| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
clarithromycin
clarithromycin is a lipid of Polyketides (PK) class. Clarithromycin is associated with abnormalities such as Helicobacter Pylori Infection, Infection, Coinfection, Gastritis and Peptic Ulcer. The involved functions are known as Point Mutation, Increased Sensitivy, Bacterial resistance, urease activity and Mutation. Clarithromycin often locates in Blood, Gastric mucosa, Biopsy sample, Respiratory System and Entire gastrointestinal tract. The associated genes with clarithromycin are Genes, rRNA, rRNA Operon, Genome, HM13 gene and GDF15 gene. The related lipids are 9,11-linoleic acid, Steroids, Lysophosphatidylcholines, Lipopolysaccharides and 4-hydroxycholesterol. The related experimental models are Mouse Model, Knock-out and Experimental Pneumococcal Meningitis.
Cross Reference
Introduction
To understand associated biological information of clarithromycin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with clarithromycin?
clarithromycin is suspected in Infection, Helicobacter Pylori Infection, Pneumonia, Respiratory Tract Infections, PARKINSON DISEASE, LATE-ONSET, Community acquired pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Antimicrob. Agents Chemother. (63)
- J. Antimicrob. Chemother. (56)
- J. Clin. Microbiol. (39)
- Others (258)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with clarithromycin
PubChem Associated disorders and diseases
What pathways are associated with clarithromycin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with clarithromycin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
- J. Antimicrob. Chemother. (25)
- Antimicrob. Agents Chemother. (20)
- J. Clin. Microbiol. (9)
- Others (66)
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with clarithromycin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with clarithromycin?
Related references are published most in these journals:
- Antimicrob. Agents Chemother. (5)
- Drug Metab. Dispos. (1)
- FEMS Immunol. Med. Microbiol. (1)
- Others (5)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with clarithromycin?
Related references are published most in these journals:
- J. Antimicrob. Chemother. (20)
- Antimicrob. Agents Chemother. (17)
- J. Clin. Microbiol. (13)
- Others (57)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with clarithromycin?
Mouse Model
Mouse Model are used in the study 'Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone.' (Hirao S et al., 2011), Mouse Model are used in the study 'Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers.' (Hafner R et al., 1998), Mouse Model are used in the study 'Clarithromycin attenuates mastectomy-induced acute inflammatory response.' (Chow LW et al., 2000) and Mouse Model are used in the study 'In vitro and in vivo influence of adjunct clarithromycin on the treatment of mucoid Pseudomonas aeruginosa.' (Bui KQ et al., 2000).
Knock-out
Knock-out are used in the study 'Intrinsic macrolide resistance in Mycobacterium smegmatis is conferred by a novel erm gene, erm(38).' (Nash KA, 2003).
Experimental Pneumococcal Meningitis
Experimental Pneumococcal Meningitis are used in the study 'Failure of treatment for chronic Mycobacterium abscessus meningitis despite adequate clarithromycin levels in cerebrospinal fluid.' (Maniu CV et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with clarithromycin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Çekin AH et al. | Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance. | 2017 | Turk J Gastroenterol | pmid:28007678 |
| Yamamoto S et al. | Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production. | 2017 | Biochem. Biophys. Res. Commun. | pmid:27998764 |
| Panozzo C et al. | Chemicals or mutations that target mitochondrial translation can rescue the respiratory deficiency of yeast bcs1 mutants. | 2017 | Biochim. Biophys. Acta | pmid:28888990 |
| Santos MA et al. | Nothing to (S)cough at: Pulmonary Mycobacterium avium Complex Infection. | 2017 | Am. J. Med. | pmid:27984010 |
