents | pmid:12385696 |
Tuuminen T et al. | A casuistic immunologic response in primary and repeated Chlamydophila pneumoniae infections in an immunocompetent individual. | 2002 | J. Infect. | pmid:12387780 |
Signorini L et al. | Co-infection with Esptein-Barr virus and Bartonella henselae resulting in systemic bartonellosis. | 2002 | J. Infect. | pmid:12387781 |
Murakami K et al. | Eradication rates of clarithromycin-resistant Helicobacter pylori using either rabeprazole or lansoprazole plus amoxicillin and clarithromycin. | 2002 | Aliment. Pharmacol. Ther. | pmid:12390102 |
Taneike I et al. | Emergence of clarithromycin-resistant Helicobacter pylori (CRHP) with a high prevalence in children compared with their parents. | 2002 | Helicobacter | pmid:12390209 |
Perez Aldana L et al. | The relationship between consumption of antimicrobial agents and the prevalence of primary Helicobacter pylori resistance. | 2002 | Helicobacter | pmid:12390210 |
Yoshimura M et al. | A case of acute gastric mucosal lesions associated with Helicobacter heilmannii infection. | 2002 | Helicobacter | pmid:12390213 |
Ling TK et al. | The antimicrobial susceptibility of Helicobacter pylori in Hong Kong (1997-2001). | 2002 | Helicobacter | pmid:12390214 |
Farup PG et al. | The effect of Helicobacter pylori retreatment with ranitidine bismuth citrate, clarithromycin, and metronidazole depends on the first-line therapy. | 2002 Nov-Dec | J. Clin. Gastroenterol. | pmid:12394224 |
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Jernigan DB et al. | Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings. | 2002 | Emerging Infect. Dis. | pmid:12396909 |
Gaig P et al. | Efficacy of the eradication of Helicobacter pylori infection in patients with chronic urticaria. A placebo-controlled double blind study. | 2002 Sep-Oct | Allergol Immunopathol (Madr) | pmid:12396958 |
Fischer T et al. | Diagnostic odyssey of a cutaneous mycobacteriosis rare in central Europe. | 2002 | Dermatology (Basel) | pmid:12399680 |
Freund YR et al. | Prophylactic clarithromycin to treat mycobacterium avium in HIV patients receiving zidovudine may significantly increase mortality by suppressing lymphopoiesis and hematopoiesis. | 2002 | Int. Immunopharmacol. | pmid:12400876 |
Marchi S et al. | Thrombocytopenic purpura: an unusual complication of eradication therapy for Helicobacter pylori. | 2002 | Dig Liver Dis | pmid:12405255 |
Alexopoulou A et al. | Thrombotic thrombocytopenic purpura in a patient treated with clarithromycin. | 2002 | Eur. J. Haematol. | pmid:12406017 |
Mainz D et al. | Pharmacokinetics of lansoprazole, amoxicillin and clarithromycin after simultaneous and single administration. | 2002 | J. Antimicrob. Chemother. | pmid:12407126 |
Main KM et al. | Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient. | 2002 | Acta Paediatr. | pmid:12412882 |
Kawai T et al. | A new serum antibody test kit (E plate) for evaluation of Helicobacter pylori eradication. | 2002 | Intern. Med. | pmid:12412995 |
Veneri D et al. | Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura. | 2002 | Haematologica | pmid:12414347 |
Shafran SD et al. | Successful discontinuation of therapy for disseminated Mycobacterium avium complex infection after effective antiretroviral therapy. | 2002 | Ann. Intern. Med. | pmid:12416943 |
Kubo JI et al. | Pharmacokinetic evaluation of high pulmonary disposition of clarithromycin after systemic administration. | 2002 | Xenobiotica | pmid:12419017 |
Garza-González E et al. | Antibiotic susceptibility patterns of Helicobacter pylori strains isolated from northeastern Mexico. | 2002 | J Chemother | pmid:12420850 |
