clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with clarithromycin
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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de Jong J et al. | Antibiotic usage, dosage and course length in children between 0 and 4 years. | 2009 | Acta Paediatr. | pmid:19397542 |
Hurduc V et al. | A randomized, open trial evaluating the effect of Saccharomyces boulardii on the eradication rate of Helicobacter pylori infection in children. | 2009 | Acta Paediatr. | pmid:18681892 |
Hu YY et al. | Antimicrobial susceptibility of Haemophilus influenzae among children in Beijing, China, 1999-2000. | 2002 | Acta Paediatr. | pmid:11951998 |
Forslöw U et al. | Early chemotherapy for non-tuberculous mycobacterial infections in patients with cystic fibrosis. | 2003 | Acta Paediatr. | pmid:12948065 |
Germanakis I et al. | Clarithromycin treatment and QT prolongation in childhood. | 2006 | Acta Paediatr. | pmid:17129988 |
König C et al. | Legionella waltersii--a novel cause of pneumonia? | 2005 | Acta Paediatr. | pmid:16299887 |
Luo X et al. | Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism. | 2009 | Acta Pharmacol. Sin. | pmid:19701237 |
Cao S et al. | Pharmacokinetic interactions between ilaprazole and clarithromycin following ilaprazole, clarithromycin and amoxicillin triple therapy. | 2012 | Acta Pharmacol. Sin. | pmid:22820908 |
Qiao AM et al. | Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in human cervical cancer HeLa cell. | 2006 | Acta Pharmacol. Sin. | pmid:17112418 |
Zhang L et al. | P-glycoprotein restricted transport of nimodipine across blood-brain barrier. | 2003 | Acta Pharmacol. Sin. | pmid:12956939 |
UÄŸurlu T et al. | Optimization and evaluation of clarithromycin floating tablets using experimental mixture design. | 2014 Mar-Apr | Acta Pol Pharm | pmid:25272652 |
Ozkan Y et al. | Clarithromycin targeting to lung: optimization of the size, morphology and release characteristics of albumin microspheres. | 2000 Sep-Oct | Acta Pol Pharm | pmid:11126029 |
Patel SS et al. | Formualtion and evaluation of floating drug delivery system containing clarithromycin for Helicobacter pylori. | 2006 Jan-Feb | Acta Pol Pharm | pmid:17515330 |
Baranowski WJ | Clarithromycin-induced hypomania in a child - a case report. | 2010 | Acta Psychiatr Scand | pmid:20491717 |
Cameselle D et al. | [Sporotrichoid cutaneous infection by Mycobacterium haemophilum in an AIDS patient]. | 2007 | Actas Dermosifiliogr | pmid:17504704 |
Gutiérrez-de la Peña J et al. | [Three cases of panniculitis due to Mycobacterium abscessus after mesotherapy]. | 2010 | Actas Dermosifiliogr | pmid:20223169 |
Iwańczak BM et al. | Assessment of Sequential and Standard Triple Therapy in Treatment of Helicobacter pylori Infection in Children Dependent on Bacteria Sensitivity to Antibiotics. | Adv Clin Exp Med | pmid:27629844 | |
Gościniak G et al. | Frequency of infection with Helicobacter pylori isolates of different antimicrobial profiles in children and adolescents: A preliminary study. | Adv Clin Exp Med | pmid:28791844 | |
Radzikowska E et al. | Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia. | Adv Clin Exp Med | pmid:28028949 | |
Tuchman SA et al. | Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma. | 2012 | Adv Hematol | pmid:22690220 |