| Smibert OC et al. | Short Communication: Mycobacterium avium Complex Infection and Immune Reconstitution Inflammatory Syndrome Remain a Challenge in the Era of Effective Antiretroviral Therapy. | 2017 | AIDS Res. Hum. Retroviruses | pmid:28791872 |
| Hiroi S et al. | Impact of health insurance coverage for gastritis on the trends in eradication therapy in Japan: retrospective observational study and simulation study based on real-world data. | 2017 | BMJ Open | pmid:28760790 |
| Jenkins H et al. | Effect of Multiple Oral Doses of the Potent CYP3A4 Inhibitor Clarithromycin on the Pharmacokinetics of a Single Oral Dose of Vonoprazan: A Phase I, Open-Label, Sequential Design Study. | 2017 | Clin Drug Investig | pmid:27928738 |
| Takemoto Y et al. | Disseminated Mycobacterium scrofulaceum Infection in an Immunocompetent Host. | 2017 | Intern. Med. | pmid:28717096 |
| Alba C et al. | Antibiotic resistance in Helicobacter pylori. | 2017 | Curr. Opin. Infect. Dis. | pmid:28704226 |
| Mishima E et al. | Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic CYP3A4 Inhibition by Clarithromycin Plus Voriconazole. | 2017 | Intern. Med. | pmid:28674358 |
| Shimoyama T et al. | Randomized Trial Comparing Esomeprazole and Rabeprazole in First-line Eradication Therapy for Helicobacter pylori Infection based on the Serum Levels of Pepsinogens. | 2017 | Intern. Med. | pmid:28674348 |
| Stieler Stewart AL et al. | Effects of clarithromycin, azithromycin and rifampicin on terbutaline-induced sweating in foals. | 2017 | Equine Vet. J. | pmid:28238211 |
| Bichler EK et al. | Clarithromycin increases neuronal excitability in CA3 pyramidal neurons through a reduction in GABAergic signaling. | 2017 | J. Neurophysiol. | pmid:27733592 |
| Tsugawa K et al. | Clarithromycin attenuates the expression of monocyte chemoattractant protein-1 by activating toll-like receptor 4 in human mesangial cells. | 2017 | Clin. Exp. Nephrol. | pmid:27614743 |
| Okuda M et al. | Nationwide survey of Helicobacter pylori treatment for children and adolescents in Japan. | 2017 | Pediatr Int | pmid:27223686 |
| Bewick J et al. | The value of a feasibility study into long-term macrolide therapy in chronic rhinosinusitis. | 2017 | Clin Otolaryngol | pmid:27223120 |
| Abadi ATB | Resistance to clarithromycin and gastroenterologist's persistence roles in nomination for Helicobacter pylori as high priority pathogen by World Health Organization. | 2017 | World J. Gastroenterol. | pmid:29085187 |
| Pastukh N et al. | GenoType® HelicoDR test in comparison with histology and culture for Helicobacter pylori detection and identification of resistance mutations to clarithromycin and fluoroquinolones. | 2017 | Helicobacter | pmid:29058343 |
| Tognetti L et al. | Bullous impetigo during interstitial pneumonitis. | 2017 | G Ital Dermatol Venereol | pmid:29050448 |
| Manniello MD et al. | Clarithromycin and N-acetylcysteine co-spray-dried powders for pulmonary drug delivery: A focus on drug solubility. | 2017 | Int J Pharm | pmid:28377314 |
| Van der Paardt AL et al. | Safety and tolerability of clarithromycin in the treatment of multidrug-resistant tuberculosis. | 2017 | Eur. Respir. J. | pmid:28331034 |
| Souto Filho JTD et al. | Long-term complete remission of primary gastric plasmacytoma following endoscopic resection. | 2017 | Ann. Hematol. | pmid:28315923 |
| Antonakos N et al. | Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome. | 2017 | Crit Care | pmid:28274246 |
| Chew KL et al. | Predominance of clarithromycin-susceptible Mycobacterium massiliense subspecies: Characterization of the Mycobacterium abscessus complex at a tertiary acute care hospital. | 2017 | J. Med. Microbiol. | pmid:28874233 |
| Miura S et al. | [Effective BiRd Therapy after the Addition of Clarithromycin for Lenalidomide and Dexamethasone Resistant Multiple Myeloma Ineligible for Stem Cell Transplantation]. | 2017 | Gan To Kagaku Ryoho | pmid:28860442 |
| McCallum GB et al. | Antibiotics for persistent cough or wheeze following acute bronchiolitis in children. | 2017 | Cochrane Database Syst Rev | pmid:28828759 |