Skerk V et al. | Comparative analysis of azithromycin and clarithromycin efficacy and tolerability in the treatment of chronic prostatitis caused by Chlamydia trachomatis. | 2002 | J Chemother | pmid:12420857 |
Ciftçi E et al. | Investigation of risk factors for tonsillopharyngitis with macrolide resistant Streptococcus pyogenes in Turkish children. | 2002 | Pediatr Int | pmid:12421263 |
Bago J et al. | The impact of primary antibiotic resistance on the efficacy of ranitidine bismuth citrate- vs. omeprazole-based one-week triple therapies in H. pylori eradication--a randomised controlled trial. | 2002 | Wien. Klin. Wochenschr. | pmid:12422579 |
Jacks S et al. | Disposition of oral clarithromycin in foals. | 2002 | J. Vet. Pharmacol. Ther. | pmid:12423226 |
Hirayama F et al. | Long-term effects of Helicobacter pylori eradication in Mongolian gerbils. | 2002 | J. Gastroenterol. | pmid:12424560 |
Cremonini F et al. | Effect of different probiotic preparations on anti-helicobacter pylori therapy-related side effects: a parallel group, triple blind, placebo-controlled study. | 2002 | Am. J. Gastroenterol. | pmid:12425542 |
Domingo D et al. | [Microbiological factors that influence the eradication of Helicobacter pylori in adults and children]. | 2002 | Enferm. Infecc. Microbiol. Clin. | pmid:12425876 |
Lõivukene K et al. | Prevalence of antibiotic resistance of Helicobacter pylori isolates in Estonia during 1995-2000 in comparison to the consumption of antibiotics used in treatment regimens. | 2002 | Clin. Microbiol. Infect. | pmid:12427220 |
Pastor E et al. | [Macrolide consumption according to geographic areas in the province of Valladolid]. | 2002 | Enferm. Infecc. Microbiol. Clin. | pmid:12433351 |
Fontana C et al. | New site of modification of 23S rRNA associated with clarithromycin resistance of Helicobacter pylori clinical isolates. | 2002 | Antimicrob. Agents Chemother. | pmid:12435674 |
Noreddin AM et al. | Pharmacodynamic modeling of clarithromycin against macrolide-resistant [PCR-positive mef(A) or erm(B)] Streptococcus pneumoniae simulating clinically achievable serum and epithelial lining fluid free-drug concentrations. | 2002 | Antimicrob. Agents Chemother. | pmid:12435719 |
Mantzaris GJ et al. | Omeprazole triple therapy versus omeprazole quadruple therapy for healing duodenal ulcer and eradication of Helicobacter pylori infection: a 24-month follow-up study. | 2002 | Eur J Gastroenterol Hepatol | pmid:12439119 |
Go MF | Treatment and management of Helicobacter pylori infection. | 2002 | Curr Gastroenterol Rep | pmid:12441037 |
Ibrahim RB et al. | Tacrolimus-clarithromycin interaction in a patient receiving bone marrow transplantation. | 2002 | Ann Pharmacother | pmid:12452763 |
Feydt-Schmidt A et al. | Fluorescence in situ hybridization vs. epsilometer test for detection of clarithromycin-susceptible and clarithromycin-resistant Helicobacter pylori strains in gastric biopsies from children. | 2002 | Aliment. Pharmacol. Ther. | pmid:12452940 |
Ruiz A et al. | [Community-acquired pneumonia: usefulness of clinical presentation in the selection of antibiotic treatment]. | 2002 | Med Clin (Barc) | pmid:12453372 |
Katelaris PH et al. | A randomized comparison of quadruple and triple therapies for Helicobacter pylori eradication: The QUADRATE Study. | 2002 | Gastroenterology | pmid:12454831 |
Matysiak-Budnik T et al. | In vitro transfer of clarithromycin and amoxicillin across the epithelial barrier: effect of Helicobacter pylori. | 2002 | J. Antimicrob. Chemother. | pmid:12461005 |
Ahrén IL et al. | Comparison of the antibacterial activities of ampicillin, ciprofloxacin, clarithromycin, telithromycin and quinupristin/dalfopristin against intracellular non-typeable Haemophilus influenzae. | 2002 | J. Antimicrob. Chemother. | pmid:12461011 |
