clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Schmidt BJ and Hermansen MN | [Late debut of neonatal pneumonia caused by Chlamydia trachomatis]. | 2013 | Ugeskr. Laeg. | pmid:23428270 |
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| Buch T and Andersen SE | [Combination therapy with fluconazole and other QTc-prolonging drugs increase the QTc interval]. | 2015 | Ugeskr. Laeg. | pmid:26471025 |
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| Tezer H et al. | Mycoplasma pneumoniae-associated transverse myelitis with unexpected rapid response to macrolide therapy: a case report. | 2008 Nov-Dec | Turk. J. Pediatr. | pmid:19227425 |
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| Sezgin O et al. | Detection of point mutations on 23S rRNA of Helicobacter pylori and resistance to clarithromycin with PCR-RFLP in gastric biopsy specimens in Mersin, Turkey. | 2008 | Turk J Gastroenterol | pmid:19115151 |
| Tümgör G et al. | Comparison of standard and standard plus vitamin E therapy for Helicobacter pylori eradications in children. | 2014 | Turk J Gastroenterol | pmid:25910378 |
| Çiftci İH et al. | Comparison of FISH, RFLP and agar dilution methods for testing clarithromycin resistance of Helicobacter pylori. | 2014 | Turk J Gastroenterol | pmid:25910373 |
| Oztürk K et al. | Diagnosis of helicobacter pylori infection. | 2014 | Turk J Gastroenterol | pmid:25141328 |
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| Zhen-Hua Z et al. | Characterization of 23S rRNA gene mutation in primary and secondary clarithromycin-resistant Helicobacter pylori strains from East China. | 2013 | Turk J Gastroenterol | pmid:23794337 |
| Baysal B et al. | Effect of pantoprazole and Helicobacter pylori therapy on uninvestigated dyspeptic patients. | 2015 | Turk J Gastroenterol | pmid:25698264 |
| Uygun A et al. | Recent success of pantoprazole -or lansoprazole- based clarithromycin plus amoxicillin treatment in the eradication of Helicobacter pylori. | 2004 | Turk J Gastroenterol | pmid:16249974 |
| Yakut M et al. | Sequential therapy for Helicobacter pylori eradication. | 2010 | Turk J Gastroenterol | pmid:20931421 |
| Güliter S et al. | Can lansoprazole, amoxicillin, and clarithromycin combination still be used as a first-line therapy for eradication of helicobacter pylori? | 2005 | Turk J Gastroenterol | pmid:16252185 |
| Cinar K et al. | The effect of Helicobacter pylori eradication in patients with functional dyspepsia: assessment of different diagnostic tests. | 2004 | Turk J Gastroenterol | pmid:15492914 |
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| AladaÄŸ M et al. | Comparison of pantoprazole- vs. omeprazole- based triple therapy regimens in the treatment of Helicobacter pylori infection and duodenal ulcer healing in a Turkish population. | 2005 | Turk J Gastroenterol | pmid:16547858 |
| Sarkeshikian SS et al. | Azithromycin based triple therapy versus standard clarithromycin based triple therapy in eradication of Helicobacter pylori infection in Iran: a randomized controlled clinical trial. | 2013 | Turk J Gastroenterol | pmid:23794338 |
| Sezgin O et al. | Bismuth-based therapies for the first step eradication of Helicobacter pylori. | 2006 | Turk J Gastroenterol | pmid:16830288 |
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| Loghmari H et al. | Clarithromycin versus metronidazole in first-line Helicobacter pylori eradication. Prospective randomized study of 85 Tunisian adults. | 2012 | Tunis Med | pmid:22311445 |
| Miyamoto S et al. | Analysis of Helicobacter pylori genotypes in clinical gastric wash samples. | 2016 | Tumour Biol. | pmid:26825980 |
| Oikawa R et al. | Enrichment of Helicobacter pylori mutant strains after eradication therapy analyzed by gastric wash-based quantitative pyrosequencing. | 2017 | Tumour Biol. | pmid:28990461 |
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| Falkinham JO et al. | Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria. | 2012 | Tuberculosis (Edinb) | pmid:22209468 |
| Clarithromycin. | 2008 | Tuberculosis (Edinb) | pmid:18486039 | |
| Howard ST | Recent progress towards understanding genetic variation in the Mycobacterium abscessus complex. | 2013 | Tuberculosis (Edinb) | pmid:24388643 |
| Jamal MA et al. | Molecular basis of clarithromycin-resistance in Mycobacterium avium intracellulare complex. | 2000 | Tuber. Lung Dis. | pmid:10897378 |
| Lazard T et al. | Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages. | 1994 | Tuber. Lung Dis. | pmid:7949074 |
| Sanchez T et al. | Quantitation of mycobacteria in blood specimens from patients with AIDS. | 1994 | Tuber. Lung Dis. | pmid:7841433 |
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