| de Ãvila BE et al. | Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. | 2017 | Nat Commun | pmid:28814725 |
| Zhang D et al. | Berberine containing quadruple therapy for initial Helicobacter pylori eradication: An open-label randomized phase IV trial. | 2017 | Medicine (Baltimore) | pmid:28796053 |
| Fraser AG | Editorial: replacing standard proton pump inhibitors with vonoprazan may breathe new life into triple therapy for Helicobacter pylori. | 2017 | Aliment. Pharmacol. Ther. | pmid:28776748 |
| Kadota JI et al. | The clinical efficacy of a clarithromycin-based regimen for Mycobacterium avium complex disease: A nationwide post-marketing study. | 2017 | J. Infect. Chemother. | pmid:28254517 |
| Ufuk A et al. | In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages. | 2017 | Mol. Pharm. | pmid:28252969 |
| Iwayama K et al. | Long-term treatment of clarithromycin at a low concentration improves hydrogen peroxide-induced oxidant/antioxidant imbalance in human small airway epithelial cells by increasing Nrf2 mRNA expression. | 2017 | BMC Pharmacol Toxicol | pmid:28235416 |
| Komiya K et al. | Clarithromycin attenuates IL-13-induced periostin production in human lung fibroblasts. | 2017 | Respir. Res. | pmid:28219384 |
| Sakurai K et al. | Comparative study: Vonoprazan and proton pump inhibitors in eradication therapy. | 2017 | World J. Gastroenterol. | pmid:28216974 |
| Awan S et al. | Is clarithromycin a potential treatment for cachexia in people with lung cancer? A feasibility study. | 2017 | Lung Cancer | pmid:28213005 |
| Quinn KL et al. | Macrolides, Digoxin Toxicity and the Risk of Sudden Death: A Population-Based Study. | 2017 | Drug Saf | pmid:28421551 |
| Huang CC et al. | In vitro activity of aminoglycosides, clofazimine, d-cycloserine and dapsone against 83 Mycobacterium avium complex clinical isolates. | 2018 | J Microbiol Immunol Infect | pmid:28705770 |
| Kelly C et al. | Macrolide antibiotics for bronchiectasis. | 2018 | Cochrane Database Syst Rev | pmid:29543980 |
| Yeo YH et al. | First-line eradication therapies in countries with high and low clarithromycin resistance: a systematic review and network meta-analysis. | 2018 | Gut | pmid:27670375 |
| Suzuki R et al. | Sinobronchial syndrome treated as intractable asthma. | 2018 | Pediatr Int | pmid:30320426 |
| Mégraud F | Antibiotic Resistance Is the Key Element in Treatment of Helicobacter pylori Infection. | 2018 | Gastroenterology | pmid:30308190 |
| Mieras LF et al. | An enhanced regimen as post-exposure chemoprophylaxis for leprosy: PEP+. | 2018 | BMC Infect. Dis. | pmid:30290790 |
| Liou JM et al. | Toward population specific and personalized treatment of Helicobacter pylori infection. | 2018 | J. Biomed. Sci. | pmid:30285834 |
| Liu HY et al. | Bilateral Non-tuberculous Mycobacterial Keratitis After Small Incision Lenticule Extraction. | 2018 | J Refract Surg | pmid:30199569 |
| Kabakambira JD et al. | Efficacy of Helicobacter pylori eradication regimens in Rwanda: a randomized controlled trial. | 2018 | BMC Gastroenterol | pmid:30165823 |
| Yotsu RR et al. | Drugs for treating Buruli ulcer (Mycobacterium ulcerans disease). | 2018 | Cochrane Database Syst Rev | pmid:30136733 |
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| Park CG et al. | Clinical relevance of point mutations in the 23S rRNA gene in Helicobacter pylori eradication: A prospective, observational study. | 2018 | Medicine (Baltimore) | pmid:30113472 |
| Morgene MF et al. | HaCaT epithelial cells as an innovative novel model of rhinovirus infection and impact of clarithromycin treatment on infection kinetics. | 2018 | Virology | pmid:30077071 |
| Shinozaki S et al. | Pre-treatment with proton pump inhibitors decreases the success of primary Helicobacter pylori eradication using a vonoprazan-based regimen. | 2018 | Kaohsiung J. Med. Sci. | pmid:30041763 |
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| Heffernan CB et al. | Does Clarithromycin Cause Hearing Loss? A 12-Year Review of Clarithromycin Therapy for Nontuberculous Mycobacterial Lymphadenitis in Children. | 2018 | Ann. Otol. Rhinol. Laryngol. | pmid:30032669 |