Tsukada K et al. | Seven-day triple therapy with omeprazole, amoxycillin and clarithromycin for Helicobacter pylori infection in haemodialysis patients. | 2002 | Scand. J. Gastroenterol. | pmid:12465723 |
Kuran G et al. | [The efficacy of combined medical treatment (antihistaminics, steroids, and macrolide antibiotics) in patients with nasal polyposis: preliminary results]. | 2002 Sep-Oct | Kulak Burun Bogaz Ihtis Derg | pmid:12471282 |
Jones ME et al. | The activity of levofloxacin and comparator agents against clinical isolates of Streptococcus pneumoniae collected worldwide during 1999 and 2000. | 2002 | Chemotherapy | pmid:12476039 |
Hauke W et al. | Esberitox N as supportive therapy when providing standard antibiotic treatment in subjects with a severe bacterial infection (acute exacerbation of chronic bronchitis). A multicentric, prospective, double-blind, placebo-controlled study. | 2002 | Chemotherapy | pmid:12476043 |
Catalano F et al. | Eradication therapy with rabeprazole versus omeprazole in the treatment of active duodenal ulcer. | 2002 | Digestion | pmid:12481161 |
Wibawa JI et al. | Quantification of clarithromycin, its 14-hydroxy and decladinose metabolites in rat plasma, gastric juice and gastric tissue using high-performance liquid chromatography with electrochemical detection. | 2003 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:12482478 |
Kim JI et al. | The effects of nocturnal acid breakthrough on Helicobacter pylori eradication. | 2002 | Helicobacter | pmid:12485118 |
Felley CP et al. | Oxidative stress in gastric mucosa of asymptomatic humans infected with Helicobacter pylori: effect of bacterial eradication. | 2002 | Helicobacter | pmid:12485120 |
Rai R and Rai S | Pseudomembranous colitis requiring surgical intervention following triple therapy for Helicobacter pylori eradication. | 2002 | ANZ J Surg | pmid:12485235 |
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Broutet N et al. | Risk factors for failure of Helicobacter pylori therapy--results of an individual data analysis of 2751 patients. | 2003 | Aliment. Pharmacol. Ther. | pmid:12492738 |
Higuchi K et al. | Is eradication sufficient to heal gastric ulcers in patients infected with Helicobacter pylori? A randomized, controlled, prospective study. | 2003 | Aliment. Pharmacol. Ther. | pmid:12492739 |
Murakami K et al. | Efficacy of triple therapy comprising rabeprazole, amoxicillin and metronidazole for second-line Helicobacter pylori eradication in Japan, and the influence of metronidazole resistance. | 2003 | Aliment. Pharmacol. Ther. | pmid:12492740 |
Coelho LG et al. | Once-daily, low-cost, highly effective Helicobacter pylori treatment to family members of gastric cancer patients. | 2003 | Aliment. Pharmacol. Ther. | pmid:12492742 |
Sauermann R et al. | Phenotypes of macrolide resistance of group A streptococci isolated from outpatients in Bavaria and susceptibility to 16 antibiotics. | 2003 | J. Antimicrob. Chemother. | pmid:12493787 |
Debets-Ossenkopp YJ et al. | Characteristics of clinical Helicobacter pylori strains from Ecuador. | 2003 | J. Antimicrob. Chemother. | pmid:12493799 |
Dantas da Silva LL et al. | Antibacterial activity of a stearic acid derivative from Stemodia foliosa. | 2002 | Planta Med. | pmid:12494347 |
Thong-Ngam D et al. | Effectiveness of ranitidine bismuth citrate based triple therapy for treating Helicobacter pylori. | 2002 | J Med Assoc Thai | pmid:12501895 |
Vasil'ev IuV | [Pharmacoeconomic aspects of the 1-week eradication treatment of duodenal ulcer associated with Helicobacter pylori]. | 2002 | Eksp Klin Gastroenterol | pmid:12503280 |
Tietz A et al. | Fulminant liver failure associated with clarithromycin. | 2003 | Ann Pharmacother | pmid:12503933 |
Dauendorffer JN et al. | In vitro sensitivity of Mycobacterium xenopi to five antibiotics. | 2002 | Pathol. Biol. | pmid:12504367 |
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Parkash P et al. | Phototoxic reaction due to clarithromycin. | 2002 | J Assoc Physicians India | pmid:12516710 |
Oleastro M et al. | Real-time PCR assay for rapid and accurate detection of point mutations conferring resistance to clarithromycin in Helicobacter pylori. | 2003 | J. Clin. Microbiol. | pmid:12517879 |
Alarcón T et al. | Clarithromycin resistance among Helicobacter pylori strains isolated from children: prevalence and study of mechanism of resistance by PCR-restriction fragment length polymorphism analysis. | 2003 | J. Clin. Microbiol. | pmid:12517902 |
Malekzadeh R et al. | Low Helicobacter pylori eradication rates with 4- and 7-day regimens in an Iranian population. | 2003 | J. Gastroenterol. Hepatol. | pmid:12519218 |
Farup PG et al. | Comparison of three triple regimens with omeprazole or ranitidine bismuth citrate for Helicobacter pylori eradication. | 2002 | Scand. J. Gastroenterol. | pmid:12523585 |
Salem II and Düzgünes N | Efficacies of cyclodextrin-complexed and liposome-encapsulated clarithromycin against Mycobacterium avium complex infection in human macrophages. | 2003 | Int J Pharm | pmid:12527166 |
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Stratton CW | Dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistance. | 2003 | Emerging Infect. Dis. | pmid:12533275 |
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Baumgartner JC and Xia T | Antibiotic susceptibility of bacteria associated with endodontic abscesses. | 2003 | J Endod | pmid:12540219 |
Meyer JM and Hopkins RJ | Helicobacter pylori. | 2003 | N. Engl. J. Med. | pmid:12540657 |
Chaudhuri S et al. | Anti-Helicobacter pylori therapy in India: differences in eradication efficiency associated with particular alleles of vacuolating cytotoxin (vacA) gene. | 2003 | J. Gastroenterol. Hepatol. | pmid:12542605 |
Rosales CM et al. | AIDS presenting with cutaneous Kaposi's sarcoma and bacillary angiomatosis in the bone marrow mimicking Kaposi's sarcoma. | 2002 | AIDS Patient Care STDS | pmid:12542930 |
Samra Z et al. | In vitro susceptibility of Mycoplasma hominis clinical isolates to tetracyclines, quinolones and macrolides. | 2002 | Diagn. Microbiol. Infect. Dis. | pmid:12543541 |
Hoffman HL et al. | Influence of macrolide susceptibility on efficacies of clarithromycin and azithromycin against Streptococcus pneumoniae in a murine lung infection model. | 2003 | Antimicrob. Agents Chemother. | pmid:12543686 |
Miki I et al. | Impact of clarithromycin resistance and CYP2C19 genetic polymorphism on treatment efficacy of Helicobacter pylori infection with lansoprazole- or rabeprazole-based triple therapy in Japan. | 2003 | Eur J Gastroenterol Hepatol | pmid:12544691 |
Knuf M et al. | [Lymphadenitis colli due to non-tuberculous mycobacteria (NTM): a case-series and review of the literature]. | 2003 Jan-Feb | Klin Padiatr | pmid:12545419 |
Torres-Rojas JR et al. | Short course of clarithromycin in an immunocompetent patient with BCG-induced regional complications. | 2002 | Dermatol. Online J. | pmid:12546761 |
Henderson SM et al. | Opportunistic mycobacterial granuloma in a cat associated with a member of the Mycobacterium terrae complex. | 2003 | J. Feline Med. Surg. | pmid:12547621 |
Chang HY et al. | Knowledge, attitudes, and practice styles of North American pediatric gastroenterologists: Helicobacter pylori infection. | 2003 | J. Pediatr. Gastroenterol. Nutr. | pmid:12548060 |
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