| Abu-Khalaf N et al. | The Taste of Commercially Available Clarithromycin Oral Pharmaceutical Suspensions in the Palestinian Market: Electronic Tongue and In Vivo Evaluation. | 2018 | Sensors (Basel) | pmid:29401675 |
| Jin BH et al. | Pharmacokinetic drug interaction and safety after coadministration of clarithromycin, amoxicillin, and ilaprazole: a randomised, open-label, one-way crossover, two parallel sequences study. | 2018 | Eur. J. Clin. Pharmacol. | pmid:29846770 |
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| Chai KY et al. | Roxithromycin monotherapy inducing a partial response in a patient with myeloma: a case report. | 2018 | J Med Case Rep | pmid:29743095 |
| Strouvalis I et al. | Early increase of VEGF-A is associated with resolution of ventilator-associated pneumonia: Clinical and experimental evidence. | 2018 | Respirology | pmid:29741298 |
| Long X et al. | Bismuth improves efficacy of proton-pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance. | 2018 | Helicobacter | pmid:29696736 |
| Fiorini G et al. | Antibiotic resistance pattern of Helicobacter pylori strains isolated in Italy during 2010-2016. | 2018 | Scand. J. Gastroenterol. | pmid:29688095 |
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| Berende A et al. | Cost-effectiveness of longer-term versus shorter-term provision of antibiotics in patients with persistent symptoms attributed to Lyme disease. | 2018 | PLoS ONE | pmid:29608590 |
| Mabe K et al. | Randomized controlled trial: PPI-based triple therapy containing metronidazole versus clarithromycin as first-line treatment for Helicobacter pylori in adolescents and young adults in Japan. | 2018 | J. Infect. Chemother. | pmid:29605555 |
| Chen SA et al. | HLA-A*02:07 Allele Associates with Clarithromycin-Induced Cutaneous Adverse Drug Reactions in Chinese Patients. | 2018 | Basic Clin. Pharmacol. Toxicol. | pmid:29575644 |
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| Takahashi E et al. | Clarithromycin suppresses induction of monocyte chemoattractant protein-1 and matrix metalloproteinase-9 and improves pathological changes in the lungs and heart of mice infected with influenza A virus. | 2018 | Comp. Immunol. Microbiol. Infect. Dis. | pmid:29406285 |
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| Nakase K et al. | Long-term administration of oral macrolides for acne treatment increases macrolide-resistant Propionibacterium acnes. | 2018 | J. Dermatol. | pmid:29235673 |
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| Beer-Davidson G et al. | Detection of Helicobacter pylori in stool samples of young children using real-time polymerase chain reaction. | 2018 | Helicobacter | pmid:29181860 |
| Muñoz-Gómez P et al. | Macrolide use in the previous years is associated with failure to eradicate Helicobacter pylori with clarithromycin-containing regimens. | 2018 | Helicobacter | pmid:29178562 |
| Haj Yahia S et al. | Colchicine intoxication in familial Mediterranean fever patients using clarithromycin for the treatment of Helicobacter pylori: a series of six patients. | 2018 | Rheumatol. Int. | pmid:28975396 |
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| Popovic V et al. | Mycobacterium shimoidei-cavitary pulmonary disease with favorable outcome. | 2018 | Folia Microbiol. (Praha) | pmid:28913757 |
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| Hosono Y et al. | The association between erythromycin monotherapy for Mycobacterium avium complex lung disease and cross-resistance to clarithromycin: A retrospective case-series study. | 2018 | J. Infect. Chemother. | pmid:29361415 |
| Alenezi A et al. | Controlled release of clarithromycin from PLGA microspheres enhances bone regeneration in rabbit calvaria defects. | 2018 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:28067984 |
| Choi IJ et al. | Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer. | 2018 | N. Engl. J. Med. | pmid:29562147 |
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